Downregulation of HLA class I gene transcription in choriocarcinoma cells is controlled by the proximal promoter element and can be reversed by CIITA.

abstract：:The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that ...

journal_title：Placenta

authors： Patel J,Shafiee A,Wang W,Fisk NM,Khosrotehrani K

更新日期：2014-11-01 00:00:00

abstract：:Intra-uterine growth restriction (IUGR) is defined by a restriction of fetal growth during gestation. It is a prevalent significant public health problem that jeopardizes neonatal health but also that can have deleterious consequences later in adult life. Cullins constitute a family of seven proteins involved in cell ...

journal_title：Placenta

authors： Gascoin-Lachambre G,Buffat C,Rebourcet R,Chelbi ST,Rigourd V,Mondon F,Mignot TM,Legras E,Simeoni U,Vaiman D,Barbaux S

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS:A tota...

journal_title：Placenta

authors： Xu T,Zhou Z,Liu N,Deng C,Huang G,Zhou F,Liu X,Wang X

更新日期：2019-08-01 00:00:00

abstract：:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...

journal_title：Placenta

authors： Demir R,Kayisli UA,Seval Y,Celik-Ozenci C,Korgun ET,Demir-Weusten AY,Huppertz B

更新日期：2004-07-01 00:00:00

abstract：:Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development. In this study, we first confirmed these findings using cRNA probes for TF, and then adapted the TF reverse haemolytic plaque ...

journal_title：Placenta

authors： Boockfor FR,Harris SE,Barto JM,Bonner JM

更新日期：1994-07-01 00:00:00

abstract：:Early placental development is characterised by rapid cell differentiation and migration, matrix remodelling and angiogenesis. The enzyme NAD(P)H oxidase is a major source of superoxide anions implicated in signalling pathways regulating these processes in other systems. It is also thought to be involved in oxygen sen...

journal_title：Placenta

authors： Raijmakers MT,Burton GJ,Jauniaux E,Seed PT,Peters WH,Steegers EA,Poston L

更新日期：2006-02-01 00:00:00

abstract：:The possible roles of the allantoic sac in metabolism of uteroferrin, the iron-containing, purple phosphatase, were examined. This protein, which originates in the maternal endometrium, was measured in allantoic fluid by a specific double-antibody radioimmunoassay and by its beta-mercaptoethanol-activated acid phospha...

journal_title：Placenta

authors： Buhi WC,Ducsay CA,Bartol FF,Bazer FW,Roberts RM

更新日期：1983-01-01 00:00:00

abstract：:Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential. It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause of infant mortality and morbidity. There is no treatment currently available for FGR. Its primary cause, when not attributable...

journal_title：Placenta

authors： Swanson AM,David AL

更新日期：2015-06-01 00:00:00

abstract：:Apoptosis is thought to participate pathophysiologically in the rupture of human fetal membranes (ROM). The aim of this study was to assess apoptosis of the amnion and the chorion in relation to ROM and chorioamnionitis (CAM). The amnion and chorion at the position of the cervical os and fundus of the uterus were obta...

journal_title：Placenta

authors： Kataoka S,Furuta I,Yamada H,Kato EH,Ebina Y,Kishida T,Kobayashi N,Fujimoto S

更新日期：2002-02-01 00:00:00

abstract：INTRODUCTION:The placenta is a transient organ the functioning of which has health consequences far beyond the embryo/fetus. Understanding the biology of any system (organ, organism, single cell, etc) requires a comprehensive and inclusive approach which embraces all the biomedical disciplines and 'omic' technologies a...

journal_title：Placenta

authors： Mayhew TM

更新日期：2015-04-01 00:00:00

abstract：:We have shown that oestrogen has a central integrative role in regulating key components of the progesterone biosynthetic and corticosteroid metabolic pathways within syncytiotrophoblasts that govern placental function and maturation of the fetal pituitary-adrenocortical axis. Studies utilizing classic binding procedu...

journal_title：Placenta

authors： Billiar RB,Pepe GJ,Albrecht ED

更新日期：1997-05-01 00:00:00

abstract：:Combined staining of non-cultured interphase nuclei from hydatidiform moles with distamycin A and DAPI resulted in the presence of specific stained interphase bodies. A mean number of six interphase bodies was observed in moles with a diploid karyotype and a mean number of nine interphase bodies was observed in triplo...

journal_title：Placenta

authors： Tommerup N,Vejerslev LO

更新日期：1985-07-01 00:00:00

abstract：:Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord...

journal_title：Placenta

authors： Mantri S,Sheikali A,Binns C,Lyell DJ,DiGiusto DL,Porteus MH,Agarwal-Hashmi R

更新日期：2020-10-13 00:00:00

abstract：INTRODUCTION:Maternal risk factors associated with placenta previa are well documented in the literature. However, there are limited studies identifying maternal characteristics associated with the persistence of placenta previa. The objective of the study was to determine maternal characteristics associated with the p...

journal_title：Placenta

authors： King LJ,Dhanya Mackeen A,Nordberg C,Paglia MJ

更新日期：2020-09-15 00:00:00

abstract：:Alphafetoprotein (AFP) is detectable in maternal serum from around six weeks of gestation and is synthesised by the yolk sac and the fetal liver. The role of the placenta in the transport and possible synthesis of AFP is uncertain. The aim of this study was to investigate placental expression of AFP and the AFP recept...

