Abstract:
:Autophagy is an inducible catabolic process activated during compromised conditions, such as hypoxia. Neonatal encephalopathy (NE) is a syndrome of disturbed neurological function. No absolute prognostic indicators are available at birth to identify neonates at high risk to develop NE. Immunohistochemical staining with LC3 antibody was performed on 40 placentas from uneventful term singleton pregnancies with umbilical artery pH ≤ 7.00 at birth; semi-quantitative analysis was carried-out to estimate autophagy level. 6/40 (15%) neonates developed NE. Placentas from newborns with NE exhibited a higher LC3 expression. Autophagy protein expression in placentas with severe acidosis is a potential marker for poor outcome.
journal_name
Placentajournal_title
Placentaauthors
Avagliano L,Danti L,Doi P,Felis S,Guala M,Locatelli A,Maffeo I,Mecacci F,Plevani C,Simeone S,Bulfamante GPdoi
10.1016/j.placenta.2013.09.004subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1091-4issue
11eissn
0143-4004issn
1532-3102pii
S0143-4004(13)00730-3journal_volume
34pub_type
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