当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

Abstract：

:The establishment of an appropriate fetomaternal vessel system is a prerequisite for prevention of pregnancy associated pathologies. Notch receptors and ligands are manifoldly involved in vascular development and angiogenesis. To further characterize the process of human placental vasculo- and angiogenesis we investigated the expression pattern of Notch receptors and their ligands during pregnancy. Real time RT-PCR, immunohistochemistry and flow cytometry analysis were performed in early (6-12) weeks of gestation (w.o.g.) and late placenta (37-41 w.o.g.). To specify the exact cellular localization immunofluorescent labelling of epithelial and endothelial cells (EC), respectively, with cytokeratin-7 and vonWillebrand factor (vWF) was done. One placenta from a patient with Alagille syndrome (AGS) was examined with real time RT-PCR and immunohistochemistry. The receptors Notch2, -3, -4 and their ligands Jagged1, -2 and Delta1, -4 were detected at both the mRNA and protein level in early and late placenta. Notch1 was only detected at protein level. The expression was found mainly in the stromal compartment: placental EC expressed Notch1, Delta4, Jagged1 and Delta1. A strong Jagged1 expression was found in the endothelium of arteries and veins supporting a role in differentiation of capillaries. Hofbauer cells (HC) primarily displayed the receptors Notch2, -3 and -4. Placental stromal cells (SC) were positive for Jagged2. The syncytiotrophoblast (ST) and cytotrophoblast (CT) cells revealed a weak but detectable co-localization with cytokeratin-7 and Notch1, -3 and Delta1. These results were verified by flow cytometry of freshly isolated placental cells of placental tissue. Interestingly Jagged1 expression was absent in endothelial cells from an AGS placenta. The Notch receptors and their ligands are expressed in human placental ST, CT, EC, SC and HC. The distribution pattern of Notch receptors and their ligands suggests their involvement in the process of placental vasculo- and angiogenesis via cell-cell communication between trophoblast, -stroma and endothelial cells.

journal_name

Placenta

journal_title

Placenta

authors

Herr F,Schreiner I,Baal N,Pfarrer C,Zygmunt M

doi

10.1016/j.placenta.2011.04.018

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

554-63

issue

8

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(11)00172-X

journal_volume

32

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • IFPA meeting 2008 workshops report.

    abstract：:Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...

    journal_title：Placenta

    pub_type：

    doi：10.1016/j.placenta.2008.11.014

    authors： Lash GE,Ansari T,Bischof P,Burton GJ,Chamley L,Crocker I,Dantzer V,Desoye G,Drewlo S,Fazleabas A,Jansson T,Keating S,Kliman HJ,Lang I,Mayhew T,Meiri H,Miller RK,Nelson DM,Pfarrer C,Roberts C,Sammar M,Sharma S,

    更新日期：2009-03-01 00:00:00

  • Bovine placental steroid sulphatase: molecular cloning and expression pattern in placentomes during gestation and at parturition.

    abstract：:Apart from during the prepartal period, the main oestrogen produced by the bovine trophoblast is oestrone sulphate (E1S) which does not bind to nuclear oestrogen receptors (ER). High steroid sulphatase (StS) activities previously detected in the maternal part of bovine placentomes (caruncles) suggest the local activat...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2007.01.008

    authors： Greven H,Kowalewski MP,Hoffmann B,Geyer J,Rex-Haffner M,Ugele B,Schuler G

    更新日期：2007-08-01 00:00:00

  • The Role of E-cadherin in the Motility and Invasion of Implantation Site Intermediate Trophoblast.

    abstract：:During early pregnancy, intermediate (extravillous) trophoblast infiltrates the basal plate and invades the spiral arteries, a physiological process required to establish the maternal-fetal circulation. Immunostaining studies have shown that differentiation of trophoblast into this invasive subpopulation is associated...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(02)90864-7

    authors： Shih IeM,Hsu MY,Oldt RJ 3rd,Herlyn M,Gearhart JD,Kurman RJ

    更新日期：2002-11-01 00:00:00

  • Differential placental methylation in preeclampsia, preterm and term pregnancies.

    abstract：INTRODUCTION:Preeclampsia (PE) is one of the leading causes of maternal mortality and morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has been a focus of research. This study was to identified genes or pathways that may be associated with PE, and discuss whether the changes in the me...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2020.02.009

    authors： Li Y,Cui S,Shi W,Yang B,Yuan Y,Yan S,Li Y,Xu Y,Zhang Z,Linlin Zhang

    更新日期：2020-04-01 00:00:00

  • TMED2/p24β1 is expressed in all gestational stages of human placentas and in choriocarcinoma cell lines.

