Potential clinical applications of placental stem cells for use in fetal therapy of birth defects.

Abstract:

:Placental stem cells are of growing interest for a variety of clinical applications due to their multipotency and ready availability from otherwise frequently discarded biomaterial. Stem cells derived from the placenta have been investigated in a number of disease processes, including wound healing, ischemic heart disease, autoimmune disorders, and chronic lung or liver injury. Fetal intervention for structural congenital defects, such as spina bifida, has rapidly progressed as a field due to advances in maternal-fetal medicine and improving surgical techniques. In utero treatment of structural, as well as non-structural, congenital disorders with cell-based therapies is of particular interest given the immunologic immaturity and immunotolerant environment of the developing fetus. A comprehensive literature review was performed to assess the potential utilization of placenta-derived stem cells for in utero treatment of congenital disorders. Most studies are still in the preclinical phase, utilizing animal models of common congenital disorders. Future research endeavors may include autologous transplantation, gene transfers, induced pluripotent stem cells, or cell-free therapies derived from the stem cell secretome. Though much work still needs to be done, placental stem cells are a promising therapeutic agent for fetal intervention for congenital disease.

journal_name

Placenta

journal_title

Placenta

authors

Vanover M,Wang A,Farmer D

doi

10.1016/j.placenta.2017.05.010

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

107-112

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(17)30276-X

journal_volume

59

pub_type

杂志文章,评审

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