当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Review: Modelling placental amino acid transfer--from transporters to placental function.

Review: Modelling placental amino acid transfer--from transporters to placental function.

Abstract：

:Amino acid transfer to the fetus is dependent on several different factors. While these factors can be understood in isolation, it is still not possible to predict the function of the system as a whole. In order to do this an integrated approach is required which incorporates the interactions between the different determinants of amino acid transfer. Computational modelling of amino acid transfer in the term human placenta provides a mechanism by which this integrated approach can be delivered. Such a model would be invaluable for understanding amino acid transfer in both normal and pathological pregnancies. In order to develop a computational model it is necessary to determine all the biological factors which are important contributors to net amino acid transfer and the ways in which they interact. For instance, how different classes of amino acid transporter must interact to transfer amino acids across the placenta. Mathematically, the kinetics of each type of transporter can be represented by separate equations that describe their transfer rate as a non-linear function of amino acid concentrations. These equations can then be combined in the model to predict the overall system behaviour. Testing these predictions experimentally will demonstrate the strengths and weaknesses of the model, which can then be refined with increasing complexity and retested in an iterative fashion. In this way we hope to develop a functional computational model which will allow exploration of the factors that determine amino acid transfer across the placenta. This model may also allow the development of strategies to optimise placental transfer in pathologies associated with impaired amino acid transfer such as fetal growth restriction.

journal_name

Placenta

journal_title

Placenta

authors

Lewis RM,Brooks S,Crocker IP,Glazier J,Hanson MA,Johnstone ED,Panitchob N,Please CP,Sibley CP,Widdows KL,Sengers BG

doi

10.1016/j.placenta.2012.10.010

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

S46-51

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(12)00403-1

journal_volume

34 Suppl

pub_type

杂志文章,评审

相关文献

PLACENTA文献大全
  • Gross abnormalities of the umbilical cord: related placental histology and clinical significance.

    abstract：OBJECTIVE:To evaluate umbilical cord abnormalities predisposing to mechanical cord compression and determine their relationship to adverse clinical outcomes and stasis-associated histologic changes in the placenta. METHODS:Placental slides of 224 singleton pregnancies with gross cord abnormality (true knots, long cord...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.09.005

    authors： Tantbirojn P,Saleemuddin A,Sirois K,Crum CP,Boyd TK,Tworoger S,Parast MM

    更新日期：2009-12-01 00:00:00

  • Inconsistency of fetal trophoblast cells in first trimester maternal peripheral blood prevents non-invasive fetal testing using this cell target.

    abstract：:We have investigated whether maternal peripheral blood from the first trimester of pregnancy is a reliable source of identifiable trophoblast cells. The cells were enriched from 30 ml of venous blood, with multiple antibodies shown previously to enrich trophoblasts and a new cocktail based on known trophoblast surface...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0704

    authors： Schueler PA,Yamanishi DT,Pearson J,Lee Y,Wu X,Hashima S,Madlansacay MR,Cain CA,Collarini EJ,Foltz L,Mahoney W

    更新日期：2001-09-01 00:00:00

  • Differential expression of serum proteins before 20 weeks gestation in women with hypertensive disorders of pregnancy: A potential role for SH3BGRL3.

    abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.10.031

    authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

    更新日期：2020-11-14 00:00:00

  • Altered maternal and placental lipid metabolism and fetal fat development in obesity: Current knowledge and advances in non-invasive assessment.

    abstract：:Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The meta...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2018.05.011

    authors： Delhaes F,Giza SA,Koreman T,Eastabrook G,McKenzie CA,Bedell S,Regnault TRH,de Vrijer B

    更新日期：2018-09-01 00:00:00

  • Expression and localisation of FoxO3 and FoxO4 in human placenta and fetal membranes.

