Abstract:
:The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (FGR). Here, we investigated pregnancies of ANP wild type (ANP(+/+)), heterozygous (ANP(+/-)) and knockout (ANP(-/-)) mice. Maternal blood pressure did not differ between genotypes (E12.5, E17.5), and fetal weight (E18.5) was unaffected. Placental weight was greater in ANP(-/-) versus ANP(+/+) mice. Therefore, in our hands, the ANP model does not express phenotypic features of PE with FGR.
journal_name
Placentajournal_title
Placentaauthors
Finn-Sell SL,Renshall LJ,Cowley EJ,Dilworth MR,Wareing M,Greenwood SL,Sibley CP,Cottrell ECdoi
10.1016/j.placenta.2016.04.003subject
Has Abstractpub_date
2016-06-01 00:00:00pages
25-7eissn
0143-4004issn
1532-3102pii
S0143-4004(16)30054-6journal_volume
42pub_type
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