Abstract:
INTRODUCTION:Research suggests that autism spectrum disorder (ASD) has its origins in utero. This study examines the association between evidence of placental histopathology and ASD. METHODS:Administrative claims data and medical records data were used to identify ASD cases (N = 55) and matched controls (N = 199) born at New York Methodist Hospital between 2007 and 2014 and subsequently seen in affiliated pediatrics clinics. Placentas from all births during this time period were reviewed as part of routine care. Data were analyzed using conditional logistic regression to account for the matched (gender, gestational age, and birth weight) design. RESULTS:Acute placental inflammation, regardless of type was associated with an increased risk of ASD (odds ratio [OR] = 3.14, 95% CI = 1.39, 6.95). Chronic uteroplacental vasculitis (OR = 7.13; 95% CI = 1.17, 43.38), the fetal inflammatory response in the chorionic plate vessels (OR = 5.12; 95% CI = 2.02, 12.96), and maternal vascular malperfusion pathology (OR = 12.29; 95% CI = 1.37, 110.69) were associated with an increased risk of ASD. Placental villous edema was associated with a decreased risk of ASD (OR = 0.05; 95% CI = 0.0005, 0.42). In subanalyses among male placentas acute inflammation overall, fetal inflammatory response in the chorionic plate vessels, and maternal vascular malperfusion pathology remained significantly associated with an increased risk of ASD whereas placental villous edema remained associated with a decreased risk of ASD. DISCUSSION:Histologic evidence of placental inflammation and maternal vascular malperfusion pathology are associated with ASD.
journal_name
Placentajournal_title
Placentaauthors
Straughen JK,Misra DP,Divine G,Shah R,Perez G,VanHorn S,Onbreyt V,Dygulska B,Schmitt R,Lederman S,Narula P,Salafia CMdoi
10.1016/j.placenta.2017.07.006subject
Has Abstractpub_date
2017-09-01 00:00:00pages
183-188eissn
0143-4004issn
1532-3102pii
S0143-4004(17)30655-0journal_volume
57pub_type
杂志文章相关文献
PLACENTA文献大全abstract::The keratin cytoskeleton is present in all trophoblast cell subtypes of the mouse and human placenta and is required to maintain the structural integrity of these cells. Recently, various genetic mouse models have shown that a normal keratin network is necessary for placental development. Keratin-deficiency leads to t...
journal_title:Placenta
pub_type:
doi:10.1016/j.placenta.2007.01.006
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:Histologic placental and/or intra-amniotic inflammation is frequently documented during ascending intra-uterine infections in patients with preterm labor and intact membranes. Placenta previa can be a clinical situation that shows the successive schema of histologic placental and intra-amniotic inflammation d...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2009.04.005
更新日期:2009-07-01 00:00:00
abstract::Minerals, such as calcium and potassium, are essential for fetal development, but their transplacental transport, and in particular, the effect of hormones on this process has not been extensively studied. Human alpha-calcitonin gene-related peptide (h alpha CGRP), a hormone constituted of 37 amino acids, is obtained ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(97)90091-6
更新日期:1997-03-01 00:00:00
abstract::Despite the vital and diverse roles of the placenta, remarkably little is known about its actual composition. Moreover, as placentophagy becomes increasingly popular, understanding the nutritional and heavy metal composition of the human placenta has practical implications. Here we evaluated the carbohydrate, sugar, p...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2017.07.013
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:Infection accounts for over 40% of preterm premature rupture of the fetal membranes (PPROM), a major cause of preterm birth. Toll-like receptors (TLR) play key roles in pathogen surveillance but their expression and function in amnion mesenchymal cells (AMC) is unclear. The aims of this study were to deter...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2016.06.005
更新日期:2016-08-01 00:00:00
abstract::The IPL/TSSC3 gene is expressed nearly exclusively from the maternal allele, and its protein product acts to limit placental growth in mice. This protein specifically marks Type II trophoblast in the labyrinthine layer of the mouse placenta. To investigate mouse-human homologies, we carried out immunohistochemistry wi...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(03)00130-9
更新日期:2003-09-01 00:00:00
abstract::Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialised topics. At IFPA meeting 2013 there were twelve themed workshops, three of which are summarized in this report. These workshops related to various aspects of placental biology but collectively covered areas of placent...
