Transplacental lactate dehydrogenase-elevating virus (LDV) transmission: immune inhibition of umbilical cord infection, and correlation of fetal virus susceptibility with development of F4/80 antigen expression.

abstract：INTRODUCTION:In the placenta, the (pro)renin receptor (ATP6AP2) is localised to the syncytiotrophoblast. ATP6AP2 can activate the placental renin-angiotensin system (RAS), producing Angiotensin II (Ang II) which, acting via the angiotensin II type 1 receptor (AGTR1), is important for placental development and function....

journal_title：Placenta

authors： Morosin SK,Delforce SJ,Lumbers ER,Pringle KG

更新日期：2020-08-01 00:00:00

abstract：:Stereological methods were used to test whether or not altitudinal, ethnic and sex differences in birthweight in Bolivia are associated with differences in placental morphology. Estimates of the volumes, surface areas, lengths and diameters of villi and of fetal capillaries were obtained by analysing paraffin sections...

journal_title：Placenta

authors： Jackson MR,Mayhew TM,Haas JD

更新日期：1987-09-01 00:00:00

abstract：:Embryo implantation in the human and rodents relies on the trophoblast's ability to invade into the uterine stroma, partly depending on proteinases degrading components of basement membrane and underlying extracellular matrix (ECM). We have utilized mouse trophoblast stem (TS) cells (Science, 1998, 282:2072) to study ...

journal_title：Placenta

authors： Lei T,Hohn HP,Behr R,Denker HW

更新日期：2007-01-01 00:00:00

abstract：:Workshops are an important part of the IFPA annual meeting. At the IFPA meeting 2008 diverse topics were discussed in 12 themed workshops. Topics covered included: immunology of placentation; galectins and trophoblast invasion; signaling in implantation and invasion; markers to identify trophoblast subpopulations; pla...

journal_title：Placenta

authors： Lash GE,Ansari T,Bischof P,Burton GJ,Chamley L,Crocker I,Dantzer V,Desoye G,Drewlo S,Fazleabas A,Jansson T,Keating S,Kliman HJ,Lang I,Mayhew T,Meiri H,Miller RK,Nelson DM,Pfarrer C,Roberts C,Sammar M,Sharma S,

更新日期：2009-03-01 00:00:00

abstract：:Maturation of the fetal hypothalamic-pituitary-axis may be an important factor in the stimulation of the onset of parturition. Recent studies have found that corticotrophin-releasing hormone (CRH), the hypothalamic component of this axis is also present in the placenta and the fetal membranes. We review the evidence d...

journal_title：Placenta

authors： Riley SC,Challis JR

更新日期：1991-03-01 00:00:00

abstract：INTRODUCTION:The placenta is a transient organ the functioning of which has health consequences far beyond the embryo/fetus. Understanding the biology of any system (organ, organism, single cell, etc) requires a comprehensive and inclusive approach which embraces all the biomedical disciplines and 'omic' technologies a...

journal_title：Placenta

authors： Mayhew TM

更新日期：2015-04-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is a major serum glycoprotein synthesized during fetal life mainly by the yolk sac and the fetal liver. At term, it reaches high concentrations in the maternal intervillous blood, which is in direct contact with the placental trophoblastic microvillous membrane, and this suggests the placental ...

journal_title：Placenta

authors： Lafuste P,Robert B,Mondon F,Danan JL,Rossi B,Duc-Goiran P,Mignot TM,Nunez EA,Benassayag C,Ferré F

更新日期：2002-09-01 00:00:00

abstract：:The placental endothelium contributes to regulating transplacental exchange and maintaining the immunological maternofetal barrier. We characterized the endothelial phenotype in human normal term placentae with a panel of antibodies to endothelial antigens using a standardized immunofluorescence method. Placental endo...

journal_title：Placenta

authors： Dye JF,Jablenska R,Donnelly JL,Lawrence L,Leach L,Clark P,Firth JA

更新日期：2001-01-01 00:00:00

abstract：:Somatic gene delivery in utero is a novel approach to gene therapy for genetic disease. It is based on the concept that application of gene therapy vectors to the fetus in utero may prevent the development of early disease related tissue damage, may allow targeting of otherwise inaccessible organs, tissues and still e...

journal_title：Placenta

authors： Coutelle C,Themis M,Waddington S,Gregory L,Nivsarkar M,Buckley S,Cook T,Rodeck C,Peebles D,David A

