Accelerated expression of Ca antigen by placental villous trophoblast in pre-eclampsia.

abstract：:During placental development, human cytotrophoblast cells can differentiate to either villous syncytiotrophoblast cells or invasive extravillous trophoblast cells. We hypothesize that oxygen tension plays a critical role in determining the pathway of cytotrophoblast differentiation. A highly purified preparation of cy...

journal_title：Placenta

authors： Robins JC,Heizer A,Hardiman A,Hubert M,Handwerger S

更新日期：2007-11-01 00:00:00

abstract：:The diversity of placental structures in Eutherian mammals is such that drawing generalizations from the definitive forms is problematic. There are always areas of reduced interhaemal distance whether the placenta is epitheliochorial, synepitheliochorial, endotheliochorial or haemochorial. However, the thinning may be...

journal_title：Placenta

authors： Enders AC,Carter AM

更新日期：2004-04-01 00:00:00

abstract：:Mitochondrial function is required to support energetically-demanding processes in the placenta. As such, a compromise in mitochondrial function could severely impact fetal growth and development. Respirometry is a highly useful method for studying mitochondrial function, but is not possible in freeze-thawed mitochond...

journal_title：Placenta

authors： Colleoni F,Morash AJ,Ashmore T,Monk M,Burton GJ,Murray AJ

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...

journal_title：Placenta

authors： Chen CP,Huang JP,Chu TY,Aplin JD,Chen CY,Wu YH

更新日期：2013-10-01 00:00:00

abstract：:Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological functi...

journal_title：Placenta

authors： Hutson JR,Koren G,Matthews SG

更新日期：2010-05-01 00:00:00

abstract：:Maternal diabetes affects the development of the offspring by altering the uterine environment. We aimed to investigate the extent to which the blood flow (measured as Tissue Perfusion Units; TPU) to implantation sites and the expression of developmentally important genes in the offspring are affected by maternal diab...

journal_title：Placenta

authors： Zabihi S,Wentzel P,Eriksson UJ

更新日期：2008-05-01 00:00:00

abstract：:Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study ...

journal_title：Placenta

authors： Lei T,Hohn HP,Behr R,Denker HW

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:The state of activation of dendritic cells (DCs) at the feto-maternal interface critically contributes to optimal decidual immune responses needed to support fetal-placental development. We recently demonstrated that during healthy pregnancy also peripheral blood DCs (PBDCs), which are easily accessible, a...

journal_title：Placenta

authors： Cappelletti M,Giannelli S,Martinelli A,Cetin I,Colombo E,Calcaterra F,Mavilio D,Della Bella S

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS:In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T I...

journal_title：Placenta

authors： Ho A,Hutter J,Slator P,Jackson L,Seed PT,Mccabe L,Al-Adnani M,Marnerides A,George S,Story L,Hajnal JV,Rutherford M,Chappell LC

更新日期：2020-12-13 00:00:00

abstract：:Peroxidase (Donor: H(2)O(2)oxidoreductase EC 1.11.1.7) from human term placentae of non-smokers was purified to homogeneity by a combination of NH(4)Cl extraction, affinity chromatography, (NH(4))(2)SO(4)precipitation, ion-exchange and gel filtration chromatography. The homogeneity of purified human placental peroxida...

journal_title：Placenta

authors： Madhavan ND,Naidu KA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...

journal_title：Placenta

authors： Gui J,Ling Z,Hou X,Fan Y,Xie K,Shen R

更新日期：2020-01-01 00:00:00

abstract：:Human placental villi from both normal and complicated pregnancies were examined by both light and scanning electron microscopy. The findings provide evidence that histological features such as syncytial sprouts, bridges, and a net-like arrangement of villi represent tangential sections of irregularly shaped villi rat...

journal_title：Placenta

authors： Kaufmann P,Luckhardt M,Schweikhart G,Cantle SJ

更新日期：1987-05-01 00:00:00

abstract：INTRODUCTION:Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS:This was a prosp...

journal_title：Placenta

authors： Widnes C,Flo K,Acharya G

更新日期：2017-01-01 00:00:00

abstract：:The morphometric oxygen diffusive conductance (D(p)) of the placenta provides a measure of the efficiency of oxygen transfer between the mother and the developing fetus. Any change in the D(p)may point towards possible adaptation in the light of altered oxygen transfer. Placentae from normal (n=40) and small for gesta...

journal_title：Placenta

authors： Ansari T,Fenlon S,Pasha S,O'Neill B,Gillan JE,Green CJ,Sibbons PD

更新日期：2003-07-01 00:00:00

abstract：:Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the place...

journal_title：Placenta

authors： Zhao S,Gu Y,Dong Q,Fan R,Wang Y

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Epigenetics is tissue-specific and potentially even cell-specific, but little information is available from human reproductive studies about the concordance of DNA methylation patterns in cord blood and placenta, as well as within-placenta variations. We evaluated methylation levels at promoter regions of ca...

journal_title：Placenta

authors： Janssen BG,Byun HM,Cox B,Gyselaers W,Izzi B,Baccarelli AA,Nawrot TS

更新日期：2014-09-01 00:00:00

abstract：:Placental ultrasonographic, bio- and histochemical studies were performed on four unrelated fetuses affected with Niemann-Pick disease Type A, following prostaglandin-induced abortion at about the 19th week of gestation. An accumulation of sphingomyelin in the placentae of affected fetuses indicates the essential role...

