Abstract：
:It has been suggested that adenosine is involved in the acute effects of ethanol in a number of tissues. The present study was undertaken to evaluate the role of adenosine on the vascular responses of perfused isolated human placental cotyledons after the acute administration of ethanol. The possibility that ethanol may effect the uptake and metabolism adenosine was also investigated. Uptake of adenosine was studied using the single-circulation paired-tracer dilution technique. Both adenosine and ethanol caused a dose-related increase in perfusion pressure of placental lobules. Pharmacologically relevant concentrations of ethanol (10-65 mM) significantly inhibited the uptake of [3H]adenosine between 25 and 50 per cent. Thin-layer chromatographic analysis of the perfusate after the administration of ethanol showed in a 17.9 +/- 0.6 per cent reduction of [3H]adenosine metabolism. These findings support the working hypothesis that placental adenosine, at least partially, mediates the placental disturbance elicited by the administration of acute ethanol, which may contribute to the pathogenesis of fetal alcohol syndrome.
journal_name
Placentajournal_title
Placentaauthors
Acevedo CG,Huambachano A,Perez E,Rojas S,Bravo I,Contreras Edoi
10.1016/s0143-4004(97)80038-0subject
Has Abstractpub_date
1997-07-01 00:00:00pages
387-92issue
5-6eissn
0143-4004issn
1532-3102pii
S0143-4004(97)80038-0journal_volume
18pub_type
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