Abstract：
OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hypertension. METHODS:Placental histopathology focusing on inflammatory markers of a cohort of normal weight (BMI = 20-24.9) and obese (BMI ≥ 30) patients was characterized. Demographic, obstetric and neonatal variables were assessed. RESULTS:192 normal and 231 obese women were included. Placental characteristics associated with obesity and fetal sex independent of diabetes and hypertension were placental disc weight >90(th) percentile, decreased placental efficiency, chronic villitis (CV), fetal thrombosis, and normoblastemia. Additionally, female fetuses of obese mothers had higher rates of CV and fetal thrombosis. Increasing BMI increased the risk of normoblastemia and CV. The final grade and extent of CV was significantly associated with obesity and BMI, but not fetal gender. Finally, CV was less common in large-for-gestation placentas. CONCLUSIONS:Maternal obesity results in placental overgrowth and fetal hypoxia as manifested by normoblastemia; it is also associated with an increased incidence of CV and fetal thrombosis, both more prevalent in female placentas. We have shown for the first time that the effect of maternal obesity on placental inflammation is independent of diabetes and hypertension, but significantly affected by fetal sex. Our data also point to the intriguing possibility that CV serves to normalize placental size, and potentially fetal growth, in the setting of maternal obesity.
journal_name
Placentajournal_title
Placentaauthors
Leon-Garcia SM,Roeder HA,Nelson KK,Liao X,Pizzo DP,Laurent LC,Parast MM,LaCoursiere DYdoi
10.1016/j.placenta.2015.12.006subject
Has Abstractpub_date
2016-02-01 00:00:00pages
33-40eissn
0143-4004issn
1532-3102pii
S0143-4004(15)30102-8journal_volume
38pub_type
杂志文章相关文献
PLACENTA文献大全abstract：:Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstr...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2005.05.002
更新日期：2006-04-01 00:00:00
abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.07.004
更新日期：2008-10-01 00:00:00
abstract：:The recent discovery of a local renin-angiotensin system in trophoblastic tissues has raised many questions regarding its role in the physiology of normal gestation and its implications in the pathophysiology of hypertension during pregnancy. In this article, the authors first review the most interesting aspects of th...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/s0143-4004(96)80003-8
更新日期：1996-03-01 00:00:00
abstract：:Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80020-4
更新日期：1983-01-01 00:00:00
abstract：INTRODUCTION:Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal s...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.02.004
更新日期：2017-03-01 00:00:00
abstract：:Gestational diabetes mellitus is a common medical complication in pregnancy. Recent findings demonstrate that glyburide is effluxed against a concentration gradient from the fetal to the maternal circulation. However, the transport systems involved in the active efflux of glyburide in the human placenta have not yet b...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.05.001
更新日期：2008-08-01 00:00:00
abstract：:Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2006.01.016
更新日期：2007-01-01 00:00:00
abstract：INTRODUCTION:The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS:A tota...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.06.378
更新日期：2019-08-01 00:00:00
abstract：INTRODUCTION:Perfluorinated alkyl acids (PFAAs) are widely used in industry and consumer products. Pregnant women are exposed to PFAAs and their presence in umbilical cord blood represents fetal exposure. Interestingly, PFAAs are substrates for organic anion transporters (OAT) of which OAT4 is expressed in human placen...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2015.07.119
更新日期：2015-10-01 00:00:00
abstract：:The EAT/mcl-1 gene was isolated during the early differentiation of a retinoic acid-induced human embryonal carcinoma cell line to the trophectoderm lineage. EAT/mcl-1, a bcl-2 related gene, is involved in the genetic pathway of apoptosis; this suggests a role for apoptosis and the involvement of this gene in early pl...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.1999.0458
更新日期：2000-03-01 00:00:00
abstract：INTRODUCTION:Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. MET...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.10.008
更新日期：2014-01-01 00:00:00
abstract：:The fetus has a substantial demand for glycine, which is satisfied in part by placental formation. The ability to form glycine through the activity of alanine:glyoxylate aminotransferase enzyme was measured in placentae from normal term human pregnancies and placentae from rats at day 20 of gestation. There was no det...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(98)90066-2
更新日期：1998-05-01 00:00:00
abstract：OBJECTIVES:To gain insight into the process of labor and the effects of labor on placental gene expression, we performed a microarray analysis to identify the differentially expressed transcripts that may participate in labor onset and progression. METHODS:We compared expression profiles in placentas from 16 women who...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.05.006
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:To evaluate pregnancy outcome and ultrasound diagnosis in patients with histologically-confirmed placental chorioangioma. STUDY DESIGN:Placentas with histological diagnosis of chorioangioma were identified and medical charts were reviewed for findings of ultrasound examinations. Pregnancy outcomes were compa...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2011.06.007
