Abstract:
:Early placental development is characterised by rapid cell differentiation and migration, matrix remodelling and angiogenesis. The enzyme NAD(P)H oxidase is a major source of superoxide anions implicated in signalling pathways regulating these processes in other systems. It is also thought to be involved in oxygen sensing and regulation of the expression of antioxidant genes. We therefore investigated NAD(P)H oxidase activity in placental tissues in early pregnancy and at term, and correlated this with antioxidant capacity. We collected placental tissues from women undergoing termination of pregnancy (n=19; gestational age 11(+6)+/-1(+0) weeks), and those with elective caesarean section at term after uncomplicated pregnancy (n=15; gestational age 38(+6)+/-0(+4) weeks). Tissues were assayed for superoxide production, using lucigenin chemiluminescence, and three independent markers of antioxidant capacity. In human placentas from normal deliveries at term substantial basal NAD(P)H activity was present. Activity was almost threefold higher in early pregnancy (P<0.0001). This was paralleled by higher total antioxidant capacity (P<0.0001), tissue glutathione concentrations (P<0.01) and gluthathione S-transferase enzyme activity (P<0.05) when compared to corresponding term placental values. NAD(P)H oxidase mediated superoxide generation could be an important modulator of the antioxidant defence response in early pregnancy.
journal_name
Placentajournal_title
Placentaauthors
Raijmakers MT,Burton GJ,Jauniaux E,Seed PT,Peters WH,Steegers EA,Poston Ldoi
10.1016/j.placenta.2005.02.013keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
158-63issue
2-3eissn
0143-4004issn
1532-3102pii
S0143-4004(05)00062-7journal_volume
27pub_type
杂志文章相关文献
PLACENTA文献大全abstract::The uptake of [3H]choline and its conversion to [3H]acetylcholine were investigated in term human placental tissue in vitro. Although the net uptake of [3H]choline increased throughout a 45 min incubation period, intracellular [3H]choline levels reach a plateau after 2 min. There was a constant increase in [3H]acetylc...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80036-3
更新日期:1984-05-01 00:00:00
abstract::Human placental villi from both normal and complicated pregnancies were examined by both light and scanning electron microscopy. The findings provide evidence that histological features such as syncytial sprouts, bridges, and a net-like arrangement of villi represent tangential sections of irregularly shaped villi rat...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90047-6
更新日期:1987-05-01 00:00:00
abstract:INTRODUCTION:The breast cancer resistance protein (BCRP/ABCG2) is an efflux transporter in the placental barrier. By transporting chemicals from the fetal to the maternal circulation, BCRP limits fetal exposure to a range of drugs, toxicants, and endobiotics such as bile acids and hormones. The purpose of the present s...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.04.006
更新日期:2017-07-01 00:00:00
abstract::Antigen expression by villous and extravillous human trophoblast populations at discrete anatomical sites has been reviewed. The various different antigenic phenotypes have been highlighted using a panel of monoclonal antibodies reactive with characteristic trophoblast membrane antigens, a trophoblast-leucocyte common...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(85)80063-1
更新日期:1985-03-01 00:00:00
abstract::It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(05)80220-6
更新日期:1990-07-01 00:00:00
abstract::Receptors for complexes between alpha 2-macroglobulin (alpha 2M) and proteinases (e.g. trypsin) were identified and characterized in the human placenta. The receptors also bound the complex formed between pregnancy zone protein (PZP) and chymotrypsin, although with slightly lower affinity, whereas binding of alpha 2M ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90019-7
更新日期:1988-09-01 00:00:00
abstract:INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.05.009
更新日期:2020-08-01 00:00:00
abstract::Eleven placentae and one fibroblast cell culture from pregnancies complicated by various inherited metabolic disorders, together with five chorionic villus biopsies from pregnancies at risk, were examined for ultrastructural evidence of accumulation of metabolites. Abnormal ultrastructural features were present as ear...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80215-2
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:To evaluate pregnancy outcome and ultrasound diagnosis in patients with histologically-confirmed placental chorioangioma. STUDY DESIGN:Placentas with histological diagnosis of chorioangioma were identified and medical charts were reviewed for findings of ultrasound examinations. Pregnancy outcomes were compa...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.06.007
更新日期:2011-09-01 00:00:00
abstract::Corticosteroid conversion by early (7 to 10 weeks) and late (36 to 42 weeks) human placenta, fetal membranes and decidua was studied. Tritiated cortisol, cortisone, corticosterone, 11-dehydrocorticosterone (DHC) and 11-deoxycorticosterone (DOC) were incubated in vitro with homogenates of these tissues and extracts chr...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(81)80025-2
更新日期:1981-10-01 00:00:00
abstract::Placentae from controls and two groups of diabetic women (one White classes A, B, C and the other classes D, F/R) were collected at 37-42 weeks of gestation. Tissue sections were analysed using stereological methods in order to quantify the growth and maturational status of villi. Birth and placental weights were reco...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80236-x
更新日期:1994-01-01 00:00:00
