Abstract:
:Superficial invasion of extravillous trophoblasts (EVTs) and impaired spiral artery remodelling are characterizing phenomena in pregnancies complicated by pre-eclampsia (PE) and fetal growth restriction (FGR). However, the underlying causes remain unclear. In this study, gene expression in decidua basalis tissue from pregnancies complicated with PE and/or FGR (n = 18) and normal pregnancies (n = 17) was assessed by Affymetrix HG Focus microarray to obtain hints of mechanisms involved in the pathogenesis. A total of 200 differentially expressed transcripts were detected at a false discovery rate (FDR) journal_name journal_title authors doi subject pub_date pages issue eissn issn pii journal_volume pub_type
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PLACENTA文献大全abstract::The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preecl...
journal_title:Placenta
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doi:10.1016/j.placenta.2016.10.004
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abstract::The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related...
journal_title:Placenta
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journal_title:Placenta
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abstract::Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/s0143-4004(05)80638-1
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abstract::The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology si...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2011.06.019
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abstract::Physiological data indicate that both a transcellular and a paracellular pathway are available for transfer across the human placenta but the morphological correlate of the latter is uncertain. We measured the permeability of the dually perfused human placental cotyledon to the predominantly cationic protein horseradi...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80249-8
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abstract:OBJECTIVES:The epithelium of the human placenta comprises an inner cytotrophoblast (CT) which proliferates and fuses with the outer differentiated syncytiotrophoblast (ST). Turnover has been studied focussing on second and third trimester placentas but with a paucity of data describing the normal first trimester tropho...
journal_title:Placenta
pub_type: 杂志文章
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journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.08.014
更新日期:2013-11-01 00:00:00
abstract::A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1...
journal_title:Placenta
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abstract::Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...
journal_title:Placenta
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abstract::Interleukin-6 (IL-6) and its receptor complex, IL-6 receptor (IL-6R) and gp130, are critical in induction of suppressor of cytokine signalling-3 (SOCS-3) protein, a negative cytokine regulator and anti-inflammatory mediator, in a biological system. Increased inflammatory response is believed to contribute to the place...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.09.011
更新日期:2008-12-01 00:00:00
abstract::The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine:glyoxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no det...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90066-2
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abstract::The binding of oestradiol in human placental tissue obtained from spontaneous and caesarean deliveries was investigated. Villous tissue was homogenized and the 800 g 'cytosol' supernatant treated with ammonium sulphate. The precipitate was redissolved and the preparation then equilibrated with [3H]oestradiol. After se...
journal_title:Placenta
pub_type: 杂志文章
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journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0704
更新日期:2001-09-01 00:00:00
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journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.06.001
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:Escherichia coli is recognized as an etiological bacteria associated with chorioamnionitis and the preterm premature rupture of fetal membranes. This pathological condition induces pro-inflammatory cytokines and degradative metalloproteinases, which are considered biological markers secreted in an acute st...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.12.011
更新日期:2015-03-01 00:00:00
abstract::We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0610
更新日期:2001-02-01 00:00:00
abstract:INTRODUCTION:We have identified some critical aspects concerning umbilical cord tissue mesenchymal stem cells: the lack of standards for cell isolation, expansion and cryopreservation, the lack of unanimous opinions upon their multilineage differentiation potential and the existence of very few results related to the f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.08.011
更新日期:2015-10-01 00:00:00
abstract::Maternal diabetes affects the development of the offspring by altering the uterine environment. We aimed to investigate the extent to which the blood flow (measured as Tissue Perfusion Units; TPU) to implantation sites and the expression of developmentally important genes in the offspring are affected by maternal diab...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.02.005
更新日期:2008-05-01 00:00:00
abstract:INTRODUCTION:Abnormally invasive placenta (AIP) is a rare pregnancy complication often resulting in postpartum haemorrhage (PPH) and emergency peripartum hysterectomy (EPH). The risk of developing post traumatic stress disorder (PTSD) following unexpectedly traumatic childbirth is known however there is no evidence reg...
journal_title:Placenta
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doi:10.1016/j.placenta.2019.04.004
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journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.03.011
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journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.02.005
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abstract::Vascularization within the human placenta is the result of the de novo formation of vessels derived from pluripotent precursor cells in the mesenchymal core of the villi. Vascularization of placental villi starts at around day 21 post conception (p.c.) with a four somite embryo. At this stage progenitors of haemangiog...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2003.11.011
更新日期:2004-07-01 00:00:00
abstract::Several recent publications have focused on the association between the occurrence of twin-to-twin transfusion syndrome (TTTS) in diamniotic-monochorionic twins and the presence of a number of selected anatomic placental characteristics (distribution of vascular territory, cord insertion, type and number of inter-twin...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.06.014
更新日期:2005-07-01 00:00:00
abstract::The diversity of placental structures in Eutherian mammals is such that drawing generalizations from the definitive forms is problematic. There are always areas of reduced interhaemal distance whether the placenta is epitheliochorial, synepitheliochorial, endotheliochorial or haemochorial. However, the thinning may be...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2004.01.011
更新日期:2004-04-01 00:00:00
abstract::The aim of the present study was to evaluate the relationship between the retention of fetal membranes (RFM) and apoptosis of the cells in fetal membranes. The present study investigated mRNA and protein expressions of apoptosis-regulating factors: FAS, cellular FLICE-like inhibiting protein (cFLIP), BAX, BCL2, caspas...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.10.016
更新日期:2011-01-01 00:00:00
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journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80071-9
更新日期:1997-05-01 00:00:00
abstract::Glycogen storage disease type IV (GSD IV) is a rare autosomal recessive disorder caused by glycogen branching enzyme (GBE) deficiency and resulting in the storage of abnormal glycogen (polyglucosan). Prenatal diagnosis is based on biochemical assay of GBE activity or on mutation analysis, but polyglucosan can also be ...
journal_title:Placenta
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更新日期:2008-04-01 00:00:00
abstract::Cytophotometric measurement of the DNA content of Feulgen-stained nuclei in touch preparations of bovine placentomes (n =5) revealed that 8C nuclei occurred in all, 16C nuclei in two, and 32C nuclei in one specimen. The determination of ploidy level by in situ hybridization with a Y-chromosome specific DNA probe showe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0402
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.07.001
更新日期:2009-09-01 00:00:00