Abstract:
INTRODUCTION:Transfer of glucose across the human placenta is directly proportional to maternal glucose concentrations even when these are well above the physiological range. This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta. METHODS:Transfer of d-glucose, (3)H-3-o-methyl-d-glucose ((3)H-3MG) and (14)C-l-glucose across the isolated perfused human placental cotyledon was determined for maternal and fetal arterial d-glucose concentrations between 0 and 20 mmol/l. RESULTS:Clearance of (3)H-3MG or (14)C-l-glucose was not affected by maternal or fetal d-glucose concentrations in either circulation. DISCUSSION:Based on the arterial glucose concentrations and the reported KM for GLUT1, the transfer of d-glucose and (3)H-3MG would be expected to show signs of saturation as d-glucose concentrations increased but this did not occur. One explanation for this is that incomplete mixing of maternal blood and the rate of diffusion across unstirred layers may lower the effective concentration of glucose at the microvillous membrane and subsequently at the basal membrane. Uncertainties about the affinity of GLUT1 for glucose, both outside and inside the cell, may also contribute to the difference between the predicted and observed kinetics. CONCLUSION:These factors may therefore help explain why the observed and predicted kinetics differ and they emphasise the importance of understanding the function of transport proteins in their physiological context. The development of a computational model of glucose transfer may improve our understanding of how the determinants of placental glucose transfer interact and function as a system.
journal_name
Placentajournal_title
Placentaauthors
Day PE,Cleal JK,Lofthouse EM,Hanson MA,Lewis RMdoi
10.1016/j.placenta.2013.07.001subject
Has Abstractpub_date
2013-10-01 00:00:00pages
953-8issue
10eissn
0143-4004issn
1532-3102pii
S0143-4004(13)00588-2journal_volume
34pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Previous clinical studies have shown the efficacy of a two-stage surgical procedure - the induced membrane (IM) technique - for reconstruction of large bone defects or bone non-union. The first stage involves radical debridement and insertion of a cement spacer into the bone defect. The second stage, performed weeks t...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2017.06.340
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Receptor-activator of NF-κB ligand (TNFSF11, also known as RANKL) and its receptor RANK are essential regulators on bone remodeling, mammary gland development and hormone-associated breast cancer development. However, the expression pattern and role of RANKL/RANK axis in decidual stromal cells (DSCs) are uncl...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.04.020
更新日期:2013-08-01 00:00:00
abstract::Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.01.017
更新日期:2012-05-01 00:00:00
abstract::In primates and rodents, trophoblast cells synthesize and secrete into the maternal circulation a family of proteins known as pregnancy specific glycoproteins (PSG). The current study was undertaken to characterize the receptor for two members of the murine PSG family, PSG17 and PSG23. Binding of recombinant PSG17 and...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.05.008
更新日期:2011-08-01 00:00:00
abstract:INTRODUCTION:Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. METHODS:Eleven sheep ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.301
更新日期:2013-09-01 00:00:00
abstract::Placental development is a highly regulated process requiring signals from both fetal and maternal uterine compartments. Within this complex system, trophoblasts, placental cells of epithelial lineage, form the maternal-fetal interface controlling nutrient, gas and waste exchange. The commitment of progenitor villous ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2014.12.016
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.031
更新日期:2020-11-14 00:00:00
abstract:INTRODUCTION:Escherichia coli is recognized as an etiological bacteria associated with chorioamnionitis and the preterm premature rupture of fetal membranes. This pathological condition induces pro-inflammatory cytokines and degradative metalloproteinases, which are considered biological markers secreted in an acute st...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.12.011
更新日期:2015-03-01 00:00:00
abstract:INTRODUCTION:Type 1 diabetes (T1D) is associated with adverse pregnancy outcome, usually attributed to hyperglycemia. Recently, we showed that pregnancy outcome in normoglycemic T1D rats was characterized by decreased fetal and placental weight, suggesting impaired placental development. In the present study, we tested...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.12.004
更新日期:2015-02-01 00:00:00
abstract::We investigated whether histological evidence of early atherosclerosis was present in the umbilical artery of 21 pregnancies complicated by severe perinatal inflammation, and 21 controls matched for gestational age, sex and birth weight. Severe chorioamnionitis with funisitis was associated with increased numbers of C...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.12.021
更新日期:2017-02-01 00:00:00
abstract::Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0774
更新日期:2002-02-01 00:00:00
abstract::The recent demonstration of multiple high-affinity leucine-sensitive cationic transport systems prompted this investigation of their role in lysine uptake in basal cell membrane. Transport of lysine by basal membrane was saturable at both 22 and 37 degrees C and linear in time to 1 min and 30 sec, respectively. At 22 ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)90006-0
