Abstract:
:11β-Hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2) are involved in the complex mechanism of human parturition. The present study examined mRNA expression and activity of membrane 11β-HSD1 and placental 11β-HSD2 in postdate pregnancies according to response of labor induction. In comparison to postdate women who had spontaneous delivery or after induction the non-responders showed significantly low c and high 11β-HSD2 expression and activity These data suggest that disrupted expression and activity of 11β-HSDs may occur in some postdate pregnancies.
journal_name
Placentajournal_title
Placentaauthors
Novembri R,Voltolini C,Torricelli M,Severi FM,Marcolongo P,Benedetti A,Challis JR,Petraglia Fdoi
10.1016/j.placenta.2013.08.011subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1102-4issue
11eissn
0143-4004issn
1532-3102pii
S0143-4004(13)00696-6journal_volume
34pub_type
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