Abstract：
:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and niche. Putative hematopoietic foci were present on 10.5 and 11.5 gd but not 9.5 or 12.5 gd and was restricted to the placental labyrinth. Two major niches each with distinctive hematopoietic cell clusters were present. One type of hematopoietic cell cluster involved the chorioallantoic vasculature and fetal vessels near the chorionic plate. These clusters resembled the hematopoietic stem cells produced by large embryonic arteries such as aorta that persist in postnatal marrow. The other type of hematopoietic cell cluster identified was at the opposite side of labyrinth next to the junctional zone and was composed of erythropoietic foci. Our results suggest that mouse placenta not only produces hematopoietic stem/progenitor cells but also a second wave of primitive erythrocytes that may support a rapid, mid-pregnancy, fetal growth trajectory. Our data also point to a close relationships in the origins of hematopoietic and endothelial cells within placenta.
journal_name
Placentajournal_title
Placentaauthors
Azevedo Portilho N,Tavares Guedes P,Croy BA,Pelajo-Machado Mdoi
10.1016/j.placenta.2016.08.081subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1-11eissn
0143-4004issn
1532-3102pii
S0143-4004(16)30487-8journal_volume
47pub_type
杂志文章相关文献
PLACENTA文献大全abstract：:As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are lik...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2018.01.002
更新日期：2018-09-01 00:00:00
abstract：:Pregnancy-associated plasma protein-A was assayed in the blood of 347 women during pregnancy, using a new primary standard of PAPP-A as reference. The protein was assayed by antibody-antigen crossed electrophoresis with the lower limit of confident assay being 9.5 micrograms PAPP-A/ml (13 pmol/ml). PAPP-A was first de...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(82)80020-9
更新日期：1982-01-01 00:00:00
abstract：:Maternal feed allowance during pregnancy can affect the development of the ovine placenta and fetus. The impact of variations in feed allowance prior to as well as throughout pregnancy has received less attention. Ewes were offered 0.6 (R), 1.2 (C) or 1.8 (AL) maintenance requirements from 89 days before conception un...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.02.014
更新日期：2008-06-01 00:00:00
abstract：:The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (F...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.04.003
更新日期：2016-06-01 00:00:00
abstract：INTRODUCTION:Non-invasive 3D imaging that enables clear visualization of placental margins is of interest in the accurate diagnosis of placental pathologies. This study investigated if contrast-enhanced MRI performed using a liposomal gadolinium blood-pool contrast agent (liposomal-Gd) enables clear visualization of th...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.06.008
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Pre-gravid obesity is associated with increased morbidity and mortality for both mother and offspring. Recent studies have demonstrated a heightened inflammatory response both systemically and locally within the adipose and placental tissue in women with pre-gravid obesity, which may play a role in mediating...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.12.023
更新日期：2011-03-01 00:00:00
abstract：:The placenta provides all energy and nutrient requirements for healthy fetal development. The placenta in rats is capable of storing glycogen, although the placenta cells must therefore mobilize stored glycogen to its own glucose supply. Moreover, maternal glucose and/or placental lactate furnished the fetal growth. A...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2003.11.005
更新日期：2004-05-01 00:00:00
abstract：:The fusion of villous cytotrophoblast into the placental syncytium is the quintessential process in maintenance of a healthy pregnancy. Efficient fusion requires a phosphatidylserine (PS)-rich cytotrophoblast surface, expression of fusion proteins, cessation of cell cycling, and rearrangement of cytoskeleton to accomm...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2009.12.014
更新日期：2010-02-01 00:00:00
abstract：INTRODUCTION:Maternal nutrition is an extremely important health issue. We evaluated the impact of maternal high fat diet (HFD) on pregnancy outcomes, elucidated how the rat placenta and fetus respond to diet manipulation based on fetal sex, and identified candidate genes and pathways. METHODS:Rats were fed a normal o...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.03.004
更新日期：2019-03-01 00:00:00
abstract：:In the present study, we characterized the expression of lymphocyte antigen 6, locus E (Ly6e) in mouse placental trophoblast. We identified Ly6e mRNA expression in trophoblast stem (TS) cells by a gene expression screen. In vivo, Ly6e was first detectable by mRNA in situ hybridization in the chorion beginning at E8.5 ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.05.011
更新日期：2013-09-01 00:00:00
abstract：:The walls of uterine spiral arteries are invaded by extravillous trophoblast cells and are thereby converted to the uteroplacental arteries of pregnancy. The mechanisms by which this invasion occurs are not understood, but the extracellular matrices that are breached suggest participation by specific proteinases. In t...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80454-0
更新日期：1994-02-01 00:00:00
abstract：:In the present study the possible role of decidual cells in the pregnancy-associated increased sensitivity of glomerular ecto-ADP-ase to endotoxin was investigated. Early (day 5) pregnant (E-Pr; n = 10), pseudopregnant (E-PSP; n = 10), (day 5), pseudopregnant rats with a decidualized uterus (E-DEC; n - 10), as well as...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(96)80013-0
更新日期：1996-03-01 00:00:00
abstract：:The visceral yolk sac (VYS) is responsible for a major part of the amino acid nutrition of the early post-implantation rat embryo and possibly also at the fetal stage of gestation. The mechanism involves endocytic uptake of proteins by the tissue's epithelial cells followed by intralysosomal digestion to amino acids. ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(77)90009-1
更新日期：1997-09-01 00:00:00
abstract：:Human placental villi from both normal and complicated pregnancies were examined by both light and scanning electron microscopy. The findings provide evidence that histological features such as syncytial sprouts, bridges, and a net-like arrangement of villi represent tangential sections of irregularly shaped villi rat...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(87)90047-6
更新日期：1987-05-01 00:00:00
abstract：:Dynamics of genome multiplication during establishment of interrelations between trophoblast and glandular epithelium of the endometrium has been studied in the course of formation of placenta in the silver fox. During formation of the placenta, penetration of the trophoblast into the zone of the endometrial glandular...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0675
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...
