当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy.

Expression of hypoxia-regulated genes and glycometabolic genes in placenta from patients with intrahepatic cholestasis of pregnancy.

Abstract：

INTRODUCTION:Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder unique to pregnancy that is associated with increased rates of fetal distress and demise. While acute hypoxia is believed to cause the pathophysiology of ICP, direct molecular evidence for this is lacking. Here, we analyzed expression of three hypoxia-regulated genes and several of their downstream target genes involved in glucose metabolism in placenta. METHODS:Placental tissue was collected from 20 women with normal pregnancies and 20 women with ICP. RNA and protein levels of hypoxia inducible transcription factors -1α (HIF-1α), development and DNA protein damage response 1 (REDD1), mammalian target of rapamycin (mTOR), glucose transporter type 1 (GLUT1), phosphoglycerate kinase1 (PGK1) and lacticdehydrogenase (LDHA) in placental tissue were measured by reverse transcriptase real time PCR and Western Blot. Proteins were also located by immunohistochemistry. RESULTS:Transcript levels were similar for all genes between the two types of placental tissue. In contrast, all protein levels except that of mTOR were significantly higher in placentas from ICP patients than the controls (P < 0.05). All proteins localized to the cytotrophoblast and syncytiotrophoblast. DISCUSSION:The placenta from ICP patients is more vulnerable to acute hypoxia and ischemia reperfusion injury. In response to hypoxia stress and oxidative damage in ICP, the placenta activates HIF-1α and REDD1, which in turn may up-regulates glucose transport and anaerobic glycolysis. CONCLUSIONS:HIF-1α, REDD1 and mTOR may play a significant role in the reaction to hypoxia and oxidative stress and regulate glucose metabolism in the placenta of ICP patients.

journal_name

Placenta

journal_title

Placenta

authors

Wei W,Hu YY

doi

10.1016/j.placenta.2014.06.372

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

732-6

issue

9

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(14)00598-0

journal_volume

35

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • SNAT expression in rat placenta.

    abstract：:Amino acid transport System A (SysA) activity is present within the rodent and human placentas. Inhibition of this transport system is associated with fetal growth retardation. Several cDNAs encoding SysA transport proteins have been discovered, and their presence documented within the human placenta. We have demonstr...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.05.002

    authors： Novak D,Lehman M,Bernstein H,Beveridge M,Cramer S

    更新日期：2006-04-01 00:00:00

  • Treatment with low-dose aspirin increased the level LIF and integrin β3 expression in mice during the implantation window.

    abstract：:Embryo implantation is the group of processes by which the developing blastocyst adheres to, and embeds into, the receptive endometrium. Changes in the expression of molecules on the cell surface have been seen in the conversion of the endometrial surface from a non-receptive to a receptive state. Cell adhesion molecu...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2010.10.002

    authors： Zhao M,Chang C,Liu Z,Chen LM,Chen Q

    更新日期：2010-12-01 00:00:00

  • Animal models of fetal growth restriction: Considerations for translational medicine.

    abstract：:Fetal growth restriction (FGR) is the failure of a fetus to reach its full genetic growth potential. It occurs in up to 8% of pregnancies, and after premature birth is the second leading cause of infant mortality and morbidity. There is no treatment currently available for FGR. Its primary cause, when not attributable...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.03.003

    authors： Swanson AM,David AL

    更新日期：2015-06-01 00:00:00

  • In vitro fertilization is associated with the onset and progression of preeclampsia.

    abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2019.09.011

    authors： Gui J,Ling Z,Hou X,Fan Y,Xie K,Shen R

    更新日期：2020-01-01 00:00:00

  • Expression of extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinase in the invasive trophoblasts at the human placental bed.

    abstract：BACKGROUND:Mitogen-activated protein kinases (MAP kinases) participate in signal transduction pathways that control embryogenesis, cell differentiation, cell proliferation and cell death. The roles of extracellular signal-regulated kinase1/2 (ERK1/2) and p38 MAP kinase in the differentiation and invasion of human troph...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.02.001

    authors： Moon KC,Park JS,Norwitz ER,Kim DI,Oh KJ,Park CW,Jun JK,Syn HC

    更新日期：2008-05-01 00:00:00

  • Bovine placental steroid sulphatase: molecular cloning and expression pattern in placentomes during gestation and at parturition.

