Abstract:
INTRODUCTION:We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. METHODS:In 33 chronically instrumented fetal sheep, placental volume blood flow (QPlac) and umbilical artery (UA) vascular impedance were measured by Doppler ultrasonography. Fetal carotid artery blood pressure and blood gas values were monitored. After baseline data collection, maternal and fetal hypoxemia were induced. Following hypoxemia phase data collection, 12 fetuses received sildenafil and 9 fetuses nifedipine infusion, and 12 fetuses served as controls receiving saline infusion. Data were collected 30 and 120 min after infusion was started. Then maternal oxygenation was normalized and normoxemia phase data were collected, while infusion was continued. RESULTS:Hypoxemia significantly decreased fetal pO2 and blood pressure. In the sildenafil group at 30- and 120-min hypoxemia + infusion phases, fetal blood pressure and QPlac were significantly lower and pCO2 higher than at baseline without returning to baseline level at normoxemia + infusion phase. In hypoxemia, nifedipine did not affect fetal blood pressure or placental hemodynamics. Both in the sildenafil and nifedipine groups, fetal pO2 remained significantly lower at normoxemia + infusion phase than in the control group. Umbilical artery vascular impedance did not change during the experiment. DISCUSSION:In fetal hypoxemia, sildenafil had detrimental effects on placental hemodynamics that disturbed placental gas exchange. Nifedipine did not alter placental hemodynamics in hypoxemia but disturbed placental gas exchange upon returning to normoxemia. Umbilical artery vascular impedance did not reflect alterations in placental hemodynamics.
journal_name
Placentajournal_title
Placentaauthors
Alanne L,Bhide A,Hoffren J,Lantto J,Huhta H,Kokki M,Haapsamo M,Acharya G,Räsänen Jdoi
10.1016/j.placenta.2019.12.014subject
Has Abstractpub_date
2020-01-15 00:00:00pages
103-108eissn
0143-4004issn
1532-3102pii
S0143-4004(19)30725-8journal_volume
90pub_type
杂志文章相关文献
PLACENTA文献大全abstract::Two groups of placentae from 18 cases of maternal rubella were examined morphologically and virologically. Placentae in Group I (four cases) had a mean gestational age of 21 +/- 1.9 weeks, whilst those in Group 2 (14 cases) had a mean gestational age of 38 +/- 2.8 weeks. A tendency to hypoplasia was observed. The micr...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(85)80038-2
更新日期:1985-07-01 00:00:00
abstract::The placental renin-angiotensin system (RAS) is involved in placentation. We have shown that prorenin mRNA (REN) is expressed in a first trimester trophoblast cell line (HTR-8/SVneo) but not in a choriocarcinoma cell line (BeWo). We attempted to stimulate RAS expression in these cells by cAMP, 5'-aza-2'-deoxycytidine ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.12.018
更新日期:2013-03-01 00:00:00
abstract::Antigenic material previously detected in human placental trophoblastic cells by immunoperoxidase staining using a goat antiserum against the feline RD114 retrovirus structural protein p30 was isolated by immunochromatography from normal syncytiotrophoblast. The antigen was used to immunize mice, and of the monoclonal...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80001-6
更新日期:1984-11-01 00:00:00
abstract::The clinical features of the maternal syndrome of pre-eclampsia can be explained by generalised maternal endothelial cell dysfunction, which is a part of a more global maternal systemic inflammatory response. There is growing evidence that these effects are associated with the shedding of cellular debris, including sy...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.08.018
更新日期:2008-11-01 00:00:00
abstract::The visceral yolk sac (VYS) is responsible for a major part of the amino acid nutrition of the early post-implantation rat embryo and possibly also at the fetal stage of gestation. The mechanism involves endocytic uptake of proteins by the tissue's epithelial cells followed by intralysosomal digestion to amino acids. ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(77)90009-1
更新日期:1997-09-01 00:00:00
abstract:INTRODUCTION:Placental thickness in the second trimester of pregnancy has been associated with risks of placenta-mediated complications of pregnancy. We aimed to estimate the association between first-trimester maximum placental thickness and the subsequent risk of preeclampsia and/or the delivery of small-for-gestatio...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.06.016
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...
