Polymorphonuclear leukocytes in the fetal membranes are activated in patients with preterm delivery: ultrastructural and enzyme-histochemical evidence.

abstract：INTRODUCTION:We investigated the feasibility of dynamic glucose enhanced (DGE) MRI in accessing placental function in a mouse model of intrauterine inflammatory injury (IUI). DGE uses the glucose chemical exchange saturation transfer (glucoCEST) effect to reflect infused d-glucose. METHODS:IUI was induced in pregnant ...

journal_title：Placenta

authors： Wu D,Xu J,Lei J,Mclane M,van Zijl PC,Burd I

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Preeclampsia is characterized by maternal endothelial dysfunction. While the mechanisms leading to preeclampsia are unclear, a factor(s) from the placenta is responsible for triggering the disease. One placental factor implicated in triggering preeclampsia is trophoblast debris which may transmit pathogeni...

journal_title：Placenta

authors： Shen F,Wei J,Snowise S,DeSousa J,Stone P,Viall C,Chen Q,Chamley L

更新日期：2014-10-01 00:00:00

abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

journal_title：Placenta

authors： Loke YW,King A

更新日期：1990-07-01 00:00:00

abstract：INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...

journal_title：Placenta

authors： Li C,Raikwar NS,Santillan MK,Santillan DA,Thomas CP

更新日期：2015-04-01 00:00:00

abstract：:The binding of oestradiol in human placental tissue obtained from spontaneous and caesarean deliveries was investigated. Villous tissue was homogenized and the 800 g 'cytosol' supernatant treated with ammonium sulphate. The precipitate was redissolved and the preparation then equilibrated with [3H]oestradiol. After se...

journal_title：Placenta

authors： Laminski NA,Hammond KD

更新日期：1985-09-01 00:00:00

abstract：:Bovine nuclear transfer pregnancies are characterized by a high incidence of placental abnormalities, notably, increased placentome size and deficiencies in trophoblast cell function and establishment of placental vasculature. Alterations in gene expression during placental growth and development may contribute to the...

journal_title：Placenta

authors： Ravelich SR,Shelling AN,Wells DN,Peterson AJ,Lee RS,Ramachandran A,Keelan JA

更新日期：2006-02-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. Th...

journal_title：Placenta

authors： van der Ven K,Pfeiffer K,Skrablin S

更新日期：2000-03-01 00:00:00

abstract：:Placental ultrasonographic, bio- and histochemical studies were performed on four unrelated fetuses affected with Niemann-Pick disease Type A, following prostaglandin-induced abortion at about the 19th week of gestation. An accumulation of sphingomyelin in the placentae of affected fetuses indicates the essential role...

journal_title：Placenta

authors： Schoenfeld A,Abramovici A,Klibanski C,Ovadia J

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Maternal magnesium (Mg) deficiency has been associated with fetal growth restriction. Using a mouse model of maternal Mg deficiency-induced fetal growth restriction, we sought to investigate the effect of Mg deficiency on placental physiology and function. METHODS:In vivo: Pregnant Swiss Webster mice were fe...

journal_title：Placenta

authors： Rosner JY,Gupta M,McGill M,Xue X,Chatterjee PK,Yoshida-Hay M,Robeson W,Metz CN

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...

journal_title：Placenta

authors： Carter AM

更新日期：2018-07-01 00:00:00

abstract：:Placentas from women with preeclampsia overexpress the hypoxia-inducible transcription factor proteins, HIF-1alpha and -2alpha (Rajakumar 2001, Biol Reprod 64; p499-506 and p1019-1020). As a first step in evaluating whether HIF-alpha overexpressed in preeclamptic placentae is capable of transactivation, we tested its ...

journal_title：Placenta

authors： Rajakumar A,Brandon HM,Daftary A,Ness R,Conrad KP

更新日期：2004-11-01 00:00:00

abstract：:Implantation in the dusky leaf monkey, Presbytis obscura, is superficial; the placenta is of the double discoid villous haemochorial type. Immediately prior to implantation the thick endometrium contains highly active uterine glands. There is an early uterine epithelial proliferation at the implantation site but no st...

journal_title：Placenta

authors： Burton GJ

更新日期：1980-07-01 00:00:00

abstract：INTRODUCTION:Chronic histiocytic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by an intervillous mononuclear inflammatory infiltrate of maternal origin. Although the mechanism and origin of these lesions are currently not understood, they appear to be related to an immune conflict...

journal_title：Placenta

authors： Capuani C,Meggetto F,Duga I,Danjoux M,March M,Parant O,Brousset P,Aziza J

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:The objective of this study was to explore serum levels of differentially abundant proteins between women with hypertensive disorders of pregnancy (HDP) and women with normal-term pregnancy, and to explore the contribution of SH3BGRL3 to the pathogenesis of HDP. METHODS:At 6-20 weeks gestation 48 pregnant...

journal_title：Placenta

authors： Jiang M,Lash GE,Zeng S,Liu F,Han M,Long Y,Cai M,Hou H,Ning F,Hu Y,Yang H

更新日期：2020-11-14 00:00:00

abstract：:This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...

journal_title：Placenta

authors： Santos TC,Dantzer V,Jones CJ,Oliveira MF,Miglino MA

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Epigenetics is tissue-specific and potentially even cell-specific, but little information is available from human reproductive studies about the concordance of DNA methylation patterns in cord blood and placenta, as well as within-placenta variations. We evaluated methylation levels at promoter regions of ca...

