Abstract:
:Pre-eclampsia and placenta accreta have opposite histological features of placentation. This study set out to test the hypotheses that the sex ratios in these two pregnancy complications are opposite and that these conditions are mutually exclusive. A population-based database covering all deliveries in South Australia between 1986 and 1995 and the hospital-based obstetric database of the Adelaide Women's and Children's Hospital, covering 8549 births between 1993 and 1995, were used to ascertain the sex ratios in singleton pregnancies and the sex ratios in those pregnancies in which there was retained placenta, hypertension in pregnancy, or pre-eclampsia. The likelihood of independence of occurrence or mutual exclusivity of retained placenta and hypertension in pregnancy or pre-eclampsia were also examined. The male:female sex ratio in the South Australian population was 1.077. In pregnancies with hypertension in pregnancy it was 1.165 (P<0.001) and in pregnancies with retained placenta it was 0.883 (P<0.0001). There was a trend to an increased sex ratio in pre-eclamptic pregnancy (1.248 in primigravid and 1.092 in multigravid women) but there was insufficient power to detect significance (P=0.207 and 0.470, respectively). Neither hypertension in pregnancy nor pre-eclampsia were mutually exclusive of placenta accreta: hypertensive disorders of pregnancy and placenta accreta occurred independently of each other. Our findings suggest that sex-linked antigens are unlikely to influence maternofetal interactions consistently to give rise to one but not the other pregnancy complication.
journal_name
Placentajournal_title
Placentaauthors
Khong TY,Staples A,Chan AS,Keane RJ,Wilkinson CSdoi
10.1016/s0143-4004(98)90017-0subject
Has Abstractpub_date
1998-11-01 00:00:00pages
577-80issue
8eissn
0143-4004issn
1532-3102pii
S0143-4004(98)90017-0journal_volume
19pub_type
杂志文章相关文献
PLACENTA文献大全abstract::The syncytiotrophoblast layer plays a major role throughout pregnancy, since it is the site of numerous placental functions, including ion and nutrient exchange and the synthesis of steroid and peptide hormones required for fetal growth and development. Inadequate formation and regeneration of this tissue contributes ...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2011.11.007
更新日期:2012-02-01 00:00:00
abstract::The aim of the present study was to evaluate the relationship between the retention of fetal membranes (RFM) and apoptosis of the cells in fetal membranes. The present study investigated mRNA and protein expressions of apoptosis-regulating factors: FAS, cellular FLICE-like inhibiting protein (cFLIP), BAX, BCL2, caspas...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.10.016
更新日期:2011-01-01 00:00:00
abstract::The transcription factor Krüppel-Like Factor 6 (KLF6) has important roles in cell differentiation, angiogenesis, apoptosis, and proliferation. Furthermore, there is evidence that KLF6 is required for proper placental development. While oxygen is a critical mediator of trophoblast differentiation and function, the invo...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.07.006
更新日期:2016-09-01 00:00:00
abstract::In view of the pathological placental features of pre-eclampsia and intrauterine growth restriction (IUGR), and the angiogenic effects of vascular endothelial growth factor (VEGF), the aim of this study was to determine the expression of VEGF in placentae from normal pregnancies and to compare the results with placent...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)80061-6
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Discrepancies in the results from studies of early events in human trophoblast invasion of decidua have been acknowledged and are attributed largely to deficiencies in the accuracy of sampling of the decidual tissue used in the research. We describe a novel technique of biopsy of decidua parietalis and basal...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.02.018
更新日期:2012-06-01 00:00:00
abstract::Eighty-one placentae from women with leprosy and 17 placentae from healthy controls were subjected to a detailed macroscopic, light microscopic, ultrastructural, immunopathological, microbiological and biochemical study. The placental morphology and immunohistology were normal, and there was no morphological evidence ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(84)80028-4
更新日期:1984-05-01 00:00:00
abstract::The permeability of the rat placenta at 21 days' gestation (term is 23 days) has been measured with fetuses intact in situ and by perfusion of the fetal circulation. Intact measurements were made by removal of fetuses at known time intervals after injection of radioisotopes to the anaesthetized mother and measurement ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90049-5
更新日期:1988-07-01 00:00:00
abstract:INTRODUCTION:The velocities of the lateral shear waves (Vs; m s⁻¹) generated by an acoustic radiation force impulse (ARFI) correlate with Young's modulus. Therefore, ARFI can be used as a new method to evaluate tissue elasticity. The aim of this study was to investigate the safety of ARFI imaging and the differences in...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.08.014
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Preeclampsia (PE) is one of the leading causes of maternal mortality and morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has been a focus of research. This study was to identified genes or pathways that may be associated with PE, and discuss whether the changes in the me...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.02.009
更新日期:2020-04-01 00:00:00
abstract::Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2008.08.007
更新日期:2008-10-01 00:00:00
abstract::Alpha-fetoprotein (AFP) is a major serum glycoprotein synthesized during fetal life mainly by the yolk sac and the fetal liver. At term, it reaches high concentrations in the maternal intervillous blood, which is in direct contact with the placental trophoblastic microvillous membrane, and this suggests the placental ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0816
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Notch signalling has been shown to control cytotrophoblast (CTB) proliferation, differentiation and motility suggesting that the conserved signalling pathway could be critical for human placental development. Since individual Notch receptors have not been elucidated, we herein investigated expression patte...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.01.009
更新日期:2015-04-01 00:00:00
abstract::We present a mathematical model for maternal blood flow in a placental circulatory unit (a placentone), describing flow of maternal blood via Darcy's law and steady advective transport of a dissolved nutrient. The method of images and computational integration along streamlines are employed to find flow and solute con...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.11.003
