Doppler evaluation of the effects of propofol, etomidate and alphaxalone on fetoplacental circulation hemodynamics in the pregnant ewe.

Abstract:

INTRODUCTION:Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. METHODS:Eleven sheep fetuses were examined at 90-109 days of gestation. UA Doppler ultrasound was performed before and after administration of a single intravenous bolus of propofol, etomidate, or alphaxalone. UA Doppler velocities (peak systolic velocity, end diastolic velocity, and mean velocity), vascular indices (pulsatility index, resistance index, and S/D ratio), blood flow, and fetal heart rate were recorded during the experimental period and UA Doppler waveforms were characterized. RESULTS:A laminar, parabolic, low resistance flow was observed in the UA of the sheep fetuses. No statistically significant changes were observed in the UA Doppler waveforms or in the UA Doppler hemodynamics after anesthesia induction. DISCUSSION:Changes in placental vascular resistance may alter the corresponding UA Doppler waveforms. When resistance in the fetal placenta increases, blood flow in the UA becomes more pulsatile. In the present study, umbilical arteries showed a parabolic flow with low resistance in all cases, as it occurs in normal human pregnancy. The administration of these anesthetics did not cause abnormalities in the normal UA Doppler pattern, inducing no changes in the resistance of the placenta in any case. CONCLUSION:These results suggest that intravenous anesthetic induction with propofol, etomidate, or alphaxalone does not cause significant detrimental effects on the placental circulation of the pregnant ewe.

journal_name

Placenta

journal_title

Placenta

authors

Domínguez E,Rivera Del Álamo MM,Novellas R,Espada Y,Santos L,García F,Andaluz A,Fresno L

doi

10.1016/j.placenta.2013.06.301

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

738-44

issue

9

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(13)00575-4

journal_volume

34

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system.

    abstract:INTRODUCTION:Perfluorinated alkyl acids (PFAAs) are widely used in industry and consumer products. Pregnant women are exposed to PFAAs and their presence in umbilical cord blood represents fetal exposure. Interestingly, PFAAs are substrates for organic anion transporters (OAT) of which OAT4 is expressed in human placen...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2015.07.119

    authors: Kummu M,Sieppi E,Koponen J,Laatio L,Vähäkangas K,Kiviranta H,Rautio A,Myllynen P

    更新日期:2015-10-01 00:00:00

  • Placental release of distinct DNA-associated micro-particles into maternal circulation: reflective of gestation time and preeclampsia.

    abstract:BACKGROUND:The aim of this study was to determine whether DNA-associated micro-particles (MPs) in maternal plasma express fetal-derived human leukocyte antigen-G (HLA-G) or placental alkaline phosphatase (PLAP) and whether the levels differ between women with normotensive pregnancies and preeclampsia. METHODS:DNA-asso...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2009.06.012

    authors: Orozco AF,Jorgez CJ,Ramos-Perez WD,Popek EJ,Yu X,Kozinetz CA,Bischoff FZ,Lewis DE

    更新日期:2009-10-01 00:00:00

  • Polymorphonuclear leukocytes in the fetal membranes are activated in patients with preterm delivery: ultrastructural and enzyme-histochemical evidence.

    abstract::The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.1998.0366

    authors: Matsubara S,Yamada T,Minakami H,Watanabe T,Takizawa T,Sato I

    更新日期:1999-03-01 00:00:00

  • Expression of thioredoxin and thioredoxin reductase in placentae of pregnant mice exposed to lipopolysaccharide.

    abstract::We have previously shown that thioredoxin and thioredoxin reductase were immunohistochemically localized in cytotrophoblasts, decidua and stromal cells in the stem villi of human placenta and that the addition of exogenous thioredoxin and thioredoxin reductase to mitochondrial fractions from human placenta displayed a...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.1999.0415

    authors: Ejima K,Koji T,Nanri H,Kashimura M,Ikeda M

    更新日期:1999-09-01 00:00:00

  • Exploring sexual dimorphism in placental circulation at 22-24 weeks of gestation: A cross-sectional observational study.

