Abstract：
:Indiscriminate invasion upon the endometrium by normal trophoblasts is strictly regulated unlike that by choriocarcinoma cells. In this study, we focused on the activity of matrix metalloproteinase (MMP)-2 and MMP-9 as parameters of invasion in normal human placenta. In situ hybridization (ISH), immunohistochemical staining (IH) and film in situ zymography (FIZ) were performed to identify cells having MMP-2 or MMP-9 expression and activity. Purified cytotrophoblasts (CTs) were used to examine the expression and activity of MMP-2 and MMP-9, and their invasive ability. In first trimester placental tissue, the MMP-2 expression was observed in extravillous trophoblasts (EVTs), and MMP-9 mainly in villous cytotrophoblasts (VCTs). FIZ revealed marked gelatinase activity in the EVTs which MMP-2 expression was observed in. In full-term placental tissue, the MMP-2 expressions was observed in the EVTs similar to that in first trimester, whereas the gelatinase activity in these cells was decreased or completely lost. Using purified CTs, the gelatinase activity was marked in early CTs, but not term CTs. Invasive ability of early CTs was inhibited by tissue inhibitor of metalloproteinase (TIMP)-2 and MMP-2 antibody in a dose dependent manner. These suggests that the invasive ability of trophoblasts may be regulated by the enzyme activity of gelatinases, especially MMP-2.
journal_name
Placentajournal_title
Placentaauthors
Isaka K,Usuda S,Ito H,Sagawa Y,Nakamura H,Nishi H,Suzuki Y,Li YF,Takayama Mdoi
10.1053/plac.2002.0867keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
53-64issue
1eissn
0143-4004issn
1532-3102pii
S0143400402908672journal_volume
24pub_type
杂志文章相关文献
PLACENTA文献大全abstract：BACKGROUND:Discrepancies in the results from studies of early events in human trophoblast invasion of decidua have been acknowledged and are attributed largely to deficiencies in the accuracy of sampling of the decidual tissue used in the research. We describe a novel technique of biopsy of decidua parietalis and basal...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.02.018
更新日期：2012-06-01 00:00:00
abstract：:Placenta accreta is a pregnancy complication characterized by the presence of life-threatening uteroplacental neovascularization. The factors involving its development are unknown. Vascular endothelial growth factor (VEGF), placenta growth factor (PlGF) and their receptors (VEGFR) have important roles in vascular remo...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2004.12.011
更新日期：2006-01-01 00:00:00
abstract：:Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2002.0944
更新日期：2003-05-01 00:00:00
abstract：:Hyperplastic placentas have been reported in several experimental mouse models, including animals produced by somatic cell nuclear transfer, by inter(sub)species hybridization, and by somatic cytoplasm introduction to oocytes followed by intracytoplasmic sperm injection. Of great interest are the gross and histologica...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2008.05.008
更新日期：2008-08-01 00:00:00
abstract：INTRODUCTION:We have identified some critical aspects concerning umbilical cord tissue mesenchymal stem cells: the lack of standards for cell isolation, expansion and cryopreservation, the lack of unanimous opinions upon their multilineage differentiation potential and the existence of very few results related to the f...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2015.08.011
更新日期：2015-10-01 00:00:00
abstract：:Placental pathology is a valuable link explaining how underlying pregnancy risk factors result in adverse pregnancy outcome. This potentially useful information is currently underutilized due to a general lack of rigor in placental diagnosis. This lack of rigor is in large part due to a failure to appreciate the impor...
journal_title：Placenta
pub_type：
doi：10.1016/j.placenta.2005.02.009
更新日期：2005-04-01 00:00:00
abstract：INTRODUCTION:Human decidual stromal cells (DSCs) play a key role in maternal-fetal interactions. Precursors of DSCs (preDSCs) localize around vessels in both the endometrium and decidua. Previous studies suggested a relationship between preDSCs and pericytes because these cells share a perivascular location, alpha smoo...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.11.010
更新日期：2018-01-01 00:00:00
abstract：INTRODUCTION:During a pregnancy complicated by diabetes, the human placenta undergoes a number of functional and structural pathologic changes, such as increased placental weight and increased incidence of placental lesions including villous maturational defects and fibrinoid necrosis. The pathologic findings reported ...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2014.11.021
更新日期：2015-02-01 00:00:00
abstract：:Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2006.01.016
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:MicroRNAs (miRNAs) are small single-stranded RNA molecules working as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous group of fetal cells forming the feto-maternal interface and displaying a wide spectrum of functions. The regulation of their behavior may partly unde...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.05.009
更新日期：2012-09-01 00:00:00
abstract：:The recent discovery of a local renin-angiotensin system in trophoblastic tissues has raised many questions regarding its role in the physiology of normal gestation and its implications in the pathophysiology of hypertension during pregnancy. In this article, the authors first review the most interesting aspects of th...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/s0143-4004(96)80003-8
更新日期：1996-03-01 00:00:00
abstract：:This study examines the vasorelaxation of isolated human placental chorionic plate arteries and the perfused fetal-placental vasculature, in vitro, to a variety of nitrovasodilator compounds including glyceryl trinitrate (GTN) sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP), S-nitroso-N-glutathione ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0625
更新日期：2001-04-01 00:00:00
abstract：:We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were n...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.09.012
更新日期：2012-12-01 00:00:00
abstract：:Glutamine is the most versatile amino acid and its plasma concentration is the highest of all amino acid. Many transporters are therefore involved in glutamine uptake or efflux. Glutamine is actively released from the placenta into fetal circulation. In this study, we examined the alteration of transporters that trans...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2009.09.009
