当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Morphometric assessment of the oxygen diffusion conductance in placentae from pregnancies complicated by intra-uterine growth restriction.

Morphometric assessment of the oxygen diffusion conductance in placentae from pregnancies complicated by intra-uterine growth restriction.

Abstract：

:The morphometric oxygen diffusive conductance (D(p)) of the placenta provides a measure of the efficiency of oxygen transfer between the mother and the developing fetus. Any change in the D(p)may point towards possible adaptation in the light of altered oxygen transfer. Placentae from normal (n=40) and small for gestational age SGA (n=24) pregnancies were analysed using stereological techniques. Each placenta was uniform randomly sampled and tissue samples processed to wax infiltration and embedding using conventional histological preparatory methods. A combination of stereological techniques and physiological constants were used to estimate the partial conductances across the five major tissue compartments involved in oxygen transfer. There was a significant reduction in both fetal birthweight and placental weight in the SGA group when compared with controls. A decrease in both chorionic (S(cv)) and fetal capillary (S(fc)) surface area was also observed in SGA placentae when compared with controls (P>0.001). Villous membrane harmonic thickness (T(vm)) was reduced in the SGA placentae (2.33 microm) when compared with controls (2.67 microm P=0.019). This resulted in a reduction in the minimum D(p)in SGA placentae when compared with controls (P=0.023). Adjusting for fetal weight resulted in no difference in the specific diffusive conductance. Changes in T(vm)in SGA placentae combined with changes in basic surface areas were insufficient to maintain overall D(p)values comparable with control placentae.

journal_name

Placenta

journal_title

Placenta

authors

Ansari T,Fenlon S,Pasha S,O'Neill B,Gillan JE,Green CJ,Sibbons PD

doi

10.1016/s0143-4004(03)00044-4

keywords:

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

618-26

issue

6

eissn

0143-4004

issn

1532-3102

pii

S0143400403000444

journal_volume

24

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis.

    abstract：:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2003.11.011

    authors： Demir R,Kayisli UA,Seval Y,Celik-Ozenci C,Korgun ET,Demir-Weusten AY,Huppertz B

    更新日期：2004-07-01 00:00:00

  • Altered gene expression of H19 and IGF2 in placentas from ART pregnancies.

    abstract：INTRODUCTION:The aim of this study is to determine whether the gene expression and associated DNA methylation regulation of H19 and IGF2 are altered in placentas conceived by assisted reproductive technologies (ART) compared to natural conceptions. METHODS:113 pregnancies were recruited resulting in 119 placentas (83 ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.08.008

    authors： Sakian S,Louie K,Wong EC,Havelock J,Kashyap S,Rowe T,Taylor B,Ma S

    更新日期：2015-10-01 00:00:00

  • Biological features of placental programming.

    abstract：:The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2016.10.012

    authors： Thornburg KL,Kolahi K,Pierce M,Valent A,Drake R,Louey S

    更新日期：2016-12-01 00:00:00

  • Placenta-bound and body fluid PP13 and its mRNA in normal pregnancy compared to preeclampsia, HELLP and preterm delivery.

    abstract：OBJECTIVES:To compare the distribution of placental protein 13 (PP13) in fetal and maternal blood and amnionic fluid and to correlate it with PP13 protein and mRNA in the placenta. METHODS:Umbilical arterial serum, amnionic fluid, maternal venous serum and placental tissues were collected from normal outcome pregnanci...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2010.09.006

    authors： Sammar M,Nisemblat S,Fleischfarb Z,Golan A,Sadan O,Meiri H,Huppertz B,Gonen R

    更新日期：2011-02-01 00:00:00

  • Influences of extracellular matrix and of conditioned media on differentiation and invasiveness of trophoblast stem cells.

    abstract：:Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2006.01.020

    authors： Lei T,Hohn HP,Behr R,Denker HW

    更新日期：2007-01-01 00:00:00

  • Three-dimensional growth of extravillous cytotrophoblasts promotes differentiation and invasion.

