Characterization of receptors for murine pregnancy specific glycoproteins 17 and 23.

Abstract:

:In primates and rodents, trophoblast cells synthesize and secrete into the maternal circulation a family of proteins known as pregnancy specific glycoproteins (PSG). The current study was undertaken to characterize the receptor for two members of the murine PSG family, PSG17 and PSG23. Binding of recombinant PSG17 and PSG23 to CHO-K1 and L929 cells and their derived mutants was performed to determine whether these proteins bound to cell surface proteoglycans. We also examined binding of these proteins to cells transfected with syndecans and glypican-1 by flow cytometry. The interaction with glycosaminoglycans was confirmed in solid phase assays. Our results show that PSG17 binds to CD9 and to cell surface proteoglycans while PSG23 binds only to the latter. We found that the amino acids involved in CD9 binding reside in the region of highest divergence between the N1-domains of murine PSGs. For both proteins, the N-terminal domain (designated as N1) is sufficient for binding to cells and the ability to bind cell surface proteoglycans is affected by the cell line employed to generate the recombinant proteins. We conclude that while substantially different at the amino acid level, some murine PSGs share with human PSG1 the ability to bind to cell surface proteoglycans and that at least one PSG binds to more than one type of molecule on the cell surface.

journal_name

Placenta

journal_title

Placenta

authors

Sulkowski GN,Warren J,Ha CT,Dveksler GS

doi

10.1016/j.placenta.2011.05.008

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

603-10

issue

8

eissn

0143-4004

issn

1532-3102

pii

S0143-4004(11)00199-8

journal_volume

32

pub_type

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