Effects of nifedipine and sildenafil on placental hemodynamics and gas exchange during fetal hypoxemia in a chronic sheep model.

Abstract:

INTRODUCTION:We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. METHODS:In 33 chronically instrumented fetal sheep, placental volume blood flow (QPlac) and umbilical artery (UA) vascular impedance were measured by Doppler ultrasonography. Fetal carotid artery blood pressure and blood gas values were monitored. After baseline data collection, maternal and fetal hypoxemia were induced. Following hypoxemia phase data collection, 12 fetuses received sildenafil and 9 fetuses nifedipine infusion, and 12 fetuses served as controls receiving saline infusion. Data were collected 30 and 120 min after infusion was started. Then maternal oxygenation was normalized and normoxemia phase data were collected, while infusion was continued. RESULTS:Hypoxemia significantly decreased fetal pO2 and blood pressure. In the sildenafil group at 30- and 120-min hypoxemia + infusion phases, fetal blood pressure and QPlac were significantly lower and pCO2 higher than at baseline without returning to baseline level at normoxemia + infusion phase. In hypoxemia, nifedipine did not affect fetal blood pressure or placental hemodynamics. Both in the sildenafil and nifedipine groups, fetal pO2 remained significantly lower at normoxemia + infusion phase than in the control group. Umbilical artery vascular impedance did not change during the experiment. DISCUSSION:In fetal hypoxemia, sildenafil had detrimental effects on placental hemodynamics that disturbed placental gas exchange. Nifedipine did not alter placental hemodynamics in hypoxemia but disturbed placental gas exchange upon returning to normoxemia. Umbilical artery vascular impedance did not reflect alterations in placental hemodynamics.

journal_name

Placenta

journal_title

Placenta

authors

Alanne L,Bhide A,Hoffren J,Lantto J,Huhta H,Kokki M,Haapsamo M,Acharya G,Räsänen J

doi

10.1016/j.placenta.2019.12.014

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

103-108

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(19)30725-8

journal_volume

90

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Protection of murine gestational tissues from picornavirus infection in the preimplantation period.

    abstract::Mice were inoculated with Theiler's murine encephalomyelitis virus (TMEV) on gestational days 1-3 (pre-implantation) or days 4-5 (peri- or post-implantation) or with control cell lysate (days 1-5). Dams were subsequently sacrificed between days 11-14 of gestation, and placentae and fetuses were harvested. Few placenta...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.1999.0488

    authors: Abzug MJ,Tyson RW

    更新日期:2000-05-01 00:00:00

  • Fetal growth retardation and second trimester maternal serum human chorionic gonadotrophin levels.

    abstract::Second trimester maternal serum human chorionic gonadotrophin (hCG) levels in women who remained normotensive but delivered an unexplained growth retarded infant were compared with those from a control group and a group of women who developed pre-eclampsia in a retrospective observational study. Our hypothesis was tha...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(98)90002-9

    authors: Luckas MJ,Sandland R,Hawe J,Neilson JP,McFadyen IR,Meekins JW

    更新日期:1998-03-01 00:00:00

  • Gross patterns of umbilical cord coiling: correlations with placental histology and stillbirth.

    abstract:INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2013.04.002

    authors: Ernst LM,Minturn L,Huang MH,Curry E,Su EJ

    更新日期:2013-07-01 00:00:00

  • Aberrantly up-regulated miR-142-3p inhibited the proliferation and invasion of trophoblast cells by regulating FOXM1.

    abstract:INTRODUCTION:Preeclampsia is one of the main causes of morbidity and mortality in pregnant women and mothers. Numerous studies showed that microRNAs (miRNAs) played important roles in the occurrence and development of preeclampsia. However, the regulation of microRNA-142-3p (miR-142-3p) in preeclampsia has not been cla...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2021.01.002

    authors: Mao Y,Hou B,Shan L,Sun X,Wang L

    更新日期:2021-01-06 00:00:00

  • SNAT expression in rat placenta.

    abstract::Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstr...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2005.05.002

    authors: Novak D,Lehman M,Bernstein H,Beveridge M,Cramer S

    更新日期:2006-04-01 00:00:00

  • Characterization of rat placental TRH-like material and the ontogeny of placental and fetal brain TRH.