journal_title：Placenta

authors： Janssen BG,Byun HM,Cox B,Gyselaers W,Izzi B,Baccarelli AA,Nawrot TS

更新日期：2014-09-01 00:00:00

abstract：:Recently, the gene encoding a new stress-induced protein termed reducing agent and tunicamycin-responsive protein (RTP) was identified. The function of RTP is unknown, however, the strong upregulation of RTP during cellular differentiation, and exposure to stress conditions including hypoxia suggests a specific role f...

journal_title：Placenta

authors： Gratton RJ,Gluszynski M,Nygard K,Mazzuca DM,Graham CH,Han VK

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...

journal_title：Placenta

authors： Gui J,Ling Z,Hou X,Fan Y,Xie K,Shen R

更新日期：2020-01-01 00:00:00

abstract：:The human placenta is capable of producing a variety of haematopoietic growth factors in vitro. It is not clear, however, whether the placenta produces such factors in vivo and if so, whether placental production of haematopoietic growth factors has a physiological role in fetal haematopoietic development. As a step t...

journal_title：Placenta

authors： Li Y,Calhoun DA,Polliotti BM,Sola MC,al-Mulla Z,Christensen RD

更新日期：1996-11-01 00:00:00

abstract：:Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...

journal_title：Placenta

authors： Guibourdenche J,Frendo JL,Pidoux G,Bertin G,Luton D,Muller F,Porquet D,Evain-Brion D

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:Pregnancy complicated by diabetes mellitus (DM) is a central obstetric problem often complicated by fetal macrosomia and increased risk of intrapartum asphyxia. This risk might be explained by fetoplacental vascular abnormalities. This study aimed to investigate the fetoplacental vascular volume by placent...

journal_title：Placenta

authors： Thunbo MØ,Sinding M,Bogaard P,Korsager AS,Frøkjær JB,Østergaard LR,Petersen A,Sørensen A

更新日期：2018-09-01 00:00:00

abstract：:Peroxidase (Donor: H(2)O(2)oxidoreductase EC 1.11.1.7) from human term placentae of non-smokers was purified to homogeneity by a combination of NH(4)Cl extraction, affinity chromatography, (NH(4))(2)SO(4)precipitation, ion-exchange and gel filtration chromatography. The homogeneity of purified human placental peroxida...

journal_title：Placenta

authors： Madhavan ND,Naidu KA

更新日期：2000-07-01 00:00:00

abstract：INTRODUCTION:Infection accounts for over 40% of preterm premature rupture of the fetal membranes (PPROM), a major cause of preterm birth. Toll-like receptors (TLR) play key roles in pathogen surveillance but their expression and function in amnion mesenchymal cells (AMC) is unclear. The aims of this study were to deter...

journal_title：Placenta

authors： Sato BL,Collier ES,Vermudez SA,Junker AD,Kendal-Wright CE

更新日期：2016-08-01 00:00:00

abstract：:The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preecl...

journal_title：Placenta

authors： Xie L,Sadovsky Y

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...

journal_title：Placenta

authors： Lei D,Deng N,Wang S,Huang J,Fan C

更新日期：2020-01-01 00:00:00

abstract：:The sites of localization of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), adrenocorticotrophic hormone (ACTH) and prolactin (PRL) within placental tissues have been studied by an immunoperoxidase technique. The syncytiotrophoblast is the sole significant site of localization of LH...

journal_title：Placenta

authors： Al-Timimi A,Fox H

更新日期：1986-03-01 00:00:00

abstract：:Hofbauer cells have been identified by morphological criteria in human placentae and are considered to be mononuclear phagocytes. An increasing recognition of the morphological heterogeneity of mononuclear phagocytes and of the considerable difficulty in their recognition in histological sections has suggested that th...

journal_title：Placenta

authors： Wood GW

更新日期：1980-04-01 00:00:00

abstract：:The ovaries and uteri were removed from four pregnant camels on days 14, 25, 35 and 56 after ovulation. The day 14 and 25 uteri were perfuse-fixed with 3 per cent glutaraldehyde: 3 per cent paraformaldehyde whereas the day 35 and 56 specimens were opened dorsally for photography before biopsies of allantochorion attac...

journal_title：Placenta

authors： Skidmore JA,Wooding FB,Allen WR

更新日期：1996-05-01 00:00:00

abstract：:Placentae from controls and two groups of diabetic women (one White classes A, B, C and the other classes D, F/R) were collected at 37-42 weeks of gestation. Tissue sections were analysed using stereological methods in order to quantify the growth and maturational status of villi. Birth and placental weights were reco...

journal_title：Placenta

authors： Mayhew TM,Sørensen FB,Klebe JG,Jackson MR

更新日期：1994-01-01 00:00:00

abstract：:We have shown that oestrogen has a central integrative role in regulating key components of the progesterone biosynthetic and corticosteroid metabolic pathways within syncytiotrophoblasts that govern placental function and maturation of the fetal pituitary-adrenocortical axis. Studies utilizing classic binding procedu...

journal_title：Placenta

authors： Billiar RB,Pepe GJ,Albrecht ED

更新日期：1997-05-01 00:00:00