    abstract：:Forkhead box O (FoxO) proteins regulate inflammation, extracellular matrix (ECM) remodelling and apoptosis. We have previously identified FoxO1 proteins in human gestational tissues, and demonstrated a link between FoxO1 and rupture of fetal membranes. There is, however, no data available on the expression and localis...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2010.09.009

    authors： Lappas M,Lim R,Riley C,Menon R,Permezel M

    更新日期：2010-12-01 00:00:00

  • Production of interleukin (IL)-6 and IL-8 by a choriocarcinoma cell line, BeWo.

    abstract：:To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells after stimulation with various modulatory agents of cytokine ex...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1999.0494

    authors： Fujisawa K,Nasu K,Arima K,Sugano T,Narahara H,Miyakawa I

    更新日期：2000-05-01 00:00:00

  • Multiscale three-dimensional imaging of the placenta.

    abstract：:Placental function involves multiple different processes which operate at different scales from centimetres to nanometres. Everything that the placenta does from mediating blood flow to gene expression, occurs within a three-dimensional anatomical framework. This review outlines how multiscale three-dimensional imagin...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2020.01.016

    authors： Lewis RM,Pearson-Farr JE

    更新日期：2020-12-01 00:00:00

  • HLA-G polymorphisms and molecule function--questions and more questions--a review.

    abstract：:Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. Th...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1053/plac.1999.0515

    authors： van der Ven K,Pfeiffer K,Skrablin S

    更新日期：2000-03-01 00:00:00

  • Amnion-derived cells as a reliable resource for next-generation regenerative medicine.

    abstract：:The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine....

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2019.06.381

    authors： Umezawa A,Hasegawa A,Inoue M,Tanuma-Takahashi A,Kajiwara K,Makino H,Chikazawa E,Okamoto A

    更新日期：2019-09-01 00:00:00

  • Placental function and structure at term is altered in broodmares fed with cereals from mid-gestation.

    abstract：INTRODUCTION:Feeding pregnant broodmares with cereal concentrates has been shown to increase maternal insulin resistance and affect foal metabolism in the short and long-term. These effects are likely to be mediated by the placenta. Here, we investigated feto-placental biometry and placental structure and function at t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2018.02.003

    authors： Robles M,Peugnet P,Dubois C,Piumi F,Jouneau L,Bouchez O,Aubrière MC,Dahirel M,Aioun J,Wimel L,Couturier-Tarrade A,Chavatte-Palmer P

    更新日期：2018-04-01 00:00:00

  • The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction.

    abstract：:The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (F...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.04.003

    authors： Finn-Sell SL,Renshall LJ,Cowley EJ,Dilworth MR,Wareing M,Greenwood SL,Sibley CP,Cottrell EC

    更新日期：2016-06-01 00:00:00

  • The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast.

    abstract：:During early pregnancy, intermediate (extravillous) trophoblast infiltrates the basal plate and invades the spiral arteries, a physiological process required to establish the maternal-fetal circulation. Immunostaining studies have shown that differentiation of trophoblast into this invasive subpopulation is associated...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(02)90864-7

    authors： Shih IeM,Hsu MY,Oldt RJ 3rd,Herlyn M,Gearhart JD,Kurman RJ

    更新日期：2002-11-01 00:00:00

  • Three-dimensional arrangement of the capillary bed and its relationship to microrheology in the terminal villi of normal term placenta.

    abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.07.004

    authors： Jirkovská M,Janácek J,Kaláb J,Kubínová L

    更新日期：2008-10-01 00:00:00

  • Paracellular permeability pathways in the human placenta: a quantitative and morphological study of maternal-fetal transfer of horseradish peroxidase.

    abstract：:Physiological data indicate that both a transcellular and a paracellular pathway are available for transfer across the human placenta but the morphological correlate of the latter is uncertain. We measured the permeability of the dually perfused human placental cotyledon to the predominantly cationic protein horseradi...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(05)80249-8

    authors： Edwards D,Jones CJ,Sibley CP,Nelson DM

    更新日期：1993-01-01 00:00:00

  • Investigation of the rate-limiting step in the synthesis of acetylcholine by the human placenta.