    abstract：:Members of the transmembrane emp24 domain (Tmed)/p24 family of proteins are required for transport of proteins between the endoplasmic reticulum and the Golgi. One member of this family, Tmed2/p24β1, is expressed during placental development in mice and its expression is required for normal development of the labyrint...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.12.009

    authors： Zakariyah A,Hou W,Slim R,Jerome-Majewska L

    更新日期：2012-03-01 00:00:00

  • ATP dependent Ca2+ transport across basal membrane of human syncytiotrophoblast in pregnancies complicated by intrauterine growth restriction or diabetes.

    abstract：:Neonates born after pregnancies complicated by diabetes or intrauterine growth restriction (IUGR) have increased incidence of hypocalcaemia. Furthermore, IUGR is associated with reduced bone mineralization in infancy and osteoporosis in adult life. We tested the hypothesis that placental calcium transport is altered i...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0941

    authors： Strid H,Bucht E,Jansson T,Wennergren M,Powell TL

    更新日期：2003-05-01 00:00:00

  • Aberrations of early trophoblast differentiation predispose to pregnancy failure: lessons from the anti-phospholipid syndrome.

    abstract：OBJECTIVES:The epithelium of the human placenta comprises an inner cytotrophoblast (CT) which proliferates and fuses with the outer differentiated syncytiotrophoblast (ST). Turnover has been studied focussing on second and third trimester placentas but with a paucity of data describing the normal first trimester tropho...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.09.007

    authors： Bose P,Kadyrov M,Goldin R,Hahn S,Backos M,Regan L,Huppertz B

    更新日期：2006-08-01 00:00:00

  • A function of the allantoic sac in the metabolism of uteroferrin and maternal iron by the fetal pig.

    abstract：:The possible roles of the allantoic sac in metabolism of uteroferrin, the iron-containing, purple phosphatase, were examined. This protein, which originates in the maternal endometrium, was measured in allantoic fluid by a specific double-antibody radioimmunoassay and by its beta-mercaptoethanol-activated acid phospha...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：

    authors： Buhi WC,Ducsay CA,Bartol FF,Bazer FW,Roberts RM

    更新日期：1983-01-01 00:00:00

  • 2005 Trophoblast Research Award Lecture: Defects in the keratin cytoskeleton disrupt normal murine placental development and trophoblast cell function.

    abstract：:The keratin cytoskeleton is present in all trophoblast cell subtypes of the mouse and human placenta and is required to maintain the structural integrity of these cells. Recently, various genetic mouse models have shown that a normal keratin network is necessary for placental development. Keratin-deficiency leads to t...

    journal_title：Placenta

    pub_type：

    doi：10.1016/j.placenta.2007.01.006

    authors： Watson ED

    更新日期：2007-04-01 00:00:00

  • Variation of DNA methylation in candidate age-related targets on the mitochondrial-telomere axis in cord blood and placenta.

    abstract：BACKGROUND:Epigenetics is tissue-specific and potentially even cell-specific, but little information is available from human reproductive studies about the concordance of DNA methylation patterns in cord blood and placenta, as well as within-placenta variations. We evaluated methylation levels at promoter regions of ca...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.06.371

    authors： Janssen BG,Byun HM,Cox B,Gyselaers W,Izzi B,Baccarelli AA,Nawrot TS

    更新日期：2014-09-01 00:00:00

  • A novel hysteroscopic technique for the accurate biopsy of decidua parietalis and basalis.

    abstract：BACKGROUND:Discrepancies in the results from studies of early events in human trophoblast invasion of decidua have been acknowledged and are attributed largely to deficiencies in the accuracy of sampling of the decidual tissue used in the research. We describe a novel technique of biopsy of decidua parietalis and basal...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.02.018

    authors： Talaulikar VS,Bax BE,Page NM,Manyonda I

    更新日期：2012-06-01 00:00:00

  • Localization of transient immature hematopoietic cells to two distinct, potential niches in the developing mouse placenta.

    abstract：:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.08.081

    authors： Azevedo Portilho N,Tavares Guedes P,Croy BA,Pelajo-Machado M

    更新日期：2016-11-01 00:00:00

  • Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: A retrospective cohort study of 21 cases.