    abstract：:Human trophoblast research relies on a combination of in vitro models, including isolated primary cultures, explant cultures, and trophoblast cell lines. In the present study, we have utilized the rotating wall vessel (RWV) bioreactor to generate a three-dimensional (3-D) model of human placentation for the study of c...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2004.11.003

    authors： LaMarca HL,Ott CM,Höner Zu Bentrup K,Leblanc CL,Pierson DL,Nelson AB,Scandurro AB,Whitley GS,Nickerson CA,Morris CA

    更新日期：2005-11-01 00:00:00

  • Umbilical cord plasma-derived exosomes from preeclamptic women induce vascular dysfunction by targeting HMGCS1 in endothelial cells.

    abstract：:Hypertension is one of the major clinical manifestations of preeclampsia. Vascular dysfunction is crucial for the occurrence and progression of hypertension. Exosomes are emerging as mediators of intercellular communication and can participate in angiogenesis. In this study, we hypothesize that umbilical cord plasma-d...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.10.022

    authors： Ying X,Zhu Y,Jin X,Chang X

    更新日期：2020-10-20 00:00:00

  • Review: The role of autophagy in extravillous trophoblast function under hypoxia.

    abstract：:Autophagy, a process for cellular cleaning through the removal of intracellular components in lysosomes, is a well conserved mechanism from yeast to mammalian cells, and also contributes to the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodeling, and cellular defense aga...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2012.11.026

    authors： Saito S,Nakashima A

    更新日期：2013-03-01 00:00:00

  • Epidermal growth factor (EGF) in the human placental infection with Trypanosoma cruzi.

    abstract：:Maternal infection of Trypanosoma cruzi is associated with premature births, abortions and placentitis. A decrease in EGF levels has been suggested to occur in animals infected by T. cruzi, but there is no research about the levels of EGF in human patients with Chagas' disease. We evaluated serum EGF levels in pregnan...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2003.09.008

    authors： Lin S,Sartori MJ,Mezzano L,de Fabro SP

    更新日期：2004-04-01 00:00:00

  • Three-dimensional arrangement of the capillary bed and its relationship to microrheology in the terminal villi of normal term placenta.

    abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.07.004

    authors： Jirkovská M,Janácek J,Kaláb J,Kubínová L

    更新日期：2008-10-01 00:00:00

  • Macroscopic and microscopic aspects of collared peccary and white-lipped peccary placenta.

    abstract：:This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.02.017

    authors： Santos TC,Dantzer V,Jones CJ,Oliveira MF,Miglino MA

    更新日期：2006-02-01 00:00:00

  • Trophoblast deportation part II: a review of the maternal consequences of trophoblast deportation.

    abstract：:The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology si...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2011.06.019

    authors： Pantham P,Askelund KJ,Chamley LW

    更新日期：2011-10-01 00:00:00

  • The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour.

    abstract：:The aim of this study was to investigate localization and content of activin beta A-subunit and activin receptors in gestational tissues throughout pregnancy and in association with term labour. Placenta and fetal membranes were collected from women undergoing first and second trimester terminations and from women bef...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0787

    authors： Schneider-Kolsky ME,Manuelpillai U,Waldron K,Dole A,Wallace EM

    更新日期：2002-04-01 00:00:00

  • Dynamic changes in maternal decidual leukocyte populations from first to second trimester gestation.

    abstract：INTRODUCTION:Decidual leukocytes are critical to the development of the fetomaternal interface, regulating tolerance to the semi-allogeneic fetus and vascular transformation of the uterine spiral arteries. Despite the continuation of these processes beyond the first trimester of pregnancy, the second trimester has larg...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.09.018

    authors： Kwan M,Hazan A,Zhang J,Jones RL,Harris LK,Whittle W,Keating S,Dunk CE,Lye SJ

    更新日期：2014-12-01 00:00:00

  • Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter.

