Three-dimensional growth of extravillous cytotrophoblasts promotes differentiation and invasion.

abstract：:Alphafetoprotein (AFP) is detectable in maternal serum from around six weeks of gestation and is synthesised by the yolk sac and the fetal liver. The role of the placenta in the transport and possible synthesis of AFP is uncertain. The aim of this study was to investigate placental expression of AFP and the AFP recept...

journal_title：Placenta

authors： Newby D,Dalgliesh G,Lyall F,Aitken DA

更新日期：2005-02-01 00:00:00

abstract：INTRODUCTION:We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS:In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T I...

journal_title：Placenta

authors： Ho A,Hutter J,Slator P,Jackson L,Seed PT,Mccabe L,Al-Adnani M,Marnerides A,George S,Story L,Hajnal JV,Rutherford M,Chappell LC

更新日期：2020-12-13 00:00:00

abstract：INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...

journal_title：Placenta

authors： Ernst LM,Minturn L,Huang MH,Curry E,Su EJ

更新日期：2013-07-01 00:00:00

abstract：:The effect of a hyposmotic challenge and hence cell-swelling upon the efflux of a variety of solutes from isolated human placental tissue has been examined. A hyposmotic shock increased the fractional release of taurine, the most abundant free amino acid in placental tissue, via a pathway sensitive to niflumic acid, D...

journal_title：Placenta

authors： Shennan DB,McNeillie SA

更新日期：1995-04-01 00:00:00

abstract：:Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imagin...

journal_title：Placenta

authors： Lewis RM,Pearson-Farr JE

更新日期：2020-12-01 00:00:00

abstract：:Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined. We used whole-mount immunofluorescence analyses to compare uterus and gestation day 4.5-9.5 mouse implantation sites that differed genetically in fetal or mate...

journal_title：Placenta

authors： Rätsep MT,Carmeliet P,Adams MA,Croy BA

更新日期：2014-09-01 00:00:00

abstract：:Recently, the gene encoding a new stress-induced protein termed reducing agent and tunicamycin-responsive protein (RTP) was identified. The function of RTP is unknown, however, the strong upregulation of RTP during cellular differentiation, and exposure to stress conditions including hypoxia suggests a specific role f...

journal_title：Placenta

authors： Gratton RJ,Gluszynski M,Nygard K,Mazzuca DM,Graham CH,Han VK

更新日期：2004-01-01 00:00:00

abstract：:Autophagy, a process for cellular cleaning through the removal of intracellular components in lysosomes, is a well conserved mechanism from yeast to mammalian cells, and also contributes to the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodeling, and cellular defense aga...

journal_title：Placenta

authors： Saito S,Nakashima A

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

journal_title：Placenta

authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

更新日期：2020-11-14 00:00:00

abstract：:Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...

journal_title：Placenta

authors： Lash GE,Ansari T,Bischof P,Burton GJ,Chamley L,Crocker I,Dantzer V,Desoye G,Drewlo S,Fazleabas A,Jansson T,Keating S,Kliman HJ,Lang I,Mayhew T,Meiri H,Miller RK,Nelson DM,Pfarrer C,Roberts C,Sammar M,Sharma S,

更新日期：2009-03-01 00:00:00

abstract：:The effects of 8-epi-prostaglandin F(2alpha)(8-epi-PGF(2alpha)) and the thromboxane A(2)-mimetic U46619 were examined on isolated human fetal placental arteries obtained from normal pregnancies and from those complicated by pre-eclampsia. The effects of these agents were examined on both conduit and resistance arterie...

journal_title：Placenta

authors： Kwek K,Read MA,Khong TY,Bisits AT,Walters WA

更新日期：2001-07-01 00:00:00

abstract：:The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...

journal_title：Placenta

authors： Poisner AM,Thrailkill K,Poisner R,Handwerger S

更新日期：1991-05-01 00:00:00

abstract：:The possible roles of the allantoic sac in metabolism of uteroferrin, the iron-containing, purple phosphatase, were examined. This protein, which originates in the maternal endometrium, was measured in allantoic fluid by a specific double-antibody radioimmunoassay and by its beta-mercaptoethanol-activated acid phospha...

journal_title：Placenta

authors： Buhi WC,Ducsay CA,Bartol FF,Bazer FW,Roberts RM

更新日期：1983-01-01 00:00:00

abstract：INTRODUCTION:Research suggests that autism spectrum disorder (ASD) has its origins in utero. This study examines the association between evidence of placental histopathology and ASD. METHODS:Administrative claims data and medical records data were used to identify ASD cases (N = 55) and matched controls (N = 199) born...

journal_title：Placenta

authors： Straughen JK,Misra DP,Divine G,Shah R,Perez G,VanHorn S,Onbreyt V,Dygulska B,Schmitt R,Lederman S,Narula P,Salafia CM

更新日期：2017-09-01 00:00:00

abstract：:The recent discovery of a local renin-angiotensin system in trophoblastic tissues has raised many questions regarding its role in the physiology of normal gestation and its implications in the pathophysiology of hypertension during pregnancy. In this article, the authors first review the most interesting aspects of th...

