Chorionic prostaglandin catabolism is decreased in the lower uterine segment with term labour.

abstract：:Preeclampsia (PE) affects 5-8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammat...

journal_title：Placenta

authors： Muralimanoharan S,Maloyan A,Myatt L

更新日期：2013-12-01 00:00:00

abstract：:The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...

journal_title：Placenta

authors： Poisner AM,Thrailkill K,Poisner R,Handwerger S

更新日期：1991-05-01 00:00:00

abstract：:Glucose residues were revealed by light microscopic and fine structural analysis using hexokinase-gold conjugate. In human term placenta specific staining was detected over the stroma of placental villi. Colloidal gold particles were found over the collagen fibrils and reticular lamina of basal membrane. Syncytiotroph...

journal_title：Placenta

authors： Glazyrin AL,Kolesnikov SI

更新日期：1993-09-01 00:00:00

abstract：:Receptors for complexes between alpha 2-macroglobulin (alpha 2M) and proteinases (e.g. trypsin) were identified and characterized in the human placenta. The receptors also bound the complex formed between pregnancy zone protein (PZP) and chymotrypsin, although with slightly lower affinity, whereas binding of alpha 2M ...

journal_title：Placenta

authors： Jensen PH,Moestrup SK,Sottrup-Jensen L,Petersen CM,Gliemann J

更新日期：1988-09-01 00:00:00

abstract：:Uptake and metabolism of adenosine by human placenta were studied using the single-circulation paired-tracer technique. When isolated cotyledons were perfused through the fetal (basal) circulation at mean pressures of 36 +/- 3.3 mmHg and mean flow rates of 6.6 +/- 0.3 ml/min the maximal [3H]adenosine uptake was 51.3 +...

journal_title：Placenta

authors： Acevedo CG,Rojas S,Ramirez M,Bravo I

更新日期：1995-10-01 00:00:00

abstract：:An area of the fetal membranes, within the rupture tear after spontaneous delivery at term, exhibits altered morphology compared to more distal sites. It is characterized by marked swelling of the amniotic and chorionic connective tissue layers, consistent with structural weakness, and a marked reduction of the thickn...

journal_title：Placenta

authors： McParland PC,Taylor DJ,Bell SC

更新日期：2000-01-01 00:00:00

abstract：:Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining wit...

journal_title：Placenta

authors： Avagliano L,Danti L,Doi P,Felis S,Guala M,Locatelli A,Maffeo I,Mecacci F,Plevani C,Simeone S,Bulfamante GP

更新日期：2013-11-01 00:00:00

abstract：:Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...

journal_title：Placenta

authors： Udagawa K,Yasumitsu H,Esaki M,Sawada H,Nagashima Y,Aoki I,Jin M,Miyagi E,Nakazawa T,Hirahara F,Miyazaki K,Miyagi Y

更新日期：2002-02-01 00:00:00

abstract：INTRODUCTION:Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS:This was a prosp...

journal_title：Placenta

authors： Widnes C,Flo K,Acharya G

更新日期：2017-01-01 00:00:00

abstract：:The localization of 5-hydroxytryptamine (5-HT) and its receptors in human placenta was studied under light and electron microscopy using immunohistochemistry and in situ hybridization. The syncytiotrophoblast, cytotrophoblast, stromal cells and decidual cells in human placentae all appeared to be 5-HT immunoreactive. ...

journal_title：Placenta

authors： Huang WQ,Zhang CL,Di XY,Zhang RQ

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Discrepancies in the results from studies of early events in human trophoblast invasion of decidua have been acknowledged and are attributed largely to deficiencies in the accuracy of sampling of the decidual tissue used in the research. We describe a novel technique of biopsy of decidua parietalis and basal...

journal_title：Placenta

authors： Talaulikar VS,Bax BE,Page NM,Manyonda I

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Knockout mouse model has shown a relationship between Slit2/Robo1 signalling and altered fertility. Altered expression by endometrial epithelium and trophoblast and is associated with the pathogenesis of pregnancy complications but few studies have investigated the expression of decidual Slit2 in miscarria...

journal_title：Placenta

authors： Chen J,Liu J,Gao S,Qiu Y,Wang Y,Zhang Y,Gao L,Qi G,Wu Y,Lash GE,Li P

更新日期：2020-10-09 00:00:00

abstract：:Homeodomain (HDM) proteins encoded by homeobox (HBX) genes represent a large family of transcriptional factors that control differentiation and development in certain cell types. DLX4 is a member of Distal-less (DLX) family of HBX genes. Recent studies have demonstrated that abnormal expression of DLX4 is present in s...

journal_title：Placenta

authors： Sun Y,Lu X,Yin L,Zhao F,Feng Y

更新日期：2006-04-01 00:00:00

abstract：:Angiotensinogen is the substrate for the enzyme renin. In addition to the well-characterized low molecular weight forms of angiotensinogen, a high molecular weight form (HMrA) comprises about 15 per cent of the total angiotensinogen in plasma of pregnant women. In the current study the different forms of angiotensinog...

journal_title：Placenta

authors： Lenz T,Sealey JE,Tewksbury DA

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVES:Microbial-specific factors are likely critical in determining whether bacteria trigger preterm labor. Structural variations in lipopolysaccharide (LPS), a component of gram-negative bacteria, can determine whether LPS has an inflammatory (agonist) or anti-inflammatory (antagonist) effect through Toll-like re...

journal_title：Placenta

authors： Chang J,Jain S,Carl DJ,Paolella L,Darveau RP,Gravett MG,Adams Waldorf KM

