Vasoactive effects of 8-epi-prostaglandin F(2alpha)in isolated human placental conduit and resistance blood vessels in vitro.

abstract：INTRODUCTION:Preeclampsia is characterized by maternal endothelial dysfunction. While the mechanisms leading to preeclampsia are unclear, a factor(s) from the placenta is responsible for triggering the disease. One placental factor implicated in triggering preeclampsia is trophoblast debris which may transmit pathogeni...

journal_title：Placenta

authors： Shen F,Wei J,Snowise S,DeSousa J,Stone P,Viall C,Chen Q,Chamley L

更新日期：2014-10-01 00:00:00

abstract：:Human chorionic gonadotropin (hCG) is the first hormonal message from the placenta to the mother. It is detectable in maternal blood two days after implantation and behaves like an agonist of LH stimulating progesterone secretion by the corpus luteum. hCG has also a role in quiescence of the myometrium and local immun...

journal_title：Placenta

authors： Fournier T,Guibourdenche J,Evain-Brion D

更新日期：2015-04-01 00:00:00

abstract：:The dynamics of nickel (Ni) uptake, transfer, retention and clearance in fetuses and late gestational rats were investigated by assessing its distributions in placenta, maternal and fetal organs and tissues during the 24 h period after a single dose of (63)Ni intraperitoneal injection on gestational day 20. Peak (63)N...

journal_title：Placenta

authors： Hou YP,Gu JY,Shao YF,Song YF,Jing YH,Wu WS,Pu S

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Pregestational maternal obesity (PGMO) associates with foetoplacental vascular endothelial dysfunction and higher risk for insulin resistance in the neonate. We characterised the PGMO consequences on the insulin response of the human foetoplacental vasculature. METHODS:Umbilical veins were from pregnancies w...

journal_title：Placenta

authors： Villalobos-Labra R,Westermeier F,Pizarro C,Sáez PJ,Toledo F,Pardo F,Kusanovic JP,Mardones F,Poblete JA,Sobrevia L,Farías M

更新日期：2019-10-01 00:00:00

abstract：:Xanthine dehydrogenase/oxidase (XDH, EC 1.1.1.204, XO, EC 1.2.3.2) produces uric acid, and in the oxidase form also generates the free radical superoxide. Previous reports failed to demonstrate XDH/XO activity in human placenta. Our objective was to determine evidence of XDH/XO in human placenta. We developed a cDNA p...

journal_title：Placenta

authors： Many A,Westerhausen-Larson A,Kanbour-Shakir A,Roberts JM

更新日期：1996-07-01 00:00:00

abstract：:Chemokines are small polypeptides that attract specific leukocyte subsets by binding to cell-surface receptors. In reproductive biology, they have been implicated in ovulation, menstruation, and embryo implantation, and pathological processes such as preterm delivery, HIV infection, and endometriosis. It is known that...

journal_title：Placenta

authors： Dominguez F,Pellicer A,Simon C

更新日期：2003-10-01 00:00:00

abstract：:The uterine endometrium responds to blastocyst implantation with extensive proliferation and differentiation of stromal cells into decidual cells, forming the antimesometrial and mesometrial decidua. These undergo regression by apoptosis but as this process occurs at different time periods suggest that there is spatia...

journal_title：Placenta

authors： Correia-da-Silva G,Bell SC,Pringle JH,Teixeira NA

更新日期：2005-11-01 00:00:00

abstract：:We tested the hypothesis that crossing two mouse models of fetal growth restriction (FGR) of differing phenotype would induce more severe FGR than either model alone. Female endothelial nitric oxide synthase knockout mice (eNOS(-/-)) were mated with placental-specific Igf2 knockout males (P0). Resultant fetuses were n...

journal_title：Placenta

authors： Dilworth MR,Kusinski LC,Baker BC,Renshall LJ,Baker PN,Greenwood SL,Wareing M,Sibley CP

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The introduction of the Solomon technique for the treatment of twin-twin transfusion syndrome (TTTS) increased placental exposure to laser energy. This study aims to identify the impact of power and energy used in laser treatment on placental tissue and pregnancy outcome. METHODS:Pictures of all dye-injecte...

journal_title：Placenta

authors： Akkermans J,de Vries SM,Zhao D,Peeters SHP,Klumper FJ,Middeldorp JM,Oepkes D,Slaghekke F,Lopriore E

