Increased apoptosis of human fetal membranes in rupture of the membranes and chorioamnionitis.

abstract：:The placental renin-angiotensin system (RAS) is involved in placentation. We have shown that prorenin mRNA (REN) is expressed in a first trimester trophoblast cell line (HTR-8/SVneo) but not in a choriocarcinoma cell line (BeWo). We attempted to stimulate RAS expression in these cells by cAMP, 5'-aza-2'-deoxycytidine ...

journal_title：Placenta

authors： Wang Y,Pringle KG,Lumbers ER

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Pregestational maternal obesity (PGMO) associates with foetoplacental vascular endothelial dysfunction and higher risk for insulin resistance in the neonate. We characterised the PGMO consequences on the insulin response of the human foetoplacental vasculature. METHODS:Umbilical veins were from pregnancies w...

journal_title：Placenta

authors： Villalobos-Labra R,Westermeier F,Pizarro C,Sáez PJ,Toledo F,Pardo F,Kusanovic JP,Mardones F,Poblete JA,Sobrevia L,Farías M

更新日期：2019-10-01 00:00:00

abstract：:Antigenic material previously detected in human placental trophoblastic cells by immunoperoxidase staining using a goat antiserum against the feline RD114 retrovirus structural protein p30 was isolated by immunochromatography from normal syncytiotrophoblast. The antigen was used to immunize mice, and of the monoclonal...

journal_title：Placenta

authors： Wahlström T,Nieminen P,Närvänen A,Suni J,Lehtovirta P,Saksela E,Vaheri A

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that pregnancies complicated by placentas with an isolated single umbilical artery (iSUA) are at increased risk for small-for-gestational-age (SGA) births. The etiology of SGA in this population, however, remains unknown. OBJECTIVE:The primary objective of this study was to evalu...

journal_title：Placenta

authors： Battarbee AN,Palatnik A,Ernst LM,Grobman WA

更新日期：2017-11-01 00:00:00

abstract：:The proliferation and differentiation of trophoblast cells is under the control of a variety of hormones and growth factors and is influenced by nutrient availability. The intracellular signaling pathways acting downstream of these mitogenic factors and nutrients to regulate trophoblast proliferation and placental dev...

journal_title：Placenta

authors： Wen HY,Abbasi S,Kellems RE,Xia Y

更新日期：2005-04-01 00:00:00

abstract：:Transfection using cationic lipid reagents such as DharmaFECT2 is an efficient tool for introducing siRNA into primary human cytotrophoblast cells. However, we now report a limitation to the use of this method as the concentration of DharamFECT2 needed for effective siRNA delivery causes ligand-independent activation ...

journal_title：Placenta

authors： Desforges M,Westwood M

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:To examine the expression of multifunctional Na(+)-independent organic anion transporting polypeptide, termed OATP-E, involved in the transport of thyroid hormone in human placenta. METHODS:Western blot analysis was performed using a specific antibody against OATP-E in human placenta to confirm the expression ...

journal_title：Placenta

authors： Sato K,Sugawara J,Sato T,Mizutamari H,Suzuki T,Ito A,Mikkaichi T,Onogawa T,Tanemoto M,Unno M,Abe T,Okamura K

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:To gain insight into the process of labor and the effects of labor on placental gene expression, we performed a microarray analysis to identify the differentially expressed transcripts that may participate in labor onset and progression. METHODS:We compared expression profiles in placentas from 16 women who...

journal_title：Placenta

authors： Lee KJ,Shim SH,Kang KM,Kang JH,Park DY,Kim SH,Farina A,Shim SS,Cha DH

更新日期：2010-08-01 00:00:00

abstract：:The possible roles of the allantoic sac in metabolism of uteroferrin, the iron-containing, purple phosphatase, were examined. This protein, which originates in the maternal endometrium, was measured in allantoic fluid by a specific double-antibody radioimmunoassay and by its beta-mercaptoethanol-activated acid phospha...

journal_title：Placenta

authors： Buhi WC,Ducsay CA,Bartol FF,Bazer FW,Roberts RM

更新日期：1983-01-01 00:00:00

abstract：:Intrauterine growth and development can impact upon the long-term health of an individual. The fetus is dependent upon the placenta for its supply of nutrients and oxygen from the mother. In turn, the functional capacity of the placenta to supply that demand is under the control of the fetal and maternal genomes. Rece...

journal_title：Placenta

authors： Angiolini E,Fowden A,Coan P,Sandovici I,Smith P,Dean W,Burton G,Tycko B,Reik W,Sibley C,Constância M

