Abstract:
INTRODUCTION:Pregnancy complicated by diabetes mellitus (DM) is a central obstetric problem often complicated by fetal macrosomia and increased risk of intrapartum asphyxia. This risk might be explained by fetoplacental vascular abnormalities. This study aimed to investigate the fetoplacental vascular volume by placental CT angiography in normal pregnancies and in pregnancies complicated by type 1 DM (T1DM), diet controlled gestational DM (GDMd), and insulin treated gestational DM (GDMi). METHODS:Postpartum, barium contrast enhanced placental CT angiography was performed in 27 normal pregnancies and 25 DM pregnancies (8 T1DM, 8 GDMd, and 9 GDMi). The fetoplacental vascular volume/placenta weight (FVV/PW)-ratio and fetoplacental vascular volume/birth weight (FVV/BW)-ratio of each diabetic group were compared to the normal group with multiple regression analysis adjusted for GA. In all pregnancies a standardized histopathological placental examination was performed postpartum. RESULTS:In normal pregnancies, the fetoplacental vascular volume increased with GA (p < 0.001), placental weight (p < 0.001), and birth weight (p < 0.001). In T1DM and GDMi pregnancies, the gestational age adjusted placental weight and the birth weight were increased when compared to normal pregnancies (p < 0.05). The FVV/BW-ratio was significantly reduced in both T1DM and GDMi pregnancies when compared to normal pregnancies (p = 0.003 and p = 0.009, respectively). DISCUSSION:This study demonstrates, that in insulin treated DM pregnancies the fetus as well as the placenta is larger than normal. However, despite a large placenta, a relatively smaller fetoplacental vascular volume supplies the macrosomic fetus. This finding might explain why fetuses from insulin treated DM pregnancies have high vulnerability to intrauterine and intrapartum asphyxia.
journal_name
Placentajournal_title
Placentaauthors
Thunbo MØ,Sinding M,Bogaard P,Korsager AS,Frøkjær JB,Østergaard LR,Petersen A,Sørensen Adoi
10.1016/j.placenta.2018.06.309subject
Has Abstractpub_date
2018-09-01 00:00:00pages
20-25eissn
0143-4004issn
1532-3102pii
S0143-4004(18)30183-8journal_volume
69pub_type
杂志文章相关文献
PLACENTA文献大全abstract::During the first trimester in normal human pregnancy, endovascular trophoblast migrate along the decidual spiral arteries and invade their walls to produce physiological change. There is controversy as to whether invading trophoblast plug the arteries and prevent blood flow into the intervillous space. Using light mic...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80048-3
更新日期:1997-07-01 00:00:00
abstract::Homogenates of first (10.1 +/- 1.0 weeks) and third trimester placental villi were analysed for free amino acid concentrations. As has been previously reported, several amino acids showed increased concentrations during early pregnancy when compared to term. In addition, marked differences were seen in the levels of e...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(94)90037-x
更新日期:1994-10-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to define gross patterns of umbilical cord hypercoiling and determine correlations with histological features in the placenta and/or perinatal outcomes such as stillbirth. METHODS:Gross images of placentas with hypercoiled umbilical cords (>3 coils/10 cm) were assigned a majo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.04.002
更新日期:2013-07-01 00:00:00
abstract::There is inconsistent use of Matrigel for experiments with the HTR8/SVneo first trimester trophoblast and other cell lines. We quantified the effects of Matrigel on the expression of genes considered to be markers of extravillous cytotrophoblast (EVT) differentiation and invasive potential. Culture on Matrigel promote...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.04.003
更新日期:2012-07-01 00:00:00
abstract::Eighty-one placentae from women with leprosy and 17 placentae from healthy controls were subjected to a detailed macroscopic, light microscopic, ultrastructural, immunopathological, microbiological and biochemical study. The placental morphology and immunohistology were normal, and there was no morphological evidence ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80028-4
更新日期:1984-05-01 00:00:00
abstract::A rapid method to determine quality for placental proteomic studies is required due to varying lengths of time between delivery and sampling in routine protocols. We developed a rapid 10 min LC-MS based scanning method to profile free peptides liberated from natural proteolytic degradation. The assay was applied to pl...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.04.014
更新日期:2016-08-01 00:00:00
abstract::Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological functi...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2010.02.010
更新日期:2010-05-01 00:00:00
abstract::The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development, and directly influence pregnancy outcome. Dysregulation of these processes has been associated with placental dysfunction, implicated in clinical conditions such as preecl...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2016.10.004
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:Women with adverse pregnancy outcomes (APOs) have excess risk of later life cardiovascular disease (CVD) perhaps related to an underlying high-risk vascular phenotype. We sought to determine if placental evidence of maternal malperfusion in uncomplicated pregnancies is associated with an increased risk of ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2018.12.008
更新日期:2018-12-15 00:00:00
abstract::The interaction of cocaine and its analog 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane (RTI-55) with the human placental serotonin transporter was investigated. The function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush bord...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(94)90018-3
更新日期:1994-04-01 00:00:00
abstract:INTRODUCTION:Little is known about the interaction between human placental multipotent mesenchymal stromal cell (hPMSC) and trophoblast. We hypothesize that hPMSCs produce hepatocyte growth factor (HGF) which may interact with trophoblasts and regulate their migration during placentation. METHODS:hPMSCs were isolated ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.311