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To evaluate umbilical cord abnormalities predisposing to mechanical cord compression and determine their relationship to adverse clinical outcomes and stasis-associated histologic changes in the placenta. METHODS:Placental slides of 224 singleton pregnancies with gross cord abnormality (true knots, long cord...

journal_title：Placenta

authors： Tantbirojn P,Saleemuddin A,Sirois K,Crum CP,Boyd TK,Tworoger S,Parast MM

更新日期：2009-12-01 00:00:00

abstract：:The human placenta possesses a large capacity for inactivation of prostanoids. This is due to the presence of large quantities of the NAD(+)-linked 15-hydroxy-prostaglandin dehydrogenase (PGDH type I; EC 1.1.1.141). In order to investigate whether a specific localization of PGDH is at the origin of the increasing plac...

journal_title：Placenta

authors： Erwich JJ,Keirse MJ

更新日期：1992-05-01 00:00:00

abstract：:Previous studies have shown that human and mouse placentas have hematopoietic potential during mid-gestation. In this investigation, we used histological and immunohistological approaches to visualize hematopoietic cells in mouse placenta between 9.5 and 12.5 days of gestation (gd), identifying their topography and ni...

journal_title：Placenta

authors： Azevedo Portilho N,Tavares Guedes P,Croy BA,Pelajo-Machado M

更新日期：2016-11-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is a major serum glycoprotein synthesized during fetal life mainly by the yolk sac and the fetal liver. At term, it reaches high concentrations in the maternal intervillous blood, which is in direct contact with the placental trophoblastic microvillous membrane, and this suggests the placental ...

journal_title：Placenta

authors： Lafuste P,Robert B,Mondon F,Danan JL,Rossi B,Duc-Goiran P,Mignot TM,Nunez EA,Benassayag C,Ferré F

更新日期：2002-09-01 00:00:00

abstract：INTRODUCTION:The ratio of birthweight to placental weight (BW:PW) is often used as a measure of placental efficiency in humans and animals. However, ratios have properties that are known to lead to spurious results. An alternative approach is the use of residuals from regression, which reflect whether birthweight is hi...

journal_title：Placenta

authors： Christians JK,Grynspan D,Greenwood SL,Dilworth MR

更新日期：2018-08-01 00:00:00

abstract：:Human placental villi are surfaced by an outer multinucleated syncytiotrophoblast and underlying mononucleated cytotrophoblasts. Conflicting data have attributed one, or the other, of these villous trophoblast phenotypes to undergo enhanced apoptosis in complicated pregnancies, compared to term, normotensive pregnanci...

journal_title：Placenta

authors： Longtine MS,Chen B,Odibo AO,Zhong Y,Nelson DM

更新日期：2012-05-01 00:00:00

abstract：:Recent studies have illustrated the importance of placental drug transport proteins, such as P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) in limiting fetal exposure to drugs and toxins. Moreover, increasing evidence supports a role for Pgp and BCRP in the normal development and physiological functi...

journal_title：Placenta

authors： Hutson JR,Koren G,Matthews SG

更新日期：2010-05-01 00:00:00

abstract：:This study examines the vasorelaxation of isolated human placental chorionic plate arteries and the perfused fetal-placental vasculature, in vitro, to a variety of nitrovasodilator compounds including glyceryl trinitrate (GTN) sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP), S-nitroso-N-glutathione ...

journal_title：Placenta

authors： Zhang XQ,Kwek K,Read MA,Donoghue JF,Walters WA

更新日期：2001-04-01 00:00:00

abstract：:Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...

journal_title：Placenta

authors： Cetin I,Cozzi V,Antonazzo P

更新日期：2008-10-01 00:00:00

abstract：:The permeability of the rat placenta at 21 days' gestation (term is 23 days) has been measured with fetuses intact in situ and by perfusion of the fetal circulation. Intact measurements were made by removal of fetuses at known time intervals after injection of radioisotopes to the anaesthetized mother and measurement ...

journal_title：Placenta

authors： Robinson NR,Atkinson DE,Jones CJ,Sibley CP

更新日期：1988-07-01 00:00:00

abstract：:Despite the vital and diverse roles of the placenta, remarkably little is known about its actual composition. Moreover, as placentophagy becomes increasingly popular, understanding the nutritional and heavy metal composition of the human placenta has practical implications. Here we evaluated the carbohydrate, sugar, p...