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVES:Microbial-specific factors are likely critical in determining whether bacteria trigger preterm labor. Structural variations in lipopolysaccharide (LPS), a component of gram-negative bacteria, can determine whether LPS has an inflammatory (agonist) or anti-inflammatory (antagonist) effect through Toll-like re...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.06.010
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:The placenta is a transient organ the functioning of which has health consequences far beyond the embryo/fetus. Understanding the biology of any system (organ, organism, single cell, etc) requires a comprehensive and inclusive approach which embraces all the biomedical disciplines and 'omic' technologies a...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2015.01.001
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:Miscarriage is the most common placental-related complication of pregnancy. It has been extensively investigated to discover the underlying mechanism(s) by which miscarriage occurs, but in many cases the etiology still remains unclear. The aim of this study was to analyze genome-wide expression profiles of...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.12.003
更新日期:2013-02-01 00:00:00
abstract::A localized intrauterine inflammatory response is often associated with the initiation of normal human parturition, whereas infection causes a similar but more florid response initiating preterm labor. Pre-B-cell colony-enhancing factor (PBEF) is expressed in the human fetal membranes and is up-regulated by labor, sev...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.03.011
更新日期:2007-04-01 00:00:00
abstract::Placental size has been an interesting topic of research for many years. The main aim of this study was to investigate the feasibility of measuring the placental volume at the end of the first trimester using three-dimensional (3D) ultrasound and to correlate these volumes to known placental functional indices and to ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0684
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.09.011
更新日期:2020-01-01 00:00:00
abstract::Epidermal growth factor (EGF) and its homologue, transforming growth factor-alpha (TGF-alpha), regulate human chorionic gonadotropin (hCG) synthesis in the human placenta. The current study was designed to investigate the involvement of the protein kinase C pathway in EGF-mediated hCG-beta production by JAr choriocarc...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)91040-2
更新日期:1998-09-01 00:00:00
abstract::Corticotrophin-releasing factor (CRF) immunoreactivity was demonstrated by immunohistochemical staining in the cytotrophoblast of the early pregnancy placenta, in the decidua and in the amnion. This localization is different from that of adrenocorticotrophic hormone (ACTH) and beta-endorphin, which are present in the ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90050-1
更新日期:1988-07-01 00:00:00
abstract::The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.02.004
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:Increasing evidence suggests an association between periodontal disease and low birthweight (LBW); however the underlying molecular mechanisms are yet to be fully elucidated. In this study, we performed a microarray analysis to observe the human placental trophoblast-like BeWo cells response to lipopolysaccha...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.10.007
更新日期:2011-01-01 00:00:00
abstract::Several recent publications have focused on the association between the occurrence of twin-to-twin transfusion syndrome (TTTS) in diamniotic-monochorionic twins and the presence of a number of selected anatomic placental characteristics (distribution of vascular territory, cord insertion, type and number of inter-twin...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.06.014
更新日期:2005-07-01 00:00:00
abstract::The human placenta is capable of producing a variety of haematopoietic growth factors in vitro. It is not clear, however, whether the placenta produces such factors in vivo and if so, whether placental production of haematopoietic growth factors has a physiological role in fetal haematopoietic development. As a step t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(96)80079-8
更新日期:1996-11-01 00:00:00
abstract::We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.11.003
更新日期:2010-01-01 00:00:00
abstract::Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CR...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.10.015
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Knockout mouse model has shown a relationship between Slit2/Robo1 signalling and altered fertility. Altered expression by endometrial epithelium and trophoblast and is associated with the pathogenesis of pregnancy complications but few studies have investigated the expression of decidual Slit2 in miscarria...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.008
更新日期:2020-10-09 00:00:00
abstract::Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.11.005
更新日期:2015-01-01 00:00:00
abstract::We investigated the localization of the three subtypes of (Fc gamma R) in the normal human placenta using immunohistochemical and immunocytochemical techniques with specific monoclonal antibodies. The analysis revealed that Fc gamma RI was expressed on Hofbauer cells, that Fc gamma RII was expressed on Hofbauer cells ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(91)90506-b
更新日期:1991-01-01 00:00:00
abstract::Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0944
更新日期:2003-05-01 00:00:00