Abstract:
:The keratin cytoskeleton is present in all trophoblast cell subtypes of the mouse and human placenta and is required to maintain the structural integrity of these cells. Recently, various genetic mouse models have shown that a normal keratin network is necessary for placental development. Keratin-deficiency leads to trophoblast giant cell fragility, breaking the barrier between the conceptus and the maternal blood circulation. Alternatively, keratin aggregation prevents chorioallantoic attachment, a key developmental milestone required for the formation of the labyrinth within the mouse placenta. These models give us insight into cytokeratin function in human trophoblast cell subtypes and suggest that defects in the keratin cytoskeleton may result in intrauterine growth restriction or miscarriage.
journal_name
Placentajournal_title
Placentaauthors
Watson EDdoi
10.1016/j.placenta.2007.01.006subject
Has Abstractpub_date
2007-04-01 00:00:00pages
S111-5eissn
0143-4004issn
1532-3102pii
S0143-4004(07)00009-4journal_volume
28 Suppl Apub_type
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