journal_title：Placenta

authors： Chang S,Lodico L,Williams Z

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate whether currently available fetal Magnetic Resonance Imaging (MRI/MR) techniques are sufficient for the assessment of placental pathologies. We hypothesized that placental pathologies as detected and evaluated by MRI, would correlate with histological findings. PA...

journal_title：Placenta

authors： Linduska N,Dekan S,Messerschmidt A,Kasprian G,Brugger PC,Chalubinski K,Weber M,Prayer D

更新日期：2009-06-01 00:00:00

abstract：:Placentae from normal term pregnancies, from "normal" preterm pregnancies and from pregnancies complicated by pre-eclampsia have been analysed by computerized histometry. An immunoperoxidase technique was used to stain specifically human placental lactogen in the syncytiotrophoblast. The percentage and mass of syncyti...

journal_title：Placenta

authors： Boyd PA,Brown RA,Coghill GR,Slidders W,Stewart WJ

更新日期：1983-07-01 00:00:00

abstract：INTRODUCTION:Abnormally invasive placenta (AIP) is a rare pregnancy complication often resulting in postpartum haemorrhage (PPH) and emergency peripartum hysterectomy (EPH). The risk of developing post traumatic stress disorder (PTSD) following unexpectedly traumatic childbirth is known however there is no evidence reg...

journal_title：Placenta

authors： Tol ID,Yousif M,Collins SL

更新日期：2019-06-01 00:00:00

abstract：:Effects of placental growth factor (PGF), an angiokine product of fetal trophoblasts and maternal decidual cells, on early decidual angiogenesis are undefined. We used whole-mount immunofluorescence analyses to compare uterus and gestation day 4.5-9.5 mouse implantation sites that differed genetically in fetal or mate...

journal_title：Placenta

authors： Rätsep MT,Carmeliet P,Adams MA,Croy BA

更新日期：2014-09-01 00:00:00

abstract：:In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal ce...

journal_title：Placenta

authors： Nanaev AK,Kohnen G,Milovanov AP,Domogatsky SP,Kaufmann P

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are small single-stranded RNA molecules working as post-transcriptional modulators of gene expression. Trophoblast cells are a heterogenous group of fetal cells forming the feto-maternal interface and displaying a wide spectrum of functions. The regulation of their behavior may partly unde...

journal_title：Placenta

authors： Morales-Prieto DM,Chaiwangyen W,Ospina-Prieto S,Schneider U,Herrmann J,Gruhn B,Markert UR

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVES:To compare the distribution of placental protein 13 (PP13) in fetal and maternal blood and amnionic fluid and to correlate it with PP13 protein and mRNA in the placenta. METHODS:Umbilical arterial serum, amnionic fluid, maternal venous serum and placental tissues were collected from normal outcome pregnanci...

journal_title：Placenta

authors： Sammar M,Nisemblat S,Fleischfarb Z,Golan A,Sadan O,Meiri H,Huppertz B,Gonen R

更新日期：2011-02-01 00:00:00

abstract：:Cytosol preparations of human term placenta in Tris-HCl buffer containing dithiothreitol were incubated with [3H]dexamethasone at 4 degrees C. Under these conditions the specific binding of [3H]dexamethasone was low when compared with cytosol preparations of sheep fetal lung or ovine placenta. The inclusion of sodium ...

journal_title：Placenta

authors： López Bernal A,Anderson AB,Turnbull AC

更新日期：1984-03-01 00:00:00

abstract：:We investigated whether histological evidence of early atherosclerosis was present in the umbilical artery of 21 pregnancies complicated by severe perinatal inflammation, and 21 controls matched for gestational age, sex and birth weight. Severe chorioamnionitis with funisitis was associated with increased numbers of C...

journal_title：Placenta

authors： Rafferty AR,D'Arcy C,Cann L,Pyman J,Rogers P,Davis PG,Nowell C,Burgner D

更新日期：2017-02-01 00:00:00

abstract：:Growth characteristics and the expression of trophoblast-associated markers by six cell lines generated from midgestation chorioallantoic placentas of outbred (Holtzman) and inbred (Lewis, PVG.RT Ir8) rats were evaluated. The cells comprising all cell lines were epithelioid (contained cytokeratin-type intermediate fil...

journal_title：Placenta

authors： Hunt JS,Deb S,Faria TN,Wheaton D,Soares MJ

更新日期：1989-03-01 00:00:00