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...

journal_title：Placenta

authors： Carter AM

更新日期：2018-07-01 00:00:00

abstract：:Wharton's jelly contains large amounts of hyaluronic acid, and glucosamine is an important constituent of this macromolecule. In order to evaluate the placental vascular effects of this aminosugar, small chorionic and stem villous arteries were dissected from placental specimens obtained at normal term vaginal deliver...

journal_title：Placenta

authors： Uldbjerg N,Allen J,Maigaard S,Forman A

更新日期：1987-07-01 00:00:00

abstract：INTRODUCTION:Preeclampsia (PE) is one of the leading causes of maternal mortality and morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has been a focus of research. This study was to identified genes or pathways that may be associated with PE, and discuss whether the changes in the me...

journal_title：Placenta

authors： Li Y,Cui S,Shi W,Yang B,Yuan Y,Yan S,Li Y,Xu Y,Zhang Z,Linlin Zhang

更新日期：2020-04-01 00:00:00

abstract：:The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...

journal_title：Placenta

authors： Schneider H

更新日期：2000-03-01 00:00:00

abstract：:The ontogeny of Ia antigen expression on cells within the decidua basalis of the placenta and on decidual cells differentiating in vitro was investigated in the mouse. The results indicate that Ia antigen expression is temporarily restricted and can be detected in short-term cultures of decidual tissue only during the...

journal_title：Placenta

authors： Searle RF,Bell SC,Billington WD

更新日期：1983-04-01 00:00:00

abstract：UNLABELLED:Placental hypoxia has been implicated in pregnancy pathologies such as preeclampsia. We have previously reported that AQP9 is highly expressed in syncytiotrophoblast from normal placentas and shows an overexpression in preeclamptic placentas, with a lack of functionality for water transport. Up to now, the r...

journal_title：Placenta

authors： Castro-Parodi M,Szpilbarg N,Dietrich V,Sordelli M,Reca A,Abán C,Maskin B,Farina MG,Damiano AE

更新日期：2013-08-01 00:00:00

abstract：:A long and productive history of studies at high altitude has demonstrated that chronic hypoxia plays a key role in the aetiology of intrauterine growth restriction (IUGR) and pre-eclampsia. Susceptibility to altitude-associated IUGR varies among high-altitude populations in relation to their duration of altitude expo...

journal_title：Placenta

authors： Moore LG,Shriver M,Bemis L,Hickler B,Wilson M,Brutsaert T,Parra E,Vargas E

更新日期：2004-04-01 00:00:00

abstract：:We tested the hypothesis that the expression of placental connective tissue growth factor (CTGF) is enhanced in pregnancies complicated by severe preeclampsia (PE) or fetal growth restriction (FGR). CTGF expression was analyzed using immunostaining, western blot and real-time quantitative PCR in placental samples obta...

journal_title：Placenta

authors： Oh SY,Song SE,Seo ES,Kim KH,Choi SJ,Suh YL,Sadovsky Y,Roh CR

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Pre-gravid obesity is associated with increased morbidity and mortality for both mother and offspring. Recent studies have demonstrated a heightened inflammatory response both systemically and locally within the adipose and placental tissue in women with pre-gravid obesity, which may play a role in mediating...

journal_title：Placenta

authors： Roberts KA,Riley SC,Reynolds RM,Barr S,Evans M,Statham A,Hor K,Jabbour HN,Norman JE,Denison FC

更新日期：2011-03-01 00:00:00

abstract：:Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteropl...

journal_title：Placenta

authors： David AL

更新日期：2017-11-01 00:00:00

abstract：:Maternal fever is common during pregnancy and has for many years been suspected to harm the developing fetus. Whether increased maternal temperature produces exaggerated apoptosis in trophoblast cells remains unclear. Since p53 is a critical regulator of apoptosis we hypothesized that increased temperature in placenta...

journal_title：Placenta

authors： Pérez-Pérez A,Toro AR,Vilarino-Garcia T,Guadix P,Maymó JL,Dueñas JL,Varone CL,Sánchez-Margalet V

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:In maternal diabetes the placenta is large with abnormal vascular development and increased villous volume. We used a novel stereological 3D power Doppler ultrasound technique to investigate differences in-vivo in the placental fractional volume of power Doppler signal (FrVol-PD) between women with and witho...

journal_title：Placenta

authors： Jones NW,Deshpande R,Mousa HA,Mansell P,Raine-Fenning N,Bugg G

更新日期：2013-11-01 00:00:00

abstract：:Based on a variety of tissue samples, including Caesarean hysterectomy specimens with the placenta in situ, a detailed map of uteroplacental vascular lesions was established in over a century of research. One such lesion is acute atherosis of unremodelled basal and uteroplacental arteries, defined by the presence of f...

journal_title：Placenta

authors： Brosens I,Brosens JJ,Muter J,Benagiano G

更新日期：2020-08-01 00:00:00

abstract：:Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...

journal_title：Placenta

authors： Longtine MS,Chen B,Odibo AO,Zhong Y,Nelson DM

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION AND METHODS:Tragulus, the mouse deer, is considered the most primitive ruminant, with a diffuse placenta grossly quite unlike the cotyledonary type of the other ruminants. This immunocytochemical investigation of placental transporters was designed to elucidate possible mechanisms of evolution to the cotyl...

journal_title：Placenta

authors： Wooding FB,Kimura J,Forhead AJ

更新日期：2014-05-01 00:00:00