Abstract：
:Pregnancy-associated plasma protein-A was assayed in the blood of 347 women during pregnancy, using a new primary standard of PAPP-A as reference. The protein was assayed by antibody-antigen crossed electrophoresis with the lower limit of confident assay being 9.5 micrograms PAPP-A/ml (13 pmol/ml). PAPP-A was first detected at 14 weeks of gestation; by term it had risen to within the range 20 to 320 micrograms/ml. There was an indication that pregnancies involving a male baby had higher PAPP-A levels in blood than did those involving female babies. In 51 blood samples from 30 patients with gestational diabetes (taken between 28 weeks of pregnancy and term) there was no significant alteration in PAPP-A values compared with controls. In 35 blood samples from 15 patients with insulin-dependent diabetes, levels of PAPP-A were significantly lower than in controls or in gestational diabetes. In 43 blood samples from 35 patients with babies affected with intrauterine growth retardation (between 28 weeks and term), there was no significant difference in PAPP-A levels compared with controls. The effect of insulin on the blood levels of PAPP-A suggests that the concentration of PAPP-A is capable of altering significantly in response to certain physiological changes associated with the control of carbohydrate metabolism.
journal_name
Placentajournal_title
Placentaauthors
Sutcliffe RG,Kukulska-Langlands BM,Horne CH,Maclean AB,Jandial V,Sutherland HW,Gibb S,Bowman AWdoi
10.1016/s0143-4004(82)80020-9subject
Has Abstractpub_date
1982-01-01 00:00:00pages
71-80issue
1eissn
0143-4004issn
1532-3102pii
S0143-4004(82)80020-9journal_volume
3pub_type
杂志文章相关文献
PLACENTA文献大全abstract：:The interaction of cocaine and its analog 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane (RTI-55) with the human placental serotonin transporter was investigated. The function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush bord...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(94)90018-3
更新日期：1994-04-01 00:00:00
abstract：:This study was conducted to investigate the association between uterine artery Doppler flow patterns and uteroplacental vascular pathology in normal and complicated pregnancies in view of the recently described concept of heterogeneous causes of hypertensive pregnancy complications. Forty-three women whose pregnancies...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0676
更新日期：2001-05-01 00:00:00
abstract：INTRODUCTION:Placental blood flow is closely associated with fetal growth and wellbeing. Recent studies suggest that there are differences in blood flow between male and female fetuses. We hypothesized that sexual dimorphism exists in fetal and placental blood flow at 22-24 weeks of gestation. METHODS:This was a prosp...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.11.005
更新日期：2017-01-01 00:00:00
abstract：:Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0774
更新日期：2002-02-01 00:00:00
abstract：INTRODUCTION:Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal s...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.02.004
更新日期：2017-03-01 00:00:00
abstract：:The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.1998.0366
更新日期：1999-03-01 00:00:00
abstract：:Bidirectional transplacental exchange characterizes human pregnancy. Cells exchanged between mother and fetus can durably persist as microchimerism and may have both short- and long-term consequences for the recipient. The amount, type, and persistence of microchimerism are influenced by obstetric characteristics, pre...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2017.08.071
更新日期：2017-12-01 00:00:00
abstract：:Gestational diabetes mellitus is a common medical complication in pregnancy. Recent findings demonstrate that glyburide is effluxed against a concentration gradient from the fetal to the maternal circulation. However, the transport systems involved in the active efflux of glyburide in the human placenta have not yet b...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.05.001
更新日期：2008-08-01 00:00:00
abstract：INTRODUCTION:Human decidual stromal cells (DSCs) play a key role in maternal-fetal interactions. Precursors of DSCs (preDSCs) localize around vessels in both the endometrium and decidua. Previous studies suggested a relationship between preDSCs and pericytes because these cells share a perivascular location, alpha smoo...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.11.010
更新日期：2018-01-01 00:00:00
abstract：:The keratin cytoskeleton is present in all trophoblast cell subtypes of the mouse and human placenta and is required to maintain the structural integrity of these cells. Recently, various genetic mouse models have shown that a normal keratin network is necessary for placental development. Keratin-deficiency leads to t...
journal_title：Placenta
pub_type：
doi：10.1016/j.placenta.2007.01.006
更新日期：2007-04-01 00:00:00
abstract：:We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2009.11.003
更新日期：2010-01-01 00:00:00
abstract：:An interaction between heparin and circulating pregnancy-associated plasma protein A (PAPP-A) has been observed. This interaction could be reversed by the addition of the specific heparin antagonist protamine sulphate. In the presence of heparin, crossed immunoelectrophoretic analysis revealed an alteration in the ele...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80013-7
更新日期：1983-01-01 00:00:00
abstract：BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...
