Involvement of EAT/mcl-1, a bcl-2 related gene, in the apoptotic mechanisms underlying human placental development and maintenance.

abstract：:ED(27) trophoblast-like cells were prepared from human chorionic villus samples obtained at 9 weeks gestation and have been grown continuously in vitro without phenotypic drift for nearly a decade. These cells express many trophoblast markers, including cytokeratin, placental alkaline phosphatase (PLAP), secretion of ...

journal_title：Placenta

authors： Kniss DA,Xie Y,Li Y,Kumar S,Linton EA,Cohen P,Fan-Havard P,Redman CW,Sargent IL

更新日期：2002-01-01 00:00:00

abstract：:Human trophoblast research relies on a combination of in vitro models, including isolated primary cultures, explant cultures, and trophoblast cell lines. In the present study, we have utilized the rotating wall vessel (RWV) bioreactor to generate a three-dimensional (3-D) model of human placentation for the study of c...

journal_title：Placenta

authors： LaMarca HL,Ott CM,Höner Zu Bentrup K,Leblanc CL,Pierson DL,Nelson AB,Scandurro AB,Whitley GS,Nickerson CA,Morris CA

更新日期：2005-11-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...

journal_title：Placenta

authors： Ernst LM,Minturn L,Huang MH,Curry E,Su EJ

更新日期：2013-07-01 00:00:00

abstract：:Autophagy, a process for cellular cleaning through the removal of intracellular components in lysosomes, is a well conserved mechanism from yeast to mammalian cells, and also contributes to the maintenance of cellular homeostasis and of the energetic balance, in cellular and tissue remodeling, and cellular defense aga...

journal_title：Placenta

authors： Saito S,Nakashima A

更新日期：2013-03-01 00:00:00

abstract：INTRODUCTION:Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder unique to pregnancy that is associated with increased rates of fetal distress and demise. While acute hypoxia is believed to cause the pathophysiology of ICP, direct molecular evidence for this is lacking. Here, we analyzed expression of three...

journal_title：Placenta

authors： Wei W,Hu YY

更新日期：2014-09-01 00:00:00

abstract：:Several recent publications have focused on the association between the occurrence of twin-to-twin transfusion syndrome (TTTS) in diamniotic-monochorionic twins and the presence of a number of selected anatomic placental characteristics (distribution of vascular territory, cord insertion, type and number of inter-twin...

journal_title：Placenta

authors： De Paepe ME,DeKoninck P,Friedman RM

更新日期：2005-07-01 00:00:00

abstract：:Chorioallantoic placentae were obtained from a reproductively synchronized wild population of greater mustache bats for ultrastructural and immunocytochemical examination. The single discoidal placenta was always located in a lateral to mesometrial position on the right side of the uterus, which in the non-pregnant st...

journal_title：Placenta

authors： Badwaik NK,Rasweiler JJ 4th

更新日期：1998-07-01 00:00:00

abstract：INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...

journal_title：Placenta

authors： Li C,Raikwar NS,Santillan MK,Santillan DA,Thomas CP

更新日期：2015-04-01 00:00:00

abstract：:Placental size has been an interesting topic of research for many years. The main aim of this study was to investigate the feasibility of measuring the placental volume at the end of the first trimester using three-dimensional (3D) ultrasound and to correlate these volumes to known placental functional indices and to ...

journal_title：Placenta

authors： Metzenbauer M,Hafner E,Hoefinger D,Schuchter K,Stangl G,Ogris E,Philipp K

更新日期：2001-07-01 00:00:00

abstract：:Transfection using cationic lipid reagents such as DharmaFECT2 is an efficient tool for introducing siRNA into primary human cytotrophoblast cells. However, we now report a limitation to the use of this method as the concentration of DharamFECT2 needed for effective siRNA delivery causes ligand-independent activation ...