更新日期：2006-04-01 00:00:00

abstract：:Involvement of the maternal and fetal immune systems in the events of pregnancy was generally overlooked by reproductive biologists until the mid-twentieth century when many landmark explorations were reported. Now, more than half a century later, it is well understood that with the initiation of pregnancy, immune cel...

journal_title：Placenta

authors： Hunt JS,Petroff MG

更新日期：2013-03-01 00:00:00

abstract：:The dynamics of nickel (Ni) uptake, transfer, retention and clearance in fetuses and late gestational rats were investigated by assessing its distributions in placenta, maternal and fetal organs and tissues during the 24 h period after a single dose of (63)Ni intraperitoneal injection on gestational day 20. Peak (63)N...

journal_title：Placenta

authors： Hou YP,Gu JY,Shao YF,Song YF,Jing YH,Wu WS,Pu S

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:Bioinformatics analysis indicated that the arrestin ARRDC3 was upregulated in placental tissue from patients with preeclampsia (PE). The study aimed to confirm the finding by examining placenta samples from women with and without early-onset PE and to investigate ARRDC3 roles in trophoblast function. METHODS...

journal_title：Placenta

authors： Lei D,Deng N,Wang S,Huang J,Fan C

更新日期：2020-01-01 00:00:00

abstract：:The purpose of this study was to examine evidence for the presence of activated leukocytes in the fetal membranes from patients with preterm delivery. Polymorphonuclear leukocytes in fetal membranes from seven patients with preterm delivery (26-32 weeks of gestation) were analysed using transmission electron microscop...

journal_title：Placenta

authors： Matsubara S,Yamada T,Minakami H,Watanabe T,Takizawa T,Sato I

更新日期：1999-03-01 00:00:00

abstract：INTRODUCTION:Research suggests that autism spectrum disorder (ASD) has its origins in utero. This study examines the association between evidence of placental histopathology and ASD. METHODS:Administrative claims data and medical records data were used to identify ASD cases (N = 55) and matched controls (N = 199) born...

journal_title：Placenta

authors： Straughen JK,Misra DP,Divine G,Shah R,Perez G,VanHorn S,Onbreyt V,Dygulska B,Schmitt R,Lederman S,Narula P,Salafia CM

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate whether currently available fetal Magnetic Resonance Imaging (MRI/MR) techniques are sufficient for the assessment of placental pathologies. We hypothesized that placental pathologies as detected and evaluated by MRI, would correlate with histological findings. PA...

journal_title：Placenta

authors： Linduska N,Dekan S,Messerschmidt A,Kasprian G,Brugger PC,Chalubinski K,Weber M,Prayer D

更新日期：2009-06-01 00:00:00

abstract：:Apart from during the prepartal period, the main oestrogen produced by the bovine trophoblast is oestrone sulphate (E1S) which does not bind to nuclear oestrogen receptors (ER). High steroid sulphatase (StS) activities previously detected in the maternal part of bovine placentomes (caruncles) suggest the local activat...

journal_title：Placenta

authors： Greven H,Kowalewski MP,Hoffmann B,Geyer J,Rex-Haffner M,Ugele B,Schuler G

更新日期：2007-08-01 00:00:00

abstract：:Placentae from both smoking and non-smoking mothers were studied with respect to P450-dependent xenobiotic and steroid-metabolizing reactions, GSHt activity with different substrates and umbilical blood cotinine levels. Catalytic activities were determined in both freshly prepared homogenate subfractions and subfracti...

journal_title：Placenta

authors： Pasanen M,Pelkonen O

更新日期：1990-01-01 00:00:00

abstract：:Preterm birth is a leading cause of child morbidity and mortality, so strategies to reduce early birth must remain a priority. One key approach to enhancing birth outcomes is improving maternal dietary intake. Therefore, the purpose of this review is to discuss mechanisms on perinatal status of fat-soluble nutrients (...

journal_title：Placenta

authors： Thoene M,Van Ormer M,Yuil-Valdes A,Bruett T,Natarajan SK,Mukherjee M,Thompson M,Nordgren TM,Van Lippevelde W,Overby NC,Adu-Bonsaffoh K,Anderson-Berry A,Hanson C

更新日期：2020-09-01 00:00:00

abstract：:Preeclampsia (PE) affects 5-8% of pregnancies and is responsible for 18% of maternal deaths in the US, and for long-term complications in mother and child. PE is an inflammatory state and may influence placental function in a sex-specific manner. We determined if there is a sexual dimorphism in the placental inflammat...

