Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia.

Abstract:

:Accumulation of advanced oxidation protein products (AOPPs) is prevalent in obesity, advanced maternal age, diabetes mellitus, and polycystic ovary syndrome. Alterations in the regulation and signaling of angiogenic pathways have been recognized as a link between these conditions and pre-eclampsia. To investigate the possible impact of AOPPs on soluble Fms-like tyrosine kinase 1 (sFlt-1) expression in trophoblasts. A trophoblast cell line (HRT-8/SVneo) was treated with various concentrations of AOPPs. The mRNA expression of sFlt-1, vascular endothelial growth factor (VEGF), and placental growth factor (PlGF) in trophoblasts were measured with the use of real-time polymerase chain reaction; and the secretion of sFlt-1, VEGF, and PlGF protein from trophoblasts were detected with the use of ELISA. Exposure of HRT-8/SVneo cells to AOPPs induced overexpression of sFlt-1 at mRNA and protein levels in a dose dependent manner. These effects could be inhibited by apocynin, an inhibitors of NADPH oxidase. Our data identified AOPPs as a class of important mediator in the regulation and signaling of angiogenic pathways of trophoblasts. Accumulation of AOPPs might contributes to the pathogenesis of preeclampsia by promoting sFlt-1 production in trophoblasts.

journal_name

Placenta

journal_title

Placenta

authors

Huang QT,Wang SS,Zhang M,Huang LP,Tian JW,Yu YH,Wang ZJ,Zhong M

doi

10.1016/j.placenta.2013.06.308

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

949-52

issue

10

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(13)00584-5

journal_volume

34

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Determinants of species- and placenta-specific expression of p100 GAP.

    abstract::This study was based on the hypothesis that both primary sequence and methylation status of the GTPase activating protein (GAP) gene limits expression of p100 GAP to primate placenta. Due to alternate splicing, a 65-bp insert appears between the first and second coding exons of p100 GAP mRNA, and translation of p100 G...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(98)90012-1

    authors: Liao L,Trouba KJ,Vorce RL

    更新日期:1998-03-01 00:00:00

  • Sexual dimorphism in the effect of maternal obesity on antioxidant defense mechanisms in the human placenta.

    abstract:INTRODUCTION:Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal s...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2017.02.004

    authors: Evans L,Myatt L

    更新日期:2017-03-01 00:00:00

  • Review: Annexin-A5 and cell membrane repair.

    abstract::Annexins are soluble proteins that bind to biological membranes containing negatively charged phospholipids, principally phosphatidylserine, in a Ca(2+)-dependent manner. Annexin-A5 (AnxA5), the smallest member of the annexin family, presents unique properties of membrane binding and self-assembly into ordered two-dim...

    journal_title:Placenta

    pub_type: 杂志文章,评审

    doi:10.1016/j.placenta.2015.01.193

    authors: Bouter A,Carmeille R,Gounou C,Bouvet F,Degrelle SA,Evain-Brion D,Brisson AR

    更新日期:2015-04-01 00:00:00

  • Isolation of phenotypically distinct trophoblast cell lines from normal rat chorioallantoic placentas.

    abstract::Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(89)90038-6

    authors: Hunt JS,Deb S,Faria TN,Wheaton D,Soares MJ

    更新日期:1989-03-01 00:00:00

  • The effect of pre-eclampsia on human placental corticotrophin-releasing hormone content and processing.

    abstract::Prior studies have shown that levels of corticotrophin-releasing hormone (CRH) in the umbilical cord blood of infants born after pregnancies complicated by pre-eclampsia are significantly higher than fetal plasma CRH concentrations in uncomplicated pregnancies. In the present study we have measured CRH by radioimmunoa...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(95)90095-0

    authors: Goland RS,Conwell IM,Jozak S

    更新日期:1995-06-01 00:00:00

  • Three-dimensional growth of extravillous cytotrophoblasts promotes differentiation and invasion.