更新日期：2009-12-01 00:00:00
abstract：:Chemokines are small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors. In reproductive biology, they have been implicated in ovulation, menstruation, and embryo implantation, and pathological processes such as preterm delivery, HIV infection, and endometriosis. It is known that...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/s0143-4004(03)00134-6
更新日期：2003-10-01 00:00:00
abstract：:We investigated whether histological evidence of early atherosclerosis was present in the umbilical artery of 21 pregnancies complicated by severe perinatal inflammation, and 21 controls matched for gestational age, sex and birth weight. Severe chorioamnionitis with funisitis was associated with increased numbers of C...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.12.021
更新日期：2017-02-01 00:00:00
abstract：:The fusion of villous cytotrophoblast into the placental syncytium is the quintessential process in maintenance of a healthy pregnancy. Efficient fusion requires a phosphatidylserine (PS)-rich cytotrophoblast surface, expression of fusion proteins, cessation of cell cycling, and rearrangement of cytoskeleton to accomm...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2009.12.014
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine whether DNA-associated micro-particles (MPs) in maternal plasma express fetal-derived human leukocyte antigen-G (HLA-G) or placental alkaline phosphatase (PLAP) and whether the levels differ between women with normotensive pregnancies and preeclampsia. METHODS:DNA-asso...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2009.06.012
更新日期：2009-10-01 00:00:00
abstract：:The present study was designed to localize some important enzymes, such as adenosine diphospate-degrading enzyme (ADP-degrading enzyme) (plasma membrane enzyme), cytochrome c oxidase (mitochondrial enzyme) and glucose-6-phosphatase (endoplasmic reticulum enzyme), in placentae from patients with idiopathic fetal growth...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.1999.0474
更新日期：2000-03-01 00:00:00
abstract：:This study examines middle and late gestational placentae from 13 Tayassu tajacu (collared peccary) and 3 Tayassu pecari (white-lipped peccary), which are Artiodactyla belonging to the Family Tayassuidae. The chorionic sac of Tayassu species is diffuse and chorioallantoic. These epitheliochorial placentae show no trop...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2005.02.017
更新日期：2006-02-01 00:00:00
abstract：:Decidualization process involves the morphological and functional transformation of endometrial stromal cells into decidual cells. This is a finely regulated process, which involves proliferation and differentiation of stromal cells into decidual cells, which is followed by regression of the decidual tissue, mainly by...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2011.03.007
更新日期：2011-06-01 00:00:00
abstract：:Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80020-4
更新日期：1983-01-01 00:00:00
abstract：:Changes in placental lipid content in rats at the 15th and 20th days of pregnancy were investigates. It was found that progress of gestation is accompanied by a significant increase in triglycerides per mg placental DNA. Maternal starvation caused additional increase in the placental triglyceride content. By incubatio...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(80)80033-6
更新日期：1980-10-01 00:00:00
abstract：INTRODUCTION:The velocities of the lateral shear waves (Vs; m s⁻¹) generated by an acoustic radiation force impulse (ARFI) correlate with Young's modulus. Therefore, ARFI can be used as a new method to evaluate tissue elasticity. The aim of this study was to investigate the safety of ARFI imaging and the differences in...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.08.014
更新日期：2013-11-01 00:00:00
abstract：:The sites of localization of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH), adrenocorticotrophic hormone (ACTH) and prolactin (PRL) within placental tissues have been studied by an immunoperoxidase technique. The syncytiotrophoblast is the sole significant site of localization of LH...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(86)80007-8
更新日期：1986-03-01 00:00:00
abstract：INTRODUCTION:Imprinted genes are preferentially expressed from one parentally inherited allele, and many are crucial to the regulation of placental function and fetal growth. Murine Krüppel-like factor 14 (Klf14) is a maternally expressed imprinted transcription factor that is a component of the Mest imprinted gene clu...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2019.09.013
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:The state of activation of dendritic cells (DCs) at the feto-maternal interface critically contributes to optimal decidual immune responses needed to support fetal-placental development. We recently demonstrated that during healthy pregnancy also peripheral blood DCs (PBDCs), which are easily accessible, a...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.10.016
更新日期：2013-01-01 00:00:00
abstract：:A long and productive history of studies at high altitude has demonstrated that chronic hypoxia plays a key role in the aetiology of intrauterine growth restriction (IUGR) and pre-eclampsia. Susceptibility to altitude-associated IUGR varies among high-altitude populations in relation to their duration of altitude expo...
journal_title：Placenta
pub_type： 杂志文章,多中心研究,评审
doi：10.1016/j.placenta.2004.01.008
更新日期：2004-04-01 00:00:00
abstract：:The placenta receives two arterial blood supplies, i.e. one maternal and one fetal. It has been suggested that placental infarction should occur only if both blood supplies are compromised (Wigglesworth, 1984). This hypothesis has not been tested. Haemosiderosis of the trophoblast basement membrane (TBMH) has recently...
journal_title：Placenta
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0143-4004(95)90005-5
更新日期：1995-03-01 00:00:00
abstract：:Recent demonstrations of transferrin (TF) mRNA in placental tissue raised the possibility that the placenta may serve as an extra-hepatic source of this iron-binding protein during development. In this study, we first confirmed these findings using cRNA probes for TF, and then adapted the TF reverse haemolytic plaque ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(05)80419-9
更新日期：1994-07-01 00:00:00
