Abstract:
:Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the placental dysfunction in pre-eclampsia (PE). However, it is not known if altered IL-6 receptor signalling and decreased SOCS-3 expression occur in placentas from PE. To study this, we examined IL-6, soluble IL-6R (sIL-6R) and soluble gp130 (sgp130) production by villous tissue from normal and PE placentas. Hypoxia effects on IL-6, sIL-6R and sgp130 production was determined. IL-6R, gp130 and SOCS-3 expression were determined by immunohistochemical staining and by Western blot. Our results showed that under normoxic conditions (21% O(2)), villous tissue from PE placentas produced relative more sgp130, but significantly less IL-6 and sIL-6R (p<0.01) than normal placental tissue. The ratio of sgp130/sIL-6R release was significantly higher by PE placentas than normal placentas, p<0.01. Under hypoxic conditions (2% O(2)), IL-6 production was significantly reduced by both normal (p<0.01) and PE (p<0.05) placental tissue. Hypoxia promoted sgp130 release by normal, but not by PE, placental tissue. Reduced IL-6R and SOCS-3 immunostaining and expression were found in PE placentas. We concluded that increased ratio of sgp130/sIL-6R production and/or reduced sIL-6R production combined with down-regulation of IL-6R and SOCS-3 expression in trophoblasts may lead to less cytokine inhibitory activity in PE placentas, which may account for the increased placental inflammatory response in PE.
journal_name
Placentajournal_title
Placentaauthors
Zhao S,Gu Y,Dong Q,Fan R,Wang Ydoi
10.1016/j.placenta.2008.09.011subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1024-8issue
12eissn
0143-4004issn
1532-3102pii
S0143-4004(08)00313-5journal_volume
29pub_type
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