更新日期：2003-10-01 00:00:00

abstract：:Studies in primary human trophoblasts provide critical insights into placental function in normal and complicated pregnancies. Mechanistic studies in these cells require experimental tools to modulate gene expression. Lipid-based methods to transfect primary trophoblasts are fairly simple to use and allow for the effi...

journal_title：Placenta

authors： Rosario FJ,Sadovsky Y,Jansson T

更新日期：2012-10-01 00:00:00

abstract：:In view of the pathological placental features of pre-eclampsia and intrauterine growth restriction (IUGR), and the angiogenic effects of vascular endothelial growth factor (VEGF), the aim of this study was to determine the expression of VEGF in placentae from normal pregnancies and to compare the results with placent...

journal_title：Placenta

authors： Lyall F,Young A,Boswell F,Kingdom JC,Greer IA

更新日期：1997-05-01 00:00:00

abstract：:Eleven placentae and one fibroblast cell culture from pregnancies complicated by various inherited metabolic disorders, together with five chorionic villus biopsies from pregnancies at risk, were examined for ultrastructural evidence of accumulation of metabolites. Abnormal ultrastructural features were present as ear...

journal_title：Placenta

authors： Jones CJ,Lendon M,Chawner LE,Jauniaux E

更新日期：1990-09-01 00:00:00

abstract：:The aim of our work was to investigate the presence of non-selective cation channels (NSCC) in freshly isolated smooth muscle cells from the human umbilical artery (HUA), one of the vessels involved in fetal-placental circulation. We studied the electrophysiological properties of NSCC using the patch-clamp technique i...

journal_title：Placenta

authors： Raingo J,Rebolledo A,Iveli F,Grassi de Gende AO,Milesi V

更新日期：2004-09-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-G is a non-classical HLA-class I antigen which is predominantly expressed on invasive trophoblastic cells and is postulated to be a mediator of maternal-fetal tolerance. HLA-G interacts with NK cells, can present nonamer peptides and binds CD8 in an analogous manner to classical HLA-I. Th...

journal_title：Placenta

authors： van der Ven K,Pfeiffer K,Skrablin S

更新日期：2000-03-01 00:00:00

abstract：:In order to assess the characteristics of its stromal cells and the distribution of extracellular matrix proteins, we investigated, immunohistochemically and ultrastructurally, term, first and second trimester human umbilical cords. A differential distribution pattern of the various cytoskeletal proteins of stromal ce...

journal_title：Placenta

authors： Nanaev AK,Kohnen G,Milovanov AP,Domogatsky SP,Kaufmann P

更新日期：1997-01-01 00:00:00

abstract：:The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology si...

journal_title：Placenta

authors： Pantham P,Askelund KJ,Chamley LW

更新日期：2011-10-01 00:00:00

abstract：INTRODUCTION:Alcohol consumption is a common social practice among women of childbearing age. With 50% of pregnancies being unplanned, many embryos are exposed to alcohol prior to pregnancy recognition and formation of the placenta. The effects of periconceptional (PC) alcohol exposure on the placenta are unknown. MET...

journal_title：Placenta

authors： Gårdebjer EM,Cuffe JS,Pantaleon M,Wlodek ME,Moritz KM

更新日期：2014-01-01 00:00:00

abstract：:Intrauterine growth and development can impact upon the long-term health of an individual. The fetus is dependent upon the placenta for its supply of nutrients and oxygen from the mother. In turn, the functional capacity of the placenta to supply that demand is under the control of the fetal and maternal genomes. Rece...

journal_title：Placenta

authors： Angiolini E,Fowden A,Coan P,Sandovici I,Smith P,Dean W,Burton G,Tycko B,Reik W,Sibley C,Constância M

更新日期：2006-04-01 00:00:00

abstract：:The dynamics of nickel (Ni) uptake, transfer, retention and clearance in fetuses and late gestational rats were investigated by assessing its distributions in placenta, maternal and fetal organs and tissues during the 24 h period after a single dose of (63)Ni intraperitoneal injection on gestational day 20. Peak (63)N...

journal_title：Placenta

authors： Hou YP,Gu JY,Shao YF,Song YF,Jing YH,Wu WS,Pu S

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate whether currently available fetal Magnetic Resonance Imaging (MRI/MR) techniques are sufficient for the assessment of placental pathologies. We hypothesized that placental pathologies as detected and evaluated by MRI, would correlate with histological findings. PA...