    abstract：:Apart from during the prepartal period, the main oestrogen produced by the bovine trophoblast is oestrone sulphate (E1S) which does not bind to nuclear oestrogen receptors (ER). High steroid sulphatase (StS) activities previously detected in the maternal part of bovine placentomes (caruncles) suggest the local activat...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2007.01.008

    authors： Greven H,Kowalewski MP,Hoffmann B,Geyer J,Rex-Haffner M,Ugele B,Schuler G

    更新日期：2007-08-01 00:00:00

  • The increased endotoxin-sensitivity of pregnant rats, as reflected by glomerular ecto-ADP-ase activity, is not dependent on the presence of decidual cells.

    abstract：:In the present study the possible role of decidual cells in the pregnancy-associated increased sensitivity of glomerular ecto-ADP-ase to endotoxin was investigated. Early (day 5) pregnant (E-Pr; n = 10), pseudopregnant (E-PSP; n = 10), (day 5), pseudopregnant rats with a decidualized uterus (E-DEC; n - 10), as well as...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(96)80013-0

    authors： Faas MM,Schuiling GA,Baller JF,Valkhof N,Bakker WW

    更新日期：1996-03-01 00:00:00

  • Three-dimensional arrangement of the capillary bed and its relationship to microrheology in the terminal villi of normal term placenta.

    abstract：:Spatial arrangement of the capillary bed, manifestations of its growth and symmetry of capillary branching were studied in peripheral villi of normal human placenta at term using confocal microscopy and image analysis. Unlike the model that has been accepted so far, it was shown that the arrangement of the capillary b...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2008.07.004

    authors： Jirkovská M,Janácek J,Kaláb J,Kubínová L

    更新日期：2008-10-01 00:00:00

  • Modulation of the biochemical composition of amniotic and allantoic fluids as a control mechanism of feline foetal development.

    abstract：:Amniotic fluid exerts a protective function and is an essential component for foetal development and maturation during pregnancy. However, little is known about the exact physiological functions of foetal fluids in this process as well as their biochemical composition in cats. In the present study, the biochemical com...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.03.002

    authors： Fresno L,Rodriguez-Gil JE,Rigau T,Pastor J,Rivera del Alamo MM

    更新日期：2012-06-01 00:00:00

  • The effects of angiogenic growth factors on extravillous trophoblast invasion and motility.

    abstract：:There is accumulating evidence that deficient trophoblast invasion of the placental bed spiral arteries is crucial to the pathogenesis of pre-eclampsia and intrauterine growth restriction. However, the factors which regulate the process of trophoblast invasion remain unclear. We have investigated whether extravillous ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1999.0427

    authors： Lash GE,Cartwright JE,Whitley GS,Trew AJ,Baker PN

    更新日期：1999-11-01 00:00:00

  • Periconceptional alcohol consumption causes fetal growth restriction and increases glycogen accumulation in the late gestation rat placenta.

    abstract：INTRODUCTION:Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. MET...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.10.008

    authors： Gårdebjer EM,Cuffe JS,Pantaleon M,Wlodek ME,Moritz KM

    更新日期：2014-01-01 00:00:00

  • Human placenta: a direct target for cocaine action.

    abstract：:Use of cocaine during pregnancy is known to have harmful effects on the mother and her fetus. Currently available models describing the pathogenesis of these effects focus on the involvement of cocaine target systems, primarily the noradrenaline transporter, in the mother and the fetus. The placenta which lies between...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(05)80181-x

    authors： Ganapathy V,Leibach FH

    更新日期：1994-12-01 00:00:00

  • Mechanisms of oxygen sensing in human trophoblast cells.

    abstract：:During pregnancy, changes in oxygen tension are essential for proper embryonic and placental development. Little is known about the mechanisms underlying mammalian cellular adaptations to changes in oxygen tension. Currently, we have explored putative mechanisms by which human trophoblast cells may sense oxygen. In or...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0809

    authors： De Marco CS,Caniggia I

    更新日期：2002-04-01 00:00:00

  • Amniotic epithelium in rhesus incompatibility: light and electron microscopic examination.

