Abstract:
:Endothelium-derived nitric oxide (NO) plays a key role in the regulation of vascular tone in health and disease. The present study addresses the contribution of NO to the baseline vascular tone in the fetal placental circulation of type 1 diabetic women. To this end, we performed ex-vivo dual perfusions of isolated cotyledons from seven women with type 1 diabetes mellitus and 24 healthy women. The fetal arterial pressure was considered to be a measure of fetal vascular resistance. The contribution of NO to the baseline vascular tone of the fetal placental circulation was quantified by addition of the NO-synthase inhibitor N(G)-nitro-arginine-methylester (L-NAME). Apart from the diabetic state, we studied the influence of exogenous insulin on the response to L-NAME. Mean (+/-SEM) baseline fetal arterial pressure was higher in diabetes (25.7+/-3.4 mm Hg vs 18.0+/-1.7 mm Hg, P<0.05). Maximum perfusion pressure after L-NAME was 87.9+/-7.1 mm Hg in diabetes vs 58.9+/-4.5 mm Hg in controls (P<0.01). The net L-NAME-induced increase in fetal arterial pressure was higher in diabetes (62.2+/-9.1 mm Hg vs 40.9+/-3.5 mm Hg, P<0.05). Although insulin induced a shift to the left of the L-NAME-curve, the net L-NAME-induced increase in fetal arterial pressure was not affected. We conclude that diabetes is associated with an increased baseline vascular tone of the fetal placental vascular bed. This can not be explained by attenuated NO-mediated effects. In contrast, the activity of the NO-pathway seems to be increased in diabetes. The latter observation seems not to be caused by high insulin levels.
journal_name
Placentajournal_title
Placentaauthors
Bisseling TM,Wouterse AC,Steegers EA,Elving L,Russel FG,Smits Pdoi
10.1016/s0143-4004(03)00171-1keywords:
subject
Has Abstractpub_date
2003-11-01 00:00:00pages
974-8issue
10eissn
0143-4004issn
1532-3102pii
S0143400403001711journal_volume
24pub_type
杂志文章相关文献
PLACENTA文献大全abstract::In the present study the possible role of decidual cells in the pregnancy-associated increased sensitivity of glomerular ecto-ADP-ase to endotoxin was investigated. Early (day 5) pregnant (E-Pr; n = 10), pseudopregnant (E-PSP; n = 10), (day 5), pseudopregnant rats with a decidualized uterus (E-DEC; n - 10), as well as...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(96)80013-0
更新日期:1996-03-01 00:00:00
abstract::The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1998.0366
更新日期:1999-03-01 00:00:00
abstract:INTRODUCTION:Gestational diabetes mellitus (GDM) is an increasing harm in pregnancy. Inflammatory processes in the placenta seem to have an influence on pathogenesis besides known factors like maternal BMI. Galectin-13 (gal-13) is an immunoregulatory protein, which is suspected to play a role in development of GDM in t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.11.019
更新日期:2015-02-01 00:00:00
abstract::In the present study, we characterized the expression of lymphocyte antigen 6, locus E (Ly6e) in mouse placental trophoblast. We identified Ly6e mRNA expression in trophoblast stem (TS) cells by a gene expression screen. In vivo, Ly6e was first detectable by mRNA in situ hybridization in the chorion beginning at E8.5 ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.05.011
更新日期:2013-09-01 00:00:00
abstract::The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2016.11.008
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:Miscarriage is the most common placental-related complication of pregnancy. It has been extensively investigated to discover the underlying mechanism(s) by which miscarriage occurs, but in many cases the etiology still remains unclear. The aim of this study was to analyze genome-wide expression profiles of...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.12.003
更新日期:2013-02-01 00:00:00
abstract:INTRODUCTION:Transfer of glucose across the human placenta is directly proportional to maternal glucose concentrations even when these are well above the physiological range. This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta. METHODS:Transfer of...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.07.001
更新日期:2013-10-01 00:00:00
abstract::To characterize the placental activity for the transport of amino acids, the uptake of L-alanine was investigated by rapid membrane filtration using brush border membrane vesicles separated from the human placenta of early pregnant (12-13 gestational weeks) and late pregnant (37-38 gestational weeks) women. The uptake...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(92)90032-o
更新日期:1992-03-01 00:00:00
abstract::The fusion of villous cytotrophoblast into the placental syncytium is the quintessential process in maintenance of a healthy pregnancy. Efficient fusion requires a phosphatidylserine (PS)-rich cytotrophoblast surface, expression of fusion proteins, cessation of cell cycling, and rearrangement of cytoskeleton to accomm...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2009.12.014
更新日期:2010-02-01 00:00:00
abstract::The recent demonstration of multiple high-affinity leucine-sensitive cationic transport systems prompted this investigation of their role in lysine uptake in basal cell membrane. Transport of lysine by basal membrane was saturable at both 22 and 37 degrees C and linear in time to 1 min and 30 sec, respectively. At 22 ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)90006-0
更新日期:1997-11-01 00:00:00
abstract::The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1053/plac.1999.0512
更新日期:2000-03-01 00:00:00
abstract::Human placental fragments concentrate 86Rb 10--20-fold during a two-hour incubation period. Inhibition of ouabain is dose-dependent, reaching 90 + per cent at a concentration of 5 x 10(-5) M. The clearance index of 86Rb across the perfused human placenta is 0.34 +/- 0.08, comparing to previously reported indices for N...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80038-1
更新日期:1983-10-01 00:00:00
abstract::Preeclampsia (PE) is a serious pregnancy-related syndrome, which is characterized by gestational hypertension and proteinuria. The microRNA-93 (miR-93) is upregulated in the maternal plasma of patients with PE. However, the functional role of miR-93 in PE remains unknown. Here, we identified that miR-93 inhibits troph...
