Abstract：
OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For the latter group of placentas, samples were taken near the umbilical cord and at the periphery on both the maternal and fetal sides (a total of 4 samples per placenta). Cord blood samples were also obtained from all placental donors. Telomerase activity was assessed by the TRAP assay, and telomere length measured by Southern analysis of mean terminal restriction fragment (TRF) length. RESULTS:We show for the first time that telomeres are longer ( approximately 25% longer; P<0.001) in placenta tissue than in cord blood from the same donor. CONCLUSION:Telomere shortening is unlikely to have a significant role in senescence or terminal maturation of the placenta.
journal_name
Placentajournal_title
Placentaauthors
Allsopp R,Shimoda J,Easa D,Ward Kdoi
10.1016/j.placenta.2006.04.003subject
Has Abstractpub_date
2007-04-01 00:00:00pages
324-7issue
4eissn
0143-4004issn
1532-3102pii
S0143-4004(06)00116-0journal_volume
28pub_type
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