journal_title：Placenta

authors： Desforges M,Westwood M

更新日期：2011-02-01 00:00:00

abstract：:Apart from during the prepartal period, the main oestrogen produced by the bovine trophoblast is oestrone sulphate (E1S) which does not bind to nuclear oestrogen receptors (ER). High steroid sulphatase (StS) activities previously detected in the maternal part of bovine placentomes (caruncles) suggest the local activat...

journal_title：Placenta

authors： Greven H,Kowalewski MP,Hoffmann B,Geyer J,Rex-Haffner M,Ugele B,Schuler G

更新日期：2007-08-01 00:00:00

abstract：:Placental trophoblast syncytialization is a unique biological process. We have studied the time course of this process using DNA microarray in a cell model of syncytialization (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin). Total RNA was extracted from BeWo cells and labelled-...

journal_title：Placenta

authors： Kudo Y,Boyd CA,Sargent IL,Redman CW,Lee JM,Freeman TC

更新日期：2004-07-01 00:00:00

abstract：INTRODUCTION:The breast cancer resistance protein (BCRP/ABCG2) is an efflux transporter in the placental barrier. By transporting chemicals from the fetal to the maternal circulation, BCRP limits fetal exposure to a range of drugs, toxicants, and endobiotics such as bile acids and hormones. The purpose of the present s...

journal_title：Placenta

authors： Szilagyi JT,Vetrano AM,Laskin JD,Aleksunes LM

更新日期：2017-07-01 00:00:00

abstract：:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...

journal_title：Placenta

authors： Azevedo Portilho N,Tavares Guedes P,Croy BA,Pelajo-Machado M

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. METHODS:In 33 chronically instrumented fetal sheep, placental volume blood flow (QPlac) and umbilical artery (UA) vascular impedance were measured by Doppler u...

journal_title：Placenta

authors： Alanne L,Bhide A,Hoffren J,Lantto J,Huhta H,Kokki M,Haapsamo M,Acharya G,Räsänen J

更新日期：2020-01-15 00:00:00

abstract：:Two groups of placentae from 18 cases of maternal rubella were examined morphologically and virologically. Placentae in Group I (four cases) had a mean gestational age of 21 +/- 1.9 weeks, whilst those in Group 2 (14 cases) had a mean gestational age of 38 +/- 2.8 weeks. A tendency to hypoplasia was observed. The micr...

journal_title：Placenta

authors： Garcia AG,Marques RL,Lobato YY,Fonseca ME,Wigg MD

更新日期：1985-07-01 00:00:00

abstract：:The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the placenta which are associated with adult onset chronic disease. 1) Placental efficiency relates the placental mass to the fetal mass. Ratios at the extremes are related...

journal_title：Placenta

authors： Thornburg KL,Kolahi K,Pierce M,Valent A,Drake R,Louey S

更新日期：2016-12-01 00:00:00

abstract：:We have examined the hypothesis that regional differences in 15-hydroxyprostaglandin dehydrogenase (PGDH) activities occur within the human fetal membranes. Further, we reasoned that a specific reduction in PGDH in the fetal membranes at the lower uterine segment might occur with labour, providing a potential mechanis...

journal_title：Placenta

authors： Van Meir CA,Ramirez MM,Matthews SG,Calder AA,Keirse MJ,Challis JR

更新日期：1997-03-01 00:00:00

abstract：:Mice were inoculated with Theiler's murine encephalomyelitis virus (TMEV) on gestational days 1-3 (pre-implantation) or days 4-5 (peri- or post-implantation) or with control cell lysate (days 1-5). Dams were subsequently sacrificed between days 11-14 of gestation, and placentae and fetuses were harvested. Few placenta...

journal_title：Placenta

authors： Abzug MJ,Tyson RW

更新日期：2000-05-01 00:00:00

abstract：:Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...

journal_title：Placenta

authors： López Bernal A,Anderson AB,Turnbull AC

更新日期：1984-03-01 00:00:00

abstract：:Dynamics of genome multiplication during establishment of interrelations between trophoblast and glandular epithelium of the endometrium has been studied in the course of formation of placenta in the silver fox. During formation of the placenta, penetration of the trophoblast into the zone of the endometrial glandular...