    abstract::TRH immunological and biological activity was characterized in rat placental extracts. Placentae were extracted sequentially with 2 N acetic acid and glacial acetic acid. The lyophilized residues were further extracted with 90 per cent methanol, and the extracts were then dried, and reextracted with distilled water. W...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(83)80036-8

    authors: Shambaugh GE 3rd,Kubek M,Wilber JF

    更新日期:1983-10-01 00:00:00

  • Exploring sexual dimorphism in placental circulation at 22-24 weeks of gestation: A cross-sectional observational study.

    abstract:INTRODUCTION:Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS:This was a prosp...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2016.11.005

    authors: Widnes C,Flo K,Acharya G

    更新日期:2017-01-01 00:00:00

  • Cullins in human intra-uterine growth restriction: expressional and epigenetic alterations.

    abstract::Intra-uterine growth restriction (IUGR) is defined by a restriction of fetal growth during gestation. It is a prevalent significant public health problem that jeopardizes neonatal health but also that can have deleterious consequences later in adult life. Cullins constitute a family of seven proteins involved in cell ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2009.11.008

    authors: Gascoin-Lachambre G,Buffat C,Rebourcet R,Chelbi ST,Rigourd V,Mondon F,Mignot TM,Legras E,Simeoni U,Vaiman D,Barbaux S

    更新日期:2010-02-01 00:00:00

  • Placenta-bound and body fluid PP13 and its mRNA in normal pregnancy compared to preeclampsia, HELLP and preterm delivery.

    abstract:OBJECTIVES:To compare the distribution of placental protein 13 (PP13) in fetal and maternal blood and amnionic fluid and to correlate it with PP13 protein and mRNA in the placenta. METHODS:Umbilical arterial serum, amnionic fluid, maternal venous serum and placental tissues were collected from normal outcome pregnanci...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2010.09.006

    authors: Sammar M,Nisemblat S,Fleischfarb Z,Golan A,Sadan O,Meiri H,Huppertz B,Gonen R

    更新日期:2011-02-01 00:00:00

  • Villous trophoblast apoptosis is elevated and restricted to cytotrophoblasts in pregnancies complicated by preeclampsia, IUGR, or preeclampsia with IUGR.

    abstract::Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2012.01.017

    authors: Longtine MS,Chen B,Odibo AO,Zhong Y,Nelson DM

    更新日期:2012-05-01 00:00:00

  • Matrix metalloproteinase 1 in pre-eclampsia and fetal growth restriction: reduced gene expression in decidual tissue and protein expression in extravillous trophoblasts.

    abstract::Superficial invasion of extravillous trophoblasts (EVTs) and impaired spiral artery remodelling are characterizing phenomena in pregnancies complicated by pre-eclampsia (PE) and fetal growth restriction (FGR). However, the underlying causes remain unclear. In this study, gene expression in decidua basalis tissue from ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2010.04.003

    authors: Lian IA,Toft JH,Olsen GD,Langaas M,Bjørge L,Eide IP,Børdahl PE,Austgulen R

    更新日期:2010-07-01 00:00:00

  • Sex-specific differences in placental global gene expression in pregnancies complicated by asthma.

    abstract:BACKGROUND:Chronic maternal asthma is associated with reduced growth of the female fetus and normal growth of the male fetus. The mechanisms that control the differential effects of maternal asthma on the fetus have not been fully elucidated but alterations in placental function may play a role. In the current study we...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2011.05.005

    authors: Osei-Kumah A,Smith R,Jurisica I,Caniggia I,Clifton VL

    更新日期:2011-08-01 00:00:00

  • Classics revisited: C. J. van der Horst on pregnancy and menstruation in elephant shrews.

    abstract:BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...

    journal_title:Placenta

    pub_type: 传,历史文章,杂志文章,评审

    doi:10.1016/j.placenta.2018.05.010

    authors: Carter AM

    更新日期:2018-07-01 00:00:00

  • Maternal uterine artery VEGF gene therapy for treatment of intrauterine growth restriction.

