Abstract:
:Sections of human term placentae delivered at low and high altitude to indigenous and non-indigenous populations in Bolivia were analysed by stereological methods. Estimates were obtained of the arithmetic and harmonic mean thicknesses of villous membrane and of trophoblast. These values were then used to derive indices of thickness variation. No significant ethnic, sex or interaction effects were found. At high altitude, the villous membrane was significantly more variable in thickness owing to a lower harmonic mean but the same arithmetic mean thickness. Alterations in the arithmetic and harmonic mean thicknesses of the trophoblast contributed to the thinning of the villous membrane. The trophoblast was thinner and more irregular in thickness at high altitude. These findings are discussed in the context of placental diffusing capacity and the possible mechanisms for formation of vasculosyncytial membranes.
journal_name
Placentajournal_title
Placentaauthors
Jackson MR,Mayhew TM,Haas JDdoi
10.1016/0143-4004(88)90067-7subject
Has Abstractpub_date
1988-01-01 00:00:00pages
1-8issue
1eissn
0143-4004issn
1532-3102pii
0143-4004(88)90067-7journal_volume
9pub_type
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