journal_title：Placenta

authors： Zybina TG,Zybina EV,Kiknadze II,Zhelezova AI

更新日期：2001-05-01 00:00:00

abstract：INTRODUCTION:The aim of this study is to determine whether the gene expression and associated DNA methylation regulation of H19 and IGF2 are altered in placentas conceived by assisted reproductive technologies (ART) compared to natural conceptions. METHODS:113 pregnancies were recruited resulting in 119 placentas (83 ...

journal_title：Placenta

authors： Sakian S,Louie K,Wong EC,Havelock J,Kashyap S,Rowe T,Taylor B,Ma S

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Chronic abruption oligohydramnios sequence (CAOS) is histologically characterized by diffuse chorioamniotic hemosiderosis (DCH). However, the criteria for the histological evaluation of the extent of CAOS-related hemosiderin deposition (HD) of the membranes and the difference in HD between the chorionic pl...

journal_title：Placenta

authors： Ishida A,Minamiguchi S,Yamada Y,Nakagawa R,Chigusa Y,Kondoh E,Mandai M,Haga H

更新日期：2021-01-20 00:00:00

abstract：INTRODUCTION:The state of activation of dendritic cells (DCs) at the feto-maternal interface critically contributes to optimal decidual immune responses needed to support fetal-placental development. We recently demonstrated that during healthy pregnancy also peripheral blood DCs (PBDCs), which are easily accessible, a...

journal_title：Placenta

authors： Cappelletti M,Giannelli S,Martinelli A,Cetin I,Colombo E,Calcaterra F,Mavilio D,Della Bella S

更新日期：2013-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the post-transcriptional level. While mostly intracellular, a portion of cellular miRNAs is released to the circulation and their level in the plasma is altered in certain pathological conditions such as cancer, and also during pregnancy. We...

journal_title：Placenta

authors： Mouillet JF,Chu T,Hubel CA,Nelson DM,Parks WT,Sadovsky Y

更新日期：2010-09-01 00:00:00

abstract：:Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...

journal_title：Placenta

authors： Guibourdenche J,Frendo JL,Pidoux G,Bertin G,Luton D,Muller F,Porquet D,Evain-Brion D

更新日期：2003-05-01 00:00:00

abstract：:Indiscriminate invasion upon the endometrium by normal trophoblasts is strictly regulated unlike that by choriocarcinoma cells. In this study, we focused on the activity of matrix metalloproteinase (MMP)-2 and MMP-9 as parameters of invasion in normal human placenta. In situ hybridization (ISH), immunohistochemical st...

journal_title：Placenta

authors： Isaka K,Usuda S,Ito H,Sagawa Y,Nakamura H,Nishi H,Suzuki Y,Li YF,Takayama M

更新日期：2003-01-01 00:00:00

abstract：:In the present study, we characterized the expression of lymphocyte antigen 6, locus E (Ly6e) in mouse placental trophoblast. We identified Ly6e mRNA expression in trophoblast stem (TS) cells by a gene expression screen. In vivo, Ly6e was first detectable by mRNA in situ hybridization in the chorion beginning at E8.5 ...

journal_title：Placenta

authors： Hughes M,Natale BV,Simmons DG,Natale DR

更新日期：2013-09-01 00:00:00

abstract：INTRODUCTION:Chronic histiocytic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by an intervillous mononuclear inflammatory infiltrate of maternal origin. Although the mechanism and origin of these lesions are currently not understood, they appear to be related to an immune conflict...

journal_title：Placenta

authors： Capuani C,Meggetto F,Duga I,Danjoux M,March M,Parant O,Brousset P,Aziza J

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...

journal_title：Placenta

authors： Lei D,Deng N,Wang S,Huang J,Fan C

更新日期：2020-01-01 00:00:00