Abstract:
:Members of the transmembrane emp24 domain (Tmed)/p24 family of proteins are required for transport of proteins between the endoplasmic reticulum and the Golgi. One member of this family, Tmed2/p24β1, is expressed during placental development in mice and its expression is required for normal development of the labyrinth layer. Although TMED2 is conserved in humans, little is known about its expression and function in human placenta. We examined TMED2 expression in human placenta between 5.5 and 40 weeks of gestation and showed that TMED2 is expressed in syncytiotrophoblast, cytotrophoblast, and stromal cells. We also found high levels of TMED2 expression in BeWo but not in JEG-3 choriocarcinoma cell line. We used the BeWo cell line to determine TMED2 subcellular localization in placental cells and show its co-localization with the endoplasmic reticulum Golgi intermediate compartment. Our findings show conservation of TMED2 expression in human placenta and suggest that this protein may also play a role during placental development in humans.
journal_name
Placentajournal_title
Placentaauthors
Zakariyah A,Hou W,Slim R,Jerome-Majewska Ldoi
10.1016/j.placenta.2011.12.009subject
Has Abstractpub_date
2012-03-01 00:00:00pages
214-9issue
3eissn
0143-4004issn
1532-3102pii
S0143-4004(11)00589-3journal_volume
33pub_type
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