Abstract:
:Preeclampsia is a leading cause of maternal and fetal morbidity and mortality in high and low-income countries. The aetiology of preeclampsia is multifactorial and remains obscure. Some evidences suggest that altered placental fatty acid oxidation might play a role in the pathogenesis of preeclampsia. To reveal if placental fatty acid oxidation is reduced in preeclampsia, we evaluate the expression levels of enzymes of mitochondrial fatty acid oxidation using quantitative Real-time PCR and the fatty acid oxidation rate in placental explants. We found that long-chain 3-hydroxyacyl-CoA dehydrogenase levels and fatty acid oxidation capacity were significantly reduced in placentas from women with preeclampsia.
journal_name
Placentajournal_title
Placentaauthors
Bartha JL,Visiedo F,Fernández-Deudero A,Bugatto F,Perdomo Gdoi
10.1016/j.placenta.2011.11.027subject
Has Abstractpub_date
2012-02-01 00:00:00pages
132-4issue
2eissn
0143-4004issn
1532-3102pii
S0143-4004(11)00572-8journal_volume
33pub_type
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