journal_title：Placenta

authors： Linduska N,Dekan S,Messerschmidt A,Kasprian G,Brugger PC,Chalubinski K,Weber M,Prayer D

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:Gestational diabetes mellitus (GDM) is an increasing harm in pregnancy. Inflammatory processes in the placenta seem to have an influence on pathogenesis besides known factors like maternal BMI. Galectin-13 (gal-13) is an immunoregulatory protein, which is suspected to play a role in development of GDM in t...

journal_title：Placenta

authors： Unverdorben L,Hüttenbrenner R,Knabl J,Jeschke U,Hutter S

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:We aimed to estimate the risk of preeclampsia (PE) associated with in vitro fertilization (IVF) and potential predisposing factors responsible for the observed association. METHODS:This retrospective cohort study included 114485 pregnant women who delivered at the Nanjing Maternity and Child Health Care Hosp...

journal_title：Placenta

authors： Gui J,Ling Z,Hou X,Fan Y,Xie K,Shen R

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Adverse effects of obesity have been linked to inflammation in various tissues, but studies on placental inflammation and obesity have demonstrated conflicting findings. We sought to investigate the influence of pregravid obesity and fetal sex on placental histopathology while controlling for diabetes and hyp...

journal_title：Placenta

authors： Leon-Garcia SM,Roeder HA,Nelson KK,Liao X,Pizzo DP,Laurent LC,Parast MM,LaCoursiere DY

更新日期：2016-02-01 00:00:00

abstract：:The possible roles of cyclic AMP and protein kinase C in the release of renin from human decidual cells were investigated by examining renin release from monolayers of decidual cells exposed for 72 h to agents that increase intracellular cAMP or activate protein kinase C. Dibutyryl cAMP (10-1000 microM caused a dose-d...

journal_title：Placenta

authors： Poisner AM,Thrailkill K,Poisner R,Handwerger S

更新日期：1991-05-01 00:00:00

abstract：:Direct measurements of electrical potential and input resistance were performed on the syncytial membrane facing maternal blood. The potentials varied according to the external potassium ion levels and, to a lesser extent, with sodium ion concentrations. Ouabain provoked a rapid and consistent depolarization which ind...

journal_title：Placenta

authors： Bara M,Challier JC,Guiet-Bara A

更新日期：1988-03-01 00:00:00

abstract：:Telomeres are nucleoprotein structures located at the termini of chromosomes. They are essential for chromosome stability. Telomeres become shorter due to mitotic cycles and environmental factors. When telomeres are shortened and therefore dysfunctional, cellular senescence occurs and organ dysfunction might develop. ...

journal_title：Placenta

authors： Biron-Shental T,Sadeh-Mestechkin D,Amiel A

更新日期：2016-03-01 00:00:00

abstract：:Pregnancy-associated placental protein-A (PAPP-A), first isolated from maternal serum, has been identified as a metalloprotease cleaving insulin-like growth factor binding protein-4 (IGFBP-4). The source of PAPP-A during pregnancy is unclear. We therefore investigated PAPP-A expression during in vitro human villous cy...

journal_title：Placenta

authors： Guibourdenche J,Frendo JL,Pidoux G,Bertin G,Luton D,Muller F,Porquet D,Evain-Brion D

更新日期：2003-05-01 00:00:00

abstract：:Intrauterine inflammation contributes to neonatal infection-related morbidity. A new histological framework of placental inflammation has recently been proposed; however, the association between this method and clinical findings has not been defined. To assess the clinical relevance of this system, we studied placenta...

journal_title：Placenta

authors： Yamada N,Sato Y,Moriguchi-Goto S,Yamashita A,Kodama Y,Sameshima H,Asada Y

更新日期：2015-12-01 00:00:00

abstract：:Ovarian, endometrial and breast cancers are associated with several risk factors, such as low parity, infertility, early age at menarche, and late age at menopause. Frequently most of these risk factors coexist in infertile patients and some studies suggested that the different infertility causes can be involved in ca...

journal_title：Placenta

authors： Cetin I,Cozzi V,Antonazzo P

更新日期：2008-10-01 00:00:00

abstract：:The apoptosis cascade that plays a central role in normal and pathological processes is strictly controlled, in part by FLIP (Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein), an inhibitor of caspase-8. Here, we report the expression of long and short isoforms of FLIP mRNAs and ...

journal_title：Placenta

authors： Ka H,Hunt JS

更新日期：2006-06-01 00:00:00