Abstract:
INTRODUCTION:Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic characteristics. METHODS:A cross-sectional study of third trimester placentas was conducted to identify immune cell subpopulations in CVUE and MCI (n = 17/group). CVUE was diagnosed with H&E staining and antibody to CD3 in serial sections; and MCI, by the presence of massive infiltration of mononuclear cells in the intervillous spaces. Immune cells, ICAM-1 expression and nuclear factor κB (NF-κB) activation were determined immunohistochemically. RESULTS:CVUE and MCI showed similar infiltrates, mainly CD68+ and CD3+ cells. Most cells (>80%) were CD45RB+, and one third were CD45RO+ in both lesions. There were slightly more CD8+ than CD4+ cells in both CVUE and MCI. More than 90% of cells in CVUE and MCI were ICAM-1+ with NFκB nuclear localization. Syncytiotrophoblast ICAM-1 expression was significantly (p < 0.001) higher in MCI (mean of 81.0; range of 71.6-86.0) than in CVUE (52.4; 36.4-59.4) or normal placentas (0.2; 0.0-0.6). Both, failure of physiologic transformation of spiral arteries and placental atherosclerosis-like lesions of atherosis were significantly more frequent in MCI than in CVUE or normal placentas (p = 0.044 and p = 0.007, respectively). DISCUSSION:These finding suggest that MCI and CVUE have very similar infiltration of immune cells although MCI has more severe placental lesions.
journal_name
Placentajournal_title
Placentaauthors
Labarrere CA,Hardin JW,Haas DM,Kassab GSdoi
10.1016/j.placenta.2015.03.008subject
Has Abstractpub_date
2015-06-01 00:00:00pages
681-6issue
6eissn
0143-4004issn
1532-3102pii
S0143-4004(15)00865-6journal_volume
36pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Alphafetoprotein (AFP) is detectable in maternal serum from around six weeks of gestation and is synthesised by the yolk sac and the fetal liver. The role of the placenta in the transport and possible synthesis of AFP is uncertain. The aim of this study was to investigate placental expression of AFP and the AFP recept...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.06.005
更新日期:2005-02-01 00:00:00
abstract::During the first trimester in normal human pregnancy, endovascular trophoblast migrate along the decidual spiral arteries and invade their walls to produce physiological change. There is controversy as to whether invading trophoblast plug the arteries and prevent blood flow into the intervillous space. Using light mic...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80048-3
更新日期:1997-07-01 00:00:00
abstract::Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0944
更新日期:2003-05-01 00:00:00
abstract::The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine:glyoxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no det...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90066-2
更新日期:1998-05-01 00:00:00
abstract::Antigenic material previously detected in human placental trophoblastic cells by immunoperoxidase staining using a goat antiserum against the feline RD114 retrovirus structural protein p30 was isolated by immunochromatography from normal syncytiotrophoblast. The antigen was used to immunize mice, and of the monoclonal...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80001-6
更新日期:1984-11-01 00:00:00
abstract::Direct measurements of electrical potential and input resistance were performed on the syncytial membrane facing maternal blood. The potentials varied according to the external potassium ion levels and, to a lesser extent, with sodium ion concentrations. Ouabain provoked a rapid and consistent depolarization which ind...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90012-4
更新日期:1988-03-01 00:00:00
abstract:INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.05.009
更新日期:2020-08-01 00:00:00
abstract::Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development. In this study, we first confirmed these findings using cRNA probes for TF, and then adapted the TF reverse haemolytic plaque ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80419-9
更新日期:1994-07-01 00:00:00
abstract::We have previously shown that thioredoxin and thioredoxin reductase were immunohistochemically localized in cytotrophoblasts, decidua and stromal cells in the stem villi of human placenta and that the addition of exogenous thioredoxin and thioredoxin reductase to mitochondrial fractions from human placenta displayed a...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0415
更新日期:1999-09-01 00:00:00
abstract:UNLABELLED:Placental hypoxia has been implicated in pregnancy pathologies such as preeclampsia. We have previously reported that AQP9 is highly expressed in syncytiotrophoblast from normal placentas and shows an overexpression in preeclamptic placentas, with a lack of functionality for water transport. Up to now, the r...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.04.017
更新日期:2013-08-01 00:00:00
abstract::Neonates born after pregnancies complicated by diabetes or intrauterine growth restriction (IUGR) have increased incidence of hypocalcaemia. Furthermore, IUGR is associated with reduced bone mineralization in infancy and osteoporosis in adult life. We tested the hypothesis that placental calcium transport is altered i...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0941
更新日期:2003-05-01 00:00:00
abstract:INTRODUCTION:Escherichia coli is recognized as an etiological bacteria associated with chorioamnionitis and the preterm premature rupture of fetal membranes. This pathological condition induces pro-inflammatory cytokines and degradative metalloproteinases, which are considered biological markers secreted in an acute st...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.12.011