journal_title：Placenta

authors： Kalenga MK,de Gasparo M,Thomas K,de Hertogh R

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVE:Pregestational maternal obesity (PGMO) associates with foetoplacental vascular endothelial dysfunction and higher risk for insulin resistance in the neonate. We characterised the PGMO consequences on the insulin response of the human foetoplacental vasculature. METHODS:Umbilical veins were from pregnancies w...

journal_title：Placenta

authors： Villalobos-Labra R,Westermeier F,Pizarro C,Sáez PJ,Toledo F,Pardo F,Kusanovic JP,Mardones F,Poblete JA,Sobrevia L,Farías M

更新日期：2019-10-01 00:00:00

abstract：:The aim of this study was to investigate localization and content of activin beta A-subunit and activin receptors in gestational tissues throughout pregnancy and in association with term labour. Placenta and fetal membranes were collected from women undergoing first and second trimester terminations and from women bef...

journal_title：Placenta

authors： Schneider-Kolsky ME,Manuelpillai U,Waldron K,Dole A,Wallace EM

更新日期：2002-04-01 00:00:00

abstract：:Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express ...

journal_title：Placenta

authors： Neradugomma NK,Drafton K,O'Day DR,Liao MZ,Han LW,Glass IA,Mao Q

更新日期：2018-06-01 00:00:00

abstract：:The human placenta is capable of producing a variety of haematopoietic growth factors in vitro. It is not clear, however, whether the placenta produces such factors in vivo and if so, whether placental production of haematopoietic growth factors has a physiological role in fetal haematopoietic development. As a step t...

journal_title：Placenta

authors： Li Y,Calhoun DA,Polliotti BM,Sola MC,al-Mulla Z,Christensen RD

更新日期：1996-11-01 00:00:00

abstract：INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...

journal_title：Placenta

authors： Chen CP,Huang JP,Chu TY,Aplin JD,Chen CY,Wu YH

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Folates are essential nutrients for fetal development and pregnancy outcomes; they are transported to the fetus during gestation through specific folate transporters located in the placenta. In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lo...

journal_title：Placenta

authors： Piñuñuri R,Castaño-Moreno E,Llanos MN,Ronco AM

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Epigenetics is tissue-specific and potentially even cell-specific, but little information is available from human reproductive studies about the concordance of DNA methylation patterns in cord blood and placenta, as well as within-placenta variations. We evaluated methylation levels at promoter regions of ca...

journal_title：Placenta

authors： Janssen BG,Byun HM,Cox B,Gyselaers W,Izzi B,Baccarelli AA,Nawrot TS

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:To elucidate whether trophoblast expansion and invasion are modulated by androgen signaling in an in vitro co-culture model system with decidualizing endometrial stromal cells (ESCs). METHODS:We employed an in vitro co-culture model of early embryo implantation, consisting of human ESCs (EtsT499 cells) an...

journal_title：Placenta

authors： Wongwananuruk T,Sato T,Kajihara T,Matsumoto S,Akita M,Tamura K,Brosens JJ,Ishihara O

更新日期：2016-11-01 00:00:00

abstract：:We have shown that oestrogen has a central integrative role in regulating key components of the progesterone biosynthetic and corticosteroid metabolic pathways within syncytiotrophoblasts that govern placental function and maturation of the fetal pituitary-adrenocortical axis. Studies utilizing classic binding procedu...

journal_title：Placenta

authors： Billiar RB,Pepe GJ,Albrecht ED

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small single-stranded RNA molecules working as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous group of fetal cells forming the feto-maternal interface and displaying a wide spectrum of functions. The regulation of their behavior may partly unde...

journal_title：Placenta

authors： Morales-Prieto DM,Chaiwangyen W,Ospina-Prieto S,Schneider U,Herrmann J,Gruhn B,Markert UR

更新日期：2012-09-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. Th...

journal_title：Placenta

authors： van der Ven K,Pfeiffer K,Skrablin S

更新日期：2000-03-01 00:00:00

abstract：:A protein immunologically identical to the major basic protein (MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. This study demonstrates the presence of similar immunoreactive molecules in the placental X cells from sever...

journal_title：Placenta

authors： Wasmoen TL,Benirschke K,Gleich GJ

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorioni...

journal_title：Placenta

authors： Ertl J,Pichlsberger M,Tuca AC,Wurzer P,Fuchs J,Geyer SH,Maurer-Gesek B,Weninger WJ,Pfeiffer D,Bubalo V,Parvizi D,Kamolz LP,Lang I

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human troph...

journal_title：Placenta

authors： Moon KC,Park JS,Norwitz ER,Kim DI,Oh KJ,Park CW,Jun JK,Syn HC

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...

journal_title：Placenta

authors： Lei D,Deng N,Wang S,Huang J,Fan C

更新日期：2020-01-01 00:00:00