Abstract:
:Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. During pregnancy, fetal growth restriction secondary to placental insufficiency has been linked to impaired telomere homeostasis in which telomeres are shorter, telomerase is decreased, and compensatory mechanisms of telomere capture are enhanced. These characteristics, along with increased signs of senescence, indicate telomere dysfunction in trophoblasts from placentas affected by intrauterine growth restriction (IUGR). This review summarizes the information currently available regarding telomere homeostasis in trophoblasts from human pregnancies affected by IUGR. Improved understanding of placental physiology might help in the development of treatment options for fetuses with IUGR.
journal_name
Placentajournal_title
Placentaauthors
Biron-Shental T,Sadeh-Mestechkin D,Amiel Adoi
10.1016/j.placenta.2015.11.006subject
Has Abstractpub_date
2016-03-01 00:00:00pages
21-3eissn
0143-4004issn
1532-3102pii
S0143-4004(15)30088-6journal_volume
39pub_type
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