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Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor.

Abstract：

:Placental hypoxia as a result of impaired trophoblast invasion is suggested to be involved in the pathophysiology of preeclampsia. Hypoxia is a potent stimulus for the release of adenosine, and the actions of adenosine are mediated through four adenosine receptors, A(1), A(2A), A(2B) and A(3). We investigated the presence, distribution and expression of adenosine receptor subtypes in the human placenta, the expression of the adenosine receptors in placentas from pregnancies complicated by preeclampsia, small for gestational age (SGA) infants and uncomplicated pregnancies, and the effect of hypoxia on placental adenosine receptor expression. Immunofluorescent microscopy localized A(1), A(2A), A(2B) and A(3) adenosine receptors to the syncytiotrophoblast, endothelial cells and myofibroblasts within the human placenta. Adenosine receptor protein and message expression levels were significantly higher in placentas from preeclamptic pregnancies with or without SGA infants, but not different in pregnancies with SGA infants alone. In vitro exposure of placental villous explants to hypoxia (2% oxygen) increased the expression of A(2A) adenosine receptor 50%. These data indicate that all four known adenosine receptors are expressed in the human placenta and adenosine receptor expression is significantly higher in pregnancies complicated by preeclampsia. These data are consistent with the hypothesis that differences in placental adenosine receptors may contribute to alterations in placental function in preeclampsia.

journal_name

Placenta

journal_title

Placenta

authors

von Versen-Höynck F,Rajakumar A,Bainbridge SA,Gallaher MJ,Roberts JM,Powers RW

doi

10.1016/j.placenta.2009.02.004

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

434-42

issue

5

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(09)00063-0

journal_volume

30

pub_type

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