Multiscale three-dimensional imaging of the placenta.

abstract：:Minerals, such as calcium and potassium, are essential for fetal development, but their transplacental transport, and in particular, the effect of hormones on this process has not been extensively studied. Human alpha-calcitonin gene-related peptide (h alpha CGRP), a hormone constituted of 37 amino acids, is obtained ...

journal_title：Placenta

authors： Lafond J,St-Pierre S,Masse A,Savard R,Simoneau L

更新日期：1997-03-01 00:00:00

abstract：INTRODUCTION:Folates are essential nutrients for fetal development and pregnancy outcomes; they are transported to the fetus during gestation through specific folate transporters located in the placenta. In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lo...

journal_title：Placenta

authors： Piñuñuri R,Castaño-Moreno E,Llanos MN,Ronco AM

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorioni...

journal_title：Placenta

authors： Ertl J,Pichlsberger M,Tuca AC,Wurzer P,Fuchs J,Geyer SH,Maurer-Gesek B,Weninger WJ,Pfeiffer D,Bubalo V,Parvizi D,Kamolz LP,Lang I

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

journal_title：Placenta

authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

更新日期：2020-11-14 00:00:00

abstract：:Embryo implantation is the group of processes by which the developing blastocyst adheres to, and embeds into, the receptive endometrium. Changes in the expression of molecules on the cell surface have been seen in the conversion of the endometrial surface from a non-receptive to a receptive state. Cell adhesion molecu...

journal_title：Placenta

authors： Zhao M,Chang C,Liu Z,Chen LM,Chen Q

更新日期：2010-12-01 00:00:00

abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...

journal_title：Placenta

authors： Jirkovská M,Janácek J,Kaláb J,Kubínová L

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:To examine the expression of multifunctional Na(+)-independent organic anion transporting polypeptide, termed OATP-E, involved in the transport of thyroid hormone in human placenta. METHODS:Western blot analysis was performed using a specific antibody against OATP-E in human placenta to confirm the expression ...

journal_title：Placenta

authors： Sato K,Sugawara J,Sato T,Mizutamari H,Suzuki T,Ito A,Mikkaichi T,Onogawa T,Tanemoto M,Unno M,Abe T,Okamura K

更新日期：2003-02-01 00:00:00

abstract：:Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...

journal_title：Placenta

authors： Franklin GC,Adam GI,Ohlsson R

更新日期：1996-01-01 00:00:00

abstract：:Our objective was to evaluate whether antiphospholipid antibody-containing sera could play a regulatory role in signal transduction induced by gonadotrophin releasing hormone (GnRH) when incubated with normal human trophoblast cells. To test this hypothesis we established an in vitro placental culture system in which ...

journal_title：Placenta

authors： Di Simone N,De Carolis S,Lanzone A,Ronsisvalle E,Giannice R,Caruso A

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:We investigated the feasibility of dynamic glucose enhanced (DGE) MRI in accessing placental function in a mouse model of intrauterine inflammatory injury (IUI). DGE uses the glucose chemical exchange saturation transfer (glucoCEST) effect to reflect infused d-glucose. METHODS:IUI was induced in pregnant ...

journal_title：Placenta

authors： Wu D,Xu J,Lei J,Mclane M,van Zijl PC,Burd I

更新日期：2018-09-01 00:00:00

abstract：:Human placental tissues have been shown to contain gonadotrophin-releasing hormone-(GnRH)-like activity. Thus, the effect of a potent GnRH antagonist (N-Ac-Pro1,D-p-Cl-Phe2,D-Nal(2)3,6-GnRH, obtained from Syntex Laboratories) on placental hormonal release was studied. Explant cultures of placentae of 6 to 15 weeks' ge...

journal_title：Placenta

authors： Siler-Khodr TM,Khodr GS,Rhode J,Vickery BH,Nestor JJ Jr

更新日期：1987-01-01 00:00:00

abstract：:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...

journal_title：Placenta

authors： Demir R,Kayisli UA,Seval Y,Celik-Ozenci C,Korgun ET,Demir-Weusten AY,Huppertz B

更新日期：2004-07-01 00:00:00

abstract：UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...

journal_title：Placenta

authors： Braun T,Husar A,Challis JR,Dudenhausen JW,Henrich W,Plagemann A,Sloboda DM

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...

journal_title：Placenta

authors： Chen CP,Huang JP,Chu TY,Aplin JD,Chen CY,Wu YH

更新日期：2013-10-01 00:00:00

abstract：:The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine:glyoxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no det...

journal_title：Placenta

authors： Bennett FI,Jackson AA

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Chronic maternal asthma is associated with reduced growth of the female fetus and normal growth of the male fetus. The mechanisms that control the differential effects of maternal asthma on the fetus have not been fully elucidated but alterations in placental function may play a role. In the current study we...

journal_title：Placenta

authors： Osei-Kumah A,Smith R,Jurisica I,Caniggia I,Clifton VL

更新日期：2011-08-01 00:00:00

abstract：:In human placenta aminopeptidase A (APA), a principal enzyme that converts angiotensin II to angiotensin III, seems to be involved in angiotensin II metabolism during pregnancy. In this study, we investigated the possible effects of progesterone and estrogen on APA mRNA and protein levels in choriocarcinoma cells as a...