journal_title：Placenta
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/j.placenta.2018.05.010
更新日期：2018-07-01 00:00:00
abstract：:The gestational age and litter size in the guinea pig can be accurately assessed by taking an x-ray of the animal. From a measurement of the fetal head length on the x-ray plate a fetal weight can be calculated using previously accumulated data, included here. The gestational age can be assessed from this weight to wi...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(82)80022-2
更新日期：1982-01-01 00:00:00
abstract：INTRODUCTION:Alterations of apoptosis are commonly associated with pregnancy complications and abortion. Modulation of apoptosis is a relevant feature of Toxoplasma gondii infection and it is related to parasite strain types. The aim of the present study was to evaluate the possible factors that are involved in the dif...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.09.005
更新日期：2013-11-01 00:00:00
abstract：:Forkhead box O (FoxO) proteins regulate inflammation, extracellular matrix (ECM) remodelling and apoptosis. We have previously identified FoxO1 proteins in human gestational tissues, and demonstrated a link between FoxO1 and rupture of fetal membranes. There is, however, no data available on the expression and localis...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2010.09.009
更新日期：2010-12-01 00:00:00
abstract：:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2004.09.008
更新日期：2005-11-01 00:00:00
abstract：:The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (F...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.04.003
更新日期：2016-06-01 00:00:00
abstract：:Human amniotic epithelium from patients with normal pregnancy (normal amniotic epithelium) and from patients with materno-fetal rhesus incompatibility has been examined under the light and electron microscope. In comparison with normal amniotic epithelium, the epithelium in rhesus incompatibility displays the followin...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(81)80038-0
更新日期：1981-01-01 00:00:00
abstract：UNLABELLED:Betamethasone (BET) is a widely used treatment for women who are at high risk of preterm delivery. In sheep, BET-induced growth restriction was found to be associated with reduced placenta lactogen (PL), a key regulator of fetal growth. We therefore hypothesized that also in humans a single course of BET adm...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.02.002
更新日期：2013-05-01 00:00:00
abstract：:Placental endoplasmic reticulum (ER) stress has been postulated in the pathophysiology of pre-eclampsia (PE) and intrauterine growth restriction (IUGR), but its activation remains elusive. Oxidative stress induced by ischaemia/hypoxia-reoxygenation activates ER stress in vitro. Here, we explored whether exposure to la...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.11.005
更新日期：2015-01-01 00:00:00
abstract：:Antigen expression by villous and extravillous human trophoblast populations at discrete anatomical sites has been reviewed. The various different antigenic phenotypes have been highlighted using a panel of monoclonal antibodies reactive with characteristic trophoblast membrane antigens, a trophoblast-leucocyte common...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/s0143-4004(85)80063-1
更新日期：1985-03-01 00:00:00
abstract：INTRODUCTION:We hypothesized that nifedipine and sildenafil would have no detrimental effects on placental hemodynamics and gas exchange under fetal hypoxemia. METHODS:In 33 chronically instrumented fetal sheep, placental volume blood flow (QPlac) and umbilical artery (UA) vascular impedance were measured by Doppler u...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.12.014
更新日期：2020-01-15 00:00:00
abstract：:The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2005.02.004
更新日期：2005-04-01 00:00:00
abstract：:Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/s0143-4004(05)80638-1
更新日期：1996-01-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are involved in placental remodelling throughout pregnancy. Diabetes mellitus induces alterations in tissue production of NO, a regulator of MMPs activity. The present work evaluates placental and fetal MMPs and NO levels during midpregnancy in neonatal streptozotocin-induced diabetic ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2004.06.011
更新日期：2005-04-01 00:00:00
abstract：:Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2018.05.002
更新日期：2018-06-01 00:00:00
abstract：:Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...
journal_title：Placenta
pub_type：
doi：10.1016/j.placenta.2008.11.014
更新日期：2009-03-01 00:00:00
abstract：INTRODUCTION:Type 1 diabetes (T1D) is associated with adverse pregnancy outcome, usually attributed to hyperglycemia. Recently, we showed that pregnancy outcome in normoglycemic T1D rats was characterized by decreased fetal and placental weight, suggesting impaired placental development. In the present study, we tested...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.12.004
更新日期：2015-02-01 00:00:00
abstract：:Direct measurements of electrical potential and input resistance were performed on the syncytial membrane facing maternal blood. The potentials varied according to the external potassium ion levels and, to a lesser extent, with sodium ion concentrations. Ouabain provoked a rapid and consistent depolarization which ind...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(88)90012-4
更新日期：1988-03-01 00:00:00
