Abstract：
:The possible roles of the allantoic sac in metabolism of uteroferrin, the iron-containing, purple phosphatase, were examined. This protein, which originates in the maternal endometrium, was measured in allantoic fluid by a specific double-antibody radioimmunoassay and by its beta-mercaptoethanol-activated acid phosphatase activity. Total uteroferrin reaches a maximum between days 60 and 75 of pregnancy, when it constitutes up to one-third of the total protein, and then declines towards term. Fluid volume, total protein and total iron also reach a maximum around day 60. Two-dimensional polyacrylamide-gel electrophoresis was employed to identify proteins in allantoic fluid. Of the proteins detected, at least three basic and two acidic polypeptides are also characteristic of maternal uterine secretions. The remaining proteins appeared identical to those found in fetal serum and included transferrin, albumin and alpha-fetoprotein. Although uteroferrin acid phosphatase activity is stable when incubated in buffer, the enzyme loses activity in sterile allantoic fluid collected at all stages of pregnancy. Experiments with 59Fe-uteroferrin have shown that allantoic fluid promotes iron loss from uteroferrin and that the metal appears in transferrin. Thus the allantoic sac may serve not only as a depot for uteroferrin accumulation but as a site of active iron metabolism.
journal_name
Placentajournal_title
Placentaauthors
Buhi WC,Ducsay CA,Bartol FF,Bazer FW,Roberts RMsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
455-69eissn
0143-4004issn
1532-3102journal_volume
4 Spec Nopub_type
杂志文章相关文献
PLACENTA文献大全abstract：INTRODUCTION:Gestational diabetes mellitus (GDM) is an increasing harm in pregnancy. Inflammatory processes in the placenta seem to have an influence on pathogenesis besides known factors like maternal BMI. Galectin-13 (gal-13) is an immunoregulatory protein, which is suspected to play a role in development of GDM in t...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.11.019
更新日期：2015-02-01 00:00:00
abstract：:Placental trophoblast syncytialization is a unique biological process. We have studied the time course of this process using DNA microarray in a cell model of syncytialization (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin). Total RNA was extracted from BeWo cells and labelled-...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2003.12.001
更新日期：2004-07-01 00:00:00
abstract：:Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80020-4
更新日期：1983-01-01 00:00:00
abstract：:Amniotic fluid exerts a protective function and is an essential component for foetal development and maturation during pregnancy. However, little is known about the exact physiological functions of foetal fluids in this process as well as their biochemical composition in cats. In the present study, the biochemical com...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.03.002
更新日期：2012-06-01 00:00:00
abstract：:The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2016.10.012
更新日期：2016-12-01 00:00:00
abstract：:Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined. We used whole-mount immunofluorescence analyses to compare uterus and gestation day 4.5-9.5 mouse implantation sites that differed genetically in fetal or mate...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.07.006
更新日期：2014-09-01 00:00:00
abstract：:A protein immunologically identical to the major basic protein (MBP) of eosinophil granules is present in the plasma of pregnant women and has been localized to human placental X cells using immunofluorescence. This study demonstrates the presence of similar immunoreactive molecules in the placental X cells from sever...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(87)90052-x
更新日期：1987-05-01 00:00:00
abstract：:The implantation of the blastocyst and early development of the placenta are crucial for the success of implantation and pregnancy. However, the formative stages of human placental development are largely unknown because of their existence in a 'black box' where access to samples is extremely limited for ethical reaso...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2012.01.020
更新日期：2012-05-01 00:00:00
abstract：:The expression pattern of MHC class I genes in trophoblast cells at the feto-maternal interface is thought to be the basis of the maintenance of pregnancy by protecting the fetus from maternal immune rejection. Transcription of classical HLA class I genes is low or undetectable in most trophoblast cells as well as in ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.1998.0380
更新日期：1999-05-01 00:00:00
abstract：:Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2018.05.002
更新日期：2018-06-01 00:00:00
abstract：:The trophoblastic and endodermal tissues of the guinea pig were cytophotometrically examined at two stages of development, either shortly after the primary trophoblastic giant cell layer had degenerated (Sansom and Hill, 1931) and the visceral yolk sac was starting to form (Kaufman and Davidoff, 1977) (c. 10.5 days p....