journal_title:Placenta
pub_type: 杂志文章,收录出版
doi:10.1016/j.placenta.2017.03.008
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION AND METHODS:Tragulus, the mouse deer, is considered the most primitive ruminant, with a diffuse placenta grossly quite unlike the cotyledonary type of the other ruminants. This immunocytochemical investigation of placental transporters was designed to elucidate possible mechanisms of evolution to the cotyl...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.02.011
更新日期:2014-05-01 00:00:00
abstract::Maternal fever is common during pregnancy and has for many years been suspected to harm the developing fetus. Whether increased maternal temperature produces exaggerated apoptosis in trophoblast cells remains unclear. Since p53 is a critical regulator of apoptosis we hypothesized that increased temperature in placenta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.03.009
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic c...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.03.008
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal s...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.02.004
更新日期:2017-03-01 00:00:00
abstract::The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.09.008
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:Observational and empirical evidence suggest that the average placental shape is round with a centrally inserted umbilical cord. Yet variability of shape is common. When in pregnancy do shape and cord insertion variations originate? MATERIALS AND METHODS:Placental measures from published datasets obtained u...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.12.002
更新日期:2012-03-01 00:00:00
abstract::A long and productive history of studies at high altitude has demonstrated that chronic hypoxia plays a key role in the aetiology of intrauterine growth restriction (IUGR) and pre-eclampsia. Susceptibility to altitude-associated IUGR varies among high-altitude populations in relation to their duration of altitude expo...
journal_title:Placenta
pub_type: 杂志文章,多中心研究,评审
doi:10.1016/j.placenta.2004.01.008
更新日期:2004-04-01 00:00:00
abstract::We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.11.003
更新日期:2010-01-01 00:00:00
abstract::Breast Cancer Resistance Protein (BCRP), a recently-discovered transporter belonging to ABC superfamily, is highly expressed within the labyrinth of the placenta, the primary site of exchange between the maternal and fetal circulation. It has been proposed to function as an efflux pump protecting the fetus from a wide...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2007.03.010
更新日期:2007-10-01 00:00:00
abstract:INTRODUCTION:We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS:In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T I...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.12.006
更新日期:2020-12-13 00:00:00
abstract::Placental vascular tone is critically influenced by nitric oxide (NO) derived from endothelial NO synthase (eNOS) activity. Placental vessels from pregnancies complicated with intrauterine growth restriction present altered NOS-dependent vasodilation. Arginase-2 competes with eNOS for l-arginine and counteracts the NO...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.09.015
更新日期:2013-01-01 00:00:00
abstract::Pregnancy-associated plasma protein-A was assayed in the blood of 347 women during pregnancy, using a new primary standard of PAPP-A as reference. The protein was assayed by antibody-antigen crossed electrophoresis with the lower limit of confident assay being 9.5 micrograms PAPP-A/ml (13 pmol/ml). PAPP-A was first de...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(82)80020-9
更新日期:1982-01-01 00:00:00
abstract:INTRODUCTION:The aquaporins (AQP1, 3, 8, 9 and 11) are known to be expressed, and involved in the transport of water and small molecules through fetal membranes. To exert these crucial functions, these AQPs have to be finely regulated. All-trans-retinoic acid (atRA) was previously found to regulate some genes in this e...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.05.010
更新日期:2015-08-01 00:00:00
abstract::Preterm birth is a leading cause of child morbidity and mortality, so strategies to reduce early birth must remain a priority. One key approach to enhancing birth outcomes is improving maternal dietary intake. Therefore, the purpose of this review is to discuss mechanisms on perinatal status of fat-soluble nutrients (...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2019.12.002
更新日期:2020-09-01 00:00:00
abstract::The placental renin-angiotensin system (RAS) is involved in placentation. We have shown that prorenin mRNA (REN) is expressed in a first trimester trophoblast cell line (HTR-8/SVneo) but not in a choriocarcinoma cell line (BeWo). We attempted to stimulate RAS expression in these cells by cAMP, 5'-aza-2'-deoxycytidine ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.12.018
更新日期:2013-03-01 00:00:00
abstract::Antigenic material previously detected in human placental trophoblastic cells by immunoperoxidase staining using a goat antiserum against the feline RD114 retrovirus structural protein p30 was isolated by immunochromatography from normal syncytiotrophoblast. The antigen was used to immunize mice, and of the monoclonal...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80001-6
更新日期:1984-11-01 00:00:00
abstract::Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2015.11.006
更新日期:2016-03-01 00:00:00