更新日期：2011-09-01 00:00:00
abstract：:We investigated the localization of the three subtypes of (Fc gamma R) in the normal human placenta using immunohistochemical and immunocytochemical techniques with specific monoclonal antibodies. The analysis revealed that Fc gamma RI was expressed on Hofbauer cells, that Fc gamma RII was expressed on Hofbauer cells ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(91)90506-b
更新日期：1991-01-01 00:00:00
abstract：INTRODUCTION:During a pregnancy complicated by diabetes, the human placenta undergoes a number of functional and structural pathologic changes, such as increased placental weight and increased incidence of placental lesions including villous maturational defects and fibrinoid necrosis. The pathologic findings reported ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2014.11.021
更新日期：2015-02-01 00:00:00
abstract：:MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level. While mostly intracellular, a portion of cellular miRNAs is released to the circulation and their level in the plasma is altered in certain pathological conditions such as cancer, and also during pregnancy. We...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.07.001
更新日期：2010-09-01 00:00:00
abstract：:Human placental fragments concentrate 86Rb 10--20-fold during a two-hour incubation period. Inhibition of ouabain is dose-dependent, reaching 90 + per cent at a concentration of 5 x 10(-5) M. The clearance index of 86Rb across the perfused human placenta is 0.34 +/- 0.08, comparing to previously reported indices for N...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80038-1
更新日期：1983-10-01 00:00:00
abstract：:Intrauterine infection has been associated with fetal brain injury and preterm birth. We have recently shown that repeated exposure to bacterial endotoxin leads to hypoxia and brain injury in the preterm ovine fetus and we considered it possible that endotoxin could also damage the placenta. Our aim therefore was to a...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(03)00104-8
更新日期：2003-08-01 00:00:00
abstract：:Human placental villi from both normal and complicated pregnancies were examined by both light and scanning electron microscopy. The findings provide evidence that histological features such as syncytial sprouts, bridges, and a net-like arrangement of villi represent tangential sections of irregularly shaped villi rat...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(87)90047-6
更新日期：1987-05-01 00:00:00
abstract：:Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2015.11.006
更新日期：2016-03-01 00:00:00
abstract：:A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.03.015
更新日期：2010-07-01 00:00:00
abstract：:The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2016.11.008
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.10.009
更新日期：2020-01-01 00:00:00
abstract：:Human trophoblast research relies on a combination of in vitro models, including isolated primary cultures, explant cultures, and trophoblast cell lines. In the present study, we have utilized the rotating wall vessel (RWV) bioreactor to generate a three-dimensional (3-D) model of human placentation for the study of c...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2004.11.003
更新日期：2005-11-01 00:00:00
abstract：:During the first trimester in normal human pregnancy, endovascular trophoblast migrate along the decidual spiral arteries and invade their walls to produce physiological change. There is controversy as to whether invading trophoblast plug the arteries and prevent blood flow into the intervillous space. Using light mic...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(97)80048-3
更新日期：1997-07-01 00:00:00
abstract：:Homeodomain (HDM) proteins encoded by homeobox (HBX) genes represent a large family of transcriptional factors that control differentiation and development in certain cell types. DLX4 is a member of Distal-less (DLX) family of HBX genes. Recent studies have demonstrated that abnormal expression of DLX4 is present in s...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2005.03.007
更新日期：2006-04-01 00:00:00
abstract：:Nitrotyrosine residues (NT), an index of oxidative stress arising from peroxynitrite formation and action, are found in placental vasculature of pregnancies complicated by pre-eclampsia (PE) or pregestational insulin-dependent diabetes mellitus (IDDM). This study correlates conventional placental pathology with NT imm...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0634
更新日期：2001-04-01 00:00:00
abstract：INTRODUCTION:Miscarriage is the most common placental-related complication of pregnancy. It has been extensively investigated to discover the underlying mechanism(s) by which miscarriage occurs, but in many cases the etiology still remains unclear. The aim of this study was to analyze genome-wide expression profiles of...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.12.003
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Discrepancies in the results from studies of early events in human trophoblast invasion of decidua have been acknowledged and are attributed largely to deficiencies in the accuracy of sampling of the decidual tissue used in the research. We describe a novel technique of biopsy of decidua parietalis and basal...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.02.018
更新日期：2012-06-01 00:00:00