    abstract::Intrauterine growth restriction (IUGR) is a serious pregnancy complication affecting approximately 8% of all pregnancies. The aetiology is believed to be insufficient maternal uteroplacental perfusion which prevents adequate nutrient and oxygen availability for the fetus. There is no treatment that can improve uteropl...

    journal_title:Placenta

    pub_type: 杂志文章,评审

    doi:10.1016/j.placenta.2017.09.011

    authors: David AL

    更新日期:2017-11-01 00:00:00

  • Placental miR-1301 is dysregulated in early-onset preeclampsia and inversely correlated with maternal circulating leptin.

    abstract:INTRODUCTION:miRNAs are small non-coding RNAs important for the regulation of mRNA in many organs including placenta. Adipokines and specifically leptin are known to be dysregulated in preeclampsia, but little is known regarding their regulation by miRNAs during pregnancy. METHODS:We performed high-throughput sequenci...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2014.07.002

    authors: Weedon-Fekjær MS,Sheng Y,Sugulle M,Johnsen GM,Herse F,Redman CW,Lyle R,Dechend R,Staff AC

    更新日期:2014-09-01 00:00:00

  • Macroscopic and microscopic aspects of collared peccary and white-lipped peccary placenta.

    abstract::This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2005.02.017

    authors: Santos TC,Dantzer V,Jones CJ,Oliveira MF,Miglino MA

    更新日期:2006-02-01 00:00:00

  • Involvement of EAT/mcl-1, a bcl-2 related gene, in the apoptotic mechanisms underlying human placental development and maintenance.

    abstract::The EAT/mcl-1 gene was isolated during the early differentiation of a retinoic acid-induced human embryonal carcinoma cell line to the trophectoderm lineage. EAT/mcl-1, a bcl-2 related gene, is involved in the genetic pathway of apoptosis; this suggests a role for apoptosis and the involvement of this gene in early pl...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.1999.0458

    authors: Suzuki A,Umezawa A,Sano M,Nozawa S,Hata J

    更新日期:2000-03-01 00:00:00

  • Placental localization of 15-hydroxy-prostaglandin dehydrogenase in early and term human pregnancy.

    abstract::The human placenta possesses a large capacity for inactivation of prostanoids. This is due to the presence of large quantities of the NAD(+)-linked 15-hydroxy-prostaglandin dehydrogenase (PGDH type I; EC 1.1.1.141). In order to investigate whether a specific localization of PGDH is at the origin of the increasing plac...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(92)90037-t

    authors: Erwich JJ,Keirse MJ

    更新日期:1992-05-01 00:00:00

  • Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.

    abstract:INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2015.01.004

    authors: Li C,Raikwar NS,Santillan MK,Santillan DA,Thomas CP

    更新日期:2015-04-01 00:00:00

  • Localization of the placental BCRP/ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity.

    abstract:INTRODUCTION:The breast cancer resistance protein (BCRP/ABCG2) is an efflux transporter in the placental barrier. By transporting chemicals from the fetal to the maternal circulation, BCRP limits fetal exposure to a range of drugs, toxicants, and endobiotics such as bile acids and hormones. The purpose of the present s...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2017.04.006

    authors: Szilagyi JT,Vetrano AM,Laskin JD,Aleksunes LM

    更新日期:2017-07-01 00:00:00

  • Identification and estimation of cell types in mixed primary cell cultures of early and term human placenta.

    abstract::Placental villi of early and term human placentae were dissociated with trypsin and mixed cell cultures were established. The different cell types were identified and estimated over a 14-day culture period using antibodies to keratin and vimentin filaments and their capacity to phagocytose yeast. The three main cell t...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(84)80047-8

    authors: Contractor SF,Routledge A,Sooranna SR

    更新日期:1984-01-01 00:00:00

  • Uterine artery Doppler flow and uteroplacental vascular pathology in normal pregnancies and pregnancies complicated by pre-eclampsia and small for gestational age fetuses.

    abstract::This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1053/plac.2001.0676

    authors: Aardema MW,Oosterhof H,Timmer A,van Rooy I,Aarnoudse JG

    更新日期:2001-05-01 00:00:00

  • Low oxygen tension induces Krüppel-Like Factor 6 expression in trophoblast cells.