    abstract：:The uptake of [3H]choline and its conversion to [3H]acetylcholine were investigated in term human placental tissue in vitro. Although the net uptake of [3H]choline increased throughout a 45 min incubation period, intracellular [3H]choline levels reach a plateau after 2 min. There was a constant increase in [3H]acetylc...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(84)80036-3

    authors： Leventer SM,Rowell PP

    更新日期：1984-05-01 00:00:00

  • Placental magnetic resonance imaging in chronic hypertension: A case-control study.

    abstract：INTRODUCTION:We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. METHODS:In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T I...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.12.006

    authors： Ho A,Hutter J,Slator P,Jackson L,Seed PT,Mccabe L,Al-Adnani M,Marnerides A,George S,Story L,Hajnal JV,Rutherford M,Chappell LC

    更新日期：2020-12-13 00:00:00

  • Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae.

    abstract：:Placentas from women with preeclampsia overexpress the hypoxia-inducible transcription factor proteins, HIF-1alpha and -2alpha (Rajakumar 2001, Biol Reprod 64; p499-506 and p1019-1020). As a first step in evaluating whether HIF-alpha overexpressed in preeclamptic placentae is capable of transactivation, we tested its ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2004.02.011

    authors： Rajakumar A,Brandon HM,Daftary A,Ness R,Conrad KP

    更新日期：2004-11-01 00:00:00

  • Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn.

    abstract：INTRODUCTION:Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.08.070

    authors： Herzog EM,Eggink AJ,Willemsen SP,Slieker RC,Wijnands KPJ,Felix JF,Chen J,Stubbs A,van der Spek PJ,van Meurs JB,Steegers-Theunissen RPM

    更新日期：2017-10-01 00:00:00

  • Identification of two leucine-sensitive lysine transport activities in human placental basal membrane.

    abstract：:The recent demonstration of multiple high-affinity leucine-sensitive cationic transport systems prompted this investigation of their role in lysine uptake in basal cell membrane. Transport of lysine by basal membrane was saturable at both 22 and 37 degrees C and linear in time to 1 min and 30 sec, respectively. At 22 ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(97)90006-0

    authors： Furesz TC,Smith CH

    更新日期：1997-11-01 00:00:00

  • Immunolocalization of NK-1 receptor and Substance P in human normal placenta.

    abstract：:A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2010.03.015

    authors： Muñoz M,Pavón A,Rosso M,Salinas MV,Pérez A,Carranza A,González-Ortega A

    更新日期：2010-07-01 00:00:00

  • Maternal risk factors associated with persistent placenta previa.

    abstract：INTRODUCTION:Maternal risk factors associated with placenta previa are well documented in the literature. However, there are limited studies identifying maternal characteristics associated with the persistence of placenta previa. The objective of the study was to determine maternal characteristics associated with the p...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.08.004

    authors： King LJ,Dhanya Mackeen A,Nordberg C,Paglia MJ

    更新日期：2020-09-15 00:00:00

  • Placental alkaline phosphatase (PLAP) enzyme activity and binding to IgG in Chagas' disease.

    abstract：:Placentas and plasma from women with and without Chagas' disease and cultures of human placental villi with Trypanosoma cruzi, neuraminidase, phospholipase A2 and phospholipase C were analyzed in order to verify if the alterations in placental alkaline phosphatase (PLAP) enzyme activity are caused by T. cruzi as obser...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2004.08.014

    authors： Lin S,Sartori MJ,Mezzano L,de Fabro SP

    更新日期：2005-11-01 00:00:00

  • TMED2/p24β1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines.

    abstract：:Members of the transmembrane emp24 domain (Tmed)/p24 family of proteins are required for transport of proteins between the endoplasmic reticulum and the Golgi. One member of this family, Tmed2/p24β1, is expressed during placental development in mice and its expression is required for normal development of the labyrint...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.12.009

    authors： Zakariyah A,Hou W,Slim R,Jerome-Majewska L

    更新日期：2012-03-01 00:00:00

  • What is the impact of placental tissue damage after laser surgery for twin-twin transfusion syndrome? A secondary analysis of the Solomon trial.