    abstract：BACKGROUND:Alloimmunization against human platelet antigens (HPAs) can occur prenatally and induce fetal/neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to identify placental histological features associated with platelet alloimmunization and their clinical significance. METHODS:This study exam...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.10.009

    authors： Dubruc E,Lebreton F,Giannoli C,Rabilloud M,Huissoud C,Devouassoux-Shisheboran M,Allias F

    更新日期：2016-12-01 00:00:00

  • Mononuclear phagocytes in the human placenta.

    abstract：:Hofbauer cells have been identified by morphological criteria in human placentae and are considered to be mononuclear phagocytes. An increasing recognition of the morphological heterogeneity of mononuclear phagocytes and of the considerable difficulty in their recognition in histological sections has suggested that th...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(80)80019-1

    authors： Wood GW

    更新日期：1980-04-01 00:00:00

  • Gene targeting in primary human trophoblasts.

    abstract：:Studies in primary human trophoblasts provide critical insights into placental function in normal and complicated pregnancies. Mechanistic studies in these cells require experimental tools to modulate gene expression. Lipid-based methods to transfect primary trophoblasts are fairly simple to use and allow for the effi...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2012.07.003

    authors： Rosario FJ,Sadovsky Y,Jansson T

    更新日期：2012-10-01 00:00:00

  • Polyploidization in the trophoblast and uterine glandular epithelium of the endotheliochorial placenta of silver fox (Vulpes fulvus Desm.), as revealed by the DNA content.

    abstract：:Dynamics of genome multiplication during establishment of interrelations between trophoblast and glandular epithelium of the endometrium has been studied in the course of formation of placenta in the silver fox. During formation of the placenta, penetration of the trophoblast into the zone of the endometrial glandular...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2001.0675

    authors： Zybina TG,Zybina EV,Kiknadze II,Zhelezova AI

    更新日期：2001-05-01 00:00:00

  • Nitric oxide synthase activity in placentae from women with pre-eclampsia.

    abstract：:The syncytiotrophoblast (ST) cell layer of the human villous placenta expresses nitric oxide (NO) synthase. Because NO is a potent relaxant of vascular smooth muscle and inhibitor of platelet activity, we postulated that exaggerated intervillous aggregation of platelets and reduced fetoplacental blood flow in pre-ecla...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(95)90013-6

    authors： Conrad KP,Davis AK

    更新日期：1995-12-01 00:00:00

  • Lack of activation of peripheral blood dendritic cells in human pregnancies complicated by intrauterine growth restriction.

    abstract：INTRODUCTION:The state of activation of dendritic cells (DCs) at the feto-maternal interface critically contributes to optimal decidual immune responses needed to support fetal-placental development. We recently demonstrated that during healthy pregnancy also peripheral blood DCs (PBDCs), which are easily accessible, a...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.10.016

    authors： Cappelletti M,Giannelli S,Martinelli A,Cetin I,Colombo E,Calcaterra F,Mavilio D,Della Bella S

    更新日期：2013-01-01 00:00:00

  • Leptin reduces apoptosis triggered by high temperature in human placental villous explants: The role of the p53 pathway.

    abstract：:Maternal fever is common during pregnancy and has for many years been suspected to harm the developing fetus. Whether increased maternal temperature produces exaggerated apoptosis in trophoblast cells remains unclear. Since p53 is a critical regulator of apoptosis we hypothesized that increased temperature in placenta...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.03.009

    authors： Pérez-Pérez A,Toro AR,Vilarino-Garcia T,Guadix P,Maymó JL,Dueñas JL,Varone CL,Sánchez-Margalet V

    更新日期：2016-06-01 00:00:00

  • Placental oxygen consumption. Part II: in vitro studies--a review.

    abstract：:The human placenta in vivo consumes large amounts of oxygen. After delivery the placenta is exposed to anoxia and under in vitro experimental conditions oxygen consumption is only a fraction of in vivo estimates. In spite of a reduced oxygen supply, structural and functional integrity of the tissue is surprisingly wel...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1053/plac.1999.0512

    authors： Schneider H

    更新日期：2000-03-01 00:00:00

  • Transplacental lactate dehydrogenase-elevating virus (LDV) transmission: immune inhibition of umbilical cord infection, and correlation of fetal virus susceptibility with development of F4/80 antigen expression.