    abstract::The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the invo...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2016.07.006

    authors: Racca AC,Ridano ME,Bandeira CL,Bevilacqua E,Avvad Portari E,Genti-Raimondi S,Graham CH,Panzetta-Dutari GM

    更新日期:2016-09-01 00:00:00

  • IFPA meeting 2008 workshops report.

    abstract::Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...

    journal_title:Placenta

    pub_type:

    doi:10.1016/j.placenta.2008.11.014

    authors: Lash GE,Ansari T,Bischof P,Burton GJ,Chamley L,Crocker I,Dantzer V,Desoye G,Drewlo S,Fazleabas A,Jansson T,Keating S,Kliman HJ,Lang I,Mayhew T,Meiri H,Miller RK,Nelson DM,Pfarrer C,Roberts C,Sammar M,Sharma S,

    更新日期:2009-03-01 00:00:00

  • Novel isolation strategy to deliver pure fetal-origin and maternal-origin mesenchymal stem cell (MSC) populations from human term placenta.

    abstract::The placenta is an abundant source of mesenchymal stem/stromal cells (MSC). Although presumed of translationally-advantageous fetal origin, the literature instead suggests a high incidence of either contaminating or pure maternal MSC. Despite definitional criteria that MSC are CD34-, increasing evidence suggests that ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2014.09.001

    authors: Patel J,Shafiee A,Wang W,Fisk NM,Khosrotehrani K

    更新日期:2014-11-01 00:00:00

  • Primate maternal placental angiography.

    abstract:BACKGROUND:In humans, it is known that blood flow is directed to the gravid uterus from two (right and left) pelvic uterine arteries. The extent of supply from the tubo-ovarian anastomosis (joining of the ovarian and uterine arteries) is unknown. The aim of this study was to delineate the arterial blood supply to the p...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/j.placenta.2009.10.009

    authors: Balasuriya H,Bell P,Waugh R,Thompson J,Gillin A,Hennessy A,Makris A

    更新日期:2010-01-01 00:00:00

  • Determinants of species- and placenta-specific expression of p100 GAP.

    abstract::This study was based on the hypothesis that both primary sequence and methylation status of the GTPase activating protein (GAP) gene limits expression of p100 GAP to primate placenta. Due to alternate splicing, a 65-bp insert appears between the first and second coding exons of p100 GAP mRNA, and translation of p100 G...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(98)90012-1

    authors: Liao L,Trouba KJ,Vorce RL

    更新日期:1998-03-01 00:00:00

  • Localization of three subtypes of Fc gamma receptors in human placenta by immunohistochemical analysis.

    abstract::We investigated the localization of the three subtypes of (Fc gamma R) in the normal human placenta using immunohistochemical and immunocytochemical techniques with specific monoclonal antibodies. The analysis revealed that Fc gamma RI was expressed on Hofbauer cells, that Fc gamma RII was expressed on Hofbauer cells ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/0143-4004(91)90506-b

    authors: Kameda T,Koyama M,Matsuzaki N,Taniguchi T,Saji F,Tanizawa O

    更新日期:1991-01-01 00:00:00

  • The placenta in leprosy.

    abstract::Eighty-one placentae from women with leprosy and 17 placentae from healthy controls were subjected to a detailed macroscopic, light microscopic, ultrastructural, immunopathological, microbiological and biochemical study. The placental morphology and immunohistology were normal, and there was no morphological evidence ...

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(84)80028-4

    authors: Duncan ME,Fox H,Harkness RA,Rees RJ

    更新日期:1984-05-01 00:00:00

  • Placental polyploidization: a comparative study in the mouse and the guinea pig.

    abstract::The trophoblastic and endodermal tissues of the guinea pig were cytophotometrically examined at two stages of development, either shortly after the primary trophoblastic giant cell layer had degenerated (Sansom and Hill, 1931) and the visceral yolk sac was starting to form (Kaufman and Davidoff, 1977) (c. 10.5 days p....

    journal_title:Placenta

    pub_type: 杂志文章

    doi:10.1016/s0143-4004(81)80029-x

    authors: Ilgren EB

    更新日期:1981-10-01 00:00:00