journal_title:Placenta
pub_type: 传,历史文章,杂志文章,评审
doi:10.1016/j.placenta.2018.05.010
更新日期:2018-07-01 00:00:00
abstract::Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstr...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2005.05.002
更新日期:2006-04-01 00:00:00
abstract::Twinning and placental fusion occur at a low frequency in species like humans and mice. They are linked to reduced birth weight and intertwin growth discrepancy with important consequences for perinatal survival. Despite this, little is known about the histological characteristics of the twin or fused placenta and how...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.036
更新日期:2020-11-02 00:00:00
abstract::A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.03.015
更新日期:2010-07-01 00:00:00
abstract::Placentae from controls and two groups of diabetic women (one White classes A, B, C and the other classes D, F/R) were collected at 37-42 weeks of gestation. Tissue sections were analysed using stereological methods in order to quantify the growth and maturational status of villi. Birth and placental weights were reco...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80236-x
更新日期:1994-01-01 00:00:00
abstract::Eleven placentae and one fibroblast cell culture from pregnancies complicated by various inherited metabolic disorders, together with five chorionic villus biopsies from pregnancies at risk, were examined for ultrastructural evidence of accumulation of metabolites. Abnormal ultrastructural features were present as ear...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80215-2
更新日期:1990-09-01 00:00:00
abstract::The fusion of villous cytotrophoblast into the placental syncytium is the quintessential process in maintenance of a healthy pregnancy. Efficient fusion requires a phosphatidylserine (PS)-rich cytotrophoblast surface, expression of fusion proteins, cessation of cell cycling, and rearrangement of cytoskeleton to accomm...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2009.12.014
更新日期:2010-02-01 00:00:00
abstract::Mice were inoculated with Theiler's murine encephalomyelitis virus (TMEV) on gestational days 1-3 (pre-implantation) or days 4-5 (peri- or post-implantation) or with control cell lysate (days 1-5). Dams were subsequently sacrificed between days 11-14 of gestation, and placentae and fetuses were harvested. Few placenta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0488
更新日期:2000-05-01 00:00:00
abstract::Second trimester maternal serum human chorionic gonadotrophin (hCG) levels in women who remained normotensive but delivered an unexplained growth retarded infant were compared with those from a control group and a group of women who developed pre-eclampsia in a retrospective observational study. Our hypothesis was tha...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90002-9
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND/PURPOSE:Human placenta and chorion are rapidly growing transient embryonic organs built from diverse cell populations that are of either, ectodermal [placenta and chorion specific trophoblast (TB) cells], or mesodermal origin [villous core and chorionic mesenchyme]. The development of placenta and chorion is...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.05.002
更新日期:2015-07-01 00:00:00
abstract::Placental trophoblast syncytialization is a unique biological process. We have studied the time course of this process using DNA microarray in a cell model of syncytialization (the cytotrophoblast cell line BeWo following increased intracellular cAMP by forskolin). Total RNA was extracted from BeWo cells and labelled-...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2003.12.001
更新日期:2004-07-01 00:00:00
abstract::Preeclampsia (PE) affects 5-8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammat...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.09.015
更新日期:2013-12-01 00:00:00
abstract::We developed a model of maternal hyperglycaemia with secondary hyperinsulinaemia and hypoaminoacidaemia in pregnant sheep (H) to determine the effect of these conditions on uterine, uteroplacental and fetal amino-acid uptake rates and fetal amino-acid concentrations [AA]. Results were compared with normal pregnant ewe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0610
更新日期:2001-02-01 00:00:00
abstract:INTRODUCTION:To study the relationship between 2-dimensional placental ultrasound measurements and maternal serum (MS) levels of biomarkers of placentation and in pregnancies presenting with an isolated abnormally high or low birthweight at term, without evidence of placental insufficiency. METHOD:We performed a popul...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.02.005
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:In humans, it is known that blood flow is directed to the gravid uterus from two (right and left) pelvic uterine arteries. The extent of supply from the tubo-ovarian anastomosis (joining of the ovarian and uterine arteries) is unknown. The aim of this study was to delineate the arterial blood supply to the p...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.10.009
更新日期:2010-01-01 00:00:00
abstract::Members of the transmembrane emp24 domain (Tmed)/p24 family of proteins are required for transport of proteins between the endoplasmic reticulum and the Golgi. One member of this family, Tmed2/p24β1, is expressed during placental development in mice and its expression is required for normal development of the labyrint...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.12.009
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:The human placenta extrudes a variety of extracellular vesicles (EVs) into the maternal blood daily. These vesicles may be crucial to the adaptation of the maternal cardiovascular and immune systems to pregnancy. Quantifying the EVs that are released in early gestation is important to our understanding of ho...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.10.009
更新日期:2018-12-01 00:00:00
abstract::The mechanism of iron release from the placenta into the fetal circulation is not well understood. Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types. The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0582
更新日期:2000-11-01 00:00:00
abstract::We present a case of intra-amniotic umbilical vein varix with thrombosis using conventional two-dimensional (2D) sonography, power Doppler, three-dimensional (3D) HD-flow, and HDlive at 35 weeks of gestation. 2D sonography showed a large banana-like umbilical cord enlargement (100 × 43.3 × 45.9 mm) including umbilical...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.08.008
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Folates are essential nutrients for fetal development and pregnancy outcomes; they are transported to the fetus during gestation through specific folate transporters located in the placenta. In preterm newborns, we previously showed a lower placental mRNA expression of FOLR1 along with higher folate and lo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.03.009
更新日期:2020-05-01 00:00:00
abstract::Placentas and plasma from women with and without Chagas' disease and cultures of human placental villi with Trypanosoma cruzi, neuraminidase, phospholipase A2 and phospholipase C were analyzed in order to verify if the alterations in placental alkaline phosphatase (PLAP) enzyme activity are caused by T. cruzi as obser...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.08.014
更新日期:2005-11-01 00:00:00
abstract::Hyperplastic placentas have been reported in several experimental mouse models, including animals produced by somatic cell nuclear transfer, by inter(sub)species hybridization, and by somatic cytoplasm introduction to oocytes followed by intracytoplasmic sperm injection. Of great interest are the gross and histologica...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2008.05.008
更新日期:2008-08-01 00:00:00
abstract::To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells after stimulation with various modulatory agents of cytokine ex...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0494
更新日期:2000-05-01 00:00:00
abstract::The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(91)90007-3
更新日期:1991-05-01 00:00:00