journal_title：Placenta

authors： Katsumata Y,Nomura S,Ino K,Iwanaga K,Kurosawa N,Ito T,Okada M,Tsujimoto M,Kikkawa F,Mizutani S

更新日期：2001-11-01 00:00:00

abstract：:This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...

journal_title：Placenta

authors： Aardema MW,Oosterhof H,Timmer A,van Rooy I,Aarnoudse JG

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Pre-gravid obesity is associated with increased morbidity and mortality for both mother and offspring. Recent studies have demonstrated a heightened inflammatory response both systemically and locally within the adipose and placental tissue in women with pre-gravid obesity, which may play a role in mediating...

journal_title：Placenta

authors： Roberts KA,Riley SC,Reynolds RM,Barr S,Evans M,Statham A,Hor K,Jabbour HN,Norman JE,Denison FC

更新日期：2011-03-01 00:00:00

abstract：:The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related...

journal_title：Placenta

authors： Thornburg KL,Kolahi K,Pierce M,Valent A,Drake R,Louey S

更新日期：2016-12-01 00:00:00

abstract：:Pregnancy-associated plasma protein-A was assayed in the blood of 347 women during pregnancy, using a new primary standard of PAPP-A as reference. The protein was assayed by antibody-antigen crossed electrophoresis with the lower limit of confident assay being 9.5 micrograms PAPP-A/ml (13 pmol/ml). PAPP-A was first de...

journal_title：Placenta

authors： Sutcliffe RG,Kukulska-Langlands BM,Horne CH,Maclean AB,Jandial V,Sutherland HW,Gibb S,Bowman AW

更新日期：1982-01-01 00:00:00

abstract：:Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this, little is known about the histological characteristics of the twin or fused placenta and how...

journal_title：Placenta

authors： Lopez-Tello J,Sferruzzi-Perri AN

更新日期：2020-11-02 00:00:00

abstract：:Throughout its entire lifespan, the placenta is able to produce as well as respond to a variety of inflammatory stimuli. Many signaling molecules and concurrent pathways responsible for the propagation of an inflammatory response have been identified in placental cells. From early developmental stages onward, the secr...

journal_title：Placenta

authors： Hauguel-de Mouzon S,Guerre-Millo M

更新日期：2006-08-01 00:00:00

abstract：:The human placenta contains two types of 11beta-hydroxysteroid dehydrogenase (11beta-HSD). The exclusive oxidase 11beta-HSD2 has been suggested to protect the fetus from high levels of maternal glucocorticoids by converting cortisol to inactive cortisone. Perfused term human placenta was used to examine the activity o...

journal_title：Placenta

authors： Sun K,Adamson SL,Yang K,Challis JR

更新日期：1999-01-01 00:00:00

abstract：:Human trophoblast research relies on a combination of in vitro models, including isolated primary cultures, explant cultures, and trophoblast cell lines. In the present study, we have utilized the rotating wall vessel (RWV) bioreactor to generate a three-dimensional (3-D) model of human placentation for the study of c...

journal_title：Placenta

authors： LaMarca HL,Ott CM,Höner Zu Bentrup K,Leblanc CL,Pierson DL,Nelson AB,Scandurro AB,Whitley GS,Nickerson CA,Morris CA

更新日期：2005-11-01 00:00:00

abstract：:Uterine blood flow (UtBF) is a major regulator of transplacental fetal nutrient supply. The aim was to serially measure uterine blood flow from mid to late pregnancy in a paradigm of relatively late onset placental and fetal growth restriction. Singleton bearing adolescent dams was fed high (H) or control (C) nutrient...

journal_title：Placenta

authors： Wallace JM,Milne JS,Matsuzaki M,Aitken RP

更新日期：2008-08-01 00:00:00

abstract：:Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...

journal_title：Placenta

authors： Lash GE,Ansari T,Bischof P,Burton GJ,Chamley L,Crocker I,Dantzer V,Desoye G,Drewlo S,Fazleabas A,Jansson T,Keating S,Kliman HJ,Lang I,Mayhew T,Meiri H,Miller RK,Nelson DM,Pfarrer C,Roberts C,Sammar M,Sharma S,

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The human placenta extrudes a variety of extracellular vesicles (EVs) into the maternal blood daily. These vesicles may be crucial to the adaptation of the maternal cardiovascular and immune systems to pregnancy. Quantifying the EVs that are released in early gestation is important to our understanding of ho...

journal_title：Placenta

authors： Liu H,Kang M,Wang J,Blenkiron C,Lee A,Wise M,Chamley L,Chen Q

更新日期：2018-12-01 00:00:00

abstract：:Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...

journal_title：Placenta

authors： Scott JM

更新日期：1983-01-01 00:00:00

abstract：:Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA p...

journal_title：Placenta

authors： Many A,Westerhausen-Larson A,Kanbour-Shakir A,Roberts JM

更新日期：1996-07-01 00:00:00