journal_title:Placenta
pub_type:
doi:10.1016/j.placenta.2013.11.009
更新日期:2014-02-01 00:00:00
abstract::Recently, the gene encoding a new stress-induced protein termed reducing agent and tunicamycin-responsive protein (RTP) was identified. The function of RTP is unknown, however, the strong upregulation of RTP during cellular differentiation, and exposure to stress conditions including hypoxia suggests a specific role f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/S0143-4004(03)00216-9
更新日期:2004-01-01 00:00:00
abstract::We present a case of intra-amniotic umbilical vein varix with thrombosis using conventional two-dimensional (2D) sonography, power Doppler, three-dimensional (3D) HD-flow, and HDlive at 35 weeks of gestation. 2D sonography showed a large banana-like umbilical cord enlargement (100 × 43.3 × 45.9 mm) including umbilical...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.08.008
更新日期:2013-11-01 00:00:00
abstract::Based on a variety of tissue samples, including Caesarean hysterectomy specimens with the placenta in situ, a detailed map of uteroplacental vascular lesions was established in over a century of research. One such lesion is acute atherosis of unremodelled basal and uteroplacental arteries, defined by the presence of f...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.06.012
更新日期:2020-08-01 00:00:00
abstract::Hypertension is one of the major clinical manifestations of preeclampsia. Vascular dysfunction is crucial for the occurrence and progression of hypertension. Exosomes are emerging as mediators of intercellular communication and can participate in angiogenesis. In this study, we hypothesize that umbilical cord plasma-d...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.10.022
更新日期:2020-10-20 00:00:00
abstract::Placentas and plasma from women with and without Chagas' disease and cultures of human placental villi with Trypanosoma cruzi, neuraminidase, phospholipase A2 and phospholipase C were analyzed in order to verify if the alterations in placental alkaline phosphatase (PLAP) enzyme activity are caused by T. cruzi as obser...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2004.08.014
更新日期:2005-11-01 00:00:00
abstract::The implantation of the blastocyst and early development of the placenta are crucial for the success of implantation and pregnancy. However, the formative stages of human placental development are largely unknown because of their existence in a 'black box' where access to samples is extremely limited for ethical reaso...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2012.01.020
更新日期:2012-05-01 00:00:00
abstract::Pregnancy induces a number of alterations to maternal physiology to accommodate the increased demands made by the developing fetus and placenta. These alterations appear at least in part to be driven by products derived from the feto-placental unit, including microchimeric cells, as well as placental exosomes and micr...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2011.11.005
更新日期:2012-02-01 00:00:00
abstract::The intrauterine environment has an important influence on placental development. In pre-eclampsia (PE) and intrauterine growth restriction (IUGR), early remodelling of spiral arteries has repercussions for uteroplacental blood flow. The IUGR placenta exhibits compromised growth of villous trees, a smaller intervillou...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.04.005
更新日期:2010-07-01 00:00:00
abstract::The effects of 8-epi-prostaglandin F(2alpha)(8-epi-PGF(2alpha)) and the thromboxane A(2)-mimetic U46619 were examined on isolated human fetal placental arteries obtained from normal pregnancies and from those complicated by pre-eclampsia. The effects of these agents were examined on both conduit and resistance arterie...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2001.0690
更新日期:2001-07-01 00:00:00
abstract:INTRODUCTION:Preeclampsia (PE) is one of the leading causes of maternal mortality and morbidity worldwide. Recently, the role of epigenetic modifications in preeclampsia has been a focus of research. This study was to identified genes or pathways that may be associated with PE, and discuss whether the changes in the me...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2020.02.009
更新日期:2020-04-01 00:00:00
abstract::Approximately 6 per cent of placentae of babies admitted to a special care paediatric unit show evidence of peripheral villous stem branch oedema. In more than half of these cases there is evidence of fibrinous vasculosis (FV) in truncal veins. The affected placentae are generally thick and of small diameter, often of...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(83)80020-4
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:Chronic villitis of unknown etiology (CVUE) and massive chronic intervillositis (MCI) are placental lesions associated with infiltration of mononuclear cells in the chorionic villi and the intervillous spaces, respectively. It is not well known whether immune cells in CVUE and MCI have similar phenotypic c...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.03.008
更新日期:2015-06-01 00:00:00
abstract::Pregnant mothers are exposed to a wide variety of foreign chemicals. This exposure is most commonly due to maternal medication, lifestyle factors, such as smoking, drug abuse, and alcohol consumption, or occupational and environmental sources. Foreign compounds may interfere with placental functions at many levels e.g...
