当前位置： SCI文献检索 > PLACENTA期刊下所有文献 > Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn.

Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn.

Abstract：

INTRODUCTION:Preeclampsia (PE) carries increased risks of cardiovascular- and metabolic diseases in mothers and offspring during the life course. While the severe early-onset PE (EOPE) phenotype originates from impaired placentation in early pregnancy, late-onset PE (LOPE) is in particular associated with pre-existing maternal cardiovascular- and metabolic risk factors. We hypothesize that PE is associated with altered epigenetic programming of placental and fetal tissues and that these epigenetic changes might elucidate the increased cardiovascular- and metabolic disease susceptibility in PE offspring. METHODS:A nested case-control study was conducted in The Rotterdam Periconceptional Cohort comprising 13 EOPE, 16 LOPE, and three control groups of 36 uncomplicated pregnancies, 27 normotensive fetal growth restricted and 20 normotensive preterm birth (PTB) complicated pregnancies. Placental tissue, newborn umbilical cord white blood cells (UC-WBC) and umbilical vein endothelial cells were collected and DNA methylation of cytosine-guanine dinucleotides was measured by the Illumina HumanMethylation450K BeadChip. An epigenome-wide analysis was performed by using multiple linear regression models. RESULTS:Epigenome-wide tissue-specific analysis between EOPE and PTB controls revealed 5001 mostly hypermethylated differentially methylated positions (DMPs) in UC-WBC and 869 mostly hypomethylated DMPs in placental tissue, situated in or close to genes associated with cardiovascular-metabolic developmental pathways. DISCUSSION:This study shows differential methylation in UC-WBC and placental tissue in EOPE as compared to PTB, identifying DMPs that are associated with cardiovascular system pathways. Future studies should examine these loci and pathways in more detail to elucidate the associations between prenatal PE exposure and the cardiovascular disease risk in offspring.

journal_name

Placenta

journal_title

Placenta

authors

Herzog EM,Eggink AJ,Willemsen SP,Slieker RC,Wijnands KPJ,Felix JF,Chen J,Stubbs A,van der Spek PJ,van Meurs JB,Steegers-Theunissen RPM

doi

10.1016/j.placenta.2017.08.070

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

122-132

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(17)31099-8

journal_volume

58

pub_type

杂志文章

相关文献

PLACENTA文献大全
  • Sexual dimorphism in the effect of maternal obesity on antioxidant defense mechanisms in the human placenta.

    abstract：INTRODUCTION:Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal s...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.02.004

    authors： Evans L,Myatt L

    更新日期：2017-03-01 00:00:00

  • Placental pathologies in fetal MRI with pathohistological correlation.

    abstract：INTRODUCTION:The purpose of this study was to evaluate whether currently available fetal Magnetic Resonance Imaging (MRI/MR) techniques are sufficient for the assessment of placental pathologies. We hypothesized that placental pathologies as detected and evaluated by MRI, would correlate with histological findings. PA...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.03.010

    authors： Linduska N,Dekan S,Messerschmidt A,Kasprian G,Brugger PC,Chalubinski K,Weber M,Prayer D

    更新日期：2009-06-01 00:00:00

  • Immunohistochemical detection of human placental cytochrome P-450-associated mono-oxygenase system inducible by maternal cigarette smoking.

    abstract：:Several xenobiotic-metabolizing mono-oxygenase activities, in conjunction with the immunohistochemical localization of the respective cytochrome P-450 forms, were investigated in placentae from smoking and non-smoking women. The antibodies used in the immunohistochemical analyses were monoclonal antibodies (MAbs) 1-7-...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(88)90034-3

    authors： Pasanen M,Stenbäck F,Park SS,Gelboin HV,Pelkonen O

    更新日期：1988-05-01 00:00:00

  • Downregulation of protein kinase C by phorbol ester increases expression of epidermal growth factor receptors in transformed trophoblasts and amplifies human chorionic gonadotropin production.

    abstract：:Epidermal growth factor (EGF) and its homologue, transforming growth factor-alpha (TGF-alpha), regulate human chorionic gonadotropin (hCG) synthesis in the human placenta. The current study was designed to investigate the involvement of the protein kinase C pathway in EGF-mediated hCG-beta production by JAr choriocarc...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(98)91040-2

    authors： Baker VL,Murai JT,Taylor RN

    更新日期：1998-09-01 00:00:00

  • The effects of Assisted Reproductive Technologies on genomic imprinting in the placenta.