    abstract::Human trophoblast research relies on a combination of in vitro models, including isolated primary cultures, explant cultures, and trophoblast cell lines. In the present study, we have utilized the rotating wall vessel (RWV) bioreactor to generate a three-dimensional (3-D) model of human placentation for the study of c...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2004.11.003

    authors: LaMarca HL,Ott CM,Höner Zu Bentrup K,Leblanc CL,Pierson DL,Nelson AB,Scandurro AB,Whitley GS,Nickerson CA,Morris CA

    更新日期:2005-11-01 00:00:00

  • Lysophosphatidic acid increases the production of pivotal mediators of decidualization and vascularization in the rat uterus.

    abstract:INTRODUCTION:The decidual reaction and the formation of new vessels in the uterus are two crucial processes during embryo implantation. Previously, we observed that lysophosphatidic acid (LPA) increases cyclooxygenase-2 derived - prostaglandin E2 production during implantation in the rat uterus and that it augments the...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2013.06.001

    authors: Beltrame JS,Sordelli MS,Cella M,Perez Martinez S,Franchi AM,Ribeiro ML

    更新日期:2013-09-01 00:00:00

  • Modulation of the novel cannabinoid receptor - GPR55 - during rat fetoplacental development.

    abstract::Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2011.03.007

    authors: Fonseca BM,Teixeira NA,Almada M,Taylor AH,Konje JC,Correia-da-Silva G

    更新日期:2011-06-01 00:00:00

  • Relaxant effects of hexosamines on isolated small human placental arteries.

    abstract::Wharton's jelly contains large amounts of hyaluronic acid, and glucosamine is an important constituent of this macromolecule. In order to evaluate the placental vascular effects of this aminosugar, small chorionic and stem villous arteries were dissected from placental specimens obtained at normal term vaginal deliver...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(87)90069-5

    authors: Uldbjerg N,Allen J,Maigaard S,Forman A

    更新日期:1987-07-01 00:00:00

  • Downregulation of HLA class I gene transcription in choriocarcinoma cells is controlled by the proximal promoter element and can be reversed by CIITA.

    abstract::The expression pattern of MHC class I genes in trophoblast cells at the feto-maternal interface is thought to be the basis of the maintenance of pregnancy by protecting the fetus from maternal immune rejection. Transcription of classical HLA class I genes is low or undetectable in most trophoblast cells as well as in ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.1998.0380

    authors: Lefebvre S,Moreau P,Dausset J,Carosella ED,Paul P

    更新日期:1999-05-01 00:00:00

  • ATP dependent Ca2+ transport across basal membrane of human syncytiotrophoblast in pregnancies complicated by intrauterine growth restriction or diabetes.

    abstract::Neonates born after pregnancies complicated by diabetes or intrauterine growth restriction (IUGR) have increased incidence of hypocalcaemia. Furthermore, IUGR is associated with reduced bone mineralization in infancy and osteoporosis in adult life. We tested the hypothesis that placental calcium transport is altered i...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.2002.0941

    authors: Strid H,Bucht E,Jansson T,Wennergren M,Powell TL

    更新日期:2003-05-01 00:00:00

  • Maternal obesity and sex-specific differences in placental pathology.

    abstract:OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2015.12.006

    authors: Leon-Garcia SM,Roeder HA,Nelson KK,Liao X,Pizzo DP,Laurent LC,Parast MM,LaCoursiere DY

    更新日期:2016-02-01 00:00:00

  • Xanthine oxidase/dehydrogenase is present in human placenta.

    abstract::Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA p...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(96)90061-2

    authors: Many A,Westerhausen-Larson A,Kanbour-Shakir A,Roberts JM

    更新日期:1996-07-01 00:00:00

  • Classics revisited: Dietrich Starck on comparative embryology and placentation.

    abstract:BACKGROUND:Dietrich Starck (1908-2001) was a German embryologist who wrote extensive reviews on comparative placentation. FINDINGS:Starck's embryology textbook and his comprehensive review of comparative embryology and placentation give excellent insights into the foundational literature and are extensively referenced...

    journal_title:Placenta

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/j.placenta.2017.08.073

    authors: Carter AM

    更新日期:2017-10-01 00:00:00

  • The effect of labour and placental separation on the shedding of syncytiotrophoblast microparticles, cell-free DNA and mRNA in normal pregnancy and pre-eclampsia.