    abstract：:Maternal-to-fetal transmission of the murine lactate dehydrogenase-elevating virus (LDV) has been previously shown to be regulated by maternal immunity as well as gestational age. For the present study, the role of maternal immunity in placental and umbilical cord virus protection was studied, and virus targeting of u...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.2002.0829

    authors： Zitterkopf NL,Haven TR,Huela M,Bradley DS,Cafruny WA

    更新日期：2002-05-01 00:00:00

  • Current topic: interferon and human placental development.

    abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(05)80220-6

    authors： Loke YW,King A

    更新日期：1990-07-01 00:00:00

  • Corticotrophin-releasing factor in human placenta: localization, concentration and release in vitro.

    abstract：:Corticotrophin-releasing factor (CRF) immunoreactivity was demonstrated by immunohistochemical staining in the cytotrophoblast of the early pregnancy placenta, in the decidua and in the amnion. This localization is different from that of adrenocorticotrophic hormone (ACTH) and beta-endorphin, which are present in the ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(88)90050-1

    authors： Saijonmaa O,Laatikainen T,Wahlström T

    更新日期：1988-07-01 00:00:00

  • Bi-potential behaviour of cytotrophoblasts in first trimester chorionic villi.

    abstract：:Murine trophoblast stem (TS) cells express fibroblast growth factor receptor 2 (FGFR2) and are maintained in their proliferative state by fibroblast growth factor 4 (FGF4). We show in this report that in the first trimester human placenta FGFR2 expression is similarly found in a subset of villous cytotrophoblast and i...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.03.006

    authors： Baczyk D,Dunk C,Huppertz B,Maxwell C,Reister F,Giannoulias D,Kingdom JC

    更新日期：2006-04-01 00:00:00

  • Infertility as a cancer risk factor - a review.

    abstract：:Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2008.08.007

    authors： Cetin I,Cozzi V,Antonazzo P

    更新日期：2008-10-01 00:00:00

  • Determinants of species- and placenta-specific expression of p100 GAP.

    abstract：:This study was based on the hypothesis that both primary sequence and methylation status of the GTPase activating protein (GAP) gene limits expression of p100 GAP to primate placenta. Due to alternate splicing, a 65-bp insert appears between the first and second coding exons of p100 GAP mRNA, and translation of p100 G...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(98)90012-1

    authors： Liao L,Trouba KJ,Vorce RL

    更新日期：1998-03-01 00:00:00

  • Permeability of the near-term rat placenta to hydrophilic solutes.

    abstract：:The permeability of the rat placenta at 21 days' gestation (term is 23 days) has been measured with fetuses intact in situ and by perfusion of the fetal circulation. Intact measurements were made by removal of fetuses at known time intervals after injection of radioisotopes to the anaesthetized mother and measurement ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(88)90049-5

    authors： Robinson NR,Atkinson DE,Jones CJ,Sibley CP

    更新日期：1988-07-01 00:00:00

  • Trophoblast debris extruded from preeclamptic placentae activates endothelial cells: a mechanism by which the placenta communicates with the maternal endothelium.

    abstract：INTRODUCTION:Preeclampsia is characterized by maternal endothelial dysfunction. While the mechanisms leading to preeclampsia are unclear, a factor(s) from the placenta is responsible for triggering the disease. One placental factor implicated in triggering preeclampsia is trophoblast debris which may transmit pathogeni...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.07.009

    authors： Shen F,Wei J,Snowise S,DeSousa J,Stone P,Viall C,Chen Q,Chamley L

    更新日期：2014-10-01 00:00:00

  • The human placenta is encircled by a ring of smooth muscle cells.

    abstract：:The marginal zone of the human term placenta was studied by transmission electron microscopy and immunohistochemistry using antibodies against cytoskeletal filaments, extracellular matrix molecules and endothelial markers. The marginal sinus of the intervillous space is separated from the chorionic and basal plates by...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1999.0455

    authors： Nanaev AK,Kosanke G,Kemp B,Frank HG,Huppertz B,Kaufmann P

    更新日期：2000-01-01 00:00:00

  • Exploring sexual dimorphism in placental circulation at 22-24 weeks of gestation: A cross-sectional observational study.

    abstract：INTRODUCTION:Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS:This was a prosp...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2016.11.005

    authors： Widnes C,Flo K,Acharya G

    更新日期：2017-01-01 00:00:00