journal_title：Placenta

authors： Newby D,Dalgliesh G,Lyall F,Aitken DA

更新日期：2005-02-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteropl...

journal_title：Placenta

authors： David AL

更新日期：2017-11-01 00:00:00

abstract：:Amnion is the innermost layer of the fetal membrane and has been suggested to regulate the volume of amniotic fluid via the amniotic epithelium. The transepithelial pathway is generally restricted by tight junctions (TJs). Thus far, human amniotic TJs have not been identified. In this study, we determined whether the ...

journal_title：Placenta

authors： Kobayashi K,Kadohira I,Tanaka M,Yoshimura Y,Ikeda K,Yasui M

更新日期：2010-02-01 00:00:00

abstract：:Although secretory phospholipase A2 (PLA2) isozymes have been identified in human gestational tissues, their role in homeostasis and pathophysiology during pregnancy has yet to be clearly established. The aims of this brief commentary are: (1) to review recent data concerning the expression of secretory PLA2 isozymes ...

journal_title：Placenta

authors： Rice GE

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:The state of activation of dendritic cells (DCs) at the feto-maternal interface critically contributes to optimal decidual immune responses needed to support fetal-placental development. We recently demonstrated that during healthy pregnancy also peripheral blood DCs (PBDCs), which are easily accessible, a...

journal_title：Placenta

authors： Cappelletti M,Giannelli S,Martinelli A,Cetin I,Colombo E,Calcaterra F,Mavilio D,Della Bella S

更新日期：2013-01-01 00:00:00

abstract：:Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CR...

journal_title：Placenta

authors： Giovannelli A,Greenwood SL,Desforges M,Sibley CP,Petraglia F

更新日期：2011-01-01 00:00:00

abstract：:A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1...

journal_title：Placenta

authors： Muñoz M,Pavón A,Rosso M,Salinas MV,Pérez A,Carranza A,González-Ortega A

更新日期：2010-07-01 00:00:00

abstract：:We tested the hypothesis that the expression of placental connective tissue growth factor (CTGF) is enhanced in pregnancies complicated by severe preeclampsia (PE) or fetal growth restriction (FGR). CTGF expression was analyzed using immunostaining, western blot and real-time quantitative PCR in placental samples obta...

journal_title：Placenta

authors： Oh SY,Song SE,Seo ES,Kim KH,Choi SJ,Suh YL,Sadovsky Y,Roh CR

更新日期：2009-11-01 00:00:00

abstract：:Peroxidase (Donor: H(2)O(2)oxidoreductase EC 1.11.1.7) from human term placentae of non-smokers was purified to homogeneity by a combination of NH(4)Cl extraction, affinity chromatography, (NH(4))(2)SO(4)precipitation, ion-exchange and gel filtration chromatography. The homogeneity of purified human placental peroxida...

journal_title：Placenta

authors： Madhavan ND,Naidu KA

更新日期：2000-07-01 00:00:00

abstract：:Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...

journal_title：Placenta

authors： Franklin GC,Adam GI,Ohlsson R

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Hypotaurine is a precursor of taurine and an antioxidant, and is concentrated in fetal plasma compared to maternal plasma. Hypotaurine is significantly decreased in fetal plasma of ezrin (Vil2) knock-out mice, and fetuses show intrauterine growth retardation. The aim of this study was to characterize the m...

journal_title：Placenta

authors： Nishimura T,Duereh M,Sugita Y,Yoshida Y,Higuchi K,Tomi M,Nakashima E

更新日期：2015-06-01 00:00:00

abstract：:In human placenta aminopeptidase A (APA), a principal enzyme that converts angiotensin II to angiotensin III, seems to be involved in angiotensin II metabolism during pregnancy. In this study, we investigated the possible effects of progesterone and estrogen on APA mRNA and protein levels in choriocarcinoma cells as a...

journal_title：Placenta

authors： Katsumata Y,Nomura S,Ino K,Iwanaga K,Kurosawa N,Ito T,Okada M,Tsujimoto M,Kikkawa F,Mizutani S

更新日期：2001-11-01 00:00:00

abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

journal_title：Placenta

authors： Loke YW,King A

更新日期：1990-07-01 00:00:00

abstract：INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...

journal_title：Placenta

authors： Koppes E,Shaffer B,Sadovsky E,Himes K,Barak Y,Sadovsky Y,Chaillet JR

更新日期：2019-12-01 00:00:00

abstract：:Wharton's jelly contains large amounts of hyaluronic acid, and glucosamine is an important constituent of this macromolecule. In order to evaluate the placental vascular effects of this aminosugar, small chorionic and stem villous arteries were dissected from placental specimens obtained at normal term vaginal deliver...

journal_title：Placenta

authors： Uldbjerg N,Allen J,Maigaard S,Forman A

更新日期：1987-07-01 00:00:00

abstract：:The visceral yolk sac (VYS) is responsible for a major part of the amino acid nutrition of the early post-implantation rat embryo and possibly also at the fetal stage of gestation. The mechanism involves endocytic uptake of proteins by the tissue's epithelial cells followed by intralysosomal digestion to amino acids. ...

journal_title：Placenta

authors： Pratten MK,Lloyd JB

更新日期：1997-09-01 00:00:00