Abstract:
INTRODUCTION:Maternal risk factors associated with placenta previa are well documented in the literature. However, there are limited studies identifying maternal characteristics associated with the persistence of placenta previa. The objective of the study was to determine maternal characteristics associated with the persistent placenta previa. METHODS:A retrospective cohort study was conducted in which 705 pregnant women diagnosed with low-lying placenta or placenta previa between 17 and 24 weeks gestation were identified from a single institution between 2003 and 2017. The primary outcome included persistent placenta previa (i.e., persistent placental tissue within 2 cm of the internal os) at or after 36 weeks 0 days. Those with abnormal placentation (e.g., vasa previa, placenta accreta) or delivery prior to 36 weeks 0 days were excluded. Multivariable logistic regression modeling was utilized to determine significant maternal characteristics associated with persistent placenta previa among women diagnosed with either placenta previa or low-lying placenta. RESULTS:Women with a prior cesarean delivery were seven times more likely to have persistent placenta previa (odds ratio, 7.0, 95% confidence interval, 3.7-13.1). A history of intrauterine curettage or evacuation in the setting of placenta previa increases the likelihood of persistent placenta previa almost 3-fold (odds ratio, 2.5, 95% confidence interval, 1.3-5.0). DISCUSSION:To date, our study is the largest, retrospective cohort study assessing maternal risk factors associated with persistent placenta previa; and is the first to detect a statistically significant correlation between a history of intrauterine surgeries and persistent placenta previa.
journal_name
Placentajournal_title
Placentaauthors
King LJ,Dhanya Mackeen A,Nordberg C,Paglia MJdoi
10.1016/j.placenta.2020.08.004subject
Has Abstractpub_date
2020-09-15 00:00:00pages
189-192eissn
0143-4004issn
1532-3102pii
S0143-4004(20)30257-5journal_volume
99pub_type
杂志文章相关文献
PLACENTA文献大全abstract::MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level. While mostly intracellular, a portion of cellular miRNAs is released to the circulation and their level in the plasma is altered in certain pathological conditions such as cancer, and also during pregnancy. We...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.07.001
更新日期:2010-09-01 00:00:00
abstract::Maternal feed allowance during pregnancy can affect the development of the ovine placenta and fetus. The impact of variations in feed allowance prior to as well as throughout pregnancy has received less attention. Ewes were offered 0.6 (R), 1.2 (C) or 1.8 (AL) maintenance requirements from 89 days before conception un...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.02.014
更新日期:2008-06-01 00:00:00
abstract::This study examines the vasorelaxation of isolated human placental chorionic plate arteries and the perfused fetal-placental vasculature, in vitro, to a variety of nitrovasodilator compounds including glyceryl trinitrate (GTN) sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP), S-nitroso-N-glutathione ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0625
更新日期:2001-04-01 00:00:00
abstract::Heme oxygenase (HO) is the rate-limiting enzyme in the heme catabolic pathway and highly expressed in the placenta. Deficiencies in HO-1, the inducible isoform, have been associated with pregnancy disorders, such as recurrent miscarriages, intrauterine growth retardation, and pre-eclampsia. The aim of this study was t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.07.012
更新日期:2009-10-01 00:00:00
abstract::Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this, little is known about the histological characteristics of the twin or fused placenta and how...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.036
更新日期:2020-11-02 00:00:00
abstract:INTRODUCTION:During a pregnancy complicated by diabetes, the human placenta undergoes a number of functional and structural pathologic changes, such as increased placental weight and increased incidence of placental lesions including villous maturational defects and fibrinoid necrosis. The pathologic findings reported ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2014.11.021
更新日期:2015-02-01 00:00:00
abstract::Placental hypoxia as a result of impaired trophoblast invasion is suggested to be involved in the pathophysiology of preeclampsia. Hypoxia is a potent stimulus for the release of adenosine, and the actions of adenosine are mediated through four adenosine receptors, A(1), A(2A), A(2B) and A(3). We investigated the pres...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.02.004
更新日期:2009-05-01 00:00:00
abstract:INTRODUCTION:Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition. We investigated the effect of OA supplementation on PG production using an in vitro model of ovine placenta. METHO...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.07.128
更新日期:2015-09-01 00:00:00
abstract::The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology si...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2011.06.019
更新日期:2011-10-01 00:00:00
abstract::The aim of the present study was to evaluate the relationship between the retention of fetal membranes (RFM) and apoptosis of the cells in fetal membranes. The present study investigated mRNA and protein expressions of apoptosis-regulating factors: FAS, cellular FLICE-like inhibiting protein (cFLIP), BAX, BCL2, caspas...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.10.016