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(81)80029-x
更新日期：1981-10-01 00:00:00
abstract：INTRODUCTION:Women with adverse pregnancy outcomes (APOs) have excess risk of later life cardiovascular disease (CVD) perhaps related to an underlying high-risk vascular phenotype. We sought to determine if placental evidence of maternal malperfusion in uncomplicated pregnancies is associated with an increased risk of ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2018.12.008
更新日期：2018-12-15 00:00:00
abstract：:There is inconsistent use of Matrigel for experiments with the HTR8/SVneo first trimester trophoblast and other cell lines. We quantified the effects of Matrigel on the expression of genes considered to be markers of extravillous cytotrophoblast (EVT) differentiation and invasive potential. Culture on Matrigel promote...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.04.003
更新日期：2012-07-01 00:00:00
abstract：:Glycogen storage disease type IV (GSD IV) is a rare autosomal recessive disorder caused by glycogen branching enzyme (GBE) deficiency and resulting in the storage of abnormal glycogen (polyglucosan). Prenatal diagnosis is based on biochemical assay of GBE activity or on mutation analysis, but polyglucosan can also be ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.01.005
更新日期：2008-04-01 00:00:00
abstract：:Human placental tissues have been shown to contain gonadotrophin-releasing hormone-(GnRH)-like activity. Thus, the effect of a potent GnRH antagonist (N-Ac-Pro1,D-p-Cl-Phe2,D-Nal(2)3,6-GnRH, obtained from Syntex Laboratories) on placental hormonal release was studied. Explant cultures of placentae of 6 to 15 weeks' ge...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(87)90035-x
更新日期：1987-01-01 00:00:00
abstract：INTRODUCTION:The velocities of the lateral shear waves (Vs; m s⁻¹) generated by an acoustic radiation force impulse (ARFI) correlate with Young's modulus. Therefore, ARFI can be used as a new method to evaluate tissue elasticity. The aim of this study was to investigate the safety of ARFI imaging and the differences in...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.08.014
更新日期：2013-11-01 00:00:00
abstract：:Hyperplastic placentas have been reported in several experimental mouse models, including animals produced by somatic cell nuclear transfer, by inter(sub)species hybridization, and by somatic cytoplasm introduction to oocytes followed by intracytoplasmic sperm injection. Of great interest are the gross and histologica...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.05.008
更新日期：2008-08-01 00:00:00
abstract：:Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development. In this study, we first confirmed these findings using cRNA probes for TF, and then adapted the TF reverse haemolytic plaque ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80419-9
更新日期：1994-07-01 00:00:00
abstract：:Endothelium derived relaxing factor (EDRF), now widely believed to be nitric oxide (NO), may play an important part in the control of fetoplacental vascular tone. To further explore this role we have determined the relaxation responses to exogenous NO and examined the temporal relationship between intracellular concen...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(94)90004-3
更新日期：1994-06-01 00:00:00
abstract：:During placental development, human cytotrophoblast cells can differentiate to either villous syncytiotrophoblast cells or invasive extravillous trophoblast cells. We hypothesize that oxygen tension plays a critical role in determining the pathway of cytotrophoblast differentiation. A highly purified preparation of cy...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2007.05.006
更新日期：2007-11-01 00:00:00
abstract：:Placentae from controls and two groups of diabetic women (one White classes A, B, C and the other classes D, F/R) were collected at 37-42 weeks of gestation. Tissue sections were analysed using stereological methods in order to quantify the growth and maturational status of villi. Birth and placental weights were reco...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80236-x
更新日期：1994-01-01 00:00:00
abstract：:TRH immunological and biological activity was characterized in rat placental extracts. Placentae were extracted sequentially with 2 N acetic acid and glacial acetic acid. The lyophilized residues were further extracted with 90 per cent methanol, and the extracts were then dried, and reextracted with distilled water. W...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80036-8
更新日期：1983-10-01 00:00:00
abstract：:Stereological methods were used to test whether or not altitudinal, ethnic and sex differences in birthweight in Bolivia are associated with differences in placental morphology. Estimates of the volumes, surface areas, lengths and diameters of villi and of fetal capillaries were obtained by analysing paraffin sections...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(87)90077-4
更新日期：1987-09-01 00:00:00
abstract：OBJECTIVES:Observational and empirical evidence suggest that the average placental shape is round with a centrally inserted umbilical cord. Yet variability of shape is common. When in pregnancy do shape and cord insertion variations originate? MATERIALS AND METHODS:Placental measures from published datasets obtained u...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2011.12.002
更新日期：2012-03-01 00:00:00
abstract：INTRODUCTION:Preeclampsia is characterized by maternal endothelial dysfunction. While the mechanisms leading to preeclampsia are unclear, a factor(s) from the placenta is responsible for triggering the disease. One placental factor implicated in triggering preeclampsia is trophoblast debris which may transmit pathogeni...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.07.009
更新日期：2014-10-01 00:00:00
abstract：:Embryo implantation is the group of processes by which the developing blastocyst adheres to, and embeds into, the receptive endometrium. Changes in the expression of molecules on the cell surface have been seen in the conversion of the endometrial surface from a non-receptive to a receptive state. Cell adhesion molecu...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.10.002
更新日期：2010-12-01 00:00:00
abstract：:The dynamics of nickel (Ni) uptake, transfer, retention and clearance in fetuses and late gestational rats were investigated by assessing its distributions in placenta, maternal and fetal organs and tissues during the 24 h period after a single dose of (63)Ni intraperitoneal injection on gestational day 20. Peak (63)N...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.12.021
更新日期：2011-03-01 00:00:00
abstract：:The aim of this work was to characterize the uptake of 1-methyl-4-phenylpyridinium (MPP(+)) in the JAR human choriocarcinoma cell line. As JAR cells, as well as the placenta, express the neuronal serotonin transporter (SERT), a comparison between the uptake of (3)H-MPP(+) and (3)H-serotonin ((3)H-5HT) was made. Specif...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2002.0917
更新日期：2003-04-01 00:00:00
abstract：INTRODUCTION:Preeclampsia (PE) is one of the leading causes of maternal mortality and morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has been a focus of research. This study was to identified genes or pathways that may be associated with PE, and discuss whether the changes in the me...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2020.02.009
更新日期：2020-04-01 00:00:00
abstract：:Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(84)80054-5
更新日期：1984-03-01 00:00:00