journal_title：Placenta
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.placenta.2018.05.010
更新日期：2018-07-01 00:00:00
abstract：:The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preecl...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2016.10.004
更新日期：2016-12-01 00:00:00
abstract：:Intrauterine growth and development can impact upon the long-term health of an individual. The fetus is dependent upon the placenta for its supply of nutrients and oxygen from the mother. In turn, the functional capacity of the placenta to supply that demand is under the control of the fetal and maternal genomes. Rece...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2005.12.008
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVES:Prior studies have demonstrated that donor twin survival following treatment of twin-twin transfusion syndrome (TTTS) was highly associated with donor intrauterine growth restriction (IUGR). Here, we hypothesized that donor IUGR may be attributed in part to low placental share. STUDY DESIGN:The study popula...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2011.05.009
更新日期：2011-08-01 00:00:00
abstract：:Maternal fever is common during pregnancy and has for many years been suspected to harm the developing fetus. Whether increased maternal temperature produces exaggerated apoptosis in trophoblast cells remains unclear. Since p53 is a critical regulator of apoptosis we hypothesized that increased temperature in placenta...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.03.009
更新日期：2016-06-01 00:00:00
abstract：:The transport of large amounts of Ca2+ by the plasma membranes of human placental syncytiotrophoblast is essential to the mineralization of the growing fetal skeleton. We have investigated transport by the basal (fetal-facing) plasma membrane (BPM). Ca2+ was taken up by purified BPM vesicles in a time-dependent manner...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80451-5
更新日期：1994-02-01 00:00:00
abstract：:Two groups of placentae from 18 cases of maternal rubella were examined morphologically and virologically. Placentae in Group I (four cases) had a mean gestational age of 21 +/- 1.9 weeks, whilst those in Group 2 (14 cases) had a mean gestational age of 38 +/- 2.8 weeks. A tendency to hypoplasia was observed. The micr...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(85)80038-2
更新日期：1985-07-01 00:00:00
abstract：INTRODUCTION:The pro-inflammatory mediator and potent vasoconstrictor Endothelin-1 (ET-1) is known to be expressed in the placenta. We have recently demonstrated that very low, non-toxic doses of carbon monoxide (CO), prevented infection-induced preterm birth in mice. However the effect(s) of CO on human gestational ti...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.03.015
更新日期：2014-06-01 00:00:00
abstract：:The aim of the present study was to evaluate the relationship between the retention of fetal membranes (RFM) and apoptosis of the cells in fetal membranes. The present study investigated mRNA and protein expressions of apoptosis-regulating factors: FAS, cellular FLICE-like inhibiting protein (cFLIP), BAX, BCL2, caspas...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.10.016
更新日期：2011-01-01 00:00:00
abstract：:Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.01.017
更新日期：2012-05-01 00:00:00
abstract：:This study examines the vasorelaxation of isolated human placental chorionic plate arteries and the perfused fetal-placental vasculature, in vitro, to a variety of nitrovasodilator compounds including glyceryl trinitrate (GTN) sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP), S-nitroso-N-glutathione ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0625
更新日期：2001-04-01 00:00:00
abstract：:Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological functi...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2010.02.010
更新日期：2010-05-01 00:00:00
abstract：:Although secretory phospholipase A2 (PLA2) isozymes have been identified in human gestational tissues, their role in homeostasis and pathophysiology during pregnancy has yet to be clearly established. The aims of this brief commentary are: (1) to review recent data concerning the expression of secretory PLA2 isozymes ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/s0143-4004(98)90093-5
更新日期：1998-01-01 00:00:00
abstract：INTRODUCTION:The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS:A tota...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.06.378
更新日期：2019-08-01 00:00:00
abstract：:Endotheliochorial placentas occur in orders from all four major clades of eutherian mammal. Species with this type of placenta include one of the smallest (pygmy shrew) and largest (African elephant) land mammals. The endotheliochorial placenta as a definitive form has an interhemal area consisting of maternal endothe...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2012.02.008
更新日期：2012-05-01 00:00:00