    abstract：:Human amniotic epithelium from patients with normal pregnancy (normal amniotic epithelium) and from patients with materno-fetal rhesus incompatibility has been examined under the light and electron microscope. In comparison with normal amniotic epithelium, the epithelium in rhesus incompatibility displays the followin...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(81)80038-0

    authors： Wang T

    更新日期：1981-01-01 00:00:00

  • The frequency and clinical significance of intra-uterine infection and inflammation in patients with placenta previa and preterm labor and intact membranes.

    abstract：OBJECTIVE:Histologic placental and/or intra-amniotic inflammation is frequently documented during ascending intra-uterine infections in patients with preterm labor and intact membranes. Placenta previa can be a clinical situation that shows the successive schema of histologic placental and intra-amniotic inflammation d...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.04.005

    authors： Park CW,Moon KC,Park JS,Jun JK,Yoon BH

    更新日期：2009-07-01 00:00:00

  • Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells.

    abstract：BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.07.001

    authors： Nakada E,Walley KR,Nakada T,Hu Y,von Dadelszen P,Boyd JH

    更新日期：2009-09-01 00:00:00

  • Xanthine oxidase/dehydrogenase is present in human placenta.

    abstract：:Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA p...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(96)90061-2

    authors： Many A,Westerhausen-Larson A,Kanbour-Shakir A,Roberts JM

    更新日期：1996-07-01 00:00:00

  • Corticotrophin-releasing factor and urocortin inhibit system A activity in term human placental villous explants.

    abstract：:Plasma corticotrophin-releasing factor (CRF) and urocortin are elevated in preterm labour and/or fetal growth restriction (FGR). FGR is associated with reduced placental system A amino acid transporter activity and in vitro data suggest altered endocrine status could be responsible. Here we test the hypothesis that CR...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2010.10.015

    authors： Giovannelli A,Greenwood SL,Desforges M,Sibley CP,Petraglia F

    更新日期：2011-01-01 00:00:00

  • Syncytiotrophoblast extracellular vesicles - Circulating biopsies reflecting placental health.

    abstract：:The ability to directly monitor the status of the placenta throughout pregnancy would be a major advance in both general and personalized obstetric care, allowing treatments to be tailored to the dynamic changes that can occur in gestation. Syncytiotrophoblast extracellular vesicles (STBEV) are membrane bound vesicles...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2016.11.008

    authors： Tannetta D,Collett G,Vatish M,Redman C,Sargent I

    更新日期：2017-04-01 00:00:00

  • Endocannabinoid system in first trimester placenta: low FAAH and high CB1 expression characterize spontaneous miscarriage.

    abstract：:Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were the first endocannabinoids to be characterized, that bind two G protein-coupled receptors, CB1 and CB2. AEA synthesized by multiple pathways, including NAPE-specific phospholipase D (NAPE-PLD) and degraded by the fatty acid amide hydrolase (FAAH). AEA levels are ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.03.015

    authors： Trabucco E,Acone G,Marenna A,Pierantoni R,Cacciola G,Chioccarelli T,Mackie K,Fasano S,Colacurci N,Meccariello R,Cobellis G,Cobellis L

    更新日期：2009-06-01 00:00:00

  • Aberrations of early trophoblast differentiation predispose to pregnancy failure: lessons from the anti-phospholipid syndrome.

    abstract：OBJECTIVES:The epithelium of the human placenta comprises an inner cytotrophoblast (CT) which proliferates and fuses with the outer differentiated syncytiotrophoblast (ST). Turnover has been studied focussing on second and third trimester placentas but with a paucity of data describing the normal first trimester tropho...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.09.007

    authors： Bose P,Kadyrov M,Goldin R,Hahn S,Backos M,Regan L,Huppertz B

    更新日期：2006-08-01 00:00:00

  • Placental function and structure at term is altered in broodmares fed with cereals from mid-gestation.

    abstract：INTRODUCTION:Feeding pregnant broodmares with cereal concentrates has been shown to increase maternal insulin resistance and affect foal metabolism in the short and long-term. These effects are likely to be mediated by the placenta. Here, we investigated feto-placental biometry and placental structure and function at t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2018.02.003

    authors： Robles M,Peugnet P,Dubois C,Piumi F,Jouneau L,Bouchez O,Aubrière MC,Dahirel M,Aioun J,Wimel L,Couturier-Tarrade A,Chavatte-Palmer P