    abstract：:The placenta is a complex and poorly understood organ, which serves as the connection between the mother and the developing fetus. Genomic imprinting, defined as a regulatory process resulting in the expression of a gene in a parent-of-origin-specific manner, plays an important role in fetal development and placental ...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2019.02.013

    authors： Rhon-Calderon EA,Vrooman LA,Riesche L,Bartolomei MS

    更新日期：2019-09-01 00:00:00

  • Current topic: interferon and human placental development.

    abstract：:It will be apparent from this review that the exact role of IFN on human placental development remains largely undefined. However, there is now sufficient data available on the biological functions of this cytokine in other cellular systems to provide a conceptual framework upon which the influence of IFN on the human...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(05)80220-6

    authors： Loke YW,King A

    更新日期：1990-07-01 00:00:00

  • Discordance of umbilical coiling index between recipients and donors in twin-twin transfusion syndrome.

    abstract：INTRODUCTION:To compare the intertwin umbilical cord coiling in twin-twin transfusion syndrome (TTTS) before fetoscopic laser treatment and to correlate these with Doppler findings in both twins. METHODS:We performed a prospective study using three-dimensional (3D) ultrasound with color Doppler imaging of the umbilica...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2019.01.013

    authors： Bamberg C,Diemert A,Glosemeyer P,Tavares de Sousa M,Hecher K

    更新日期：2019-01-15 00:00:00

  • Galectin-13/PP-13 expression in term placentas of gestational diabetes mellitus pregnancies.

    abstract：INTRODUCTION:Gestational diabetes mellitus (GDM) is an increasing harm in pregnancy. Inflammatory processes in the placenta seem to have an influence on pathogenesis besides known factors like maternal BMI. Galectin-13 (gal-13) is an immunoregulatory protein, which is suspected to play a role in development of GDM in t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2014.11.019

    authors： Unverdorben L,Hüttenbrenner R,Knabl J,Jeschke U,Hutter S

    更新日期：2015-02-01 00:00:00

  • Role of low placental share in twin-twin transfusion syndrome complicated by intrauterine growth restriction.

    abstract：OBJECTIVES:Prior studies have demonstrated that donor twin survival following treatment of twin-twin transfusion syndrome (TTTS) was highly associated with donor intrauterine growth restriction (IUGR). Here, we hypothesized that donor IUGR may be attributed in part to low placental share. STUDY DESIGN:The study popula...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.05.009

    authors： Grubbs BH,Benirschke K,Korst LM,Llanes A,Yedigarova L,Chmait RH

    更新日期：2011-08-01 00:00:00

  • Histological distribution pattern of hemosiderin deposition on the chorionic plate and fetal membrane of diffuse chorioamniotic hemosiderosis related to chronic abruption oligohydramnios sequence.

    abstract：INTRODUCTION:Chronic abruption oligohydramnios sequence (CAOS) is histologically characterized by diffuse chorioamniotic hemosiderosis (DCH). However, the criteria for the histological evaluation of the extent of CAOS-related hemosiderin deposition (HD) of the membranes and the difference in HD between the chorionic pl...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2021.01.013

    authors： Ishida A,Minamiguchi S,Yamada Y,Nakagawa R,Chigusa Y,Kondoh E,Mandai M,Haga H

    更新日期：2021-01-20 00:00:00

  • Advanced oxidation protein products enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts: a possible link between oxidative stress and preeclampsia.

    abstract：:Accumulation of advanced oxidation protein products (AOPPs) is prevalent in obesity, advanced maternal age, diabetes mellitus, and polycystic ovary syndrome. Alterations in the regulation and signaling of angiogenic pathways have been recognized as a link between these conditions and pre-eclampsia. To investigate the ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2013.06.308

    authors： Huang QT,Wang SS,Zhang M,Huang LP,Tian JW,Yu YH,Wang ZJ,Zhong M

    更新日期：2013-10-01 00:00:00

  • Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system.

    abstract：INTRODUCTION:Perfluorinated alkyl acids (PFAAs) are widely used in industry and consumer products. Pregnant women are exposed to PFAAs and their presence in umbilical cord blood represents fetal exposure. Interestingly, PFAAs are substrates for organic anion transporters (OAT) of which OAT4 is expressed in human placen...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.07.119

    authors： Kummu M,Sieppi E,Koponen J,Laatio L,Vähäkangas K,Kiviranta H,Rautio A,Myllynen P