更新日期:2015-03-01 00:00:00
abstract::Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. Th...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1053/plac.1999.0515
更新日期:2000-03-01 00:00:00
abstract::This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.02.017
更新日期:2006-02-01 00:00:00
abstract::Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological functi...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2010.02.010
更新日期:2010-05-01 00:00:00
abstract:INTRODUCTION:Abnormally invasive placenta (AIP) is a rare pregnancy complication often resulting in postpartum haemorrhage (PPH) and emergency peripartum hysterectomy (EPH). The risk of developing post traumatic stress disorder (PTSD) following unexpectedly traumatic childbirth is known however there is no evidence reg...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.04.004
更新日期:2019-06-01 00:00:00
abstract::Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(89)90038-6
更新日期:1989-03-01 00:00:00
abstract:INTRODUCTION:Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. METHODS:Eleven sheep ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.301
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS:In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T I...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.12.006
更新日期:2020-12-13 00:00:00
abstract::Angiotensinogen is the substrate for the enzyme renin. In addition to the well-characterized low molecular weight forms of angiotensinogen, a high molecular weight form (HMrA) comprises about 15 per cent of the total angiotensinogen in plasma of pregnant women. In the current study the different forms of angiotensinog...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80386-8
更新日期:1993-11-01 00:00:00
abstract::The clinical features of the maternal syndrome of pre-eclampsia can be explained by generalised maternal endothelial cell dysfunction, which is a part of a more global maternal systemic inflammatory response. There is growing evidence that these effects are associated with the shedding of cellular debris, including sy...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.08.018
更新日期:2008-11-01 00:00:00
abstract::The intrauterine environment has an important influence on placental development. In pre-eclampsia (PE) and intrauterine growth restriction (IUGR), early remodelling of spiral arteries has repercussions for uteroplacental blood flow. The IUGR placenta exhibits compromised growth of villous trees, a smaller intervillou...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.04.005
更新日期:2010-07-01 00:00:00
abstract::Changes in placental lipid content in rats at the 15th and 20th days of pregnancy were investigates. It was found that progress of gestation is accompanied by a significant increase in triglycerides per mg placental DNA. Maternal starvation caused additional increase in the placental triglyceride content. By incubatio...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(80)80033-6
更新日期:1980-10-01 00:00:00
abstract::Maternal-to-fetal transmission of the murine lactate dehydrogenase-elevating virus (LDV) has been previously shown to be regulated by maternal immunity as well as gestational age. For the present study, the role of maternal immunity in placental and umbilical cord virus protection was studied, and virus targeting of u...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0829
更新日期:2002-05-01 00:00:00
abstract::Pregnancy-specific beta 1-glycoprotein (Schwangerschaftsprotein, SP1) is elevated in the amniotic fluid in Meckel's syndrome. In an attempt to clarify this phenomenon, we studied fetal tissues by immunohistochemistry for the distribution of SP1 in normal fetuses and fetuses with Meckel's syndrome. The amount of SP1 wa...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90070-1
更新日期:1987-07-01 00:00:00
abstract::Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteropl...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2017.09.011
更新日期:2017-11-01 00:00:00
abstract::We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0610
更新日期:2001-02-01 00:00:00
abstract::Maternal diabetes affects the development of the offspring by altering the uterine environment. We aimed to investigate the extent to which the blood flow (measured as Tissue Perfusion Units; TPU) to implantation sites and the expression of developmentally important genes in the offspring are affected by maternal diab...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.02.005
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:To study the relationship between 2-dimensional placental ultrasound measurements and maternal serum (MS) levels of biomarkers of placentation and in pregnancies presenting with an isolated abnormally high or low birthweight at term, without evidence of placental insufficiency. METHOD:We performed a popul...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.02.005
更新日期:2016-04-01 00:00:00
abstract::Several recent publications have focused on the association between the occurrence of twin-to-twin transfusion syndrome (TTTS) in diamniotic-monochorionic twins and the presence of a number of selected anatomic placental characteristics (distribution of vascular territory, cord insertion, type and number of inter-twin...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.06.014
更新日期:2005-07-01 00:00:00