    abstract：:The interaction of cocaine and its analog 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane (RTI-55) with the human placental serotonin transporter was investigated. The function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush bord...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(94)90018-3

    authors： Prasad PD,Leibach FH,Mahesh VB,Ganapathy V

    更新日期：1994-04-01 00:00:00

  • The hopes and fears of in utero gene therapy for genetic disease--a review.

    abstract：:Somatic gene delivery in utero is a novel approach to gene therapy for genetic disease. It is based on the concept that application of gene therapy vectors to the fetus in utero may prevent the development of early disease related tissue damage, may allow targeting of otherwise inaccessible organs, tissues and still e...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(03)00140-1

    authors： Coutelle C,Themis M,Waddington S,Gregory L,Nivsarkar M,Buckley S,Cook T,Rodeck C,Peebles D,David A

    更新日期：2003-10-01 00:00:00

  • Pre-B-cell colony-enhancing factor (PBEF/Visfatin) gene expression is modulated by NF-kappaB and AP-1 in human amniotic epithelial cells.

    abstract：:A localized intrauterine inflammatory response is often associated with the initiation of normal human parturition, whereas infection causes a similar but more florid response initiating preterm labor. Pre-B-cell colony-enhancing factor (PBEF) is expressed in the human fetal membranes and is up-regulated by labor, sev...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2006.03.011

    authors： Kendal CE,Bryant-Greenwood GD

    更新日期：2007-04-01 00:00:00

  • First trimester histiotrophe shows altered sialylation compared with secretory phase glycoconjugates in human endometrium.

    abstract：OBJECTIVES:Histiotrophe is now recognized as being an important feature of early human pregnancy, providing nutrients and growth factors to the developing embryo. Our aim was to examine the glycan composition of histiotrophe from first trimester decidua and to compare it with secretions present in endometrial glands fr...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2010.04.011

    authors： Jones CJ,Aplin JD,Burton GJ

    更新日期：2010-07-01 00:00:00

  • Review: Differential placental macrovascular and microvascular endothelial dysfunction in gestational diabetes.

    abstract：:Human endothelial dysfunction is a common feature in many diseases of pregnancy, such as gestational diabetes (GD). Metabolic changes include abnormal synthesis of nitric oxide (NO) and abnormal membrane transport of l-arginine and adenosine in primary cultures of human umbilical vein (HUVEC, macrovascular) and placen...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2010.12.011

    authors： Sobrevia L,Abarzúa F,Nien JK,Salomón C,Westermeier F,Puebla C,Cifuentes F,Guzmán-Gutiérrez E,Leiva A,Casanello P

    更新日期：2011-03-01 00:00:00

  • ATP dependent Ca2+ transport across basal membrane of human syncytiotrophoblast in pregnancies complicated by intrauterine growth restriction or diabetes.

    abstract：:Neonates born after pregnancies complicated by diabetes or intrauterine growth restriction (IUGR) have increased incidence of hypocalcaemia. Furthermore, IUGR is associated with reduced bone mineralization in infancy and osteoporosis in adult life. We tested the hypothesis that placental calcium transport is altered i...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0941

    authors： Strid H,Bucht E,Jansson T,Wennergren M,Powell TL

    更新日期：2003-05-01 00:00:00

  • Placental morphology: from molecule to mother -- a dedication to Peter Kaufmann -- a review.

    abstract：:Theories on the development of placental pathologies and insufficiencies are based on the assumption that the development of the placental villous trees, the invasion of extravillous trophoblast or the differentiation of the villous trophoblast is somehow dysregulated. One of the pioneers trying to answer these questi...

    journal_title：Placenta

    pub_type： 传,历史文章,杂志文章,评审

    doi：10.1016/j.placenta.2006.01.007

    authors： Huppertz B,Burton G,Cross JC,Kingdom JC

    更新日期：2006-04-01 00:00:00

  • Differential expression of serum proteins before 20 weeks gestation in women with hypertensive disorders of pregnancy: A potential role for SH3BGRL3.

    abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.10.031

    authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

    更新日期：2020-11-14 00:00:00

  • Oxygen tension modulates AQP9 expression in human placenta.

