Abstract：
OBJECTIVES:Histiotrophe is now recognized as being an important feature of early human pregnancy, providing nutrients and growth factors to the developing embryo. Our aim was to examine the glycan composition of histiotrophe from first trimester decidua and to compare it with secretions present in endometrial glands from the late secretory phase of the menstrual cycle. STUDY DESIGN:Twenty samples of decidua from pregnancies between 8 and 11 weeks were processed into epoxy resin and sections stained with a panel of 22 lectins, together with six late secretory phase endometrial biopsies. MAIN OUTCOME MEASURES:Specimens were analysed using a semi-quantitative ranking system and the density of lectin binding to the glandular secretions and the epithelium assessed. RESULTS:With the onset of pregnancy, beta-galactose, alpha-N-acetyl galactosamine and N-Acetyl lactosamine bound by Arachis hypogaea, Glycine max, Helix pomatia and Erythrina crystagalli agglutinins appeared in terminal positions on oligosaccharide chains, suggesting loss of the capping sialic acid residues present in the non-pregnant state. CONCLUSIONS:Suppression of terminal sialylation is evident during early pregnancy, suggesting that modifications to endometrial glandular activity occur in response to placental signals. The changes may facilitate absorption of histiotrophe by the trophoblast and enhance availability of substrates for degradation.
journal_name
Placentajournal_title
Placentaauthors
Jones CJ,Aplin JD,Burton GJdoi
10.1016/j.placenta.2010.04.011subject
Has Abstractpub_date
2010-07-01 00:00:00pages
576-80issue
7eissn
0143-4004issn
1532-3102pii
S0143-4004(10)00170-0journal_volume
31pub_type
杂志文章相关文献
PLACENTA文献大全abstract：:The possible roles of the allantoic sac in metabolism of uteroferrin, the iron-containing, purple phosphatase, were examined. This protein, which originates in the maternal endometrium, was measured in allantoic fluid by a specific double-antibody radioimmunoassay and by its beta-mercaptoethanol-activated acid phospha...
journal_title：Placenta
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2015.12.006
更新日期：2016-02-01 00:00:00
abstract：:The visceral yolk sac (VYS) is responsible for a major part of the amino acid nutrition of the early post-implantation rat embryo and possibly also at the fetal stage of gestation. The mechanism involves endocytic uptake of proteins by the tissue's epithelial cells followed by intralysosomal digestion to amino acids. ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(77)90009-1
更新日期：1997-09-01 00:00:00
abstract：INTRODUCTION:A major issue in the transcriptomic study of spontaneous preterm birth (sPTB) in humans is the inability to collect healthy control tissue at the same gestational age (GA) to compare with pathologic preterm tissue. Thus, gene expression differences identified after the standard comparison of sPTB and term ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.03.006
更新日期：2016-05-01 00:00:00
abstract：INTRODUCTION:Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2017.08.070
更新日期：2017-10-01 00:00:00
abstract：:We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2009.11.003
更新日期：2010-01-01 00:00:00
abstract：:Breast Cancer Resistance Protein (BCRP), a recently-discovered transporter belonging to ABC superfamily, is highly expressed within the labyrinth of the placenta, the primary site of exchange between the maternal and fetal circulation. It has been proposed to function as an efflux pump protecting the fetus from a wide...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2007.03.010
更新日期：2007-10-01 00:00:00
abstract：:Oestrogen and progesterone receptors have been implicated in human placental steroidogenesis, but studies developed to measure their concentration in this tissue at term yielded discrepant results. Potential inaccuracy of the binding assays, the technique used in previous studies, might influence the discrepancy. In t...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/0143-4004(89)90049-0
更新日期：1989-11-01 00:00:00
abstract：:Placental stem cells are of growing interest for a variety of clinical applications due to their multipotency and ready availability from otherwise frequently discarded biomaterial. Stem cells derived from the placenta have been investigated in a number of disease processes, including wound healing, ischemic heart dis...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2017.05.010
更新日期：2017-11-01 00:00:00
abstract：OBJECTIVE:Maternal magnesium (Mg) deficiency has been associated with fetal growth restriction. Using a mouse model of maternal Mg deficiency-induced fetal growth restriction, we sought to investigate the effect of Mg deficiency on placental physiology and function. METHODS:In vivo: Pregnant Swiss Webster mice were fe...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2016.01.009
更新日期：2016-03-01 00:00:00
abstract：:Second trimester maternal serum human chorionic gonadotrophin (hCG) levels in women who remained normotensive but delivered an unexplained growth retarded infant were compared with those from a control group and a group of women who developed pre-eclampsia in a retrospective observational study. Our hypothesis was tha...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(98)90002-9
更新日期：1998-03-01 00:00:00
abstract：INTRODUCTION:The interaction between trophoblast cells and maternal uterine endothelium is important for placental vascular modelling. Nitric oxide (NO) is a potent vasorelaxant that regulates systemic blood pressure and is reduced in preeclampsia. NO may affect placental cell interaction. OBJECTIVES:This study was to...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2014.03.009
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:MicroRNAs (miRNAs) are small single-stranded RNA molecules working as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous group of fetal cells forming the feto-maternal interface and displaying a wide spectrum of functions. The regulation of their behavior may partly unde...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2012.05.009
更新日期：2012-09-01 00:00:00