更新日期:2010-01-01 00:00:00
abstract::During placental development, human cytotrophoblast cells can differentiate to either villous syncytiotrophoblast cells or invasive extravillous trophoblast cells. We hypothesize that oxygen tension plays a critical role in determining the pathway of cytotrophoblast differentiation. A highly purified preparation of cy...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2007.05.006
更新日期:2007-11-01 00:00:00
abstract::Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the stimulation of the onset of parturition. Recent studies have found that corticotrophin-releasing hormone (CRH), the hypothalamic component of this axis is also present in the placenta and the fetal membranes. We review the evidence d...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/0143-4004(91)90015-8
更新日期:1991-03-01 00:00:00
abstract::When cultured in keratinocyte growth medium, mononuclear cytotrophoblast cells aggregate into multicellular colonies which then fuse to form multinucleated syncytiotrophoblast. In an attempt to characterize better the mechanism of human trophoblast differentiation and to obtain information about the role of the cytosk...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80260-7
更新日期:1993-03-01 00:00:00
abstract:INTRODUCTION:Chronic histiocytic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by an intervillous mononuclear inflammatory infiltrate of maternal origin. Although the mechanism and origin of these lesions are currently not understood, they appear to be related to an immune conflict...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2012.12.004
更新日期:2013-02-01 00:00:00
abstract::We have derived a cell line, RE1, from a pre-implantation rat blastocyst, resembling morphologically the L2 cell line from a parietal yolk sac carcinoma of the rat, as well as parietal endoderm cell lines of the mouse. The sub-cellular organization and epithelial characteristics of RE1 cells are described. The cells e...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0592
更新日期:2001-01-01 00:00:00
abstract::The human placental syncytiotrophoblast is derived from differentiating cytotrophoblasts and is in contact with maternal blood. This endothelial function positions the trophoblast to regulate maternal-fetal exchange and to influence circulatory dynamics through paracrine interactions in the placenta. Two isoforms of n...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)90056-x
更新日期:1998-05-01 00:00:00
abstract::During pregnancy, changes in oxygen tension are essential for proper embryonic and placental development. Little is known about the mechanisms underlying mammalian cellular adaptations to changes in oxygen tension. Currently, we have explored putative mechanisms by which human trophoblast cells may sense oxygen. In or...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2002.0809
更新日期:2002-04-01 00:00:00
abstract::The ANP knockout mouse is reported to exhibit pregnancy-associated hypertension, proteinuria and impaired placental trophoblast invasion and spiral artery remodeling, key features of pre-eclampsia (PE). We hypothesized that these mice may provide a relevant model of human PE with associated fetal growth restriction (F...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.04.003
更新日期:2016-06-01 00:00:00
abstract::Epidermal growth factor (EGF) and its homologue, transforming growth factor-alpha (TGF-alpha), regulate human chorionic gonadotropin (hCG) synthesis in the human placenta. The current study was designed to investigate the involvement of the protein kinase C pathway in EGF-mediated hCG-beta production by JAr choriocarc...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(98)91040-2
更新日期:1998-09-01 00:00:00
abstract:INTRODUCTION:miRNAs are small non-coding RNAs important for the regulation of mRNA in many organs including placenta. Adipokines and specifically leptin are known to be dysregulated in preeclampsia, but little is known regarding their regulation by miRNAs during pregnancy. METHODS:We performed high-throughput sequenci...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2014.07.002
更新日期:2014-09-01 00:00:00
abstract::Glucose residues were revealed by light microscopic and fine structural analysis using hexokinase-gold conjugate. In human term placenta specific staining was detected over the stroma of placental villi. Colloidal gold particles were found over the collagen fibrils and reticular lamina of basal membrane. Syncytiotroph...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80203-6
更新日期:1993-09-01 00:00:00
abstract::Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.021
更新日期:2015-12-01 00:00:00
abstract:INTRODUCTION:The feto-maternal interface during bovine implantation was studied in vivo and using three-dimensional bovine endometrial (BCECph) and trophoblast spheroids (CCS), each with underlying fibroblasts. METHODS:The expression of ezrin and cytokeratin 18 (CK18) was analyzed via immunohistochemistry (IHC), RT-PC...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.06.001
更新日期:2015-08-01 00:00:00
abstract::Direct measurements of electrical potential and input resistance were performed on the syncytial membrane facing maternal blood. The potentials varied according to the external potassium ion levels and, to a lesser extent, with sodium ion concentrations. Ouabain provoked a rapid and consistent depolarization which ind...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(88)90012-4
更新日期:1988-03-01 00:00:00
abstract::Wharton's jelly contains large amounts of hyaluronic acid, and glucosamine is an important constituent of this macromolecule. In order to evaluate the placental vascular effects of this aminosugar, small chorionic and stem villous arteries were dissected from placental specimens obtained at normal term vaginal deliver...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/0143-4004(87)90069-5
更新日期:1987-07-01 00:00:00
abstract:INTRODUCTION:The most adverse perinatal outcome of intrahepatic cholestasis of pregnancy (ICP) is sudden fetal death related to acute fetoplacental hypoxia. Corticotrophin-releasing hormone (CRH), urocortin (UCN), and Wolfram syndrome 1 (WFS1) proteins may have a compensatory response to hypoxic stress. METHODS:A tota...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.06.378
更新日期:2019-08-01 00:00:00
abstract::The human placenta contains two types of 11beta-hydroxysteroid dehydrogenase (11beta-HSD). The exclusive oxidase 11beta-HSD2 has been suggested to protect the fetus from high levels of maternal glucocorticoids by converting cortisol to inactive cortisone. Perfused term human placenta was used to examine the activity o...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.1998.0352
更新日期:1999-01-01 00:00:00