    abstract：UNLABELLED:Placental hypoxia has been implicated in pregnancy pathologies such as preeclampsia. We have previously reported that AQP9 is highly expressed in syncytiotrophoblast from normal placentas and shows an overexpression in preeclamptic placentas, with a lack of functionality for water transport. Up to now, the r...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.04.017

    authors： Castro-Parodi M,Szpilbarg N,Dietrich V,Sordelli M,Reca A,Abán C,Maskin B,Farina MG,Damiano AE

    更新日期：2013-08-01 00:00:00

  • Immunocytochemical identification of the oestrogen receptor in the nuclei of cultured human placental syncytiotrophoblasts.

    abstract：:We have shown that oestrogen has a central integrative role in regulating key components of the progesterone biosynthetic and corticosteroid metabolic pathways within syncytiotrophoblasts that govern placental function and maturation of the fetal pituitary-adrenocortical axis. Studies utilizing classic binding procedu...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(97)80071-9

    authors： Billiar RB,Pepe GJ,Albrecht ED

    更新日期：1997-05-01 00:00:00

  • Nitric oxide synthase activity in placentae from women with pre-eclampsia.

    abstract：:The syncytiotrophoblast (ST) cell layer of the human villous placenta expresses nitric oxide (NO) synthase. Because NO is a potent relaxant of vascular smooth muscle and inhibitor of platelet activity, we postulated that exaggerated intervillous aggregation of platelets and reduced fetoplacental blood flow in pre-ecla...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(95)90013-6

    authors： Conrad KP,Davis AK

    更新日期：1995-12-01 00:00:00

  • Review: Annexin-A5 and cell membrane repair.

    abstract：:Annexins are soluble proteins that bind to biological membranes containing negatively charged phospholipids, principally phosphatidylserine, in a Ca(2+)-dependent manner. Annexin-A5 (AnxA5), the smallest member of the annexin family, presents unique properties of membrane binding and self-assembly into ordered two-dim...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2015.01.193

    authors： Bouter A,Carmeille R,Gounou C,Bouvet F,Degrelle SA,Evain-Brion D,Brisson AR

    更新日期：2015-04-01 00:00:00

  • Transplacental lactate dehydrogenase-elevating virus (LDV) transmission: immune inhibition of umbilical cord infection, and correlation of fetal virus susceptibility with development of F4/80 antigen expression.

    abstract：:Maternal-to-fetal transmission of the murine lactate dehydrogenase-elevating virus (LDV) has been previously shown to be regulated by maternal immunity as well as gestational age. For the present study, the role of maternal immunity in placental and umbilical cord virus protection was studied, and virus targeting of u...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0829

    authors： Zitterkopf NL,Haven TR,Huela M,Bradley DS,Cafruny WA

    更新日期：2002-05-01 00:00:00

  • Fused placentas: Till birth do us part.

    abstract：:Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this, little is known about the histological characteristics of the twin or fused placenta and how...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.10.036

    authors： Lopez-Tello J,Sferruzzi-Perri AN

    更新日期：2020-11-02 00:00:00

  • Multiple human papillomavirus types replicate in 3A trophoblasts.

    abstract：:Human papillomavirus (HPV) are more prevalent in spontaneous abortions than elect abortions and preferentially infect the trophoblasts. Related to this, HPV type 16 has been shown to productively replicate in 3A trophoblasts in tissue culture. Extending these earlier studies, the described study addresses the issue wh...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2007.08.005

    authors： You H,Liu Y,Agrawal N,Prasad CK,Edwards JL,Osborne AF,Korourian S,Lowery CL,Hermonat PL

    更新日期：2008-01-01 00:00:00

  • The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase.

    abstract：:The mechanism of iron release from the placenta into the fetal circulation is not well understood. Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types. The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) f...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2000.0582

    authors： Danzeisen R,Ponnambalam S,Lea RG,Page K,Gambling L,McArdle HJ

    更新日期：2000-11-01 00:00:00