journal_title：Placenta

authors： Schoenfeld A,Abramovici A,Klibanski C,Ovadia J

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...

journal_title：Placenta

authors： Carter AM

更新日期：2018-07-01 00:00:00

abstract：:The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine....

journal_title：Placenta

authors： Umezawa A,Hasegawa A,Inoue M,Tanuma-Takahashi A,Kajiwara K,Makino H,Chikazawa E,Okamoto A

更新日期：2019-09-01 00:00:00

abstract：:Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CR...

journal_title：Placenta

authors： Giovannelli A,Greenwood SL,Desforges M,Sibley CP,Petraglia F

更新日期：2011-01-01 00:00:00

abstract：:When cultured in keratinocyte growth medium, mononuclear cytotrophoblast cells aggregate into multicellular colonies which then fuse to form multinucleated syncytiotrophoblast. In an attempt to characterize better the mechanism of human trophoblast differentiation and to obtain information about the role of the cytosk...

journal_title：Placenta

authors： Douglas GC,King BF

更新日期：1993-03-01 00:00:00

abstract：INTRODUCTION:The aim of this study is to determine whether the gene expression and associated DNA methylation regulation of H19 and IGF2 are altered in placentas conceived by assisted reproductive technologies (ART) compared to natural conceptions. METHODS:113 pregnancies were recruited resulting in 119 placentas (83 ...

journal_title：Placenta

authors： Sakian S,Louie K,Wong EC,Havelock J,Kashyap S,Rowe T,Taylor B,Ma S

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition. We investigated the effect of OA supplementation on PG production using an in vitro model of ovine placenta. METHO...

journal_title：Placenta

authors： Cheng Z,Abayasekara DR,Elmes M,Kirkup S,Wathes DC

更新日期：2015-09-01 00:00:00

abstract：:Umbilical cord blood is an important graft source in the treatment of many genetic, hematologic, and immunologic disorders by hematopoietic stem cell transplantation. Millions of cord blood units have been collected and stored for clinical use since the inception of cord blood banking in 1989. However, the use of cord...

journal_title：Placenta

authors： Mantri S,Sheikali A,Binns C,Lyell DJ,DiGiusto DL,Porteus MH,Agarwal-Hashmi R

更新日期：2020-10-13 00:00:00

abstract：:Superficial invasion of extravillous trophoblasts (EVTs) and impaired spiral artery remodelling are characterizing phenomena in pregnancies complicated by pre-eclampsia (PE) and fetal growth restriction (FGR). However, the underlying causes remain unclear. In this study, gene expression in decidua basalis tissue from ...

journal_title：Placenta

authors： Lian IA,Toft JH,Olsen GD,Langaas M,Bjørge L,Eide IP,Børdahl PE,Austgulen R

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:Observational and empirical evidence suggest that the average placental shape is round with a centrally inserted umbilical cord. Yet variability of shape is common. When in pregnancy do shape and cord insertion variations originate? MATERIALS AND METHODS:Placental measures from published datasets obtained u...

journal_title：Placenta

authors： Salafia CM,Yampolsky M,Shlakhter A,Mandel DH,Schwartz N

更新日期：2012-03-01 00:00:00

abstract：:During pregnancy, changes in oxygen tension are essential for proper embryonic and placental development. Little is known about the mechanisms underlying mammalian cellular adaptations to changes in oxygen tension. Currently, we have explored putative mechanisms by which human trophoblast cells may sense oxygen. In or...

journal_title：Placenta

authors： De Marco CS,Caniggia I

更新日期：2002-04-01 00:00:00

abstract：:We have shown that oestrogen has a central integrative role in regulating key components of the progesterone biosynthetic and corticosteroid metabolic pathways within syncytiotrophoblasts that govern placental function and maturation of the fetal pituitary-adrenocortical axis. Studies utilizing classic binding procedu...

journal_title：Placenta

authors： Billiar RB,Pepe GJ,Albrecht ED

更新日期：1997-05-01 00:00:00

abstract：:Amino acid transfer to the fetus is dependent on several different factors. While these factors can be understood in isolation, it is still not possible to predict the function of the system as a whole. In order to do this an integrated approach is required which incorporates the interactions between the different det...

journal_title：Placenta

authors： Lewis RM,Brooks S,Crocker IP,Glazier J,Hanson MA,Johnstone ED,Panitchob N,Please CP,Sibley CP,Widdows KL,Sengers BG

更新日期：2013-03-01 00:00:00

abstract：:Accumulation of advanced oxidation protein products (AOPPs) is prevalent in obesity, advanced maternal age, diabetes mellitus, and polycystic ovary syndrome. Alterations in the regulation and signaling of angiogenic pathways have been recognized as a link between these conditions and pre-eclampsia. To investigate the ...

journal_title：Placenta

authors： Huang QT,Wang SS,Zhang M,Huang LP,Tian JW,Yu YH,Wang ZJ,Zhong M

更新日期：2013-10-01 00:00:00