    更新日期：2018-04-01 00:00:00

  • The expression of connective tissue growth factor in pregnancies complicated by severe preeclampsia or fetal growth restriction.

    abstract：:We tested the hypothesis that the expression of placental connective tissue growth factor (CTGF) is enhanced in pregnancies complicated by severe preeclampsia (PE) or fetal growth restriction (FGR). CTGF expression was analyzed using immunostaining, western blot and real-time quantitative PCR in placental samples obta...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.08.006

    authors： Oh SY,Song SE,Seo ES,Kim KH,Choi SJ,Suh YL,Sadovsky Y,Roh CR

    更新日期：2009-11-01 00:00:00

  • Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

    abstract：:The establishment of an appropriate fetomaternal vessel system is a prerequisite for prevention of pregnancy associated pathologies. Notch receptors and ligands are manifoldly involved in vascular development and angiogenesis. To further characterize the process of human placental vasculo- and angiogenesis we investig...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.04.018

    authors： Herr F,Schreiner I,Baal N,Pfarrer C,Zygmunt M

    更新日期：2011-08-01 00:00:00

  • Human predecidual stromal cells have distinctive characteristics of pericytes: Cell contractility, chemotactic activity, and expression of pericyte markers and angiogenic factors.

    abstract：INTRODUCTION:Human decidual stromal cells (DSCs) play a key role in maternal-fetal interactions. Precursors of DSCs (preDSCs) localize around vessels in both the endometrium and decidua. Previous studies suggested a relationship between preDSCs and pericytes because these cells share a perivascular location, alpha smoo...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.11.010

    authors： Muñoz-Fernández R,de la Mata C,Prados A,Perea A,Ruiz-Magaña MJ,Llorca T,Fernández-Rubio P,Blanco O,Abadía-Molina AC,Olivares EG

    更新日期：2018-01-01 00:00:00

  • Umbilical cord as an analytical matrix - A technical note.

    abstract：:The umbilical cord (UC) connects the fetal blood supply to the placenta, so is exposed to all systemic endo- and xenobiotics. We have extensive experience using UC as an analytical matrix for detecting and/or quantitating drugs, chemicals and endogenous compounds. This technical note describes advantages (large amount...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2019.12.001

    authors： Price HR,Chehroudi C,Knight SJ,Smith AD,Lai D,Kim H,Wright TE,Coughtrie MW,Collier AC

    更新日期：2020-01-15 00:00:00

  • Characterization of human placental activity for transport of L-alanine, using brush border (microvillous) membrane vesicles.

    abstract：:To characterize the placental activity for the transport of amino acids, the uptake of L-alanine was investigated by rapid membrane filtration using brush border membrane vesicles separated from the human placenta of early pregnant (12-13 gestational weeks) and late pregnant (37-38 gestational weeks) women. The uptake...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(92)90032-o

    authors： Iioka H,Hisanaga H,Moriyama IS,Akada S,Shimamoto T,Yamada Y,Ichijo M

    更新日期：1992-03-01 00:00:00

  • Downregulation of HLA class I gene transcription in choriocarcinoma cells is controlled by the proximal promoter element and can be reversed by CIITA.

    abstract：:The expression pattern of MHC class I genes in trophoblast cells at the feto-maternal interface is thought to be the basis of the maintenance of pregnancy by protecting the fetus from maternal immune rejection. Transcription of classical HLA class I genes is low or undetectable in most trophoblast cells as well as in ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1998.0380

    authors： Lefebvre S,Moreau P,Dausset J,Carosella ED,Paul P

    更新日期：1999-05-01 00:00:00

  • Long telomeres in the mature human placenta.

    abstract：OBJECTIVE:To investigate whether telomere shortening may play a role in senescence of the placenta. STUDY DESIGN:Villous tissue was collected from single, random sites of full-term placentas (39-41 weeks of gestation; n=10) as well as multiple, specific sites of the same placenta (39-41 weeks of gestation; n=5). For t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2006.04.003

    authors： Allsopp R,Shimoda J,Easa D,Ward K

    更新日期：2007-04-01 00:00:00

  • Stromal differentiation and architecture of the human umbilical cord.

    abstract：:In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal ce...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(97)90071-0

    authors： Nanaev AK,Kohnen G,Milovanov AP,Domogatsky SP,Kaufmann P

    更新日期：1997-01-01 00:00:00