abstract：:Placental protein 5 (PP5)/tissue factor pathway inhibitor-2 (TFPI-2), a serine proteinase inhibitor, is homologous to tissue factor pathway inhibitor (TFPI) and commonly found in peripheral blood of pregnant woman. Although TFPI is well known to be synthesized primarily in endothelium and to play an important role in ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2001.0774
更新日期：2002-02-01 00:00:00
abstract：:The expression of apolipoprotein D (apo D), a lipocalin involved in defense mechanisms against oxidative stress, in placental tissue samples of pregnancies with gestational diabetes mellitus (GDM) was compared to non-diabetic controls. We have investigated the relationship of apo D with 4-HNE, a major propagation prod...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2009.11.002
更新日期：2010-01-01 00:00:00
abstract：:It has been suggested that adenosine is involved in the acute effects of ethanol in a number of tissues. The present study was undertaken to evaluate the role of adenosine on the vascular responses of perfused isolated human placental cotyledons after the acute administration of ethanol. The possibility that ethanol m...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(97)80038-0
更新日期：1997-07-01 00:00:00
abstract：:This study was based on the hypothesis that both primary sequence and methylation status of the GTPase activating protein (GAP) gene limits expression of p100 GAP to primate placenta. Due to alternate splicing, a 65-bp insert appears between the first and second coding exons of p100 GAP mRNA, and translation of p100 G...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(98)90012-1
更新日期：1998-03-01 00:00:00
abstract：:The placental endothelium contributes to regulating transplacental exchange and maintaining the immunological maternofetal barrier. We characterized the endothelial phenotype in human normal term placentae with a panel of antibodies to endothelial antigens using a standardized immunofluorescence method. Placental endo...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2000.0579
更新日期：2001-01-01 00:00:00
abstract：:Alpha-fetoprotein (AFP) is a major serum glycoprotein synthesized during fetal life mainly by the yolk sac and the fetal liver. At term, it reaches high concentrations in the maternal intervillous blood, which is in direct contact with the placental trophoblastic microvillous membrane, and this suggests the placental ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1053/plac.2002.0816
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:Prior studies have demonstrated that donor twin survival following treatment of twin-twin transfusion syndrome (TTTS) was highly associated with donor intrauterine growth restriction (IUGR). Here, we hypothesized that donor IUGR may be attributed in part to low placental share. STUDY DESIGN:The study popula...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2011.05.009
更新日期：2011-08-01 00:00:00
abstract：:Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2006.01.016
更新日期：2007-01-01 00:00:00
abstract：:The ovaries and uteri were removed from four pregnant camels on days 14, 25, 35 and 56 after ovulation. The day 14 and 25 uteri were perfuse-fixed with 3 per cent glutaraldehyde: 3 per cent paraformaldehyde whereas the day 35 and 56 specimens were opened dorsally for photography before biopsies of allantochorion attac...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(96)90046-6
更新日期：1996-05-01 00:00:00
abstract：:Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2008.08.007
更新日期：2008-10-01 00:00:00
abstract：INTRODUCTION:Alterations of apoptosis are commonly associated with pregnancy complications and abortion. Modulation of apoptosis is a relevant feature of Toxoplasma gondii infection and it is related to parasite strain types. The aim of the present study was to evaluate the possible factors that are involved in the dif...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2013.09.005
更新日期：2013-11-01 00:00:00
abstract：:Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(83)80020-4
更新日期：1983-01-01 00:00:00
abstract：:Fetoplacental blood vessel constriction in response to reduced oxygenation has been demonstrated in placenta perfused in vitro. In pulmonary vessels, hypoxic vasoconstriction involves Ca2+ influx into smooth muscle through membrane ion channels including voltage-gated Ca2+ channels (VGCCs). We hypothesised that VGCCs ...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2005.04.012
更新日期：2006-04-01 00:00:00
abstract：:The placenta is composed of the amnion, chorionic plate, villous and smooth chorion, decidua basalis, and umbilical cord. The amnion is a readily obtainable source of a large number of cells and cell types, including epithelium, mesenchyme, and endothelium, and is thus an allogeneic resource for regenerative medicine....
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/j.placenta.2019.06.381
更新日期：2019-09-01 00:00:00
abstract：:The uptake of [3H]choline and its conversion to [3H]acetylcholine were investigated in term human placental tissue in vitro. Although the net uptake of [3H]choline increased throughout a 45 min incubation period, intracellular [3H]choline levels reach a plateau after 2 min. There was a constant increase in [3H]acetylc...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/s0143-4004(84)80036-3
更新日期：1984-05-01 00:00:00
abstract：:Highly purified (>99.99%) primary villous cytotrophoblasts from uncomplicated pregnancies and pregnancies complicated with intrauterine growth restriction (IUGR) alone, IUGR with pre-eclampsia (IUGR-PE) and PE alone were cultured for 5days and the extent of differentiation into syncytiotrophoblasts measured in terms o...
journal_title：Placenta
pub_type： 杂志文章
doi：10.1016/j.placenta.2007.04.008
更新日期：2007-10-01 00:00:00
abstract：:Antigen expression by villous and extravillous human trophoblast populations at discrete anatomical sites has been reviewed. The various different antigenic phenotypes have been highlighted using a panel of monoclonal antibodies reactive with characteristic trophoblast membrane antigens, a trophoblast-leucocyte common...
journal_title：Placenta
pub_type： 杂志文章,评审
doi：10.1016/s0143-4004(85)80063-1
更新日期：1985-03-01 00:00:00