    abstract:INTRODUCTION:Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS:This was a prosp...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2016.11.005

    authors: Widnes C,Flo K,Acharya G

    更新日期:2017-01-01 00:00:00

  • Postdate pregnancy: changes of placental/membranes 11β-hydroxysteroid dehydrogenase mRNA and activity.

    abstract::11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate wo...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2013.08.011

    authors: Novembri R,Voltolini C,Torricelli M,Severi FM,Marcolongo P,Benedetti A,Challis JR,Petraglia F

    更新日期:2013-11-01 00:00:00

  • Altered uterine perfusion is involved in fetal outcome of diabetic rats.

    abstract::Maternal diabetes affects the development of the offspring by altering the uterine environment. We aimed to investigate the extent to which the blood flow (measured as Tissue Perfusion Units; TPU) to implantation sites and the expression of developmentally important genes in the offspring are affected by maternal diab...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2008.02.005

    authors: Zabihi S,Wentzel P,Eriksson UJ

    更新日期:2008-05-01 00:00:00

  • Velamentous cord insertion in monochorionic twins with or without twin-twin transfusion syndrome: Does it matter?

    abstract:OBJECTIVE:To study the association between velamentous cord insertion (VCI) and different outcomes in monochorionic twins with and without twin-twin transfusion syndrome (TTTS). METHODS:We recorded the cord insertion type in all consecutive monochorionic placentas examined in two tertiary medical centers. The associat...

    journal_title:Placenta

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.placenta.2013.08.009

    authors: Costa-Castro T,De Villiers S,Montenegro N,Severo M,Oepkes D,Matias A,Lopriore E

    更新日期:2013-11-01 00:00:00

  • Classics revisited: C. J. van der Horst on pregnancy and menstruation in elephant shrews.

    abstract:BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...

    journal_title:Placenta

    pub_type: 传,历史文章,杂志文章,评审

    doi:10.1016/j.placenta.2018.05.010

    authors: Carter AM

    更新日期:2018-07-01 00:00:00

  • Studies on the concentration of pregnancy-associated plasma protein-A during normal and complicated pregnancy.

    abstract::Pregnancy-associated plasma protein-A was assayed in the blood of 347 women during pregnancy, using a new primary standard of PAPP-A as reference. The protein was assayed by antibody-antigen crossed electrophoresis with the lower limit of confident assay being 9.5 micrograms PAPP-A/ml (13 pmol/ml). PAPP-A was first de...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(82)80020-9

    authors: Sutcliffe RG,Kukulska-Langlands BM,Horne CH,Maclean AB,Jandial V,Sutherland HW,Gibb S,Bowman AW

    更新日期:1982-01-01 00:00:00

  • First-trimester placental thickness and the risk of preeclampsia or SGA.

    abstract:INTRODUCTION:Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestatio...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2017.06.016

    authors: Vachon-Marceau C,Demers S,Markey S,Okun N,Girard M,Kingdom J,Bujold E

    更新日期:2017-09-01 00:00:00

  • Isolation of phenotypically distinct trophoblast cell lines from normal rat chorioallantoic placentas.

    abstract::Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(89)90038-6

    authors: Hunt JS,Deb S,Faria TN,Wheaton D,Soares MJ

    更新日期:1989-03-01 00:00:00

  • Endoplasmic reticulum stress is induced in the human placenta during labour.

    abstract::Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2014.11.005

    authors: Veerbeek JH,Tissot Van Patot MC,Burton GJ,Yung HW

    更新日期:2015-01-01 00:00:00

  • The effects of Assisted Reproductive Technologies on genomic imprinting in the placenta.

    abstract::The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...