更新日期:2011-01-01 00:00:00
abstract::Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.04.012
更新日期:2006-04-01 00:00:00
abstract::Amniotic fluid exerts a protective function and is an essential component for foetal development and maturation during pregnancy. However, little is known about the exact physiological functions of foetal fluids in this process as well as their biochemical composition in cats. In the present study, the biochemical com...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.03.002
更新日期:2012-06-01 00:00:00
abstract::It has been suggested that adenosine is involved in the acute effects of ethanol in a number of tissues. The present study was undertaken to evaluate the role of adenosine on the vascular responses of perfused isolated human placental cotyledons after the acute administration of ethanol. The possibility that ethanol m...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80038-0
更新日期:1997-07-01 00:00:00
abstract:INTRODUCTION:We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS:In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T I...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.12.006
更新日期:2020-12-13 00:00:00
abstract::Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80054-5
更新日期:1984-03-01 00:00:00
abstract::Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.021
更新日期:2015-12-01 00:00:00
abstract::Endothelium-derived nitric oxide (NO) plays a key role in the regulation of vascular tone in health and disease. The present study addresses the contribution of NO to the baseline vascular tone in the fetal placental circulation of type 1 diabetic women. To this end, we performed ex-vivo dual perfusions of isolated co...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(03)00171-1
更新日期:2003-11-01 00:00:00
abstract::Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.018
更新日期:2020-10-13 00:00:00
abstract:INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.05.009
更新日期:2020-08-01 00:00:00
abstract::Chemokines are small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors. In reproductive biology, they have been implicated in ovulation, menstruation, and embryo implantation, and pathological processes such as preterm delivery, HIV infection, and endometriosis. It is known that...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(03)00134-6
更新日期:2003-10-01 00:00:00
abstract:INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.09.013
更新日期:2019-12-01 00:00:00
abstract::Placental villi of early and term human placentae were dissociated with trypsin and mixed cell cultures were established. The different cell types were identified and estimated over a 14-day culture period using antibodies to keratin and vimentin filaments and their capacity to phagocytose yeast. The three main cell t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80047-8
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For t...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.04.003
更新日期:2007-04-01 00:00:00
abstract:INTRODUCTION:Type 1 diabetes (T1D) is associated with adverse pregnancy outcome, usually attributed to hyperglycemia. Recently, we showed that pregnancy outcome in normoglycemic T1D rats was characterized by decreased fetal and placental weight, suggesting impaired placental development. In the present study, we tested...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.12.004
更新日期:2015-02-01 00:00:00
abstract::The hormone leptin (OB) and its receptor (OB-R) are key homeostatic regulators of mammalian body weight. Two predominant isoforms of OB-R are expressed by alternative splicing: the long form, OB-RL, with full signalling capacity is highly expressed in the hypothalamus and the short, signalling-defective form, OB-Rs, i...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0836
更新日期:2002-07-01 00:00:00
abstract:UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.02.002
更新日期:2013-05-01 00:00:00
abstract::An interaction between heparin and circulating pregnancy-associated plasma protein A (PAPP-A) has been observed. This interaction could be reversed by the addition of the specific heparin antagonist protamine sulphate. In the presence of heparin, crossed immunoelectrophoretic analysis revealed an alteration in the ele...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80013-7
更新日期:1983-01-01 00:00:00
abstract::The intrauterine environment has an important influence on placental development. In pre-eclampsia (PE) and intrauterine growth restriction (IUGR), early remodelling of spiral arteries has repercussions for uteroplacental blood flow. The IUGR placenta exhibits compromised growth of villous trees, a smaller intervillou...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.04.005
更新日期:2010-07-01 00:00:00
abstract::Human placental fragments concentrate 86Rb 10--20-fold during a two-hour incubation period. Inhibition of ouabain is dose-dependent, reaching 90 + per cent at a concentration of 5 x 10(-5) M. The clearance index of 86Rb across the perfused human placenta is 0.34 +/- 0.08, comparing to previously reported indices for N...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80038-1
更新日期:1983-10-01 00:00:00
abstract::Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the stimulation of the onset of parturition. Recent studies have found that corticotrophin-releasing hormone (CRH), the hypothalamic component of this axis is also present in the placenta and the fetal membranes. We review the evidence d...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/0143-4004(91)90015-8
更新日期:1991-03-01 00:00:00