journal_title：Placenta

authors： Muralimanoharan S,Maloyan A,Myatt L

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Preeclampsia is characterized by a systemic inflammatory response involving cytokines, chemokines, and anti-angiogenic factors such as sFLT-1. In many other inflammatory diseases related responses are triggered by toll-like receptor (TLR) stimulation. Therefore, we tested the hypothesis that TLR stimulation ...

journal_title：Placenta

authors： Nakada E,Walley KR,Nakada T,Hu Y,von Dadelszen P,Boyd JH

更新日期：2009-09-01 00:00:00

abstract：:Genomic imprinting, which results in the mono-allelic expression of certain genes in a parent of origin-dependent manner, represents a specialized form of gene regulation which may be vitally important for mammalian development. The mechanisms which underlie imprinting and the molecular nature of the imprint itself re...

journal_title：Placenta

authors： Franklin GC,Adam GI,Ohlsson R

更新日期：1996-01-01 00:00:00

abstract：:We present a case of intra-amniotic umbilical vein varix with thrombosis using conventional two-dimensional (2D) sonography, power Doppler, three-dimensional (3D) HD-flow, and HDlive at 35 weeks of gestation. 2D sonography showed a large banana-like umbilical cord enlargement (100 × 43.3 × 45.9 mm) including umbilical...

journal_title：Placenta

authors： Kanenishi K,Nitta E,Mashima M,Hanaoka U,Koyano K,Tanaka H,Hata T

更新日期：2013-11-01 00:00:00

abstract：:ED(27) trophoblast-like cells were prepared from human chorionic villus samples obtained at 9 weeks gestation and have been grown continuously in vitro without phenotypic drift for nearly a decade. These cells express many trophoblast markers, including cytokeratin, placental alkaline phosphatase (PLAP), secretion of ...

journal_title：Placenta

authors： Kniss DA,Xie Y,Li Y,Kumar S,Linton EA,Cohen P,Fan-Havard P,Redman CW,Sargent IL

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVES:Histiotrophe is now recognized as being an important feature of early human pregnancy, providing nutrients and growth factors to the developing embryo. Our aim was to examine the glycan composition of histiotrophe from first trimester decidua and to compare it with secretions present in endometrial glands fr...

journal_title：Placenta

authors： Jones CJ,Aplin JD,Burton GJ

更新日期：2010-07-01 00:00:00

abstract：:The diversity of placental structures in Eutherian mammals is such that drawing generalizations from the definitive forms is problematic. There are always areas of reduced interhaemal distance whether the placenta is epitheliochorial, synepitheliochorial, endotheliochorial or haemochorial. However, the thinning may be...

journal_title：Placenta

authors： Enders AC,Carter AM

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Menstruation occurs only in higher primates, some bats, the spiny mouse and the elephant shrew. Our knowledge of the latter species is due to work by C. J. van der Horst. FINDINGS:Changes in the uterine stroma are initially similar in fertile and infertile cycles and are confined to a small area. In pregnan...

journal_title：Placenta

authors： Carter AM

更新日期：2018-07-01 00:00:00

abstract：:Endotheliochorial placentas occur in orders from all four major clades of eutherian mammal. Species with this type of placenta include one of the smallest (pygmy shrew) and largest (African elephant) land mammals. The endotheliochorial placenta as a definitive form has an interhemal area consisting of maternal endothe...

journal_title：Placenta

authors： Enders AC,Carter AM

更新日期：2012-05-01 00:00:00

abstract：INTRODUCTION:Infection accounts for over 40% of preterm premature rupture of the fetal membranes (PPROM), a major cause of preterm birth. Toll-like receptors (TLR) play key roles in pathogen surveillance but their expression and function in amnion mesenchymal cells (AMC) is unclear. The aims of this study were to deter...

journal_title：Placenta

authors： Sato BL,Collier ES,Vermudez SA,Junker AD,Kendal-Wright CE

更新日期：2016-08-01 00:00:00

abstract：:Forkhead box O (FoxO) proteins regulate inflammation, extracellular matrix (ECM) remodelling and apoptosis. We have previously identified FoxO1 proteins in human gestational tissues, and demonstrated a link between FoxO1 and rupture of fetal membranes. There is, however, no data available on the expression and localis...

journal_title：Placenta

authors： Lappas M,Lim R,Riley C,Menon R,Permezel M

更新日期：2010-12-01 00:00:00