    abstract::The clinical features of the maternal syndrome of pre-eclampsia can be explained by generalised maternal endothelial cell dysfunction, which is a part of a more global maternal systemic inflammatory response. There is growing evidence that these effects are associated with the shedding of cellular debris, including sy...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2008.08.018

    authors: Reddy A,Zhong XY,Rusterholz C,Hahn S,Holzgreve W,Redman CW,Sargent IL

    更新日期:2008-11-01 00:00:00

  • Colchicine inhibits human trophoblast differentiation in vitro.

    abstract::When cultured in keratinocyte growth medium, mononuclear cytotrophoblast cells aggregate into multicellular colonies which then fuse to form multinucleated syncytiotrophoblast. In an attempt to characterize better the mechanism of human trophoblast differentiation and to obtain information about the role of the cytosk...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(05)80260-7

    authors: Douglas GC,King BF

    更新日期:1993-03-01 00:00:00

  • Increase in placental apolipoprotein D as an adaptation to human gestational diabetes.

    abstract::The expression of apolipoprotein D (apo D), a lipocalin involved in defense mechanisms against oxidative stress, in placental tissue samples of pregnancies with gestational diabetes mellitus (GDM) was compared to non-diabetic controls. We have investigated the relationship of apo D with 4-HNE, a major propagation prod...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2009.11.002

    authors: Navarro A,Alonso A,Garrido P,González C,González Del Rey C,Ordoñez C,Tolivia J

    更新日期:2010-01-01 00:00:00

  • Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells.

    abstract::Neutral endopeptidase 24.11 (NEP) is known to regulate cellular functions by degrading several bioactive peptides, such as gonadotropin-releasing hormone (GnRH). The present study was performed to clarify the mechanisms of NEP expression by GnRH in human choriocarcinoma (BeWo) cells. GnRH increased NEP expression and ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2003.09.002

    authors: Kikkawa F,Shibata K,Suzuki T,Kajiyama H,Ino K,Nomura S,Mizutani S

    更新日期:2004-02-01 00:00:00

  • On the factors which contribute to thinning of the villous membrane in human placentae at high altitude. I. Thinning and regional variation in thickness of trophoblast.

    abstract::Sections of human term placentae delivered at low and high altitude to indigenous and non-indigenous populations in Bolivia were analysed by stereological methods. Estimates were obtained of the arithmetic and harmonic mean thicknesses of villous membrane and of trophoblast. These values were then used to derive indic...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(88)90067-7

    authors: Jackson MR,Mayhew TM,Haas JD

    更新日期:1988-01-01 00:00:00

  • Oxygen tension directs the differentiation pathway of human cytotrophoblast cells.

    abstract::During placental development, human cytotrophoblast cells can differentiate to either villous syncytiotrophoblast cells or invasive extravillous trophoblast cells. We hypothesize that oxygen tension plays a critical role in determining the pathway of cytotrophoblast differentiation. A highly purified preparation of cy...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2007.05.006

    authors: Robins JC,Heizer A,Hardiman A,Hubert M,Handwerger S

    更新日期:2007-11-01 00:00:00

  • The multiplication of three different isolates of group B streptococci in pregnant mice.

    abstract::The ability of three streptococcal isolates of different pathogenicity to multiply in the tissues of pregnant mice was investigated following intravenous injection. The highly pathogenic isolate multiplied most rapidly whilst the isolate of low pathogenicity showed the least rapid growth within the observation period ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(81)80001-x

    authors: Coid CR,Nicholson J

    更新日期:1981-07-01 00:00:00

  • Accelerated expression of Ca antigen by placental villous trophoblast in pre-eclampsia.

    abstract::The Ca antigen is expressed by a range of normal tissues, as well as by many malignant neoplasms. The former includes placental villous syncytiotrophoblast where it appears first on syncytial sprouts at 20 weeks gestation, and progressively becomes more intensely and widely expressed on the surface of the trophoblast ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(05)80194-8

    authors: Bishop PW,Malam JE,Morris JA,Fox H

    更新日期:1990-11-01 00:00:00

  • First trimester histiotrophe shows altered sialylation compared with secretory phase glycoconjugates in human endometrium.

