Abstract:
:Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to labour represents an in vivo model for the study of acute placental ER stress. ER stress markers, GRP78, P-eIF2α and XBP-1, were significantly higher in laboured placentas than in Caesarean-delivered controls localised mainly in the syncytiotrophoblast. The similarities to changes observed in PE/IUGR placentas suggest exposure to labour can be used to investigate induction of ER stress in pathological placentas.
journal_name
Placentajournal_title
Placentaauthors
Veerbeek JH,Tissot Van Patot MC,Burton GJ,Yung HWdoi
10.1016/j.placenta.2014.11.005subject
Has Abstractpub_date
2015-01-01 00:00:00pages
88-92issue
1eissn
0143-4004issn
1532-3102pii
S0143-4004(14)00834-0journal_volume
36pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Placental villi of early and term human placentae were dissociated with trypsin and mixed cell cultures were established. The different cell types were identified and estimated over a 14-day culture period using antibodies to keratin and vimentin filaments and their capacity to phagocytose yeast. The three main cell t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80047-8
更新日期:1984-01-01 00:00:00
abstract::Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.021
更新日期:2015-12-01 00:00:00
abstract::The morphometric oxygen diffusive conductance (D(p)) of the placenta provides a measure of the efficiency of oxygen transfer between the mother and the developing fetus. Any change in the D(p)may point towards possible adaptation in the light of altered oxygen transfer. Placentae from normal (n=40) and small for gesta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(03)00044-4
更新日期:2003-07-01 00:00:00
abstract::The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2019.02.013
更新日期:2019-09-01 00:00:00
abstract::During the first trimester of pregnancy the human placenta develops in an hypoxic environment caused by the occlusion of uterine spiral arterioles by extravillous trophoblasts (EVT). This period of low oxygen tension is crucial for successful pregnancy. In low oxygen environments, Hypoxia Inducible Factors (HIF) are t...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2010.08.008
更新日期:2010-11-01 00:00:00
abstract:INTRODUCTION:The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived - prostaglandin E2 production during implantation in the rat uterus and that it augments the...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.001
更新日期:2013-09-01 00:00:00
abstract::The apoptosis cascade that plays a central role in normal and pathological processes is strictly controlled, in part by FLIP (Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein), an inhibitor of caspase-8. Here, we report the expression of long and short isoforms of FLIP mRNAs and ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.08.004
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.12.006
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:Folates are essential nutrients for fetal development and pregnancy outcomes; they are transported to the fetus during gestation through specific folate transporters located in the placenta. In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.03.009
更新日期:2020-05-01 00:00:00
abstract::To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells after stimulation with various modulatory agents of cytokine ex...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0494
更新日期:2000-05-01 00:00:00
abstract::Bovine nuclear transfer pregnancies are characterized by a high incidence of placental abnormalities, notably, increased placentome size and deficiencies in trophoblast cell function and establishment of placental vasculature. Alterations in gene expression during placental growth and development may contribute to the...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.03.002
更新日期:2006-02-01 00:00:00
abstract::During pregnancy, leptin concentrations in the maternal circulation are elevated in both humans and rodents but decrease to pre-pregnancy levels at birth, suggesting a role for leptin in the maintenance of pregnancy. Synthesis of leptin by the human placenta is established but whether the murine placenta synthesizes l...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.03.009
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether DNA-associated micro-particles (MPs) in maternal plasma express fetal-derived human leukocyte antigen-G (HLA-G) or placental alkaline phosphatase (PLAP) and whether the levels differ between women with normotensive pregnancies and preeclampsia. METHODS:DNA-asso...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.06.012
更新日期:2009-10-01 00:00:00
abstract::The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the invo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.07.006
更新日期:2016-09-01 00:00:00
abstract::Indiscriminate invasion upon the endometrium by normal trophoblasts is strictly regulated unlike that by choriocarcinoma cells. In this study, we focused on the activity of matrix metalloproteinase (MMP)-2 and MMP-9 as parameters of invasion in normal human placenta. In situ hybridization (ISH), immunohistochemical st...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0867
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:Observational and empirical evidence suggest that the average placental shape is round with a centrally inserted umbilical cord. Yet variability of shape is common. When in pregnancy do shape and cord insertion variations originate? MATERIALS AND METHODS:Placental measures from published datasets obtained u...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.12.002
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:Histologic placental and/or intra-amniotic inflammation is frequently documented during ascending intra-uterine infections in patients with preterm labor and intact membranes. Placenta previa can be a clinical situation that shows the successive schema of histologic placental and intra-amniotic inflammation d...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.04.005
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:Knockout mouse model has shown a relationship between Slit2/Robo1 signalling and altered fertility. Altered expression by endometrial epithelium and trophoblast and is associated with the pathogenesis of pregnancy complications but few studies have investigated the expression of decidual Slit2 in miscarria...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.008
更新日期:2020-10-09 00:00:00
abstract::We have previously shown that thioredoxin and thioredoxin reductase were immunohistochemically localized in cytotrophoblasts, decidua and stromal cells in the stem villi of human placenta and that the addition of exogenous thioredoxin and thioredoxin reductase to mitochondrial fractions from human placenta displayed a...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0415
更新日期:1999-09-01 00:00:00
abstract::Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80054-5
更新日期:1984-03-01 00:00:00
abstract::Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imagin...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2020.01.016
更新日期:2020-12-01 00:00:00
abstract::To characterize the placental activity for the transport of amino acids, the uptake of L-alanine was investigated by rapid membrane filtration using brush border membrane vesicles separated from the human placenta of early pregnant (12-13 gestational weeks) and late pregnant (37-38 gestational weeks) women. The uptake...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(92)90032-o
更新日期:1992-03-01 00:00:00
abstract::Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2015.11.006
更新日期:2016-03-01 00:00:00
abstract::An area of the fetal membranes, within the rupture tear after spontaneous delivery at term, exhibits altered morphology compared to more distal sites. It is characterized by marked swelling of the amniotic and chorionic connective tissue layers, consistent with structural weakness, and a marked reduction of the thickn...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0439
更新日期:2000-01-01 00:00:00
abstract::Although secretory phospholipase A2 (PLA2) isozymes have been identified in human gestational tissues, their role in homeostasis and pathophysiology during pregnancy has yet to be clearly established. The aims of this brief commentary are: (1) to review recent data concerning the expression of secretory PLA2 isozymes ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(98)90093-5
更新日期:1998-01-01 00:00:00
abstract::This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0676
更新日期:2001-05-01 00:00:00
abstract::11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate wo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.08.011
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Human decidual stromal cells (DSCs) play a key role in maternal-fetal interactions. Precursors of DSCs (preDSCs) localize around vessels in both the endometrium and decidua. Previous studies suggested a relationship between preDSCs and pericytes because these cells share a perivascular location, alpha smoo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.11.010
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:The ratio of birthweight to placental weight (BW:PW) is often used as a measure of placental efficiency in humans and animals. However, ratios have properties that are known to lead to spurious results. An alternative approach is the use of residuals from regression, which reflect whether birthweight is hi...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.06.311
更新日期:2018-08-01 00:00:00
abstract::Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0774
更新日期:2002-02-01 00:00:00