    journal_title:Placenta

    pub_type: 杂志文章,评审

    doi:10.1016/j.placenta.2019.02.013

    authors: Rhon-Calderon EA,Vrooman LA,Riesche L,Bartolomei MS

    更新日期:2019-09-01 00:00:00

  • What factors determine placental glucose transfer kinetics?

    abstract:INTRODUCTION:Transfer of glucose across the human placenta is directly proportional to maternal glucose concentrations even when these are well above the physiological range. This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta. METHODS:Transfer of...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2013.07.001

    authors: Day PE,Cleal JK,Lofthouse EM,Hanson MA,Lewis RM

    更新日期:2013-10-01 00:00:00

  • Growth restricting effects of a single course of antenatal betamethasone treatment and the role of human placental lactogen.

    abstract:UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2013.02.002

    authors: Braun T,Husar A,Challis JR,Dudenhausen JW,Henrich W,Plagemann A,Sloboda DM

    更新日期:2013-05-01 00:00:00

  • Immunohistochemical localization of follicle-stimulating hormone, luteinizing hormone, growth hormone, adrenocorticotrophic hormone and prolactin in the human placenta.

    abstract::The sites of localization of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), adrenocorticotrophic hormone (ACTH) and prolactin (PRL) within placental tissues have been studied by an immunoperoxidase technique. The syncytiotrophoblast is the sole significant site of localization of LH...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(86)80007-8

    authors: Al-Timimi A,Fox H

    更新日期:1986-03-01 00:00:00

  • Antigen expression by trophoblast populations in the human placenta and their possible immunobiological relevance.

    abstract::Antigen expression by villous and extravillous human trophoblast populations at discrete anatomical sites has been reviewed. The various different antigenic phenotypes have been highlighted using a panel of monoclonal antibodies reactive with characteristic trophoblast membrane antigens, a trophoblast-leucocyte common...

    journal_title:Placenta

    pub_type: 杂志文章,评审

    doi:10.1016/s0143-4004(85)80063-1

    authors: Bulmer JN,Johnson PM

    更新日期:1985-03-01 00:00:00

  • Subcellular localization of PP5/TFPI-2 in human placenta: a possible role of PP5/TFPI-2 as an anti-coagulant on the surface of syncytiotrophoblasts.

    abstract::Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.2001.0774

    authors: Udagawa K,Yasumitsu H,Esaki M,Sawada H,Nagashima Y,Aoki I,Jin M,Miyagi E,Nakazawa T,Hirahara F,Miyazaki K,Miyagi Y

    更新日期:2002-02-01 00:00:00

  • Inhibition of DLX4 promotes apoptosis in choriocarcinoma cell lines.

    abstract::Homeodomain (HDM) proteins encoded by homeobox (HBX) genes represent a large family of transcriptional factors that control differentiation and development in certain cell types. DLX4 is a member of Distal-less (DLX) family of HBX genes. Recent studies have demonstrated that abnormal expression of DLX4 is present in s...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2005.03.007

    authors: Sun Y,Lu X,Yin L,Zhao F,Feng Y

    更新日期:2006-04-01 00:00:00

  • Identification of 72-kilodalton type IV collagenase at sites of trophoblastic invasion of macaque spiral arteries.

    abstract::The walls of uterine spiral arteries are invaded by extravillous trophoblast cells and are thereby converted to the uteroplacental arteries of pregnancy. The mechanisms by which this invasion occurs are not understood, but the extracellular matrices that are breached suggest participation by specific proteinases. In t...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(05)80454-0

    authors: Blankenship TN,King BF

    更新日期:1994-02-01 00:00:00

  • Patterns of expression of Bax, Bcl-2 and Bcl-x(L) in the implantation site in rat during pregnancy.

    abstract::The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2004.09.008

    authors: Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NA

    更新日期:2005-11-01 00:00:00

  • Localization of three subtypes of Fc gamma receptors in human placenta by immunohistochemical analysis.