abstract::This study was based on the hypothesis that both primary sequence and methylation status of the GTPase activating protein (GAP) gene limits expression of p100 GAP to primate placenta. Due to alternate splicing, a 65-bp insert appears between the first and second coding exons of p100 GAP mRNA, and translation of p100 G...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90012-1
更新日期:1998-03-01 00:00:00
abstract::Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were the first endocannabinoids to be characterized, that bind two G protein-coupled receptors, CB1 and CB2. AEA synthesized by multiple pathways, including NAPE-specific phospholipase D (NAPE-PLD) and degraded by the fatty acid amide hydrolase (FAAH). AEA levels are ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.03.015
更新日期:2009-06-01 00:00:00
abstract::Members of the transmembrane emp24 domain (Tmed)/p24 family of proteins are required for transport of proteins between the endoplasmic reticulum and the Golgi. One member of this family, Tmed2/p24β1, is expressed during placental development in mice and its expression is required for normal development of the labyrint...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.12.009
更新日期:2012-03-01 00:00:00
abstract::In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal ce...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)90071-0
更新日期:1997-01-01 00:00:00
abstract::Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. Th...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1053/plac.1999.0515
更新日期:2000-03-01 00:00:00
abstract::Sections of human term placentae delivered at low and high altitude to indigenous and non-indigenous populations in Bolivia were analysed by stereological methods. Estimates were obtained of the arithmetic and harmonic mean thicknesses of villous membrane and of trophoblast. These values were then used to derive indic...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90067-7
更新日期:1988-01-01 00:00:00
abstract::We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.11.003
更新日期:2010-01-01 00:00:00
abstract::Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.008
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether DNA-associated micro-particles (MPs) in maternal plasma express fetal-derived human leukocyte antigen-G (HLA-G) or placental alkaline phosphatase (PLAP) and whether the levels differ between women with normotensive pregnancies and preeclampsia. METHODS:DNA-asso...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.06.012
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Chromatin alterations are important mediators of gene expression changes. We have recently shown that activated non-canonical NF-κB signaling (RelB/p52) recruits histone acetyltransferase CBP and deacetylase HDAC1 to selectively acetylate H3K9 (H3K9ac) to induce expression of corticotropin-releasing hormone ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.01.010
更新日期:2019-01-15 00:00:00
abstract::There is inconsistent use of Matrigel for experiments with the HTR8/SVneo first trimester trophoblast and other cell lines. We quantified the effects of Matrigel on the expression of genes considered to be markers of extravillous cytotrophoblast (EVT) differentiation and invasive potential. Culture on Matrigel promote...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.04.003
更新日期:2012-07-01 00:00:00
abstract::The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology si...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2011.06.019
更新日期:2011-10-01 00:00:00
abstract:INTRODUCTION:The interaction between trophoblast cells and maternal uterine endothelium is important for placental vascular modelling. Nitric oxide (NO) is a potent vasorelaxant that regulates systemic blood pressure and is reduced in preeclampsia. NO may affect placental cell interaction. OBJECTIVES:This study was to...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.03.009
更新日期:2014-06-01 00:00:00
abstract:INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.01.004
更新日期:2015-04-01 00:00:00
abstract::The placental renin-angiotensin system (RAS) is involved in placentation. We have shown that prorenin mRNA (REN) is expressed in a first trimester trophoblast cell line (HTR-8/SVneo) but not in a choriocarcinoma cell line (BeWo). We attempted to stimulate RAS expression in these cells by cAMP, 5'-aza-2'-deoxycytidine ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.12.018
更新日期:2013-03-01 00:00:00
abstract::Apoptosis is thought to participate pathophysiologically in the rupture of human fetal membranes (ROM). The aim of this study was to assess apoptosis of the amnion and the chorion in relation to ROM and chorioamnionitis (CAM). The amnion and chorion at the position of the cervical os and fundus of the uterus were obta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0776
更新日期:2002-02-01 00:00:00
abstract::Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CR...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.10.015
更新日期:2011-01-01 00:00:00
abstract::The molecular heterogeneity of pregnancy-specific beta 1-glycoprotein (SP1) was examined by analytical immunoelectrophoresis and a radioimmunostaining technique of immunoelectrophoretic plates. Analytical crossed immunoelectrophoretic analysis and radioimmunostaining of these plates demonstrated the presence of normal...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(81)80006-9
更新日期:1981-07-01 00:00:00
abstract::The effects of 8-epi-prostaglandin F(2alpha)(8-epi-PGF(2alpha)) and the thromboxane A(2)-mimetic U46619 were examined on isolated human fetal placental arteries obtained from normal pregnancies and from those complicated by pre-eclampsia. The effects of these agents were examined on both conduit and resistance arterie...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0690
更新日期:2001-07-01 00:00:00