更新日期:2013-10-01 00:00:00
abstract::We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were n...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.09.012
更新日期:2012-12-01 00:00:00
abstract::Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80020-4
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether DNA-associated micro-particles (MPs) in maternal plasma express fetal-derived human leukocyte antigen-G (HLA-G) or placental alkaline phosphatase (PLAP) and whether the levels differ between women with normotensive pregnancies and preeclampsia. METHODS:DNA-asso...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.06.012
更新日期:2009-10-01 00:00:00
abstract::Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2006.01.016
更新日期:2007-01-01 00:00:00
abstract::Mitochondrial function is required to support energetically-demanding processes in the placenta. As such, a compromise in mitochondrial function could severely impact fetal growth and development. Respirometry is a highly useful method for studying mitochondrial function, but is not possible in freeze-thawed mitochond...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.11.019
更新日期:2012-02-01 00:00:00
abstract:INTRODUCTION:Soluble fms-like tyrosine kinase 1 (sFLT-1) is an anti-angiogenic factor implicated in the pathogenesis of preterm preeclampsia. We evaluated sFLT-1 expression and placental pathology in pregnancies complicated by small for gestational age (SGA) infants (<10th percentile), without evidence of preeclampsia....
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.02.011
更新日期:2017-04-01 00:00:00
abstract:INTRODUCTION:The breast cancer resistance protein (BCRP/ABCG2) is an efflux transporter in the placental barrier. By transporting chemicals from the fetal to the maternal circulation, BCRP limits fetal exposure to a range of drugs, toxicants, and endobiotics such as bile acids and hormones. The purpose of the present s...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.04.006
更新日期:2017-07-01 00:00:00
abstract::The EAT/mcl-1 gene was isolated during the early differentiation of a retinoic acid-induced human embryonal carcinoma cell line to the trophectoderm lineage. EAT/mcl-1, a bcl-2 related gene, is involved in the genetic pathway of apoptosis; this suggests a role for apoptosis and the involvement of this gene in early pl...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1999.0458
更新日期:2000-03-01 00:00:00
abstract::The mechanism of iron release from the placenta into the fetal circulation is not well understood. Ceruloplasmin, a plasma ferroxidase, has been implicated in iron efflux from a variety of cell types. The hypothesis is that circulating ceruloplasmin facilitates iron efflux by oxidizing the released Fe(II) to Fe(III) f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0582
更新日期:2000-11-01 00:00:00
abstract:INTRODUCTION:Visualization of the retroplacental clear space (RPCS) may provide critical insight into the development of abnormally invasive placenta (AIP). In this pre-clinical study, we characterized the appearance of the RPCS on magnetic resonance imaging (MRI) during the second half of gestation using a liposomal g...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.01.017
更新日期:2019-02-01 00:00:00
abstract:INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.09.013
更新日期:2019-12-01 00:00:00
abstract:INTRODUCTION:Non-invasive 3D imaging that enables clear visualization of placental margins is of interest in the accurate diagnosis of placental pathologies. This study investigated if contrast-enhanced MRI performed using a liposomal gadolinium blood-pool contrast agent (liposomal-Gd) enables clear visualization of th...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.06.008
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Notch signalling has been shown to control cytotrophoblast (CTB) proliferation, differentiation and motility suggesting that the conserved signalling pathway could be critical for human placental development. Since individual Notch receptors have not been elucidated, we herein investigated expression patte...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.01.009
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Alloimmunization against human platelet antigens (HPAs) can occur prenatally and induce fetal/neonatal alloimmune thrombocytopenia (FNAIT). The aim of this study was to identify placental histological features associated with platelet alloimmunization and their clinical significance. METHODS:This study exam...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.10.009
更新日期:2016-12-01 00:00:00
abstract:INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.05.009
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:Chronic maternal asthma is associated with reduced growth of the female fetus and normal growth of the male fetus. The mechanisms that control the differential effects of maternal asthma on the fetus have not been fully elucidated but alterations in placental function may play a role. In the current study we...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.05.005
更新日期:2011-08-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are involved in placental remodelling throughout pregnancy. Diabetes mellitus induces alterations in tissue production of NO, a regulator of MMPs activity. The present work evaluates placental and fetal MMPs and NO levels during midpregnancy in neonatal streptozotocin-induced diabetic ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.06.011
更新日期:2005-04-01 00:00:00
abstract::Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.021
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:Preeclampsia is a severe pregnancy complication mostly due to inadequate vascular dilation and remodeling of spiral arteries. VEGF, the major factor for angiogenesis, is necessary for modulating angiogenic processes in the placenta. Hence reduction of VEGF in gestational hypertension may also lead to hypop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.08.088
更新日期:2016-10-01 00:00:00