journal_title:Placenta
pub_type: 杂志文章,评审
doi:10.1016/j.placenta.2004.09.006
更新日期:2005-05-01 00:00:00
abstract::Paracellular pathways in the haemotrichorial placenta of the rat were studied by electron microscopy using lanthanum hydroxide as an electron dense marker. Near term placentae were dually perfused in situ, adding lanthanum to the fetal perfusate. In some placentae outflow pressure on the fetal side was elevated (betwe...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1053/plac.2000.0558
更新日期:2000-09-01 00:00:00
abstract::Interactions between the highly invasive trophoblasts and the maternal uterine decidual extracellular matrix (ECM) are crucial in the determination of a successful pregnancy. Fibulin-5 (FBLN5) is a member of the fibulin family that alters cell adhesive and invasive properties and is expressed in human villous cytotrop...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2015.10.008
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:Prior studies have demonstrated that donor twin survival following treatment of twin-twin transfusion syndrome (TTTS) was highly associated with donor intrauterine growth restriction (IUGR). Here, we hypothesized that donor IUGR may be attributed in part to low placental share. STUDY DESIGN:The study popula...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2011.05.009
更新日期:2011-08-01 00:00:00
abstract::Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining wit...
journal_title:Placenta
pub_type: 杂志文章,多中心研究
doi:10.1016/j.placenta.2013.09.004
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:Abnormally invasive placenta (AIP) is a rare pregnancy complication often resulting in postpartum haemorrhage (PPH) and emergency peripartum hysterectomy (EPH). The risk of developing post traumatic stress disorder (PTSD) following unexpectedly traumatic childbirth is known however there is no evidence reg...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2019.04.004
更新日期:2019-06-01 00:00:00
abstract::Physiological data indicate that both a transcellular and a paracellular pathway are available for transfer across the human placenta but the morphological correlate of the latter is uncertain. We measured the permeability of the dually perfused human placental cotyledon to the predominantly cationic protein horseradi...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/s0143-4004(05)80249-8
更新日期:1993-01-01 00:00:00
abstract::The dynamics of nickel (Ni) uptake, transfer, retention and clearance in fetuses and late gestational rats were investigated by assessing its distributions in placenta, maternal and fetal organs and tissues during the 24 h period after a single dose of (63)Ni intraperitoneal injection on gestational day 20. Peak (63)N...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.12.021
更新日期:2011-03-01 00:00:00
abstract:UNLABELLED:Placental hypoxia has been implicated in pregnancy pathologies such as preeclampsia. We have previously reported that AQP9 is highly expressed in syncytiotrophoblast from normal placentas and shows an overexpression in preeclamptic placentas, with a lack of functionality for water transport. Up to now, the r...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.04.017
更新日期:2013-08-01 00:00:00
abstract:INTRODUCTION:Umbilical artery (UA) hemodynamics reflect blood flow and vascular resistance in the placental circulation. We examined non-invasively the hemodynamic effects of propofol, etomidate, and alphaxalone on the placental circulation of a sheep model by means of UA Doppler ultrasonography. METHODS:Eleven sheep ...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2013.06.301
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Increasing evidence suggests an association between periodontal disease and low birthweight (LBW); however the underlying molecular mechanisms are yet to be fully elucidated. In this study, we performed a microarray analysis to observe the human placental trophoblast-like BeWo cells response to lipopolysaccha...
journal_title:Placenta
pub_type: 杂志文章
doi:10.1016/j.placenta.2010.10.007
更新日期:2011-01-01 00:00:00