    更新日期：2015-10-01 00:00:00

  • Expression patterns of Notch receptors and their ligands Jagged and Delta in human placenta.

    abstract：:The establishment of an appropriate fetomaternal vessel system is a prerequisite for prevention of pregnancy associated pathologies. Notch receptors and ligands are manifoldly involved in vascular development and angiogenesis. To further characterize the process of human placental vasculo- and angiogenesis we investig...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2011.04.018

    authors： Herr F,Schreiner I,Baal N,Pfarrer C,Zygmunt M

    更新日期：2011-08-01 00:00:00

  • Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.

    abstract：INTRODUCTION:Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1. METHODS:Placentas from women with and without preeclampsia were collected. Prim...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2015.01.004

    authors： Li C,Raikwar NS,Santillan MK,Santillan DA,Thomas CP

    更新日期：2015-04-01 00:00:00

  • Human placenta as a target organ for cocaine action: interaction of cocaine with the placental serotonin transporter.

    abstract：:The interaction of cocaine and its analog 2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane (RTI-55) with the human placental serotonin transporter was investigated. The function of the placental serotonin transporter was assayed using three different approaches: serotonin uptake in purified human placental brush bord...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(94)90018-3

    authors： Prasad PD,Leibach FH,Mahesh VB,Ganapathy V

    更新日期：1994-04-01 00:00:00

  • Study on the expression of angiotensin II (ANG II) receptor subtype 1 (AT1R) in the placenta of pregnancy-induced hypertension.

    abstract：OBJECTIVE:To study the expression of angiotensin II (ANG II) receptor subtype 1 (AT(1)R) in the human placenta with pregnancy-induced hypertension (PIH). METHODS:Immunohistochemistry was used to detect the expression of AT(1)R in placental tissues of 30 patients with PIH and 10 patients with normal pregnancies (contro...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2004.01.026

    authors： Thapa L,He CM,Chen HP

    更新日期：2004-08-01 00:00:00

  • FLICE-inhibitory protein: expression in early and late gestation human placentas.

    abstract：:The apoptosis cascade that plays a central role in normal and pathological processes is strictly controlled, in part by FLIP (Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein), an inhibitor of caspase-8. Here, we report the expression of long and short isoforms of FLIP mRNAs and ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.08.004

    authors： Ka H,Hunt JS

    更新日期：2006-06-01 00:00:00

  • In vitro effect of antiphospholipid antibody-containing sera on basal and gonadotrophin releasing hormone-dependent human chorionic gonadotrophin release by cultured trophoblast cells.

    abstract：:Our objective was to evaluate whether antiphospholipid antibody-containing sera could play a regulatory role in signal transduction induced by gonadotrophin releasing hormone (GnRH) when incubated with normal human trophoblast cells. To test this hypothesis we established an in vitro placental culture system in which ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(95)90083-7

    authors： Di Simone N,De Carolis S,Lanzone A,Ronsisvalle E,Giannice R,Caruso A

    更新日期：1995-01-01 00:00:00

  • Placental function and structure at term is altered in broodmares fed with cereals from mid-gestation.

    abstract：INTRODUCTION:Feeding pregnant broodmares with cereal concentrates has been shown to increase maternal insulin resistance and affect foal metabolism in the short and long-term. These effects are likely to be mediated by the placenta. Here, we investigated feto-placental biometry and placental structure and function at t...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2018.02.003

    authors： Robles M,Peugnet P,Dubois C,Piumi F,Jouneau L,Bouchez O,Aubrière MC,Dahirel M,Aioun J,Wimel L,Couturier-Tarrade A,Chavatte-Palmer P

    更新日期：2018-04-01 00:00:00

  • Primate maternal placental angiography.

    abstract：BACKGROUND:In humans, it is known that blood flow is directed to the gravid uterus from two (right and left) pelvic uterine arteries. The extent of supply from the tubo-ovarian anastomosis (joining of the ovarian and uterine arteries) is unknown. The aim of this study was to delineate the arterial blood supply to the p...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2009.10.009

    authors： Balasuriya H,Bell P,Waugh R,Thompson J,Gillin A,Hennessy A,Makris A

    更新日期：2010-01-01 00:00:00

  • Placental NAD(P)H oxidase mediated superoxide generation in early pregnancy.

