Abstract:
:The deportation of trophoblast debris from the placenta was first documented over 100 years ago, and today we know that the deported material ranges from multinucleated syncytial knots/sprouts to trophoblast-derived nanoparticles. However little is known about the effect of trophoblast debris on maternal physiology since it is difficult to investigate these effects in vivo in women. Animal models have been reported but they have provided relatively little information. Most of our current knowledge regarding the effects of trophoblast debris on maternal systems is provided by studies using trophoblast debris obtained from in vitro models of the human placenta. Herein we review the animal models and the in vitro studies, which, between them, suggest that deported trophoblast material may play a role in tolerising the maternal immune system during normal pregnancy, and conversely that in pathological pregnancies aberrant maternal immune and/or endothelial/vascular responses may result from a change in either the quantity or quality of deported trophoblast debris.
journal_name
Placentajournal_title
Placentaauthors
Pantham P,Askelund KJ,Chamley LWdoi
10.1016/j.placenta.2011.06.019subject
Has Abstractpub_date
2011-10-01 00:00:00pages
724-31issue
10eissn
0143-4004issn
1532-3102pii
S0143-4004(11)00240-2journal_volume
32pub_type
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