    abstract:OBJECTIVES:Histiotrophe is now recognized as being an important feature of early human pregnancy, providing nutrients and growth factors to the developing embryo. Our aim was to examine the glycan composition of histiotrophe from first trimester decidua and to compare it with secretions present in endometrial glands fr...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2010.04.011

    authors: Jones CJ,Aplin JD,Burton GJ

    更新日期:2010-07-01 00:00:00

  • The chemokine connection: hormonal and embryonic regulation at the human maternal-embryonic interface--a review.

    abstract::Chemokines are small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors. In reproductive biology, they have been implicated in ovulation, menstruation, and embryo implantation, and pathological processes such as preterm delivery, HIV infection, and endometriosis. It is known that...

    journal_title:Placenta

    pub_type: 杂志文章,评审

    doi:10.1016/s0143-4004(03)00134-6

    authors: Dominguez F,Pellicer A,Simon C

    更新日期:2003-10-01 00:00:00

  • Human placental multipotent mesenchymal stromal cells modulate trophoblast migration via Rap1 activation.

    abstract:INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2013.06.311

    authors: Chen CP,Huang JP,Chu TY,Aplin JD,Chen CY,Wu YH

    更新日期:2013-10-01 00:00:00

  • The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole.

    abstract::The IPL/TSSC3 gene is expressed nearly exclusively from the maternal allele, and its protein product acts to limit placental growth in mice. This protein specifically marks Type II trophoblast in the labyrinthine layer of the mouse placenta. To investigate mouse-human homologies, we carried out immunohistochemistry wi...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(03)00130-9

    authors: Saxena A,Frank D,Panichkul P,Van den Veyver IB,Tycko B,Thaker H

    更新日期:2003-09-01 00:00:00

  • Identification of triploidy by DA/DAPI staining of trophoblastic interphase nuclei.

    abstract::Combined staining of non-cultured interphase nuclei from hydatidiform moles with distamycin A and DAPI resulted in the presence of specific stained interphase bodies. A mean number of six interphase bodies was observed in moles with a diploid karyotype and a mean number of nine interphase bodies was observed in triplo...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(85)80046-1

    authors: Tommerup N,Vejerslev LO

    更新日期:1985-07-01 00:00:00

  • Corticotrophin-releasing factor in human placenta: localization, concentration and release in vitro.

    abstract::Corticotrophin-releasing factor (CRF) immunoreactivity was demonstrated by immunohistochemical staining in the cytotrophoblast of the early pregnancy placenta, in the decidua and in the amnion. This localization is different from that of adrenocorticotrophic hormone (ACTH) and beta-endorphin, which are present in the ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(88)90050-1

    authors: Saijonmaa O,Laatikainen T,Wahlström T

    更新日期:1988-07-01 00:00:00

  • Acute atherosis and diffuse lipid infiltration of the placental bed: A review of historical lipid studies.

    abstract::Based on a variety of tissue samples, including Caesarean hysterectomy specimens with the placenta in situ, a detailed map of uteroplacental vascular lesions was established in over a century of research. One such lesion is acute atherosis of unremodelled basal and uteroplacental arteries, defined by the presence of f...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2020.06.012

    authors: Brosens I,Brosens JJ,Muter J,Benagiano G

    更新日期:2020-08-01 00:00:00

  • Multiple human papillomavirus types replicate in 3A trophoblasts.

    abstract::Human papillomavirus (HPV) are more prevalent in spontaneous abortions than elect abortions and preferentially infect the trophoblasts. Related to this, HPV type 16 has been shown to productively replicate in 3A trophoblasts in tissue culture. Extending these earlier studies, the described study addresses the issue wh...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2007.08.005

    authors: You H,Liu Y,Agrawal N,Prasad CK,Edwards JL,Osborne AF,Korourian S,Lowery CL,Hermonat PL

    更新日期:2008-01-01 00:00:00