    abstract：:Early placental development is characterised by rapid cell differentiation and migration, matrix remodelling and angiogenesis. The enzyme NAD(P)H oxidase is a major source of superoxide anions implicated in signalling pathways regulating these processes in other systems. It is also thought to be involved in oxygen sen...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2005.02.013

    authors： Raijmakers MT,Burton GJ,Jauniaux E,Seed PT,Peters WH,Steegers EA,Poston L

    更新日期：2006-02-01 00:00:00

  • The measurement of glucocorticoid receptors in human placental cytosol.

    abstract：:Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/s0143-4004(84)80054-5

    authors： López Bernal A,Anderson AB,Turnbull AC

    更新日期：1984-03-01 00:00:00

  • Specific infiltration pattern of FOXP3+ regulatory T cells in chronic histiocytic intervillositis of unknown etiology.

    abstract：INTRODUCTION:Chronic histiocytic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by an intervillous mononuclear inflammatory infiltrate of maternal origin. Although the mechanism and origin of these lesions are currently not understood, they appear to be related to an immune conflict...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.12.004

    authors： Capuani C,Meggetto F,Duga I,Danjoux M,March M,Parant O,Brousset P,Aziza J

    更新日期：2013-02-01 00:00:00

  • Interconversion of cortisol and cortisone by 11beta-hydroxysteroid dehydrogenases type 1 and 2 in the perfused human placenta.

    abstract：:The human placenta contains two types of 11beta-hydroxysteroid dehydrogenase (11beta-HSD). The exclusive oxidase 11beta-HSD2 has been suggested to protect the fetus from high levels of maternal glucocorticoids by converting cortisol to inactive cortisone. Perfused term human placenta was used to examine the activity o...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1053/plac.1998.0352

    authors： Sun K,Adamson SL,Yang K,Challis JR

    更新日期：1999-01-01 00:00:00

  • Genomic imprinting and mammalian development.

    abstract：:Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(05)80638-1

    authors： Franklin GC,Adam GI,Ohlsson R

    更新日期：1996-01-01 00:00:00

  • Hyperglycosylated hCG.

    abstract：:Hyperglycosylated hCG (hCG-H) is a glycosylation variant of the hormone hCG. Here we review all that is known about this independently functioning molecule. As discussed, it is a very different molecule to the hormone hCG. First, hCG-H is produced by cytotrophoblast cells while regular hCG is made in syncytiotrophobla...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/j.placenta.2007.01.011

    authors： Cole LA

    更新日期：2007-10-01 00:00:00

  • Redness discordance in monochorionic twin placentas: Correlation with clinical and placental findings.

    abstract：INTRODUCTION/OBJECTIVES:Recent studies suggest redness (color) discordance of the placental basal plate may be a marker for twin anemia-polycythemia sequence (TAPS), a recently described complication of diamniotic-monochorionic twinning characterized by marked intertwin hemoglobin (Hb) discordance in the absence of oli...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2017.10.007

    authors： De Paepe ME,Gündoğan F,Mao Q,Chu S,Shapiro S

    更新日期：2017-12-01 00:00:00

  • Crossing mice deficient in eNOS with placental-specific Igf2 knockout mice: a new model of fetal growth restriction.

    abstract：:We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were n...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/j.placenta.2012.09.012

    authors： Dilworth MR,Kusinski LC,Baker BC,Renshall LJ,Baker PN,Greenwood SL,Wareing M,Sibley CP

    更新日期：2012-12-01 00:00:00

  • Isolation of phenotypically distinct trophoblast cell lines from normal rat chorioallantoic placentas.

    abstract：:Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...

    journal_title：Placenta

    pub_type： 杂志文章

    doi：10.1016/0143-4004(89)90038-6

    authors： Hunt JS,Deb S,Faria TN,Wheaton D,Soares MJ

    更新日期：1989-03-01 00:00:00

  • Human placenta: a direct target for cocaine action.

    abstract：:Use of cocaine during pregnancy is known to have harmful effects on the mother and her fetus. Currently available models describing the pathogenesis of these effects focus on the involvement of cocaine target systems, primarily the noradrenaline transporter, in the mother and the fetus. The placenta which lies between...

    journal_title：Placenta

    pub_type： 杂志文章,评审

    doi：10.1016/s0143-4004(05)80181-x

    authors： Ganapathy V,Leibach FH

    更新日期：1994-12-01 00:00:00