Abstract:
:Dietary taurine is essential for cats and deficiency during pregnancy may lead to abortion, growth restriction or impaired neurological function of kittens. We previously described Na(+)- and Cl(-)-dependent taurine transport by system beta in fragments of freshly isolated cat placenta [Champion EE, Bailey SJ, Glazier JD, Jones CJP, Mann SJ, Rawlings JM, et al. Taurine uptake into cat placental tissue fragments. Placenta 2001;22:A.42]. Here we evaluate long term culture of cat placental explants as a model for the future study of chronic nutrient regulation of amino acid transport in this species. The cat placental explants displayed (i) Na(+)-dependent [(3)H]taurine uptake and (ii) taurine transporter protein on day 7 of culture, as observed in fresh cat placental fragments. The explants had preserved the ability to secrete PGF(2alpha) hormone until day 11 of culture and remained morphologically largely intact until day 7 of culture. This model of placental explant culture will provide an important in vitro method for the study of chronic regulation of amino acid transport in the cat.
journal_name
Placentajournal_title
Placentaauthors
Champion EE,Mann SJ,Glazier JD,Jones CJ,Rawlings JM,Sibley CP,Greenwood SLdoi
10.1016/j.placenta.2004.07.010keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
608-16issue
8-9eissn
0143-4004issn
1532-3102pii
S0143-4004(04)00250-4journal_volume
26pub_type
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