    abstract::We investigated the localization of the three subtypes of (Fc gamma R) in the normal human placenta using immunohistochemical and immunocytochemical techniques with specific monoclonal antibodies. The analysis revealed that Fc gamma RI was expressed on Hofbauer cells, that Fc gamma RII was expressed on Hofbauer cells ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(91)90506-b

    authors: Kameda T,Koyama M,Matsuzaki N,Taniguchi T,Saji F,Tanizawa O

    更新日期:1991-01-01 00:00:00

  • Cross-sectional features and three-dimensional structure of human placental villi.

    abstract::Human placental villi from both normal and complicated pregnancies were examined by both light and scanning electron microscopy. The findings provide evidence that histological features such as syncytial sprouts, bridges, and a net-like arrangement of villi represent tangential sections of irregularly shaped villi rat...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(87)90047-6

    authors: Kaufmann P,Luckhardt M,Schweikhart G,Cantle SJ

    更新日期:1987-05-01 00:00:00

  • Receptors for oestradiol in human placenta.

    abstract::The binding of oestradiol in human placental tissue obtained from spontaneous and caesarean deliveries was investigated. Villous tissue was homogenized and the 800 g 'cytosol' supernatant treated with ammonium sulphate. The precipitate was redissolved and the preparation then equilibrated with [3H]oestradiol. After se...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(85)80015-1

    authors: Laminski NA,Hammond KD

    更新日期:1985-09-01 00:00:00

  • The effect of maternal hypoaminoacidaemia on placental uptake and transport of amino acids in pregnant sheep.

    abstract::We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewe...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.2000.0610

    authors: Thureen PJ,Padbury JF,Hay WW Jr

    更新日期:2001-02-01 00:00:00

  • Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes.

    abstract:INTRODUCTION:Soluble fms-like tyrosine kinase 1 (sFLT-1) is an anti-angiogenic factor implicated in the pathogenesis of preterm preeclampsia. We evaluated sFLT-1 expression and placental pathology in pregnancies complicated by small for gestational age (SGA) infants (<10th percentile), without evidence of preeclampsia....

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2017.02.011

    authors: Spiel M,Salahuddin S,Pernicone E,Zsengeller Z,Wang A,Modest AM,Karumanchi SA,Hecht JL

    更新日期:2017-04-01 00:00:00

  • Studies on the elevated amniotic fluid SP1 in Meckel's syndrome: modified glycosylation of SP1.

    abstract::Pregnancy-specific beta 1-glycoprotein (Schwangerschaftsprotein, SP1) is elevated in the amniotic fluid in Meckel's syndrome. In an attempt to clarify this phenomenon, we studied fetal tissues by immunohistochemistry for the distribution of SP1 in normal fetuses and fetuses with Meckel's syndrome. The amount of SP1 wa...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(87)90070-1

    authors: Heikinheimo M,Jalanko H,Renlund M,Rapola J,Wahlström T

    更新日期:1987-07-01 00:00:00

  • Vascular distribution patterns in monochorionic twin placentas.

    abstract::Several recent publications have focused on the association between the occurrence of twin-to-twin transfusion syndrome (TTTS) in diamniotic-monochorionic twins and the presence of a number of selected anatomic placental characteristics (distribution of vascular territory, cord insertion, type and number of inter-twin...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2004.06.014

    authors: De Paepe ME,DeKoninck P,Friedman RM

    更新日期:2005-07-01 00:00:00

  • Human placenta: a human organ for developmental toxicology research and biomonitoring.

    abstract::Pregnant mothers are exposed to a wide variety of foreign chemicals. This exposure is most commonly due to maternal medication, lifestyle factors, such as smoking, drug abuse, and alcohol consumption, or occupational and environmental sources. Foreign compounds may interfere with placental functions at many levels e.g...

    journal_title:Placenta

    pub_type: 杂志文章,评审

    doi:10.1016/j.placenta.2004.09.006

    authors: Myllynen P,Pasanen M,Pelkonen O

    更新日期:2005-05-01 00:00:00