    abstract：BACKGROUND:The introduction of the Solomon technique for the treatment of twin-twin transfusion syndrome (TTTS) increased placental exposure to laser energy. This study aims to identify the impact of power and energy used in laser treatment on placental tissue and pregnancy outcome. METHODS:Pictures of all dye-injecte...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.02.023

    authors： Akkermans J,de Vries SM,Zhao D,Peeters SHP,Klumper FJ,Middeldorp JM,Oepkes D,Slaghekke F,Lopriore E

    更新日期：2017-04-01 00:00:00

  • IFPA Meeting 2013 Workshop Report III: maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.

    abstract：:Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2013 there were twelve themed workshops, three of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of placent...

    journal_title：Placenta

    pub_type：

    doi：10.1016/j.placenta.2013.11.009

    authors： Abumaree MH,Brownbill P,Burton G,Castillo C,Chamley L,Croy BA,Drewlo S,Dunk C,Girard S,Hansson S,Jones S,Jurisicova A,Lewis R,Letarte M,Parast M,Pehrson C,Rappolee D,Schneider H,Tannetta D,Varmuza S,Wadsack C,Wa

    更新日期：2014-02-01 00:00:00

  • Carbon monoxide attenuates bacteria-induced Endothelin-1 expression in second trimester placental explants.

    abstract：INTRODUCTION:The pro-inflammatory mediator and potent vasoconstrictor Endothelin-1 (ET-1) is known to be expressed in the placenta. We have recently demonstrated that very low, non-toxic doses of carbon monoxide (CO), prevented infection-induced preterm birth in mice. However the effect(s) of CO on human gestational ti...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.03.015

    authors： Olgun NS,Arita Y,Hanna M,Murthy A,Tristan S,Peltier MR,Hanna N

    更新日期：2014-06-01 00:00:00

  • Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts.

    abstract：INTRODUCTION:Hypotaurine is a precursor of taurine and an antioxidant, and is concentrated in fetal plasma compared to maternal plasma. Hypotaurine is significantly decreased in fetal plasma of ezrin (Vil2) knock-out mice, and fetuses show intrauterine growth retardation. The aim of this study was to characterize the m...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.02.014

    authors： Nishimura T,Duereh M,Sugita Y,Yoshida Y,Higuchi K,Tomi M,Nakashima E

    更新日期：2015-06-01 00:00:00

  • Human amnion mesenchymal cells are pro-inflammatory when activated by the Toll-like receptor 2/6 ligand, macrophage-activating lipoprotein-2.

    abstract：INTRODUCTION:Infection accounts for over 40% of preterm premature rupture of the fetal membranes (PPROM), a major cause of preterm birth. Toll-like receptors (TLR) play key roles in pathogen surveillance but their expression and function in amnion mesenchymal cells (AMC) is unclear. The aims of this study were to deter...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.06.005

    authors： Sato BL,Collier ES,Vermudez SA,Junker AD,Kendal-Wright CE

    更新日期：2016-08-01 00:00:00

  • Human placental multipotent mesenchymal stromal cells modulate trophoblast migration via Rap1 activation.

    abstract：INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.06.311

    authors： Chen CP,Huang JP,Chu TY,Aplin JD,Chen CY,Wu YH

    更新日期：2013-10-01 00:00:00

  • Sequential expression of VEGF and its receptors in human placental villi during very early pregnancy: differences between placental vasculogenesis and angiogenesis.

    abstract：:Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2003.11.011

    authors： Demir R,Kayisli UA,Seval Y,Celik-Ozenci C,Korgun ET,Demir-Weusten AY,Huppertz B

    更新日期：2004-07-01 00:00:00